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Because the prevalence of acoustic neuroma is low, and because the cost of MRI scans used in screening is very high, cost-analysis suggests that routine MRI scanning for asymmetrical hearing loss is not cost effective (Pan et al, 2015). Diagnosis of an acoustic usually requires either a physician with otologic expertise who can integrate together the entire picture, or an MRI with gadolinium. Clinicians often attempt to estimate the risk of an acoustic neuroma by looking at the pattern of hearing loss (see here for more about patterns). Hyperventilation induced nystagmus is a little known physical sign that may be far more specific for acoustic neuroma. It has recently been pointed out that some forms of acoustic neuromas have increased intralabyrinthine protein.
As mentioned above -- acoustics can be diagnosed either by a medical doctor with otologic expertise who can integrate together the entire picture, or with an MRI scan with gadolinium of the brain.
Audiogram of patient with large acoustic neuroma on left side, but (nearly) symmetrical hearing.
At this writing, we have ENG testing, Rotatory chair testing, VHIT testing, VEMP testing, and Posturography to choose from when we are attempting to diagnose dizzy patients. ENG is not a sufficient test by itself for acoustic neuroma because it is not specific, and also because there are far more other causes for caloric loss than acoustic neuromas. Otoacoustic emissions are also considered a poor test for acoustic neuroma, although one would think that they would do as well as hearing testing.
MRI scan of  brain (coronal) showing an acoustic neuroma (the white spot on the left side of the picture). MRI scan of brain (axial with contrast) showing a largely intracanalicular acoustic neuroma on right side of brain (left side of scan). CT scans with IV contrast are poor tests for diagnosis of acoustic neuromas, as they have a high false negative rate (about 37%). A comparison between two scans of the same acoustic, the CT on the left and MRI on the right is shown above. Axial image of patient with NF2 showing acoustic neuromas on both sides (Image courtesy of Dr. As CT and MRI scans become more commonly used, there are more acoustics being discovered accidentally -- serendipitously. If someone in such a situation proceeds with surgery or radiation treatment, it is certain that the surgery or radiation will create a vestibular imbalance as well deafness. According to Carlson et al (2015), about half of all patients are operated as soon as they are diagnosed, about 24% are radiated, and about 29% were observed. According to Carlson et al (2015), about 29% of acoustics are initially treated with radiation. The author of this review does not favor high-dose gamma knife because of the possibility of radiation complications at 2 years and beyond. An interesting consequence of the lower-dose radiation protocol is that patients are now seen who do not have complete loss of hearing or vestibular function after radiation.
Hyperventilation induced nystagmus for this situation beats towards the lesion (unlike vibration induced nystagmus which beats away from the lesion). The translabyrinthine approach makes no attempt to preserve hearing, and does not open the skull. The middle fossa approach (not shown above), can theoretically preserve hearing, but like the retrosigmoid, the approach is intrinsically more dangerous as it involves retraction of the brain, and also more prone to complications. Compared to radiosurgery, the primary advantage of conventional surgery is avoidance of late complications associated with radiation of neighboring structures. With respect to hearing preservation surgery, while of course this is certainly desirable, unfortunately the chance of hearing being preserved after acoustic neuroma surgery is slight. At the author's clinical practice in Chicago Illinois, it is suggested that prospective operative candidates primarily consider safety and the probability of complications when considering surgery or gamma knife. Both surgery and gamma-knife methods of managing acoustic tumors seem reasonable at this writing, with the choice depending on individual factors. Imbalance and dizziness (almost all patients who have any vestibular function prior to surgery, will have worsening of balance after surgery).
MRI scan from person who had acoustic neuroma removed via retrolab approach, and with refractory dizziness.
Residual acoustic neuroma as well as cerebellar damage, in this patient who had surgery in the remote past. One would not be likely to preserve hearing when the hearing is good, and the tumor is big. This is simple stuff -- balance deteriorates after acoustic surgery because the surgery damages or removes remaining function in the vestibular nerve (Levo et al, 2004; Tufarelli et al, 2007). At a recent meeting at the ANA (acoustic neuroma association), the author of this page participated in a 2-hour session and interviewed 8 patients who had persistent vertigo.
No standards exist regarding patient follow-up following complete acoustic neuroma resection.
Asthagiri AR, Vasquez RA, Butman JA, Wu T, Morgan K, Brewer CC, King K, Zalewski C, Kim HJ, Lonser RR.PLoS One.
