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Steve Jobs died regretting that he had spent so long attempting to treat his cancer with alternative medicine before agreeing to undergo surgery, his biographer has disclosed.
The Apple chief executive, who died this month after a pancreatic tumour spread elsewhere, delayed having operations and chemotherapy for nine months after the disease was discovered in October 2003. He reportedly restricted his diet to just fruits or just fruits and vegetables, tried out something called hydrotherapy and consulted psychics. And, although Jobs’s unconventional early-treatment choices may not have done much to stave off the spread of deadly cancer cells in his case, they provide an opportunity to discuss what makes cancer grow and how to stop it. Unlike the vast majority of pancreatic cancers (known as pancreatic adenocarcinomas) of the ductal part of the pancreas, pNET is not always deadly. For patients in whom this cancer has spread outside the pancreas, the median survival is 27 months. It’s impossible to know whether surgery would have been curative if Jobs had undergone the procedure at the time of his diagnosis. Acupuncture has gained traction in Western medicine as a helpful complementary component to cancer care. But although it may have contributed to overall well-being, acupuncture is unlikely to have had an impact on the tumor itself. As Tim Birdsall, vice president of integrative medicine at the Cancer Treatment Centers of America, explains it, cancer is a disease in which the cells become less and less responsive to their external environment. But, Birdsall says, natural therapies such as those reportedly taken by Jobs center on altering the bodily environment, not the tumor itself.

Could Jobs have put himself in greater danger by delaying surgery in favor of alternative medicine?
Evidence isn’t available showing whether the juice fasting Jobs reportedly tried accelerated the spread of cancer cells in his pancreas, and possibly other organs, but Abrams notes that he rarely recommends juicing to the cancer patients he counsels. Many news outlets have reported that Jobs had insulinoma, meaning it was the insulin-producing endocrine cells that had turned cancerous. Yet as it turns out, the idea of starving cancer cells turns out to be a key mechanism behind some of the latest medical treatments for pNET. Dietary change alone is insufficient to trigger autophagy because the human body can simply shift to converting muscle and amino acids into energy.
With few facts available, we can only speculate about whether the approach that Jobs took early on had any impact on his survival. A healthy Pancreas cannot get sick, it depends also on how good are you cleaning toxins from your body, how strong is your Immune Systems, living stressful life?
In any case, a mounting body of scientific and anecdotal reports provides compelling evidence about the potential impact, both positive and negative, of so-called complementary practices on the health and longevity of cancer patients following their diagnosis. Accounting for about 1 percent of all pancreatic cancers, pNET is a cancer of the endocrine cells, known clinically as the islets of Langerhans, which exist in small clusters throughout the pancreas. These cancer cells tend to be slow growing, and so the cancer does not spread to other sites in the body as quickly. Some clinical studies have confirmed the efficacy of this traditional Chinese medicine approach, in which needles are shallowly inserted at different points on the body, in diminishing the nausea, pain and fatigue that often follow chemotherapy, radiation and surgery, the mainstays of modern cancer treatment.
Multiple mutations in DNA—specifically, abnormalities in the p21 and p53 genes, among other changes—stop the process of apoptosis, or programmed cell death, that normal cells undergo. Because pNET grows so slowly, it’s unlikely that much damage was done either, says Yao, who often monitors pNET patients before recommending therapeutic intervention. Drinking squeezed juice delivers an intense burst of sugar to cells that would otherwise be moderated by the fiber within a fruit. In addition to producing potentially dangerous levels of insulin, the process can also harm the body overall.

He also emphasizes the importance of decreasing stress because it produces cortisol, a steroid hormone that suppresses the immune system. The growth of pNET malignant cells is closely tied to a cellular pathway known as mTOR (mammalian target of rapamycin). Take our FREE Health Assessment  to learn which of your body systems needs the most attention. These cells produce hormones such as insulin, which lowers blood sugar, and glucagon, which increases it. In addition to becoming immortal, cancer cells invade the surrounding tissue, rendering it nonfunctional.
As Yao explains, one of the functions of the mTOR pathway is to sense if a cell is not receiving its necessary nutrients.
Food and Drug Administration for the treatment of advanced pNET, the first drug in this class approved for this disease. For patients whose disease is detected while it’s still confined to the pancreas, the five-year survival rate is 87 percent—in other words, the majority of patients live for quite a while.
When that happens, mTOR can trigger the production of proteins, including several that promote cell proliferation and the growth of blood vessels.
And from the perspective of a cancer cell, fresh-squeezed juice is no different from sugary cola. In normal cells, the mTOR pathway can be turned on and off, but in some cancers mTOR becomes impossible to switch off, and the cells are left to grow without any regulation. He now provides consultations for cancer patients undergoing traditional treatment who want to incorporate complementary (or alternative) approaches into their care. As a result, the cell begins a process known as autophagy, in which it begins digesting parts of itself to try to survive—but it doesn’t.

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