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There is some conflicting evidence about using vitamin B-12 to treat elevated levels of homocysteine in the blood. Since the evidence for treating elevated levels of homocysteine in the blood remains conflicting,  the current recommendation is screening of men over 40 and women over 50.
A recent study showed that vitamin B-12, used with folic acid and vitamin B6, reduces the risk for age-related macular degeneration (AMD) in women with heart disease or multiple risk factors for heart disease.
These include fatigue, Alzheimer’s disease, heart disease, breast cancer, high cholesterol, and sickle cell disease.

It is not fully understood how or if this elevation contributes to heart disease and other problems with blood vessels, or if the elevation is a result of these conditions. For patients with elevated homocysteine levels, the recommendation is to supplement with folic acid and vitamin B-12. Vitamin B-12 is also more common in those with certain conditions, like digestive problems and some types of anemia. A high level of homocysteine in the blood is a risk factor for coronary, cerebral, and peripheral blood vessel disease.

Low vitamin B-12 can cause fatigue, weakness, memory loss, and other problems with the nervous system.

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