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Comments: ‘Hypoglycemia’ is not a medically recognized term, except in connection with diabetes and various other diseases. There is little money to be made from Nutritional Medicine by doctors, because nutrients cannot be patented. ACUPUNCTURE FOR DEPRESSION: Following treatments specifically designed to address depression, 64% of the women (n = 33) experienced full remission. ADENOSINE TRIPHOSPHATE (ATP) or biological energy, is closely related to motivationsee here. ADRENALINE “Adrenaline, secreted by the medulla of the adrenal gland, is carried by the blood to the liver, where it stimulates the breakdown of glycogen to glucose, thus increasing the blood sugar levels” Lehninger 346 See: Adrenaline to Glucose image. ALCOHOLICS IN RECOVERY: Comorbid depression appears to be a significant risk factor for relapse among recovering alcoholics. Alcohol dependency is accompanied by zinc content decrease in the hippocampus Bovt VD, 2001.
Alcoholism Statistics: Approximately 4% of adult drinkers are alcoholics, a figure calculated from the known incidence of mortality caused by cirrhosis of the liver, and therefore probably a conservative estimate.
The 2006 survey indicated very little change in drinking habits, with about half of the population (50.9 percent) reported as alcohol drinkers, about one-fifth binge drinkers and about seven percent listed as heavy drinkers.
ALCOHOLISM AND VIOLENCE: “Based on clinical observations in a series of studies on Finnish alcoholic, violent offenders, we asserted that the impulsive offenders represented an extreme group of type 2 alcoholics. ALTERNATIVE SWEETENERS: There is a lot of information on the internet, some of it rather controversial. Peripheral hyperinsulinemia correlates with an abnormal removal of the amyloid beta peptide (Abeta) and an increase of tau hyperphosphorylation as a result of augmented cdk5 and GSK3beta activities. Therapeutic applications: Effects of treating insulin resistance and normalising CNS insulin.
One in three seniors die from Alzheimer’s disease– There’s more troubling news for America’s aging population: A new report finds that one in every three seniors now dies while suffering from Alzheimer’s or another form of dementia.
Gingko may be positive for Alzheimers’s disease Weinmann 2010, Kasper 2009 go to URL, but other studies show it to be ineffective.
ANTIPSYCHOTIC MEDICATIONS: Significant weight gain experiences in children using anti-psychotic drugs, such as olanzapine (Zyprexa), ariprazole (Abilify), quetiapine (Seroquel) or resipiridone (Risperdal). AMA Statement on Hypoglycemia in 1973   Because of the possible misunderstanding about the matter, three organizations of physicians and scientists (the American Diabetes Association, the Endocrine Society, and the American Medical Association) have issued the following statement for the public concerning the diagnosis and treatment of hypoglycemia: Published 5 February 1973, Statement on hypoglycemia, editorial. There is a significant association between anxiety attacks and hypoglycemia according to these sources and here.
APPLE CIDER VINEGAR: is fermented form crushed apples alcohol into acetic acid-forming bacteria into vinegar. ATTENTION DEFICIT AND HYPERACTIVITY (ADHD) DISORDER: Lendon Smith‘s article about the non-drug treatment of ADHD. Bipolar patients can benefit from lecithin, which contains 10-20% phosphatidylcholine, the precursor of the neurotransmitter acetylcholine.
BIPOLAR DISORDER AND GENES: “Linkage evidence suggests that chromosome 13 (13q32-33) contains susceptibility genes for both bipolar disorder and schizophrenia. BITTER LEMON(Mormordica charantia): also known as Balsam pear, Bitter Gourd, Karela is tropical fruit. Doctors appear to be in denial about the significance of hypoglycemia in relation to many illnesses, probably due to the fact that it can be treated without recourse to drugs. It is a popular term used by people with hypoglycemic symptoms as a result of unstable blood sugar levels, and often seen in a special Glucose Tolerance Test. There has been much reluctance by the Medical Profession to reward doctors for non-drug therapy based on Clinical Nutrition. 1998, “God belief appears to be relatively unimportant in deriving AA-related benefit, but atheist and agnostic clients are less likely to initiate and sustain AA attendance relative to spiritual and religious clients. While few major independent studies agree the success rate is that high and more than 600 studies have consistently shown the success rate to be substantially lower (18 percent at six months and less than 10 percent at five years), this has not deterred the treatment industry from proclaiming that treatment works.” Source. International comparisons of alcoholism generally rely on data on cirrhosis of the liver (the “Jellinek formula”), and it is known that cirrhosis rates are highly correlated with overall consumption levels. Source “Estimates vary, but recent studies  at UCLA show that “the top 5% of drinkers account for 42%of the nation’s total alcohol consumption.” If 5% of all drinkers account for nearly half of total alcohol sales, it would be folly for the alcohol industry to get serious about encouraging moderation.
