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Children who take certain antibiotics called macrolides to treat an infection may experience changes in their gut bacteria, a new study suggests.
And children given more than two courses of macrolides during the first two years of life may face an increased risk of developing asthma and becoming overweight later in childhood, according to the findings. Macrolides include azithromycin and erythromycin, and are used for treating lung and chest infections. In the study of 142 Finnish children ages 2 to 7, the researchers looked at how many courses of antibiotics the children had received in their lifetimes, and the composition of their gut bacteria.
They found that, among the children who had taken macrolides in the past two years, there were differences in the composition of their gut bacteria, compared with the children who had not taken these antibiotics.
The new findings support the recommendation to avoid using macrolides as the primary antibiotics in children, and restrict the use of all antibiotics to when they are genuinely needed, the researchers said. When it comes to using antibiotics in kids, it is important to find the right balance, said Dr. Although overusing these medicines, or being too quick to use them, is not good, it is still appropriate to prescribe them if a child really needs them, she said. Gut microbes promote human health by fighting off pathogens, but they also contribute to diseases such as diabetes and cancer.
A group of Portuguese and Spanish researchers found that a chemical signal called autoinducer-2 (AI-2), which bacteria use to communicate with each other, can promote the right balance of gut microbes in antibiotic-treated mice.
Antibiotic use and dietary factors can change the composition of gut microbes and strongly reduce bacterial diversity, posing a serious threat to human health by increasing host susceptibility to harmful pathogens such as Salmonella. To test this idea, Xavier and her team focused on a small diffusible molecule called AI-2, which fosters interspecies communication throughout the bacterial kingdom.
To manipulate AI-2 levels in the mouse gut, the researchers constructed an Escherichia coli mutant that was deficient at absorbing AI-2 from the environment.
Moving forward, the researchers will examine whether AI-2 accelerates the recovery of the protective functions of gut microbes against pathogens and infectious disease after antibiotic treatment. For the first time a study led by researchers at Macquarie University has observed the presence of individual personality differences in Port Jackson sharks. Humans have changed the world's oceans in ways that have been devastating to many marine species.
A relationship that has lasted for 100 million years is at serious risk of ending, due to the effects of environmental and climate change.
The simple act of water droplets landing on a leaf causes an elaborate response inside of plants, scientists at The University of Western Australia have found.

The big news in the past few weeks has been a new study examining the effects of artificial sweeteners on the gut microbiome. Here’s a readable but thorough description with some other studies for context, from Mark’s Daily Apple.
Here’s some great in-depth reporting about the massive problem of antibiotic abuse in factory farms and how it’s about to destroy the medicines we all take for granted. Articles and information on this website may not be copied, reprinted, or redistributed without written permission. Due to its effect on the GI system, antibiotics in early life may raise infectious disease risk in later years. Researchers from the University of Chicago (Illinois, USA) report that social isolation may be detrimental to both mental and physical health. Separately, Rush University Medical Center (Illinois, USA) researchers studied 906 older men and women, testing their motor functions (including grip, pinch strength, balance, and walking) and surveying their social activity, for a period of 5 years. This site complies with the HONcode standard for trustworthy health information: verify here.
These differences had persisted since the children had taken the antibiotics, for as long as two years. Punita Ponda, assistant chief in the Division of Allergy and Immunology at Northwell Health in Great Neck, New York, who was not involved in the new study. A study published March 19th by Cell Reports reveals a potential strategy for tipping the balance in favor of good bacteria by altering the composition of the microbial community. The findings pave the way for therapeutic strategies that harness the chemical language of bacteria to foster a healthy community of gut microbes. In particular, shifts in the balance between Bacteroidetes and Firmicutesa€”the two predominant phyla in the mammalian guta€”are associated with obesity, diabetes, chronic inflammatory bowel diseases, and gastrointestinal cancer. AI-2 produced by one species can influence gene expression in another species, enabling the entire population to synchronously regulate behaviors such as virulence and biofilm formation. When this mutant was introduced into the gastrointestinal tract of mice that were being treated with an antibiotic, the resulting increase in intestinal AI-2 levels altered the composition of gut microbes to favor the expansion of the Firmicutes phylum, which had been almost eliminated by the antibiotic.
They will also determine the various functions of AI-2 signaling by examining how it affects gene expression in bacteria, as well as identify new bacterial receptors for AI-2 and other chemical signals.
The researchers found evidence that some sweeteners may reduce glucose tolerance even in amounts that normal people might reasonably eat.
A well-chosen supplement can add great things to your diet, but playing with powerful botanicals always has a risk.

Imagine a world where strep throat is potentially deadly: if we don’t get this fixed, that world could be here very soon. If only the public campaign to eat more organ meats had continued after the end of the war! Kelly McNagny, from the University of British Columbia (Canada), and colleagues tested the impact of two antibiotics, vancomycin and streptomycin, in a lab animal model. And these same changes had been tied to an increased risk of developing obesity and immune-related diseases in previous studies of animals and adult humans, the researchers said. When she is not writing, she can be found reading food blogs, lifting weights or playing with her two attention-hungry cats.
These strains are expressing yellow or blue fluorescent proteins for easy visualization in fecal samples collected from mice colonized with these strains.
The ability to drive this community from a disease state to a healthy state, by manipulating the native signals and interactions that occur between its members, offers great potential for therapeutic benefit. These features make AI-2 an excellent candidate for mediating cell-cell interactions in the mammalian gut, where hundreds of bacterial species co-exist and interact.
And contrary to the Tumblr meme, vegetables (at least in the broccoli-and-spinach sense) are not carbs! They found that streptomycin increased susceptibility to a disease known as hypersensitivity pneumonitis later in life, but vancomycin had no effect.
The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Manipulation of the Quorum-Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota. The difference in each antibiotic’s long-term effects can be attributed to how they changed the bacterial ecosystem in the gut. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay seeking it because of something you've read on the this website. All trademarks, registered trademarks and service marks mentioned on this site are the property of their respective owners.

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22.10.2015, author: admin

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