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Tinnitus is the perception of an insistent, unpleasant ringing, buzzing or other consistent noise, located in or near the skull but without a definable external source.
Tinnitus is often perceived as a ringing or persistent high tone very close to or within the ear. Tinnitus is often regarded as a symptom of auditory conditions, such as damage to the tissues in the ear that control the perception of tones and frequencies. An increasing number of researchers argue that tinnitus is a disorder of the connections between the inner ear and certain areas of the brain. Some scientists had developed a theory that tinnitus was associated with deficiencies in vitamin B12.
Chronic inflammation of the middle ear (otitis media) may also be associated with some cases of tinnitus.
Tinnitus related to otitis media may be improved by surgery to correct damage caused by this inflammation.
Although currently there is no cure for tinnitus, promising research is now showing that some supplements and vitamins for tinnitus may be helpful in relieving the symptoms, with the 3 most frequently recommended being Zinc, Vitamin B12 and Ginkgo Biloba.
Zinc is a mineral that is essential to the body’s well being and must be consumed on a regular basis. It is very important to speak with your medical practitioner about taking zinc supplements before you embark on a course of treatment.
Vitamin B12 is essential to your body’s well being and is one of the better known vitamins for tinnitus. It is vital that you consult with your Medical Practitioner before embarking upon a course of B12 treatment. The Chinese have been using Ginkgo Biloba for centuries in the treatment of improving blood flow in patients and to prevent free radicals from damaging cells.
To date no conclusive trials have been conducted on the positive effects of Ginkgo Biloba, however small trials have shown marked improvement for some tinnitus sufferers.
Before you embark on Ginkgo Biloba treatment consult your Medical Practitioner as the taking of Ginkgo Biloba will increase blood flow throughout the body.
A WORD OF CAUTION – Ginkgo Biloba seeds, unless prepared correctly, can poison the user and, although rare, have been known to result in death.
Vitamin A is stored in the inner ear; its purpose is to make it possible for the ears to interpret sounds correctly. Research to date has not been able to prove that any herbal remedies will help tinnitus sufferers.
I am a vegetarian and after reading the information on Vitamins I feel that I may have a Zinc or B12 vitamin deficiency. Hi Stan, From my research the taking of supplements, in particular Zinc and B12, needs to be endorsed by a medical practitioner due to the possibility of side effects or incompatibility with other medications you might be taking. I’ve set up this website to provide useful information and to help other tinnitus sufferers learn how to manage and live with this annoying condition. Top 3 Articles (voted by our visitors!)Tinnitus Remedies 2 CommentsTinnitus is the technical term for a persistent ringing in the ears. If you suffer from long-lasting fatigue, memory problems, or pins and needles sensations, then you should test for vitamin B12 deficiency right away. If you think you have vitamin B12 deficiency, then the first course of action will be to order a serum cobalamin test to see how much vitamin B12 is in your blood supply. Another helpful tool for accurately testing for vitamin B12 deficiency is the Methylmalonic acid (MMA) test, as MMA levels increase dramatically with vitamin B12 deficiency.
Sometimes, pernicious anemia from vitamin B12 deficiency occurs because of an autoimmune condition that destroys intrinsic factor, a digestive enzyme crucial for vitamin B12 absorption. A positive IFAB test result means that you have antibodies to intrinsic factor, resulting in the inability to digest vitamin B12 naturally from foods such as meat, fish, poultry, dairy, and egg products. Though not available in the US, the Schilling test is considered an effective method for diagnosing vitamin B12 malabsorption. A thorough physical examination and review of your medical history will help your doctor determine if you have vitamin B12 deficiency.
