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Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes. T cells, a type of white blood cells, generate immune responses to pathogens and are important in controlling infections. Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept. Genocea plans to move into Phase 2 of this trial in 2014 to further evaluate GEN 003’s safety and effectiveness in a larger group of patients. At unpredictable times in those carrying the infection, the herpes virus will come out of hiding and  surface on the genitals, sometimes producing blisters and discomfort, and sometimes arising without any noticeable symptoms.  This surfacing is called viral shedding. The results also demonstrated that immunization with GEN-003 is associated with activation of T cell immunity. The first-in-human clinical trial was not designed to test whether GEN-003 lessens symptoms or lowers how often a breakout occurs.
Genocea developed the proprietary platform ATLAS, which can identify protective T cell antigens in people exposed to a pathogen. The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M.
Justin Caba Justin Caba is a reporter for Medical Daily focusing on nutrition, fitness, and all things athletic.
A University of Queensland spin-off company is about to start clinical trials that could result in the prevention and treatment of genital herpes.
Now, Coridon Pty Ltd will soon start a Phase I HSV-2 vaccine clinical trial in Brisbane, Australia. The World Health Organization (WHO) estimates that more than half a billion people aged 15-49 years are living with HSV-2 worldwide. The vaccine will be injected into the forearms of 20 healthy volunteers in a trial designed to demonstrate its safety and how well it is tolerated. The Phase I clinical trial will be undertaken through Q-Pharm Pty Ltd's clinical trial site at the Royal Brisbane and Women's Hospital. Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff. Early clinical trials in the United States have found the vaccine can prevent infection in three out of four women. An estimated 100m people around the world are infected with what is known as herpes simplex virus type 2. The virus can cause painful itching and sores that in some cases reappear years after infection.
However, many people do not have symptoms and can therefore pass on the infection without knowing it. A vaccine could be of real benefit to the thousands of infants born every year with the virus. Dr Lawrence Stanberry and colleagues at the University of Texas Medical Branch tested the vaccine on 978 women and 1,736 men whose partners had genital herpes. Each received three injections containing the vaccine or injections containing a placebo over the course of six months.
The researchers found that the vaccine did not work well in women who had been infected with a related virus - herpes simplex virus 1. GlaxoSmithKline is now recruiting 7,550 women between the ages of 18 and 30 across the US for final stage clinical trials. The UK Herpes Viruses Association said most new cases of genital herpes are actually caused by herpes simplex virus 1 - the virus that causes cold sores. Marian Nicholson, its director, said there was a need to tackle the stigma around the virus. While the collaboration between Sanofi Pasteur (Sanofi) and Immune Design to develop a genital herpes vaccine presents a strong scientific foundation and difficult-to-match financial clout, the partnership needs to create a product with better clinical performance to compete with more advanced pipeline vaccine candidates, says an analyst with research and consulting firm GlobalData.

According to a recent announcement, Sanofi’s HSV-529, currently in Phase I of clinical trials, and Immune Design’s G103, a preclinical vaccine candidate, will be tested together in various formulations. Cheng comments: “As with previous and current genital herpes vaccine candidates, Sanofi’s HSV-529 mainly focuses on inducing B and T cell immune responses.
The analyst adds that while Sanofi and Immune Design may benefit from increased research and development expertise and financial backing, they face competition from several firms possessing more advanced pipeline candidates. Preventing disease and detecting disease early, if it occurs, are important to living a healthy life. Agenus Inc said a trial of its experimental genital herpes vaccine reduced the rate at which patients released the virus, reducing the likelihood of infecting others, sending its shares up 32 percent in premarket trading.
The 15 percent reduction in the release of the virus by patients receiving the vaccine in a mid-stage trial compared to those on a placebo, who showed no reduction. The mid-stage trial had 80 patients with a history of 1-9 herpes recurrences within the prior 12 months.
The trial tested the efficacy of the vaccine by measuring the release of the virus by patients 45 days before and after three injections of HerpV. Genital herpes, a highly contagious sexually transmitted infection, is usually caused by the herpes simplex virus (HSV). Agenus said it expected more data in the first half of 2014, showing how the patients fared after the booster shots. The company’s partners are also testing the QS-21 Stimulon adjuvant in combination with other vaccines.
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This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc. Anna Wald, University of Washington professor of medicine and laboratory medicine in the School of Medicine and professor of epidemiology in the School of Public Health, is among those leading clinical studies of GEN-003. David Koelle’s lab in the Division of Allergy and Infectious Diseases, Department of Medicine.
T cell vaccine research is trying to find safe, effective ways to spur this protective reaction.
12 at a session of the Interscience Conference on Antimicrobials Agents and Chemotherapy in Denver. The infection can provoke recurring episodes of painful genital sores.  An estimated 50 million to 60 million Americans are affected.
In those receiving the vaccine candidate, T cell immune responses increased more than 20 times to one vaccine antigen and more than 10 times to another antigen.  The vaccine candidate also increased neutralizing antibodies to the herpes simplex 2 by five times greater than baseline amounts. However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus. Sex frequency in relationships can influence overall feelings about a partner and the relationship.
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16, 2013) - A University of Queensland spin-off company is about to start clinical trials that could result in the prevention and treatment of genital herpes. It affects hundreds of thousands of people, threatens newborn babies and is believed to contribute to the development of HIV.
The trial will also serve to determine the effective dose of the vaccine and test if it generates a robust immune response. However, half of those infants who contract the virus die unless they receive powerful antiviral drugs. Sanofi will cover all development costs, with Immune Design receiving milestone and royalty payments from any resulting commercialized product.

While this vaccine demonstrated solid immunogenicity and protection against genital herpes in guinea pigs, there is no guarantee that these results can be replicated in humans. Meanwhile, Agenus announced in June that its vaccine candidate, HerpV, produced significant reduction in viral load in a Phase II clinical trial, which is near completion. Food and Pharma Systems Srl HunterLab IDBS IONICON Analytik GmbH kbiosystems ltd L.B. A majority of the patients also received a booster injection, given 6 months after the first vaccination. There are two types of HSV and Agenus’s vaccine targets HSV type 2, which most often causes genital herpes. Centers for Disease Control and Prevention, 776,000 people in the United States get new herpes infections annually and one out of six people aged 14 to 49 years has genital HSV-2 infection.
Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases.
Viral shedding is a marker both of the risk of recurrence and the transmission of infection. The adjuvant has a product that, in previous clinical studies, has been shown to stimulate B and T cell immune responses. Reducing the frequency of viral shedding is the first step to showing that a drug can reduce outbreaks or, potentially, sexual transmission to partners. Bohle Maschinen + Verfahren GmbH LabWare Linkam Scientific Instruments Limited MKS Umetrics Molins Technologies Nanosurf New England Biolabs, Inc.
Maintaining or improving your health is important - and a focus on regular preventive care, along with following the advice of your doctor, can help you stay healthy.
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Researchers have removed two key proteins from the vaccine virus to prevent the spread of genital herpes. Blood samples will be taken from each participant at the end of the study to determine if HSV529 effectively stimulates the immune system to fight off the herpes virus.

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  • Linkin_Park, 10.09.2015 at 20:23:31
    Oil) and rub directly on any sores or blisters for some skilled burning and itching sensations.
  • LOVELYBOY, 10.09.2015 at 23:58:23
    Patients 1 who had no or diminished outbreaks.
  • GOZEL_2008, 10.09.2015 at 19:48:13
    Usually people carry the any.