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The May 28 issue of The Federal Register described the study which supported the approval of meropenem for “complicated intra-abdominal infections” in children under 3 months of age. The NICHD commissioned the study to investigate meropenem use in 200 infants under 3 months of age, including premature infants.
Local workers were doing their best to treat friends and neighbors, many of whom would be lost. Wilson, a resident of Lenox and nurse with the Berkshire Visiting Nurses Association & Hospice, had experience setting up treatment centers in to fight cholera in Haiti, malnutrition in Chad and unhealthy cooking fuels in Zambia. Having traveled by plane and jeep into Liberia, the final leg of the trip was by canoe, floating all their personnel, supplies and equipment into Foya, Wilson said.
Upon arrival, she recalled, the people were welcoming to the newcomers, but a bit suspicious and fearful at the same time. Training health care workers on donning and using the protective gear, how to use IVs on patients, how to sanitize gear, and training all the support staff was a tough job and had to be done quickly, she noted.
By the time Wilson left on Oct 5, there had been no fresh Ebola cases at the clinic for two weeks. Now that she's home, one of Wilson's main concerns is for the friends she trained and worked with for more than a month in very stressful conditions.
Since the outbreak started in December, there have been more than 13,000 cases and more than 4,800 people lost to Ebola in the West African nations of Liberia, Sierre Leone and Guinea. According to Wendy McWeenie, a resident of Williamstown and advisor to the United Nations on health care financing in under-developed areas, Ebola has not only left the Liberian health system and economy in shambles, it has also left many of its citizens distrustful of health care workers and clinics.
In Liberia, McWeenie said, many more children are expected to die from malaria because parents of sick children fear going to the clinic — they think they could catch Ebola or that the clinic workers would think their child has Ebola and put them in quarantine. For the same fears, women giving birth don't seek help at clinics anymore, so the infant mortality rate also is expected to increase. Liberian President Ellen Johnson Sirleaf on Thursday lifted a state of emergency imposed to control the outbreak. Welcome to your discussion forum: Click the login link below to sign in with or to set up a Disqus account or to access your social networking account.
In a radio address she told the nation that night curfews would be reduced, weekly markets could take place and preparations were being made for the re-opening of schools. At a site yet to be officially announced, funded by the Wellcome Trust and led by the University of Oxford, using the antiviral drug brincidofovir.
In Gueckedou, Guinea, led by the French National Institute of Health and Medical Research (Inserm), using the antiviral drug favipiravir.

Around 400 people participate in the first trials and they will be extended to other centres if the early results are promising. US Secretary of State John Kerry is in Geneva in an attempt to bolster a fragile, partial ceasefire in Syria as fighting rages in Aleppo. Staff at a hospital in China have drawn lots on who will treat China’s first reported case of Mers.
Coronavirus- catches you 50% sure you will die Middle East Respiratory Syndrome MERS-CoV) Alert !!! Among preterm infants, intestinal perforation or leakage — which is part of complicated intra-abdominal infection — may be life threatening. The drug has been previously approved to treat complicated intra-abdominal infections and complicated skin infections in adults and older children, and for treating children 3 months of age and older with bacterial meningitis — an infection of the fluid bathing the brain and spinal cord. Zajicek explained that physicians often need to extrapolate from studies of adults when prescribing for pediatric patients, because many drugs have never been tested specifically for use in children. Researchers examined how the drug was absorbed and distributed throughout the body, and used that information to develop dosing recommendations for different age groups of infants, including premature infants of different ages. Wilson and a handful of other international care workers were tasked with the responsibility of setting up a 120-bed Ebola clinic, training and equipping dozens of local health care workers, and educating communities on Ebola prevention.
The visitors had to navigate carefully to learn the culture while educating folks about sanitation, prevention and how to change customs to better protect against spreading Ebola.
If the deceased was a victim of Ebola, many of the funeral-goers would contract the disease, Wilson said. Once the clinic was up and running, one of the big challenges was actually working in the protective suits in oppressive heat.
For them, she said, the dangers are still there, and the outbreak has left the Liberian health system, economy and government in extremely difficult circumstances that will take years to overcome. The World Health Organization also reports that 546 health workers have been infected with Ebola, of whom 310 have died. She said the outbreak is not over, that there are still surges in new patients in some areas, but that enough progress has been made to lift emergency measures. TrialsOne trial involves using the blood of recovered Ebola patients to treat sick people in the Guinean capital Conakry.
Prof Peter Horby, from the University of Oxford, said: "There's a great need for these trials. Figures for Liberia, Sierra Leone and Guinea up to 9 November, while those for Mali, Nigeria and the US up to 11 November.

Food and Drug Administration for treating abdominal infections in children less than 3 months of age. The study was undertaken under the terms of the Best Pharmaceuticals for Children Act, which directed NIH to conduct studies on drugs used in children but not previously tested in children or in specific pediatric age groups. During the last several years, physicians have begun prescribing meropenem for preterm infants with serious abdominal infections.
However, because of their smaller size, differences in metabolism, and other physical differences from adults, many drugs may affect children differently than they do adults. The nurses and workers had no masks or gloves, and feces and vomit covered the floors and sheets.
It was not uncommon, Wilson said, for a young pregnant woman suffering from Ebola to deliver her baby stillborn and pass away a few hours later. They were taught to sanitize and wrap the bodies of the deceased, and shown proper burial techniques.
The shifts were short, and the workers came out of the gear soaked in sweat.Debbie Wilson, who treated many victims of the disease during her time in Liberia, poses with some of the local health care personnel she trained and assisted. The approval came after a study by a National Institutes of Health research network evaluated the drug in treating children in this age group.
Because they lacked an effective alternative, many physicians had prescribed the drug for a use other than what the FDA had approved.
Under the Best Pharmaceuticals for Children Act, NICHD works with FDA to identify drugs not tested in children to determine if they are appropriate for use in children. Based on this study, treatment of infants with meropenem was safe and was not associated with increased risk for serious side effects.
And setting up their own blood analysis lab was a real boon — it cut the time needed to find out if someone had Ebola from three days to five hours. Comments made here are the sole responsibility of the person posting them; these comments do not reflect the opinion of The Berkshire Eagle. The NIH study was undertaken in response to a written request from the FDA to evaluate the dosing and safety of meropenem in the treatment of complicated intra-abdominal infections in infants under 3 months of age.
That reduced the time they had to quarantine folks who didn't have it, thus preventing many of them from contracting Ebola while in quarantine.

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