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December 1, 2011 By Marina Gutner Currently, synthetic T4 thyroid drugs are standard method of hormone replacement therapy for people with hypothyroidism. Although the use of T4 thyroid medication has been accepted for many years in conventional medicine, many patients continue to experience symptoms of underactive thyroid even if their lab test results show normal.
Beyond thyroid replacement therapy there are no other treatments for Hashimoto’s and hypothyroidism in the conventional medicine. The answer to the question why the majority of the thyroid patients do not feel well following the thyroid hormone replacement therapy lies in the human physiology and improper diagnosis.
About 20% of T3 hormone is produced by the thyroid gland and 80% comes from an inactive pro-hormone T4 through conversion in the liver, kidneys, intestines and in cells. In addition to the diminished thyroid hormone conversion people with Hashimoto’s could have other types of thyroid dysfunctions caused by the inability of thyroid hormone to enter the cell and perform its metabolic action.
Another underlying cause of Hashimoto’s and hypothyroidism mismanagement and undertreatment is that many patients are not properly diagnosed.
According to a recent study, Hashimoto’s patients with a normal TSH, T3 and T4 lab test results but TPO antibodies over 120 still can experience hypothyroid symptoms.
Synthroid, L-Thyroxin and Levothyroxin are the most prescribed synthetic T4-only thyroid drugs. Cytomel is a synthetic T3-only type of thyroid drug which releases very fast into the blood stream. To prevent this boosting effect and support steady levels of T3 a patient is usually advised to take smaller doses of Cytomel spreded throughout the day. Desiccated thyroid drug may not be the best option for people who have an autoimmune thyroid condition.
With Hashimoto’s disease, thyroid antibodies attack the thyroid gland and could also develop autoimmune reaction against T4 and T3 hormones. A combination of synthetic T4-only types of thyroid drugs and compounding pharmacy slow release T3 medication is a better choice for hypothyroid Hashimoto’s patients with T3 underconversion due to absence of the boosting effect of Cytomel and fully customizable T3 dose that slowly releases into the blood stream.
However, a common concern with using any type of the T3 medication is that the body cannot regulate the supply of T3 hormone and adjust it to the body’s needs because the portion of T3 comes externally from the thyroid drug. Switching to combined T4 and T3 medication or adding T3 type of thyroid drug can bring relief of some hypothyroid symptoms especially fatigue, hair loss, weight gain and depression in women.
Since the conventional medicine does not make any attempt to modulate the immune system in people with Hashimoto’s any stable and long lasting results are difficult to achieve using practically ANY type of available thyroid drugs alone. Any type of thyroid medication currently used by conventional medicine does not address the cause of the Hashimoto’s disease which is an overreaction of the immune system due to a combination of certain nutritional deficiencies, genetics and numerous environmental factors. Patients with Hashimoto’s disease have a latent gene that could remain in an unexpressed state for a long period of time. Thyroid drugs replace the hormones that cannot be produced and reduces inflammation of the thyroid gland, however it does not stop the autoimmune attack that causes the disease and does not eliminate any environmental factors that trigger Hashimoto’s. Recent research studies reported that hypothyroidism caused by Hashimoto’s disease is reversible in some cases. Gluten and excessive iodine are well-known dietary factors that can trigger Hashimoto’s disease and hypothyroidism.
For many of us it is not enough to just take a thyroid drugs to manage the Hashimoto’s disease and hypothyroid symptoms and to feel well.
Impaired intestinal absorption of thyroid hormone in a case of Hashimoto’s disease with anti-T3 and anti-T4 antibody. Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state. The effect of iodine restriction on thyroid function in patients with hypothyroidism due to Hashimoto’s thyroiditis.

