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All of these disease conditions have one thing in common, a well-known, well-documented nutritional deficiency. Homocysteinuria, high homocysteine levels, leading to inflammation of blood vessels and the brain. Chronic shortages of available vitamin B12 in the bloodstream are not an obscure condition no doctor has ever heard of. For over 40 years, scientists at Tufts University in Boston have been conducting ongoing observations of lifestyle and nutrition with their health outcomes in the town of Framingham, Massachusets. Most common in people of Celtic (English, Scottish, Welsh, Irish) and Scandinavian descent, full-blown pernicious anemia only occurs in 1 in 70 to 1 in 150 peoplein a lifetime. But milder forms of the disease, scientists now know, can cause a variety of symptoms that masquerade as other diseases, or that aggravate other diseases. It is not unusual for people to develop lower than optimal levels of B12 and then to develop a psychiatric condition, or have a heart attack, or just to feel or act a little "off" without any obvious reason. In Japan and Europe, a B12 level of 500 to 550 picograms per milliliter is recognized as associated with memory loss, attention deficit disorder, and cognitive decline, especially in children (who may not have lived long enough for their livers to store enough B12) and the elderly (who can have digestive disorders than keep their stomachs from producing enough of the intrinsic factor that helps the gut absorb B12). But in the USA, B12 levels of just 200 to 450 picograms per mililiter are thought to be "normal." Unfortunately, cognitive decline in the elderly is increasingly considered to be normal, too. These tests are usually covered by insurance, but even if you arrange them for yourself, they should cost $60 or less. Testing can be arranged online from testing companies such as Direct Labs even without a doctor's prescription.
Biologically active vitamin B12 isn't found in any products of non-animal origin, unless they have been fortified. Find health and lifestyle advices & Get answers!Share real-life experiences with more than 250,000 community members! Pimple-like Bumps on Penis and Testicles Consequences Of Over-masturbation Implantation bleeding or period? Sometimes we need a little help to get us through the day and nutritional supplements could be the answer. However, B12 deficiency is far more common than most health care practitioners and the general public realize. That said, B12 deficiency has been estimated to affect about 40% of people over 60 years of age.
Severe B12 deficiency in conditions like pernicious anemia (an autoimmune condition where the body destroys intrinsic factor, a protein necessary for the absorption of B12) used to be fatal until scientists figured out death could be prevented by feeding patients raw liver (which contains high amounts of B12). B12 deficiency occurs in four stages, beginning with declining blood levels of the vitamin (stage I), progressing to low cellular concentrations of the vitamin (stage II), an increased blood level of homocysteine and a decreased rate of DNA synthesis (stage III), and finally, macrocytic anemia (stage IV).
This explains why B12 deficiency can occur even in people eating large amounts of B12-containing animal products.
B12 is the only vitamin that contains a trace element (cobalt), which is why it’s called cobalamin. A common myth amongst vegetarians and vegans is that it’s possible to get B12 from plant sources like seaweed, fermented soy, spirulina and brewers yeast. This explains why studies consistently demonstrate that up to 50% of long-term vegetarians and 80% of vegans are deficient in B12. I recognize that there are many reasons why people choose to eat the way they do, and I respect people’s right to make their own choices.
One of the greatest tragedies of the B12 epidemic is that diagnosis and treatment is relatively easy and cheap – especially when compared to treatment of the diseases B12 deficiency can cause. Some recent studies have suggested that high dose oral or nasal administration may be as effective as injections for those with B12 malabsorption problems. Japanese studies indicate that methylcobalamin is even more effective in treating the neurological sequelae of B12 deficiency, and that it may be better absorbed because it bypasses several potential problems in the B12 absorption cycle. So, next time you or someone you know is “having a senior moment”, remember: it might not be “just aging”. The two vitamin B12 coenzymes known to be metabolically active in humans are methylcobalamin and adenosylcobalamin. Both vitamin B12 and folic acid are required for the synthesis of thymidylate, a component of DNA.
Methylcobalamin is a co-factor of methionine synthase, an enzyme that transfers methyl groups to homocysteine to regenerate methionine.
Cyanocobalamin is not biologically active until converted to methylcobalamin, which also means releasing its cyanide. Large amounts of cyanocobalamin can exacerbate preexisting cyanide toxicity that can result from smoking tobacco, sodium nitroprusside therapy, and phagocytosis. In a comparison of cobalamins against cancer, adenoxylcobalamin was effective against fast-growing malignant cells. Another study found a correlation between serum vitamin B12 in women and their breast milk. In conclusion, methylcobalamin can be effective in cases of neuropathy, depression, cancer, optic atrophy, heart rate variability, homocysteinemia, and sleep disturbances. This entry was posted in Aging, General Well-being, Heart Health and tagged depression, DNA, intestinal flora, metabolism, salmon.