We also observed that these subjects were vulnerable to hypoglycemia after the administration of oral glucose load. Compared to people taking another class of diabetes medications called sulfonylureas, those taking metformin had a 20 percent reduced risk of developing dementia over the five-year study period.
Glucose homeostasis is critical for energy generation, neuronal maintenance, neurogenesis, neurotransmitter regulation, cell survival and synaptic plasticity.
This leads to cellular cascades that trigger a neurodegenerative phenotype and decline in cognitive function.”Neumann KF et als (2008), Insulin resistance and Alzheimer’s Disease.
It appears it can be reversed by fluoxetine in some cases – an SSRI – indicating that it may be due to a serotonin deficiency.
15 (HealthDay News) — Diabetes patients who take a certain class of antibiotics are more likely to have severe blood sugar fluctuations than those who take other types of the drugs, a new study finds. When it occurs, it is often attended by symptoms of sweating, shakiness, trembling, anxiety, fast heart action, headache, hunger sensations, brief feelings of weakness, and, occasionally, seizures and coma.
See also:  Anxiety Attacks and Reactive Hypoglycaemia Youtube Clinical anxiety may be associated with an elevated blood lactate level and increased lactate to pyruvate ratio. Comorbid obesity and ADHD symptoms rendered treatment less successful compared to NAD counterparts. Researchers at Britain’s Oxford University Department of Biochemistry found that mannoheptulose inhibits tumor cell glucose uptake and also inhibits glucokinase, the enzyme used in glycolysis.

Recently, genes called “G72? and “G30? were identified, and polymorphisms of these overlapping genes were reported to be associated with schizophrenia. Glucose tolerance of 73% of the maturity onset diabetic patients improved with fruit juice of M.
Furthermore, brain glycogen can rebound (super-compensate) after a single episode of hypoglycemia. The difference in behaviour is thought to have something to do with the presence of large amounts of neuroglia (supporting structural tissue) found in the hypothalamus.
Moderate hypoglycemia may evoke a significant stress response, behavioral changes, and alterations in cerebral blood flow and metabolism. We as a Association will continue to support those doctors who have a professional interest in holistic medicine.
This apparent reticence to affiliate with AA ought to be clinically recognized when encouraging AA participation.” Tonigan JS, et al.
1978, “Intravenous glucose tolerance tests were given to 31 nondiabetic alcoholics and 11 healthy nonalcoholic controls. Therefore, rates of alcoholism for the countries of the world generally reflect consumption levels, so alcoholism in Canada is about average for Western countries. Furthermore, we believe that while being hypoglycemic, the impulsive offenders are particularly irritable and aggressive.” Virkkunen M, Kallio E, Rawlings R, et als. It is associated with some ‘mental’ illnesses such as anxiety, depression, bipolar disorder and schizophrenia. The increased risk was low but doctors should consider it when prescribing the class of antibiotics, known as fluoroquinolones, to people with diabetes, the researchers said. However, the majority of people with these kinds of symptoms do not have hypoglycemia; a great many patients with anxiety reactions present with similar symptoms. Reasons for the comorbidity are unknown, but may involve brain dopamine or insulin receptor activity.