But since no tests for vitamin B12 deficiency are 100% accurate, it’s important to recognize the classic symptoms of vitamin B12 deficiency, so that you can help your physician make an informed decision. If you found this article helpful, then please share with your friends, family, and coworkers by email, twitter, or Facebook. There are many causes of pernicious anemia, including autoimmune conditions, medications, and damage to the intestines. Crohn’s disease, celiac, and fibromyalgia can impair your ability to produce intrinsic factor, a digestive enzyme that is needed in order to extract vitamin B12 from food and replenish supplies of vitamin B12 in the blood stream. If either of your parents or grandparents suffered from pernicious anemia, then you are also a high risk category for vitamin B12 deficiency. Certain medications can eventually impair your ability to absorb vitamin B12, leading to pernicious anemia; these include PPIs used to treat GERD (acid reflux), metformin for diabetes, and various antibiotics, NSAIDs and antidepressants. If you have had bariatric surgery (gastric bypass) or surgical treatments for illnesses such as Crohn’s disease, then pernicious anemia may result because of vitamin B12 malabsorption. Do you get enough vitamin B12 to prevent symptoms of pernicious anemia, or would you feel better if your doctor would prescribe more vitamin B12? Tags: bariatric surgery, celiac disease and vitamin b12, Crohn’s Disease, Digestive illnesses, Fibromyalgia & Chronic Fatigue, Gastric bypass surgery, GERD, intrinsic factor, Medications vitamin B12 deficiency, metformin, pernicious anemia, pernicious anemia causes, PPIs, red blood cells, vitamin B12 deficiency Posted in Pernicious Anemia- What is it?
Pernicious anemia is a type of megaloblastic anemia that occurs with severe vitamin B12 deficiency.
There are several types of anemia, and they are usually classified by the way they impair red blood cells in size and shape.
With megaloblastic anemia, your body starts producing red blood cells that are overlarge, misshapen, and poorly developed. Your body starts receiving less oxygen, causing a breakdown in various bodily functions of the organs, tissues, and nervous system.
Pernicious anemia is a type of megaloblastic anemia caused by vitamin B12 malabsorption, the inability to digest vitamin B12 found in meat, fish, dairy, and egg products.
Pernicious anemia used to be fatal, until scientists discovered that symptoms could be cured with vitamin B12 supplementation. Even if you eat plenty of beef, chicken, and fish, you may still have vitamin B12 deficiency through lack of intrinsic factor, an enzyme needed to digest and absorb vitamin B12.
Pernicious anemia is one type of megaloblastic anemia; another type occurs with folic acid deficiency.
Tags: intrinsic factor, Large red blood cells, Megaloblastic, Megaloblastic anemia, oxygen and vitamin B12, pernicious anemia, red blood cells, Vitamin B12, vitamin B12 deficiency, vitamin B12 food sources, Vitamin B12 malabsorption Posted in Pernicious Anemia- What is it? If you suffer from pins and needles and painful burning or tingling in your hands and feet, then you may have vitamin B12 deficiency. Vitamin B12 is an essential nutrient for your nervous system, but sometimes we don’t get enough, either because of diet or underlying health issues.
Eating a vegan diet devoid of B12-rich meats, fish, and cheese is one way of developing vitamin B12 deficiency, but it is also common in the elderly and people who have had gastrointestinal surgery such as gastric bypass.
Vitamin B12 deficiency can also occur with migraine, fibromyalgia, and other forms of chronic pain, as autoimmune history and gastrointestinal problems combine to further raise your chances for developing vitamin B12 deficiency and resulting nerve pain.
If you’re experiencing constant nerve pain and numbness, then you should consider vitamin B12 deficiency as a possible cause. Vitamin B12 protects your nervous system by sustaining myelin, a fatty substance that insulates your nerve fibers and enhances intercellular communication, so that sensory messages travel along the spinal cord to the brain quickly and efficiently.
When vitamin B12 levels become depleted, you suffer symptoms resulting from demyelination, destruction of the nerve cell’s outer coating. Nervous impulses become slower, and symptoms of tingling, burning, pain and numbness from vitamin B12 deficiency become more frequent. Untreated, vitamin B12 deficiency can impair your nervous system and cause severe handicaps.