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An essential B vitamin for vegans, good for the nervous system, for intellectual and physical alertness, for RNA and DNA synthesis and for sustaining energy levels.
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Easily corrected once it is detected, vitamin B12 deficiency can cause shocking disability and death, even though the condition can be corrected at a cost of less than $100.
Known as pernicious anemia, every textbook of internal medicine and every introduction textbook of nutrition explains B12 deficiency in detail. Pseudovitamin B(12) is the predominant cobamide of an algal health food, spirulina tablets. It’s written about in every medical textbook and its causes and effects are well-established in the scientific literature.
Data from the Tufts University Framingham Offspring Study suggest that 40 percent of people between the ages of 26 and 83 have plasma B12 levels in the low normal range – a range at which many experience neurological symptoms.
It’s entirely possible that at least some of the symptoms we attribute to “normal” aging – such as memory loss, cognitive decline, decreased mobility, etc. Some experts have speculated that the acceptance of higher levels as normal in Japan and the willingness to treat levels considered “normal” in the U.S.
It’s also involved in the production of the myelin sheath around the nerves, and the conduction of nerve impulses. In fact, many of my patients that are B12 deficient are following a Paleo diet where they eat meat 2-3 times a day. But plant foods said to contain B12 actually contain B12 analogs called cobamides that block intake of and increase the need for true B12. Studies have shown that kids raised until age 6 on a vegan diet are still B12 deficient even years after they start eating at least some animal products. I also know that, like all parents, vegetarians and vegans want the best for their children. People with pernicious anemia or inflammatory gut disorders like Crohn’s disease are likely to have impaired absorption for their entire lives, and will likely require B12 injections indefinitely. However, most B12 experts still recommend injections for people with pernicious anemia and advanced B12 deficiency involving neurological symptoms. But recent evidence suggests that hydroxycobalamin (frequently used in Europe) is superior to cyanocobalamin, and methylcobalamin may be superior to both – especially for neurological disease.
On top of that, methylcobalamin provides the body with methyl groups that play an role in various biological processes important to overall health. You’re probably taking cyanocobalamin, the stable and less expensive form of vitamin B12. Vitamin B12 is usually absorbed from the gut from the fermentation of intrinsic factor by intestinal flora.
Lack of adequate DNA synthesis causes many red blood cell precursors (hematopoietic cells) to die in the bone marrow.
It is required in the synthesis of the amino acid methionine, which is involved in choline and betaine utilization. Cyanide can be toxic because it binds the iron (F3+) portion of cytochrome oxidases, preventing its reduction. However cyanocobalamin is not effective in removing cyanide because the cobalamin is already bound.(3) Since nitroprusside can induce cyanide toxicity, other cobalamins such as hydroxocobalamin should be used to bind with cyanide. Methylcobalamin was effective at elevated concentrations and cyanocobalamin had no effect in slowing the growth of any of the tumor cell lines studied.(6) In studies that show that vitamin B12 has no effect on cancer growth, we need to look closer at whether cyanocobalamin was used instead of the natural coenzyme forms (adenoxylcobalamin and methylcobalamin).
Ikeuchi and associates studied the effects of methyl-B12 on the electrical activity in hippocampal neurons and found that methyl-B12 increased post-synaptic field potential which lasted more than an hour and increased the electrical currents elicited by N-methyl-D-aspartate (NMDA). It accelerates re-entrainment of the activity rhythm to the environmental light-dark cycle. When a group of lactating women were injected with cyanocobalamin, there was also an increase of cyanocobalamin in their breast milk. Only trace amounts of cyanocobalmin are normally detectable in the human body, while significant amounts occur in patients with optic neuropathies, inborn errors of cobalamin metabolism and pernicious anemia. Plants containing S-methylmethionine include cabbage, kohlrabi, turnip, tomatoes, celery, leeks, garlic, beets, raspberries and strawberries(14). However, all cobalamin analogues are not equal and taking cyanocobalamin with already elevated levels of cyanide can actually be harmful. These articles, while of potential interest to readers of the Let's Talk Health Blog, do not necessarily represent the opinions nor constitute the advice of Let's Talk Health, Inc.
Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations.
