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Author: admin, 08.11.2015
He asked another Pfizer chemist, Willard Welch, to synthesize some previously unexplored tametraline derivatives.
Welch then prepared stereoisomers of this compound, which were tested in vivo by animal behavioral scientist Albert Weissman. Carbamazepine is used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy. You should not take carbamazepine if you have a history of bone marrow suppression, if you are also taking nefazodone, or if you are allergic to an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), desipramine (Norpramin), imipramine (Tofranil), or nortriptyline (Pamelor).
Do not start or stop taking carbamazepine during pregnancy without your doctor’s advice. Do not use carbamazepine if you also take nefazodone, or if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. You should not take carbamazepine if you have a history of bone marrow suppression, or if you are allergic to carbamazepine or to an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), desipramine (Norpramin), doxepin (Sinequan, Silenor), imipramine (Tofranil), or nortriptyline (Pamelor).
Carbamazepine may cause severe or life-threatening skin rash, and especially in people of Asian ancestry. You may open the extended-release capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. While using carbamazepine, you may need frequent blood tests at your doctor’s office. Do not stop using carbamazepine without first talking to your doctor, even if you feel fine. Overdose symptoms may include shallow breathing, urinating less or not at all, muscle twitcing, tremors, slurred speech, or staggering walk. Drinking alcohol can increase some of the side effects of carbamazepine, and can also increase your risk of seizures. Grapefruit and grapefruit juice may interact with carbamazepine and lead to unwanted side effects.
Report any new or worsening symptoms to your doctor, such as: sudden mood or behavior changes, depression, anxiety, insomnia, or if you feel agitated, hostile, restless, irritable, or have thoughts about suicide or hurting yourself. Initial dose: 200 mg orally twice a day (immediate and extended release) or 100 mg orally 4 times a day (suspension). Initial dose: 100 mg orally twice a day (immediate or extended release) or 50 mg orally 4 times a day (suspension).
Initial dose: 200 mg orally in tablet or capsule form every 12 hours or 100 mg of oral solution 4 times a day. Maintenance dose: up to 1200 mg daily in 3 or 4 divided doses may be necessary to maintain plasma levels in the therapeutic range. The dose should be adjusted in 200 mg daily increments (increase by 100 mg twice daily) to achieve optimal clinical response.


Initial dose: 100 mg orally in tablet form every 12 hours or 50 mg of oral solution 4 times a day. Maintenance dose: 600 to 1200 mg daily in 3 or 4 divided doses may be necessary to maintain plasma levels in the therapeutic range. If satisfactory response not achieved, measure levels to determine if in therapeutic range. Initial dose: 100 mg orally twice a day (immediate or extended release tablets) or 50 mg orally 4 times a day (suspension). Taking carbamazepine with other drugs that make you sleepy or slow your breathing can increase these effects. This list is not complete and there are many other drugs that can interact with carbamazepine. It is also prescribed for trigeminal neuralgia (severe pain in the jaws) and pain in the tongue and throat.In addition, some doctors use Tegretol to treat alcohol withdrawal, cocaine addiction, and emotional disorders such as depression and abnormally aggressive behavior.
Your doctor may recommend a blood test before you start the medication to determine your risk. Carbamazepine may cause harm to an unborn baby, but having a seizure during pregnancy could harm both the mother and the baby. Some drugs can raise or lower your blood levels of carbamazepine, which may cause side effects or make carbamazepine less effective. Use a barrier form of birth control (such as a condom or diaphragm with spermicide) to prevent pregnancy while taking this medicine. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. Keep using carbamazepine as directed and call your doctor promptly if this medicine seems to stop working as well in preventing your seizures.
You may have increased seizures or unpleasant withdrawal symptoms if you stop using carbamazepine suddenly. At least once every 3 months throughout the treatment period, attempts should be made to reduce the dose to the minimum effective level or to discontinue the drug. Some drugs can raise or lower your blood levels of carbamazepine, which may cause side effects or make this medicine less effective. Ask your doctor before taking carbamazepine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
The drug is also used to treat migraine headache and "restless legs."Most important fact about TegretolThere are potentially dangerous side effects associated with the use of Tegretol.
Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. Tell your doctor right away if you become pregnant while taking carbamazepine for seizures.


Carbamazepine can also affect blood levels of certain other drugs, making them less effective or increasing side effects.
Carbamazepine may cause harm to an unborn baby, but having a seizure during pregnancy could harm both mother and baby.
If you experience symptoms such as fever, sore throat, rash, ulcers in the mouth, easy bruising, or reddish or purplish spots on the skin, you should notify your doctor immediately. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Keep the liquid suspension away from light.Tegretol side effectsSide effects cannot be anticipated. There exists the strong possibility of continuous epileptic attacks without return to consciousness, leading to possible severe brain damage and death. Alert your doctor immediately if you develop such warning signs as fever, sore throat, rash, ulcers in the mouth, easy bruising or spots in the skin, swollen lymph glands, loss of appetite, nausea or vomiting, or yellowing of the skin and eyes.The coating of the Tegretol-XR tablet is not absorbed and passes through your body intact. If you notice it in your stool, it is not a cause for alarm.Possible food and drug interactions when taking TegretolThe use of the antiseizure medications phenobarbital, phenytoin (Dilantin), or primidone (Mysoline) may reduce the effectiveness of Tegretol.
Therefore, Tegretol should be used during pregnancy only if the potential benefits justify the potential risk to the fetus. If you are pregnant or plan on becoming pregnant, you should discuss this with your doctor.Tegretol appears in breast milk.
If you are breastfeeding, your doctor may advise you to discontinue doing so if taking Tegretol is essential to your health.Recommended dosage for TegretolADULTSSeizuresThe usual dose for adults and children over 12 years of age is 200 milligrams (1 tablet or 2 chewable or extended-release tablets) taken twice daily or 1 teaspoon 4 times a day. Your doctor may increase the dose at weekly intervals by adding 200-milligram doses twice a day for Tegretol-XR or 3 or 4 times per day for the other forms.
Dosage should generally not exceed 1,000 milligrams daily in children 12 to 15 years old and 1,200 milligrams daily for adults and children over 15. The usual daily maintenance dosage range is 800 to 1,200 milligrams.Trigeminal NeuralgiaThe usual dose is 100 milligrams (1 chewable or extended-release tablet) twice or one-half teaspoon 4 times on the first day.
Your doctor may increase this dose using increments of 100 milligrams every 12 hours or one-half teaspoonful 4 times daily only as needed to achieve freedom from pain.
Doses should not exceed 1,200 milligrams daily and are usually in the range of 400 to 800 milligrams a day for maintenance.CHILDRENSeizuresThe usual dose for children 6 to 12 years old is 100 milligrams twice daily or one-half teaspoon 4 times a day. Your doctor may increase the dose at weekly intervals by adding 100 milligrams twice a day for Tegretol-XR, 3 or 4 times a day for the other forms.
The total daily dose is divided into smaller doses taken 2 or 3 times a day for tablets or 4 times a day for suspension.



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