If you are a diabetic using metformin, then it’s crucial sustain vitamin B12 levels through supplementation. Vitamin B12 deficiency is harder to diagnose in people with diabetes, as the symptoms of pain and numbness are already masked by preexisting diabetic neuropathy. If nerve pain results from vitamin B12 deficiency, then it’s important to boost your intake of vitamin B12 immediately. The best, most digestible sources of vitamin B12 are non-dietary supplements that are absorbed into your bloodstream, as opposed to vitamin B12 pills that you swallow.


For best results, start out with 1,000mcg of vitamin B12 weekly or more often, as needed or recommended by your doctor.
Your doctor may prescribe antidepressants for neuropathic pain, or he may advise anti-convulsant drugs.
Topical treatments used to relive arthritis may help to relieve nerve pain, without any harmful side effects.
About half the population has a gene mutation making them prone to genetic vitamin B12 deficiency, according to researchers, which would explain the growing epidemic of pernicious anemia from untreated vitamin B12 deficiency. If you have defective MTHFR genes, then you’re not able to convert cobalamin to usable vitamin B12 as effectively as somebody without the gene defect.
However, nearly 50% of all people have a defected MTHFR gene from one parent, and 10% have mutated MTHFR genes from both parents, making them more likely to suffer genetic vitamin B12 deficiency, and also elevated levels of homocysteine, which has been linked to hardening of the arteries and increased risk for heart attack.
Vitamin B12 absorption is a complicated process, and there are many things that can go wrong. There are several ways of finding out if you have vitamin B12 deficiency, including plasma vitamin B12 level screening, complete blood count (CBC) and homocysteine blood screening for Hyperhomocysteinemia. As for testing for the MTHFR gene mutation, there are no official guidelines as to who should be tested. If you’re tested with genetic vitamin B12 deficiency caused by a gene mutation, or any form of vitamin B12 deficiency that doesn’t stem from diet, then it’s absolutely essential to supplement with vitamin B12 in order to prevent vitamin B12 deficiency and other severe malnutrition. The risk for pernicious anemia from vitamin B12 deficiency is highest among the elderly, but a significant number of people begin to notice the first symptoms in their 30s, contrary to popular belief. Vitamin B12 deficiency causes many debilitating health problems, including chronic fatigue, lethargy, weakness, memory loss and neurological and psychiatric problems – long before pernicious anemia sets in.  These symptoms can be quite misleading, leading to incorrect diagnoses. These diseases produce signs and symptoms that also occur with vitamin B12 deficiency – but are rarely diagnosed as such! If you think you might have a vitamin B12 deficiency or pernicious anemia, you should pursue blood testing immediately. Once the source of vitamin B12 deficiency is identified, you can then begin vitamin B12 supplementation. Tags: b12 and homocysteine, b12 deficiency, b12 deficiency symptoms, b12 injections, causes of b12 deficiency, pernicious anemia, Pernicious anemia and b12, symptoms of vitamin b12 deficiency, vitamin B12 deficiency, Vitamin B12 deficiency and pernicious anemia Posted in Pernicious Anemia- What is it?
The Tufts University Framingham Offspring Study suggests that 40 percent of people between the ages of 26 and 83 have plasma vitamin B12 levels in the low-normal range – a range at which many people still experience neurological symptoms such as fatigue, dizziness, and numb, tingling muscles.
Outright vitamin B12 deficiency was exhibited by 9 percent of the study participants and 16 percent exhibited “near deficiency”.  Low vitamin B12 levels were as common in younger people as they were in the elderly, to the surprise of the researchers. The human body needs vitamin B12 to make red blood cells, protect the nerves, synthesize DNA, and carry out other crucial functions.
Some people don’t consume enough vitamin B12 to meet their needs, while others can’t absorb enough, no matter how much they take in, leading to vitamin B12 deficiency that can be difficult to diagnose. Second, the low end of the laboratory reference range for vitamin B12 deficiency is too low. Usually, 1,000mcg doses of vitamin B12 taken biweekly or monthly will suffice, but it’s important to judge by your symptoms. Fortunately, vitamin B12 is safe to take in any amount, according to FDA guidelines, so you can take as much vitamin B12 as you think you need to increase your energy and improve your mood, without worrying about any harmful side effects. Are your ears ringing?  For many, vitamin B12 deficiency is a cause of tinnitus symptoms; constant sounds in your ears like ringing, beeping, humming, buzzing, or rushing sounds may indicate a need for more vitamin B12.
