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Author: admin, 07.12.2014
The word ‘tinnitus’ comes from the Latin word tinnire meaning ‘to ring’ – a reference to the high-pitched ringing sound that tinnitus commonly manifests itself as. It is not a disease, rather a condition caused by a broad range of possible underlying causes. It is commonly believed that tinnitus is a condition that only affects the elderly or the hard of hearing, however this is a popular misconception. Although noise-induced hearing loss is probably the most common cause of tinnitus, the condition can also be attributed to a huge number of neurological, medicinal, emotional or physical factors. It may arise as a result of problems, disorders or changes in the inner ear, middle ear, outer ear or the brain.
Tinnitus research studies have shown that certain medicines have also been implicated in tinnitus onset.
Keeping a set of ear plugs with you to protect your ears from loud noises is a cheap and easy way to prevent permanent hearing damage and future problems.
If you feel you may be exposed to loud sounds, always carry a pair of foam earplugs and don’t be shy about using them. The word ‘tinnitus’ comes from the Latin word tinnire meaning ‘to ring’—a reference to the high-pitched ringing sound that commonly manifests itself as. The aims of TRA are to investigate therapies which look to be promising candidates for the reduction of symptoms and to report these findings for the benefit of all sufferers. Los tipos de tinnitus, y que pruebas diagnosticas solicitar.Pulsando en el diagrama desde esta pagina aparece un PDF (en ingles) con detalles. Over 70 million people in Europe experience tinnitus, for 7 million it creates a debilitating condition. In spite of its enormous socioeconomic relevance funding for tinnitus research has been very limited (Cederroth et al., 2013). Recent advances in neuroscientific methods have led to substantial progress in the understanding of tinnitus. In addition to altered activity in central auditory pathways, recent research has increasingly identified further central nervous system components of tinnitus (Langguth et al., 2013).
This increasing knowledge prompted the development of innovative treatment approaches in the last years. The aim of TINNET is the identification of pathophysiologically and clinically meaningful subtypes of tinnitus. The strategy of TINNET is to standardize and coordinate clinical, neuroimaging and genetic assessment of tinnitus patients and to aggregate data in a large scale database in order to identify tinnitus subtypes and their neurobiological underpinnings.
The expected result is the identification of meaningful subtypes of tinnitus and their neurobiological underpinnings.
TINNET is a European research network funded by the COST program under the Action number BM1306. Although it is often described as a “ringing in the ears”, it is not always characterised by a ringing noise – in fact the sound can vary hugely from sufferer to sufferer. In fact, anyone can get tinnitus, from the very young to the very old, and regardless of gender, race or age. Tinnitus may start suddenly and seemingly out of nowhere, or it may be characterised by a slow and gradual onset. It is not usually a sign of any serious health problem, although when it is persistent or invasive it can cause feelings of anxiety, depression and stress for sufferers. Despite being a relatively harmless symptom, it is capable of causing very real emotional and mental anguish to people.