Tanbouzi Husseini S, Piccirillo E, Taibah A, Paties CT, Rizzoli R, Sanna M Malignancy in vestibular schwannoma after stereotactic radiotherapy: A case report and review of the literature. Markou K, Eimer S, Perret C, Huchet A, Goudakos J, Liguoro D, Franco-Vidal V, Maire JP, Darrouzet V. Some of the most common brain tumor symptoms include frequent headaches, hearing loss, and blurred vision. In addition to hearing and vision problems, a person with a brain tumor might also begin to lose his balance.
In some cases, these changes are so subtle that the patients themselves are more aware of their difficulties than are those around them.
Attention and Concentration: Confusion, easy distraction, difficulty multitasking and planning. Frontal lobe: Movement, intelligence, reasoning, behavior, memory, personality, planning, decision making, judgment, initiative, inhibition, mood. It is estimated that more than half of all patients with malignant brain tumors experience some behavioral changes.
Patients with brain tumors should be encouraged to undergo a complete neuropsychological evaluation. Language and Communication: Typically managed with speech and language therapy, as well as cognitive rehabilitation therapy*.
Emotional and Personality: Typically managed with cognitive rehabilitation therapy*, psychotherapy, and medication. Learning and Memory: Typically managed with cognitive rehabilitation therapy* and speech and language therapy.
Attention and Concentration: Typically managed with cognitive rehabilitation therapy* and medication. The 6% number is probably much too high as meningiomas and pituitary tumors are underreported.
A recent study suggested that the mechanism of hearing loss in NF2 is elevated intralabyrinthine protein rather than compression of the 8th nerve (Asthaqiri et al, 2012).

Because acoustic neuromas are very rare, and MRI's are very expensive, in our opinion -- all patients with a substantial risk of having an acoustic should be evaluated by a medical doctor with otologic expertise. Evaluation of HVIN requires more sophisticated equipment than is available in most offices. One would expect that this would create timing differences between the ears without spontaneous nystagmus, and result in head-shaking nystagmus, without spontaneous or hyperventilation induced nystagmus. Because MRI's are so expensive, the most cost efficient method of diagnosis (at this writing - -in 2015), is to have all patients with unexplained asymmetrical hearing loss be evaluated by a medical doctor with otologic expertise. Because hearing asymmetry is mainly due to other conditions than acoustic neuromas, other pieces of information need to be integrated to make the clinical diagnosis of acoustic neuroma. This example shows that symmetrical hearing testing does not always exclude the diagnosis of an acoustic neuroma. Because this is terribly expensive (to screen everyone with hearing impairment of any type), mistakes are sometimes made. In our clinical context in Chicago, this technique is rarely relevant as the more sensitive test for acoustics (MRI) is so common. We have diagnosed a few acoustics by noting that ENG function is lost but hearing is relatively preserved. VHIT testing is probably also less sensitive than caloric testing but it depends on the tumor size. As OAE's are generated by the cochlea, and acoustics involve the 8th nerve, which is further in, the lack of sensitivity may be due to this anatomical specificity. Chiarovano et al (2015) reported that cervical VEMPs were abnormal in 65% of patients with acoustic neuroma. Parenthetically, it is puzzling that an old technology like MRI should keep increasing in cost every year. The best protocol MRI protocol is generally a T1 with contrast (gadolinium) of the IAC, in a closed MRI with the highest resolution available (3T is the best right now -- in 2015). If a person has a pacemaker or other metallic device, then they may have to have a CT scan with contrast instead of an MRI. Once again, one looks for enhancement (lighting up of the tumor with contrast, and no lighting up without contrast).
False negative errors mainly occur in persons with very small tumors, or very bad scans (such as a scan done in a low-field unit, such as an open MRI, without contrast). Metastatic tumors usually grow rapidly -- hearing goes down quickly, and often the facial nerve is involved with a Bells palsy, over a few weeks time.
For example, a person who has a migraine headache, might get an MRI which reveals an acoustic neuroma. It is not very likely that a previously silent acoustic neuroma, will suddenly manifest itself at the same time as another problem - -such as a minor head injury or migraine. This will eventually occur anyway, but treatment of a tumor that is not growing will speed up the process. Billing for this procedure is amazingly high, so this is not something that be generally used without health insurance. They are damaged, they are scarred, but it is just not the nature of radiation to completely obliterate tumors.