However, because the vitamin B12 deficiency used to be detectable only after it had already become "pernicious," that is, the final stages of anemia made death inevitable, many clinicians fail to detect the vague symptoms of deficiency that overlap with many other diseases while the deficiency can be easily corrected.
Experts who specialize in the diagnosis and treatment of B12 deficiency, like Sally Pacholok R.N.


Long before anemia sets in, B12 deficiency causes several other problems, including fatigue, lethargy, weakness, memory loss and neurological and psychiatric problems. This is why it’s absolutely crucial for those that abstain from animal products to understand thatthere are no plant sources of B12 and that all vegans and most vegetarians should supplement with B12.
If you are B12 deficient, the next step is to identify the mechanism causing the deficiency.
However, production can be disturbed by nutritional deficiencies, intrinsic factor deficiency, bacterial overgrowth, malabsorption, alcohol, and antibiotics.
B12 assists in maintaining sulfhydryl (SH) groups in their reduced form for enzyme activity. Nitroprusside therapies should be minimized in critically ill patients and those with liver or kidney dysfunction. The suprachiasmatic nucleus (SCN) is involved in relaying photic information to the pineal gland.
He wrote that “the lead for improved prescribing must come form compilers of formularies that are highly regarded. Cyanocobalamin must first undergo conversion to the physiological forms of cobalamin before being effective against pernicious anemia. These views are not to be construed as medical advice - please consult your physician for any medical questions you may require. A wide variety of neuropsychiatric abnormalities is also seen in vitamin b 12 deficiency and appears to be due to an undefined defect involving myelin synthesis.
Most surprising to the researchers was the fact that low B12 levels were as common in younger people as they were in the elderly. This is especially important for vegetarian or vegan children or pregnant women, whose need for B12 is even greater than adults.
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Both website are dedicated to educating and informing people with articles on powerful and concealed information from around the world. However, the active form of B12 is methylcobalamin and the two are NOT equal in effectiveness. Nitrous oxide anesthesia in surgery and nitric acid from normal metabolism and inflammation also reduce our vitamin B12 levels. Gut changes due to vitamin B12 deficiency are often related to constipation whereas a folic acid deficiency is generally related to diarrhea. Vitamin B12 deficiency is associated with a decrease of reduced glutathione, needed for cell defense against pathogens (viruses, bacteria, fungi) and toxins. Elevated amounts of cyanocobalamin have been found in smokers and cases of amyotrophic lateral sclerosis and optic atrophy. These opinions have not been approved by the Pharmaceutical Association, the American Medical Association, or the Food and Drug Administration. Vitamin B12 deficiency is common in vegans who don’t eat B12 fortified foods or take B12 supplements and can result in paralysis, myelopathy, psychosis, or atherosclerosis. Once the mechanism is identified, the appropriate form (injection, oral, sublingual or nasal) of supplementation, the dose and the length of treatment can be selected. I have spent the last 36+ years researching Bible, History, Alternative Health, Secret Societies, Symbolism and many other topics that are not reported by mainstream media.
If you have symptoms of GI disorders, lethargy, confusion, slow thought processes, heart rate variability, atherosclerosis, sleep disorders, or immune dysfunction, you may need the methyl as well as the cobalamin component.
In contrast, cyanocobalamin showed no effect.(16) Methylcobalamin is also required in donating a methyl group for the synthesis of melatonin.
How much longer can we afford to allow ignorance and profit motives to undermine our nation’s health? A plant-based diet may improve Alzheimer’s symptoms, but if without B12 supplementation, a plant-based diet may make things worse. Methylcobalamin supplementation can assist in modulating melatonin secretion, enhancing light-sensitivity, normalizing circadian rhythms and improving sleep-wake cycles.(17) Methylcobalamin also helps improve heart rate variability, suggesting that it is involved in balancing sympathetic and parasympathetic nervous system function,(18) perhaps through its involvement with light entrainment and melatonin synthesis.
Freeman voiced the concern that even if hydroxocobalamin is prescribed, cyanocobalamin is administered in its place.
It is imperative that those eating plant-based diets include B12-fortified foods in their diet or take B12 supplements, especially pregnant or nursing women.
Since circadian rhythm and melatonin synthesis are key factors in health maintenance, the use of cyanocobalamin rather than methylcobalamin is undermining our health as individuals as well as a nation. The recommended intake is 4-7 micrograms a day (but to get that much in daily or weekly supplements you have to take much more). Omnivores under age 50 are rarely deficient in vitamin B12 (though may be deficient in other nutrients).Topic summary contributed by Wyatt.



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