The following is a partial list of natural elements that may help with tinnitus and provide many other healthful benefits. If you think you may require Vitamin B12 for tinnitus symptoms, ask your doctor to conduct a vitamin B12 blood screening test. Consult a qualified health care professional to find out the root cause of your condition and whether or not you have a Vitamin B12 deficiency. Vitamin B12 is safe to use without a prescription, as there are no FDA upper limits imposed on vitamin B12 supplementation. Tinnitus is a neurological disorder that causes you to hear constant noises in your ears that don’t exist in your parameter.
Pernicious Anemia, in a simplified definition is the loss of body’s ability to absorb vitamin B12. Vitamin B12 – is found naturally in meat, fish and dairy products including milk, butter and eggs. Vitamin B12 will enter the stomach bound to proteins called “Intrinsic Factor”.  The Intrinsic Factor is then absorbed, along with the B12, by the Ileum which is part of the stomach in the small bowel.
Healthy people will produce the gastric parietal cells to produce Intrinsic Factor.  However, if one’s digestive system is not functioning properly, their digestive system may fail to produce Intrinsic Factor, and thus fail to absorb Vitamin B12.
Medical conditions in which this type of self-destruction occurs are classified as Auto-Immune Diseases.
Tags: b12 deficiency, pernicious anemia, symptoms of vitamin b12 deficiency, Vitamin B12, What is pernicious anemia Posted in Pernicious Anemia- What is it? Vitamin B12 and folic acid are both essential water-soluble B vitamins that your body needs to prevent anemia, provide energy and support the nervous system.
Vitamin B12 and folic acid work together to regulate production of healthy red blood cells needed to spread oxygen throughout your body. If you were to develop a vitamin B12 deficiency (pernicious anemia), then it may not appear on a blood test when folic acid levels are high, as red blood cell production will appear normal.
Nerve damage from vitamin B12 deficiency can continue, even with normal levels of folic acid. There is a belief among scientists that overconsumption of folic acid may worsen attention and memory disorders that occur with vitamin B12 deficiency. Long term, pernicious anemia can result in severe handicaps caused by irreversible nerve damage. If you are at risk for vitamin B12 deficiency, then it’s important to have your B12 levels and folic acid levels checked regularly. The only way to treat vitamin B12 and folic acid deficiency is to replenish your levels of these important B vitamins until your achieve a normal amount.
In addition to taking vitamin B12 and folic acid supplements, try to include more foods containing B vitamins in your diet, such as beef, fish, poultry, milk, eggs, and grain products fortified with folic acid.
It is not considered to be a condition in its own right, but a syndrome or symptom related to many forms of auditory damage or disorder.
Age-related hearing impairments, or disorders of the circulatory system around the ear, may also be related to this complaint. Some scientists conclude that tinnitus is in fact related to damage of the nervous tissue in or around the auditory cortex of the brain. A recent study including 100 patients with tinnitus found that 63 of these had low vitamin B12 levels. As the natural molecule histamine is associated with the regulation of both inflammation and some auditory nervous tissue, drugs that block its receptors in the brain are currently proposed as treatments for tinnitus. Darius Kohan is renowned for his otology expertise and has been highlighted on several outlets such as a CBS spotlight on tinnitus and is often cited in WEB MD and other medical outlets. We recommend focusing on solving the root cause of the problem as this is the only sure way to give permanent relief. It is not recommended if you are pregnant, already taking blood thinning medication or if there is a possibility of surgery in the near future. Some tinnitus sufferers have found relief by taking Magnesium supplements under the control of a Medical Practitioner. Many alternative treatments can be dangerous to the patient because of underlying existing medical conditions. Tests for vitamin B12 deficiency or pernicious anemia include cobalamin level screenings, as well as tests to determine your ability to absorb vitamin B12 from food. This blood test will check for low vitamin B12 levels even in people who don’t have pernicious anemia or symptoms of vitamin B12 deficiency.