However, low dose gamma knife is looking much better and there are certainly many times when it is the best option.
In some cases this can be very annoying as it may result in nerve irritability symptoms such as hyperventilation induced nystagmus. This is a reasonable consideration which, in our opinion, makes conventional surgery advantageous when the patient is a reasonable surgical risk.
If one has serviceable hearing, and there is no other danger of waiting (such as needing a bigger operation), one might reasonably simply wait until hearing becomes unserviceable before proceeding with surgery or radiation.
El-Kashlan et al (1998) reported that dizziness from unoperated acoustic neuroma's is generally mild as damage progresses slowly and is handled with compensation. On the right side of the picture (left side of head), there is a black area where there was damage to the cerebellum, presumably associated with the surgery. This type of injury will most likely be accompanied by permanent imbalance due to the combination of a cerebellar injury and loss of inner ear function on the left. There is clear cerebellar damage on the left side of the cerebellum (right side of picture). Keep in mind also that audiograms are somewhat subjective, there is such a thing as a placebo response, and reported results may sometimes mainly be wishful thinking. The middle fossa approach has more risk to one's brain and other aspects than other approaches.
Tufarelli and associated reported that 10% of 459 patients judged their imbalance as disabling, and 73% felt that they had at least moderate oscillopsia (trouble seeing with head moving). 2 years), balance generally returns to near normal, but persons who have other deficits such as visual disturbances (e.g. As a general rule, patients who had vertigo 2 years following surgery, had had a mixture of a cerebellar injury and total vestibular loss, associated with a difficult surgery (usually for a 4cm + tumor). The timing and prognosis of this vertigo depends on the reason and associated damage to the cerebellum (if any). This probably reflects the fact that migraine is an extremely common health condition that worsens with any type of head pain.
The Changing Landscape of Vestibular Schwannoma Management in the United States-A Shift Toward Conservatism. The role of cervical and ocular vestibular evoked myogenic potentials in the assessment of patients with vestibular schwannomas.
The Solid Component of Radiographically Non-Growing, Post-Radiated Vestibular Schwannoma Retains Proliferative Capacity: Implications for Patient Counseling.
Unique case of malignant transformation of a vestibular schwannoma after fractionated radiotherapy.
Cost analysis of vestibular schwannoma screening with contrast-enhanced magnetic resonance imaging in patients with asymmetrical hearing loss. Gamma knife radiosurgery for acoustic neuromas performed by a neurotologist: early experiences and outcomes. People who have brain tumors might also begin to notice that their balance is off and that they are starting to become confused over things that would not normally confuse them.
The headaches could be minimally painful to start with, increasing in intensity as time goes by. Only a doctor can make a firm diagnosis of the presence of a brain tumor, and a person should not attempt to diagnose himself as either having or not having such a serious problem.
A dog won't be able to tell you how it feels, but if it has seizures, especially after five years of age, walks as if it is drunk, is more sensitive to touch around the neck area and has vision problems, your dog might have a tumor. Changes in personality and behavior occur in the majority of patients with brain tumors at some point during their treatment.
In others, it is the caregiver rather than the patient who first recognizes that something is different.
The diagram below shows some of the different areas of the brain that are directly related to behavior.

The location, size, and rate of growth of the tumor can have a lot to do with how a patient behaves. This detailed evaluation of a patient’s behavioral, cognitive, and emotional status can help identify issues so that the best treatment can be provided. Be sure to discuss any new symptoms or changes in existing symptoms with your doctor or nurse as soon as possible. If there is any question about the seriousness of changes in behavior or any other symptom experienced, please contact your doctor. The higher prevalence figures do not correspond to our clinical experience in our practice in Chicago, or the findings of others. While we doubt that this is always the case, we have also invoked this cause in patients with tiny tumors such as intralabyrinthine schwannomas, driven by MRI findings.
In other words, patients with unexplained stable asymmetrical hearing loss should generally all be evaluated by a physician with otologic expertise.
One might also expect abnormalities in OAE's as auditory efferents enter the cochlear area via the inferior division of the nerve. Usually this integration process is done by a medical doctor with otologic expertise, and not by allied health persons such as audiologists. While this is really a decision for health care economists, it seems to us that occasional errors are overall permissible, when one considers what is best for the population at large. Nevertheless, this method might have utility in contexts where MRI's are difficult to access.