We postulate that brain glycogen serves as an energy store during hypoglycemia and that it may participate in the creation of reduced physiological responses to hypoglycemia that are involved in a symptom often observed in patients with diabetes, hypoglycemia unawareness” Choi IY, et als. Figure 4 shows how the brain ‘reflects’ blood glucose levels yet the hypothalamus may have different glucose content. Below is just a small sample of the research carried out on topics under major headings in alphabetical order which has a bearing on hypoglycemia and Clinical Nutrition. This triggers the release of adrenaline and cortisol replenishing the brain with glucose (energy) again. In almost half of the alcoholics peak glucose concentration was higher and glucose elimination from the plasma was slower than in the controls.” Sereny G, Endrenyi L, Devenyi P. Cheek 1981, & Cheek 1981 (A), Holt AB et als 1980, Zinc administration improves gastric alcohol dehydrogenase activity in alcoholics, rat model, Caballeria J, 1997 Alcoholics may be deficient in zinc, an essential coenzyme in alcohol dehydrogenase. About 2200 persons annually die in Canada from cirrhosis of the liver, which is equivalent to a death rate per year of 8.0 per 100 000 population. 1994, “Partner violence is a serious problem for women in alcoholism treatment.” Chase KA, et als. In an insulin resistance condition, there is a reduced sensitivity to insulin resulting in hyperinsulinemia; this condition persists for several years before becoming full-blown diabetes. Furthermore, there is no good evidence that hypoglycemia causes depression, chronic fatigue, allergies, nervous breakdowns, alcoholism, juvenile delinquency, childhood behavior problems, drug addiction or inadequate sexual performance. While more studies are needed, it appears that normalizing an elevated blood lactate level will sometimes relieve anxiety”, Werbach, 1991, 48, Low levels of phosphorus (hypophosphatemia) may be associated with anxiety, irritability, numbness, paresthesia (subjective feelings, numbness, ‘pins and needles’) no abstract, mentioned in Werbach 1991, 53 A good web site dealing with the connection between anxiety and hypoglycemia is at Sweet Nothings. If replicated in further studies, these findings have important implications for treatment of severe and extreme obesity.” Altfas JR.
1978, A case study of a bipolar disorder with a deficiency of folate and vitamin B12 leading to pseudodementia. Hirsch MJ et als, 1996 Stoll AL, et als 1996 , however this should not be used in the depressive phase of bipolar disease.
Taken together with the earlier report, this is the first demonstration of a novel gene(s), discovered through a positional approach, independently associated with both bipolar illness and schizophrenia.” Hattori E, et als. It should also be remembered that hypoglycemia is one aspect of a much wider cluster of symptoms relating to degenerative diseases in general. 1988, “When a person is preoccupied with sex and continues to engage in compulsive sexual activity despite adverse consequences (eg, loss of marriage, job, health, freedom), he or she is a sex addict. Untreated depression may increase risk for relapse to problem drinking.” Lippmann S, et als. 1975, “It was concluded that glucose intolerance in alcoholic patients is a common finding that occurs in the presence or absence of liver damage.” Iturriaga H, et als.
Bahmer 1981, Lorentzen HF 2000, Menzano E et als 1994, Prasad AS 1991, See Zinc “The synthesis of serotonin involves Zn [zinc] enzymes and since serotonin is necessary for melatonin synthesis, a Zn deficiency may result in low levels of both hormones.
A few hundred more die of other alcohol-related conditions (poisoning, automobile accidents, etc). 2003, “The odds of severe male-to-female physical aggression were more than 11 times (11 times) higher on days of men’s drinking than on days of no drinking. See also Xylitol.   See also erythritol a fairly safe sweetener in addiction to stevia and xylitol Wikipedia See also Herbs with Hypoglycemic Effects.
Toxic levels of insulin negatively influence neuronal function and survival, and elevation of peripheral insulin concentration acutely increases its cerebrospinal fluid (CSF) concentration.
Reid SD 2000 Omega-3 fatty acids contained in fish oil may benefit people with bipolar disorder. Samra, 2003, Chapter 3 “The glucose solution produced more substantial EEG effects than the other three carbohydrate solutions.

When it comes to mood disorders, there are many other silent diseases that have an influence on our mind. Preferred treatment includes professional counseling and attendance at self-help programs based on the Alcoholics Anonymous model.” Schneider JP. 1987, “Sleep variables, anxiety, and depression are considered as possible markers of relapse in persons treated for alcoholism.” Mackenzie A, et als.
1986, “These findings indicate that glucose metabolism in alcoholics in a withdrawal state can be disturbed by impaired insulin secretion and insulin resistance.” Adner N, Nygren A. Rates of death caused by cirrhosis of the liver increase markedly with age and are higher in urban areas and in the west and north, the areas with the highest levels of alcohol consumption in Canada.
These findings support the proximal effect model of alcohol use and partner violence.” Fals-Stewart W.
For more information see: Anhedonia, Anhedonia related to clinical depression and insulin resistance. Absolute blood glucose level was the primary determinant of electrocortical changes found predominantly in the left parietal-occipital and left temporal cortical regions.