Brass players and those in the military (if exposed to gunshot noise and explosions) are good examples. We also undertake and fund our own development work on promising therapies in our dedicated R&D facility.
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Severe tinnitus is often associated with depression, anxiety and insomnia, resulting in an enormous socio-economic impact (Langguth, 2011). Now the European Union has approved funding for the COST Action TINNET, which aims to create a paneuropean tinnitus research network.
Both animal models of tinnitus and neuroimaging research in patients suffering from tinnitus have provided important insight into the neuronal mechanisms involved in the pathophysiology of tinnitus. Brain networks involved in tinnitus pathophysiology differ from patient to patient and include the frontal cortex, the anterior cingulate, the insula and the medial temporal lobe including amygdala, hippocampus and parahippocampus (De Ridder et al., 2013). All these methods have in common that they aim at targeted modulation of the neuroplastic changes underlying tinnitus, either by specific auditory stimulation, by conditioned learning, by pharmacologic treatment, by brain stimulation or by a combination of different treatments.
This in turn is required for increasing the efficacy of currently available treatments by assigning the most effective treatment to the individual patient. This will facilitate the developments of new therapies and improve the efficacy of currently available treatments. This in turn will improve tinnitus treatment by enabling to better assign current and to better tailor future treatments to specific patient subgroups. We hope that the program will attract many clinicians and researchers and will motivate them to join forces in order to work for a better therapy for the many people worldwide who suffer from tinnitus.
An integrative model of auditory phantom perception: Tinnitus as a unified percept of interacting separable subnetworks. However, the prevalence of tinnitus does tend to increase with age, and it’s been estimated that around 60-70% of sufferers are middle aged. Natural tinnitus treatments are available but there is currently no medical cure for tinnitus so the best action you can take is preventative, avoid exposure to excessively loud sounds at home, in your workplace or at concerts and live music events. So the best preventative action you can take is to avoid your exposure to excessively loud sound. This will help you to understand your tinnitus better and also describe some the latest research findings. Although we subsidise the cost of therapies you will be asked to contribute towards the costs and also to report regularly on your findings. We are entirely self-funded and your donation, no matter how small, would be appreciated to help us fund our work. It has been estimated that 13 million people in Western Europe and in the US approach their doctor regularly because of their tinnitus symptoms (Vio and Holme, 2005).
The COST (Cooperation in Science and Technology) program has been founded in 1972 and is Europe's longest-running research program. In short, alterations of neural along the central auditory pathways have been observed in connection with tinnitus (Eggermont and Roberts, 2004). These brain areas are related to attention-, salience-, distress- and memory-related aspects of tinnitus.
Since the high heterogeneity of tinnitus is considered as the major obstacle for the development of more effective treatment strategies, TINNET will address the current bottleneck in the development process of innovative treatment approaches.

Department of Veterans Affairs.Tinnitus is largely a mystery, a phantom sound heard in the absence of actual sound. Research also suggests that Caucasians are more prone to developing tinnitus than other ethnic groups, and additionally it appears that men are more likely to suffer from the condition than women. A quick ‘stop gap’ protective measure is to moisten some tissue paper and use that as an ear plug. These figures are expected to increase due to increasing occupational and leisure noise and due to the demographic development. COST is an intergovernmental framework for European Cooperation in Science and Technology, which promotes and coordinates nationally funded research in Europe through funding of research networks. These changes of neural activity seem to arise from dysfunctional activation of neural plasticity induced by altered sensory input, namely auditory deprivation in most cases (Norena, 2011), but also altered somatosensory input (Shore et al., 2007) in some patients.
Depending on the individual clinical characteristics different networks seem to be involved to a different extent (De Ridder et al., 2013). However, most results are characterized by a high interindividual variability, indicating the relevance of tinnitus subtypes which differ in their response to specific treatments. This requires a coordinated collaborative effort from clinicians and technicians of different centers and disciplines and bio- and health-tech companies working together in ongoing close collaboration.
About one in ten children in the UK suffer from tinnitus, although the exact number of young sufferers is difficult to find out.
It doesn’t take much to reduce excessive sound levels to acceptable ones and protecting yourself from tinnitus need not interfere with your enjoyment.
The mentioned adaptive processes are mainly driven by mechanisms of homeostatic plasticity which alter the balance between excitatory and inhibitory function of the auditory system at several levels in order to compensate for the reduced input (Norena, 2011). Thus there is an urgent need for identifying pathophysiologically distinct subgroups for optimizing and further validating these treatment interventions. It is a symptom, not a disease, and though exposure to loud noise may cause it, some cases have no apparent trigger.
The acronym TINNET stands for the planned Tinnitus research Network, but also for the goal of the action, namely New Treatments for Tinnitus. Moreover the identification of valid subtypes will enable to better predict treatment response to the various currently already available treatment.
Thus further progress is hampered by the fact that tinnitus represents a highly heterogeneous condition. The findings could lead to a testable model that helps to identify what region or regions of the brain might be responsible for causing the two conditions. Having conceptualized a broader, more comprehensive neural network, the researchers hope to eventually test the model by deactivating specific segments of the neural network. This problem is related to the current research structure with many separate groups working largely in isolation and being funded locally or nationally. In order to effectively address the heterogeneity of tinnitus a coordinated effort is required to enable the analysis of large samples. Within the TINNET project networking and capacity building activities will be supported, in order to transform the currently still separated research groups into an efficient research network.How will TINNET work? There is emotion and arousal, but the final puzzling piece to the network is activity in the cerebellum, normally activated during motor planning events like reaching for a cup or catching a ball.

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