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admin 18.03.2015

Our FocusTuberculosis, caused by Mycobacterium tuberculosis, causes one in four avoidable deaths in the Third World and kills more adults than malaria, AIDS, and all tropical diseases combined.
It is the home of exciting research on the "death defying" pathogen, Mycobacterium tuberculosis. In recent years, there have been dramatic increases in the numbers of new cases worldwide - one of the consequences of the AIDS epidemic.


These alarming trends have caused the World Health Organization to declare tuberculosis a global health emergency, a distinction never accorded another disease.
My laboratory has focused its efforts on developing systems to genetically manipulate mycobacteria, particularly M. These tools have allowed us to: 1) develop the luciferase reporter phage assay for rapid assessment of drug susceptibilities, 2) analyze the genes involved in resistance to tuberculosis drugs such as isoniazid, ethionamide, and etyhambutol, and 3) to identify specific phenotypic properties associated with a tuberculosis pathogenesis.





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