Caloric, VEMP, perhaps VHIT), do better than those that test both sides at the same time (rotatory chair, posturography).
As in the more common condition of Meniere's disease, hearing loss precedes vestibular impairment, the opposite pattern is suggestive of a tumor (especially an intralabyrinthine schwannoma). Or someone who experienced an auto accident, might get an MRI which reveals an acoustic neuroma. Rather, it is commonly the case that the person will have one of the common causes of dizziness, and just happen to also have a silent acoustic. For this reason, extreme caution is suggested -- in our opinion, except for very large tumors, it is best to have objective evidence -- i.e.
Because of this observation, some surgeons simply recommend taking out the entire 8th nerve when most convenient as this approach makes tumor recurrence very unlikely. This is probably a consequence of using a treatment methodology that works more slowly than surgery.
In persons with this sign, one can either wait for it to go away (this may take several years), try a medication that reduces nerve irritability, or reconsider surgical treatment.
A detailed discussion of dizziness, vertigo and imbalance, pre and post surgery can be found in this lecture handout. If headaches are the only symptom a person has, it is likely that he does not have a brain tumor. Floaters and flashing lights may also disrupt a person's field of vision when she has a tumor inside the brain. Coordinated movements that used to be simple might suddenly seem complicated for no apparent reason.
The symptoms of a brain tumor are serious even if they are not the result of a tumor, and evaluation by a medical professional will likely be necessary if a person has these symptoms.
Dogs with brain tumors might pace or circle constantly, seem depressed and forget learned tricks. Treatments such as radiation, surgery, and chemotherapy can also affect how the patient feels and acts. This conclusion needs to be tempered by other clinical information - -someone with a progressive asymmetrical sensorineural hearing reduction would (in our opinion) be far more likely to have an acoustic than someone with a static or improving asymmetry. Genetic testing for NF1 and NF2 is available commercially, for example, from Athena Diagnostics.
13 Gy) are presently advised because of the much lower risk of facial weakness and numbness (Wackym et al, 2004). Long term hearing preservation is very rare in persons with stereotactic radiotherapy (6.7% according to Lin et al, 2005). As a general rule, patients who have lost both inner ear function (from the acoustic), and substantial cerebellar function (from the surgery or acoustic), will have an enduring loss of balance. Cochlear implants stimulate the part of the ear prior to the wiring - -they affect the microphone. The symptoms that are typically associated with a brain tumor can often be the result of other problems, and a person who is concerned about any unusual symptoms should see a doctor immediately.
When there is a tumor inside the brain, other symptoms almost always accompany frequent headaches. Hearing brain tumor symptoms might include ringing in the ears or complete loss of hearing in either one or both ears.
Additionally, people may also begin to notice changes in their speech and difficulty with recalling and saying certain words. A loss of vision and general awareness on just one side of the body that causes them to run into doors or bump walls is another sign. Of course this statistic actually reports the number of acoustics diagnosed, not the number that might be found through a prospective study. Because of the high sensitivity but low specificity, routine use of a very expensive diagnostic test such as a gad-MRI of the IAC's in all persons with asymmetrical hearing is not always justified. Should someone be suggesting an invasive procedure, a second opinion is well worth obtaining.
Thus, one would expect that a cochlear implant would generally be ineffective in someone whose cochlear nerve has already been damaged by a tumor. Even if the headaches a person experiences are not the result of a brain tumor, she should still see her doctor to determine what exactly is causing them. If a tumor is located within close proximity to a person's eyes or ears, the vision and hearing symptoms may be worse depending on how close the tumor is to them. Sudden personality changes are also one of the typical brain tumor symptoms, and a person might notice that she is incredibly angry or euphorically happy for no obvious reason. Depending on the location of the tumor, the dog might tilt its head to the side, lean and fall to the same side of the head tilt and have an odd look in the eye. Pan et al (2015) reported that the estimated screening cost per patient for those who benefitted from surgery or radiation was $147,030 while the US compensation for unilateral hearing loss is $44,888. As we have a symptomatic population that presumably would be more likely to have acoustics than individuals with no hearing or dizziness symptoms, this implies that the prevalence in the general population is probably much lower than 1%. Of course, this does not really answer the question as to the number of persons with hearing asymmetry that have AN.

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