Legal:All publications and any information provided on this blog is for informational and educational purposes only, and should not be used as an alternative or a substitute for professional medical advice, diagnosis, or treatment. Some research suggests that overweight people with hypothyroidism who take the standard thyroid hormone replacement drug, Synthroid, T4, the inactive form of thyroid, generally do not lose much weight with treatment. In my experience, people are able to lose weight better when their body temperatures are 98.6 as measured by mouth. I suggest that if you are taking T4, and having trouble losing weight despite your best efforts, that you take your body temperature.
WTS can often be corrected with proper thyroid support, which often includes a trial of T3.
Denis Wilson, MD developed the concept of Wilson 's Temperature Syndrome in 1988 after observing people with symptoms of low thyroid and low body temperature, yet who had normal blood tests.
Thyroxine (T4) The thyroid hormones, triiodothyronine and thyroxine, are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism.
You can buy Thyroxine (T4) 50mcg tablets online without prescription (No RX) from Silkroad – Online Pharmacy.
The goal of the treatment is to bring the patient into a stable condition where the TSH is in the normal range. The patients who take the T4-only drugs depend on these conversions in the peripheral tissues as the only source of active form of the thyroid hormone T3.
At the same time, the thyroid gland produces less  and less T3 and the body becomes more dependent on the T4 to T3 conversions. According to the standard medical care, lab guidelines and medical insurance policies, TSH and free T4 thyroid hormone are tested if hypothyroidism is suspected and only a TSH test is required for the follow up visits.
If a patient has normal TSH and free T4 but low free T3 the person still can have hypothyroid symptoms and your doctor won’t be able to find it using the standard testing. All of them contain the same synthetic T4, however they are produced by different manufactures and can have different inert ingredients such as fillers.
However, due to the nature of this type of thyroid drug it is practically impossible to avoid the short lasting periods of high T3 after the Cytomel is taken. However, desiccated brands such as Armor thyroid and Naturthyroid or OTC brands such as Thiroyd and Thyroid-S have T4 to T3 in a fixed ratio determined by the manufacturer. Since desiccated thyroid is a natural compound that includes both T4 and T3 thyroid hormones as well as T1 and T2, the immune system can start to produce its own antibodies against the these hormones and make an existing autoimmune condition worse. However, with time many Hashimoto’s patients do not see much difference compared to being on T4 medication alone because the autoimmune attack and destruction of the thyroid gland remain in progress.
If some environmental and dietary factors get involved, it could “turn the gene on” and trigger the autoimmune response.
The destruction of the gland continues and the patient requires higher and higher doses of ANY type of thyroid drugs with time for treatment of hypothyroidism and symptoms relief.
If increase of dose of thyroid drugs brings only short-term temporarily relief and symptoms appear again it can be also due to adrenal fatigue. By identifying and removing ALL dietary triggers of thyroid autoimmunity and healing leaky gut syndrome all patients improve and many are able to reduce their thyroid medication and reverse thyroid disease. However, many people struggle to to it on their own and need get help of holistic health coach to get results they want. Finding and addressing the cause of the autoimmune disease and thyroid dysfunction can significantly improve the quality of life and make a true difference for many patients.
There is a vast difference between losing weight with a low temperature and losing weight with a normal temperature. In another study, NIH researchers found that even modest weight loss can reduce metabolism slightly.

You can discuss T3 therapy with your doctor and we will be happy to discuss your case with your doctor. Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine. Moderate weight loss is sufficient to affect thyroid hormone homeostasis and inhibit its peripheral conversion. He found that by normalizing their temperatures with T3 (without T4) their symptoms often remained improved even after the treatment was discontinued.
It is not recommended that patients be treated solely on the information presented here, but that physicians consider the information in the Doctor's Manual, as well as the thyroid medical literature, in the exercise of their professional judgment. Often a patient receives an antidepressant to treat thyroid related depression and sleeping pills for insomnia. The absence or deminished production of T3 by the thyroid gland and impaired hormone conversions could make a significant physiological impact leaving the patient with unresolved hypothyroid symptoms.
If the patient has any type of thyroid hormone conversion impairment the person can experience multiple hypothyroid symptoms. Based on the test results most conventional physicians prescribe medication that contains T4 only and seldom check for thyroid antibodies since it does not affect the therapy. A proper thyroid panel includes a measurement of the free T3 and thyroid antibodies test if Hashimoto’s is suspected. High boosts of the T3 levels can result in unpleasant hyperthyroid symptoms such as rapid heart beat, insomnia and anxiety and contribute to heart issues and osteoporosis. It can be a very undesirable effect especially for hypothyroid elderly patients and women going through the menopause. If a patient has  an underconversion of T4 into T3 it is seldom that both hormones are in the same proportion as the patient needs.
Poor blood sugar control, hormonal imbalances, adrenal issues, infections, irregular immune function, gluten intolerance and other food allergies are factors that can also affect thyroid function and trigger the over reaction of the immune system. Increasing thyroid medication is one of 5 crucial mistakes women with thyroid problems make. I am a researcher, medical writer, Author of forthcoming series on thyroid, hypothyroidism and autoimmune disease. For one, when people with low temperatures lose weight they tend to gain it all back and then some after their diets are over. The researchers speculate that this is due to reduced T4 to T3 conversion in peripheral tissues. If youa€™re a bodybuilder, most probably youa€™ve tried to find answers to these questions. The amount of T3 in the natural thyroid drugs is usually either too much or most likely not enough and can also differ between brands.
In this group of thyroid patients adrenal imbalance should be corrected first because it can provide some improvement of symptoms that were initially attributed to hypothyroidism and a patient often will require lower dose of thyroid medication. Youa€™ve seen in the gym people taking steroids of same type but having totally different result. In fact, research from the National Institutes of Health recently showed that even when people are getting enough T4 to restore their blood levels of TSH to normal, they may have a shortage of T3 in various tissues in their body.
Low body temperature even with normal TSH levels is a condition called Wilson’s Temperature Syndrome. And in a study where they compared equivalent doses of T4 to T3, T3 resulted in significant weight loss when substituted for T4.

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