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Anyone can submit a comment any time after publication, but only those submitted within 4 weeks of an article’s publication will be considered for print publication. From Chiron Biocine, Emeryville, California, and the University of Washington School of Medicine, Seattle, Washington.
Requests for Reprints: Andria Langenberg, MD, Chiron Biocine, Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608. Tagged: microbiology, virology, herpesvirus, herpes, virus, diagram, life cycle, infection, pathogen, disease, . Disclaimer: I reblog and post images which are mostly from other sources, so I try to cite them as best I can.
Photograph of the patient's nasal lesion caused by herpes simplex virus reactivation mimicking necrotizing fasciitis. One month after publication, editors review all posted comments and select some for publication in the Letters section of the print version of Annals.

One hundred thirty-three patients were seropositive for only HSV-2 by Western blot, and 249 patients were HSV-1-seropositive only. I try to post things relating to what's going on in the laboratory and also some other things of interest.
I do not intend ot infringe copyright, so if I give the wrong source, please tell me and I'll try to fix it. Herpes simplex 2 is an infection which appears on the epidermis in the genital area in which red sores or blisters appear.
Among HSV-1-seropositive patients, one immunization produced increases in gD2 and gB2 ELISA antibody titers and HSV-2-neutralizing antibody titers that were 3 to 5 times greater than those in persons with naturally acquired HSV-2 infection. The dose of each glycoprotein at each injection and the number of patients receiving each dose are shown.
Herpes simplex virus type 2 neutralizing antibodies in patients 2 weeks after the third immunization with the 30- micrograms vaccine.

Cause of Outbreaks General illness Fatigue Physical or emotional stress Immunosuppression Trauma to infected area Menstruation Signs and Symptoms Sores around the genitals or rectum in males and on the vagina, cervix, or buttocks area in females Blisters around the infected areas Fluid-filled blisters that form painful, crusted sores on the genitals, anus, thighs, or buttocks.
Among HSV-seronegative patients, frequency analysis assays showed a marked increase in the precursor frequency of gD2- and gB2-specific T cells after vaccination: T-cell responses after two immunizations were equal to the responses of HSV-2-seropositive patients and were sustained at day 180. The geometric mean titer (GMT) to glycoproteins B2 and D2 for persons with naturally acquired HSV-2 infection are 3560 and 1209, respectively (see text).
The virus lies inactive in the nerve cells until something triggers it to become active again.

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