If you’re suffering from extreme fatigue, unexplained bruising, or dizziness, then your doctor may order a complete blood count to count red blood cells, white blood cells, and platelets. Rather than checking for vitamin B12 levels in the blood, the Schilling test gauges your ability to absorb crystalline vitamin B12. Vitamin B12 deficiency caused by vegan dieting is not considered a cause of pernicious anemia, as it can be reversed by eating foods containing ample amounts of vitamin B12.
Pernicious anemia is often comorbid with illnesses that affect the gastrointestinal system.


With frequent testing, you can catch the onset of vitamin B12 deficiency before it advances to pernicious anemia. If you are on long-term medication, check to see if you are a risk factor for megaloblastic anemia and use vitamin B12 supplements. To find the right treatment and understand symptoms of fatigue, depression, and chronic pain, it helps to understand how pernicious anemia impairs your red blood cells and what you can do for prevention.
Specifically, megaloblastic anemia is a blood disorder in which red blood cells called megaloblasts become too large to function properly, resulting in fewer healthy red blood cells needed to deliver oxygen throughout your body; symptoms of memory loss, extreme fatigue, dizziness, and agitation occur when your vital organs and tissues don’t receive enough oxygen. Since vitamin B12 is crucial for healthy red blood cell production, long-term vitamin B12 deficiency can progress into severe pernicious anemia, a once-fatal condition that is now prevented through vitamin B12 supplementation.
If so, what kind of vitamin B12 supplements do you use- vitamin B12 shots or over-the-counter vitamin B12? There are many causes of chronic pain and numbness, most of them strongly linked to extremely low vitamin B12 levels or resulting  pernicious anemia. Diabetic neuropathy is one of the most common forms of nerve pain, but it can also occur as a result of vitamin B12 deficiency or, if prolonged, pernicious anemia.
Diabetics taking metformin are at a high risk for developing vitamin B12 deficiency, as metformin is one of several drugs that prevent absorption of vitamin B12 from foods.
All of these, over extended periods of time, may result in uncomfortable side effects, so use with caution.
About 40 percent of people between the ages of 26 and 83 have dangerously low levels of vitamin B12, and many don’t even realize it until the debilitating symptoms begin to set in. These genes are necessary for efficiently converting vitamin B12 to a usable form, and in effect also maintaining healthy homocysteine levels.
Certain health conditions, medications, invasive surgeries, dietary restrictions, and yes- genetics- can impede your ability to digest vitamin B12 properly from food sources and vitamin supplements. So unless you request a test for genetic vitamin B12 deficiency from a doctor who is able to comply, then your best bet is to stay on top of vitamin B12 and homocysteine levels, and supplement daily with vitamin B12, folate and vitamin B6. Diet alone will not provide you the amount of vitamin B12 needed in order to prevent pernicious anemia. Listed below are some common symptoms of pernicious anemia and explanations regarding your risk for developing pernicious anemia in middle age. Pernicious anemia used to be fatal until scientists figured out that death could be easily prevented by feeding patients high concentrations of Vitamin B12. To prevent pernicious anemia, it is absolutely essential that you supplement with high doses of vitamin B12. If you are vitamin B12 deficient, then the next step would be to identify the source of the deficiency. The many, long-term or permanent vitamin B12 supplementation is required in order to prevent a relapse of symptoms.
It has been well documented in much medical literature.  The causes and effects of vitamin B12 deficiency are well-known within the scientific community. But since your body can’t produce vitamin B12, it is necessary to supply it through foods containing vitamin B12 or vitamin B12 supplements. To begin with, most physicians do not routinely test for vitamin B12 deficiency, even in adults who are at high risk. Explain your symptoms to your doctor, and request a blood test to screen for vitamin B12 deficiency.