Both hypoglycemia and diabetes share Insulin Resistance and so if you want to do research into non-diabetic hypoglycemia, you need to look for medical terms such as ‘insulin resistance’, ‘hyperinsulinism’, Glucose Intolerance, hyperglycemia, HPA (hypothalamus-pituitary-adrenal axis), metabolic syndrome, cerebral glucose metabolism.
Because hypoglycemia shares with diabetes “insulin resistance”, much of the research findings concerning diabetes applies equally to hypoglycemia, but the reader should keep in mind the differences between the two, when assessing the data. Moreover, high estrogen levels tend to cause increased absorption of Cu and Cd, and smoking and eating food contaminated with Cd result in high levels of the latter. 2003, “A defect in central serotonin metabolism may manifest itself in poor impulse control leading to attempts at suicide, violence towards others, and Type II alcohol abuse. There are studies to show that the supplementation with phenylalanine (Precursor of L-tyrosine (amino acids found in food) can benefit Bipolar patients. Implications for the study and evaluation of cognitive function were discussed.” Fishbein DH, et als. Some scientists studying schizophrenia have already come up with terms such as ‘Cerebral diabetes’, ‘brain diabetes’, pointing to abnormal glucose transport systems across the membranes of brain cells.
Furthermore, ethanol ingestion increases the elimination of Zn and Mg (which acts as a cofactor for CuZnSOD)[superoxidedismutase]” Johnson S.
1987, Diabetes poses a greater risk , Frey J 2001, Prediabetes (Hypoglycemia)  linked to Alzheimer’s Disease See also Hypoglycemia and dementia. Phenylalanine with vitamin B6 are the forerunners of phenylethylamine (found in chocolate). 1990,  Nine studies showing that impairment in mitochondria energy production of ATP from glucose may be a mechanism underlying pathophysiology of psychiatric disorders, like bipolar disorder, depression and schizophrenia. This comes very close to what we understand hypoglycemia to be, but we would prefer Dr George Samra’s definition of ‘Cerebral Hypoglycia‘, in his book: The Hypoglycemic Connection II, which more accurately points out the importance of glucose transport into cell, including brain cells. Assessment revealed that 91% of the alcohol impaired drivers complained of at least some acute symptoms of depression. 2001 “Alcoholism impairs zinc absorption and increases zinc loss via urine” Milne DB et al (1993) A case study of an alcoholic with severe long-term hypoglycemia: “The probable etiology of low blood sugar in our patient was alcohol-induced inhibition of gluconeogenesis along with starvation. They showed significantly increased central noradrenaline metabolism, perhaps related to sensation seeking.” Roy A, Linnoila M.
2003, “CONCLUSIONS: The results of this study suggest that bipolar disorder is associated with alterations in the metabolism of cytosolic, choline-containing compounds in the anterior cingulate cortex.
However, in total 38% of the sample showed significant signs of a clinical psychiatric syndrome (one requiring intervention or treatment) in addition to alcohol dependence.” Sutton LR.
As this resonance arises primarily from phosphocholine and glycerophosphocholine, both of which are metabolites of phosphatidylcholine, these results are consistent with impaired intraneuronal signaling mechanisms.” Moore CM, et als. It is to be expected that the medical science will soon recognize ‘hypoglycemia’, although this term may not be used. Ten months in to follow-up patient is still in persistent vegetative state with no noticeable neurological recovery.” Jain H, et als.
Until such time when medical scientists can agree on a common term, we will be using the popular term ‘hypoglycemia’. 2002, “acute alcohol consumption brings on hypoglycemia in many individuals, since it inhibits gluconeogenesis from lactate and amino acids” Lehninger, 762 Hypoglycemia may be antecedent: “The origin of this atypical blood glucose response may antedate the onset of alcoholism, or it may be secondary to alcohol-related damage that persists beyond 6 months. The point is that ‘hypoglycemia’ is a real disease and is forgotten by the medical profession.
These findings indicate that nutrition therapy can aid in the recovery from alcoholism.” Biery JR, at als.
Previous accounts of increased sweet consumption in alcoholics were not substantiated, although they may be present in the peri-withdrawal period.” Umhau JC, et als.
The scarcity of research into hypoglycemia is due, no doubt, to the fact that most medical research is carried out by global pharmaceutical companies with an eye on profits for their investors. The financial reward for the production of xenobiotic chemical agents cannot be matched by scientific research about nutritional influences on disease and mental disorders without a ‘profit’ component.
For a critical view of the benefits of pharmaceuticals on our health see: Death by Medicine by Gary Null et als.

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