You may need to take extra vitamin B12, in addition to what your doctor prescribes, as some medical insurance plans don’t cover the amount of prescription vitamin B12 shots needed to achieve full recovery. In fact, millions of people in the United States suffer from vitamin B12 deficiency and tinnitus.
It plays an important role in the formation of red blood cells and metabolism of sugars, fats and proteins. It has been found that B12 deficiency has been linked with chronic tinnitus and noise- induced hearing loss.
With tinnitus, your brain picks up false noise signals from the nerve cells of your inner ear, resulting in persistent buzzing, ringing, whooshing, whistling or other annoying sounds in one or both ears. However, B12 is extracted from these foods via a very complex biochemical process, utilizing the gastrointestinal system. Without Intrinsic Factor, B12 cannot be absorbed into the body.  Thus, the inability of the body to absorb B12, is caused by a faulty digestive process, and not, as many people think, by a malfunction of the blood!
It is called Anti-Intrinsic Factor Antibodies.  One of the tests used to diagnose Pernicious Anemia is the test for Anti-Intrinsic Factor Antibodies. For maximum benefits, it’s important to maintain a healthy balance of vitamin B12 and folic acid. When vitamin B12 and folic acid levels fall, you may notice symptoms of anemia indicating a need for more oxygen and B vitamins. You may be required to continue taking vitamin B12 and folic acid supplements in order to prevent developing anemia again.
Other cases may be related to exposure to very loud or destructive levels of noise, such as from an explosion, industrial equipment or farming equipment.
Others have found associations between increased activity in further brain regions, age of tinnitus onset and distress caused by the syndrome. However, treating this deficiency had no significant effects on the complaint in these patients. Other new and emerging treatments for tinnitus focus on the potential indicated by the studies into its links with abnormal brain activity, as mentioned earlier. It did however show that in some cases there was an improvement in the patient’s tinnitus after a course of zinc.
Again the research to date is inconclusive, however a number of patients have experienced an improvement in the noise level after B12 treatment. The Ginkgo Biloba tree supplies the leaves and seeds from which the supplements are derived. This blog is dedicated to providing up to date research, news and resources pertaining to vitamin B12, general health information surrounding the benefits of vitamin B12. For an accurate diagnosis, it’s a good idea to take advantage of as many tests as your doctor can offer. But it is not foolproof- a false normal test result can occur, especially in people who have liver disorders, renal insufficiency, or bone marrow disease.
For prevention, check vitamin B12 levels routinely and supplement with non-pill forms of vitamin B12. Many B12 deficient people have so-called “normal” levels of B12, enough to prevent death from pernicious anemia, but not enough to prevent debilitating symptoms associated with low vitamin B12 levels. It is also helps maintain a healthy nervous system, and some research studies found it beneficial for patients of tinnitus, especially when this condition is associated with vitamin B12 deficiency. A normal healthy person will have 600 red blood cells for each one white blood cell and 40 platelets.
Tinnitus may have a significant negative impact on the life quality of those affected by it.
Different research groups have concluded that chronic tinnitus may be associated with an impaired connection between the cerebral cortex, which controls advanced functions such as memory, perception of the environment and cognition, and the thalamus, which supplies the cortex with sensory information.
A recent study, including 974 patients, indicated that hearing aids were preferable and more effective in treating blast-related tinnitus compared to noise generators. Presuming further research confirms the findings of these studies, deep brain stimulation (a form of implant placed in the brain to correct this activity) may be a viable option for severe treatment-resistant tinnitus. Learn from, and contribute to information on B12, vitamin B12 and other connected subjects. Thus, it was called “pernicious” because the condition would usually not be discovered until it was too late, and the individual with pernicious anemia would usually die. The main purpose of red blood cells is to carry oxygen from the lungs to cells throughout the body.
This syndrome may also have deleterious effects on the emotional, psychological and functional status of the patient.



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