Weight loss drug causing liver failure,workout tips to lose weight and gain muscle,foods that help lose weight faster - And More

Washington, December 11 : Weight-loss drug orlistat, known by the brand names Xenical and Alli, inhibits a key enzyme that may lead to "severe toxicity of internal organs such as the liver and kidney," according to a University of Rhode Island researcher. Professor Bingfang Yan's study funded by the National Institutes of Health, also found that the drug alters efficacy of medicines, and particularly limits the effectiveness of some anti-cancer drugs. Orlistat, which was originally approved by the FDA in 1999 as the prescription drug Exenical, was approved in 2007 as the over-the-counter medication Alli. Yan said orlistat works in the intestinal tract by preventing fat from being absorbed by the body. The study showed that the drug is a potent inhibitor of carboxylesterase-2, which is a major detoxification enzyme in the liver, kidney and gastrointestinal track. The enzyme is known to metabolize a wide range of medicines including aspirin and the cancer drugs irinotecan and pentyl carbamate of p-aminobenzyl carbamate of doxazolidine. Prior or co-presence of orlistat with one of the anti-cancer drugs resulted in cancer cells being far more prolific. Part of the research results will be published in the journal, Biochemical Pharmacology, which has the article posted on its website. Alli weight loss drug being probed by FDA for liver damage threat BY The Associated Press Friday, August 28, 2009, 12:23 PM A A A facebook Tweet email Bates for News Alli, the only over-the-counter weight loss drug approved by the FDA, is now under investigation for causing liver damage. Signs of Liver Injury: Itching, yellow eyes or skin, dark urine, loss of appetite, and light-colored stools may be signs of liver injury. Note: If you need help accessing information in different file formats, see Instructions for Downloading Viewers and Players.
One of the most popular of these weight loss drugs is called Alli, a prescription-strength version of Xenical. Sadly, this is only one of the potential adverse and serious side effects of this and many other weight loss pills. According to the preliminary studies of Alli, patients lost a whopping 1 pound per month on average. While the FDA has looked into Alli’s potential link to liver damage at an April 2009 reunion of its Drug Safety Oversight Board (DSB), a major concern involving the FDA is the fact that the organization is not issuing any warnings for those individuals currently taking the over the counter drug.
If this drug was an organic herbal supplement, the FDA would be quick to pull it from the shelves while putting the manufacturer under investigation and probably throwing them in jail. We should be aware that liver damage is a highly serious condition involving liver inflammation, necrosis (a form of hepatitis), vascular lesions, and even possible liver failure. It may be related to the fact that, last year alone, Alli generated over $130 million dollars in sales during its first year on the diet-pill market. As always, natural supplements that aid weight loss are the best support when they are combined with sustained healthy diet and lifestyle choices.

I was just recently wondering how effective this product is because I keep seeing the commercials. In years of battling my weight, the one thing I’ve constantly avoided is medicine and drugs.
I used Alli for a couple of months and I had extremely painful headaches at first I thought the headaches were coming from stress.
The Alli budget: Alli is not cheap,and it rarely goes on sale,but you can get it cheaper if you know what to look for. If you check the internet for store sales,Amazon on especially EBAY you can almost always get a 120 bottle for $39.99,and that is the going rate for 60 pills at the store. When ever I see the price i want to spend only then do i buy.Sometimes i have to wait more then a month and that is ok for my health and my pocket book. You will also notice lots more sweat around your waist from wrap.My waist can’t live without it!
You have created a superb document with a lot of reliable information about how we are able to eat to get far more feed and also healty and the same time learn how to look for the right product or service that will help us all. Information and statements made are for education purposes and are not intended to replace the advice of your treating doctor. It has been the most commonly used medicine to treat obesity for more than a decade, Yan said. It has been linked to severe liver failure, acute pancreatic failure and acute renal (kidney) failure," Yan said. It is generally accepted that orlistat remains in the intestine and that the body does not absorb it.
Yet sadly, in attempt to lose extra weight quickly, many people turn to weight-loss drugs or cheap supplements instead of the natural methods of weight loss which take more time, but work more effectively in the long run.
This drug can currently be bought over the counter, despite the fact that it is being investigated by the FDA because of orlistat, the weight-loss ingredient in Alli, that may be causing hepatoxicity (another way of saying liver damage) [1]. But, because this is a big pharmaceutical company designed to slowly make us ill and keep us in the system until we die, they allow this harmful drug to continue to be sold over-the-counter even despite the fact that it is currently under investigation for the role it plays in liver damage.
Moreover, the majority of diet pills sold over the counter in the United States do not need pre-approval by the FDA, as they are not typified as drugs, but are considered food!
What is more, it is not up to companies who sell these drugs to look into their safety, but is the job of the FDA.
It also involves important lifestyle changes such as following a frequent exercise routine and reducing the stress in your life, as well as a commitment to these processes over time. We should not wait for the FDA to come to conclusions before people should stop taking this drug.

If you are interested in natural ways to lose weight I recommend reading The 10 super Secrets to Weight Loss. Orlistat (marketed as Alli and Xenical): early communication about an ongoing safety review. Information and statements made are for education purposes and are not intended to replace the advice of your doctor. Different things work for different people and I was lucky enough to find one that worked for me.
There are many over-the-counter weight loss drugs that stimulate the metabolic process and suppress appetite through artificial means. Every pharmaceutical drug causes damage to the body and only addresses the symptoms and never the root cause! This is the only true way towards sustainable weight loss, without any of the risky potential side effects such as those discussed in this article. The views and nutritional advice expressed by Global Healing Center are not intended to be a substitute for conventional medical service.
The FDA also has not reported how many liver-damage reports from real human beings taking the drug Alli actually exist.
She said alli's safety has been studied in more 30,000 patients enrolled in 100 clinical studies."Liver changes can have many causes," said Debbie Bolding, in a statement. We are not responsible for the content or products of any linked site or any link contained in a linked site. Global Healing Center does not adopt any medical claims which may have been made in 3rd party references. Where Global Healing Center has control over the posting or other communications of such claims to the public, Global Healing Center will make its best effort to remove such claims. In some of these cases, other factors or drugs may have contributed to the development of severe liver injury. A cause-and-effect relationship of severe liver injury with orlistat use has not been established; however, because of the seriousness of this possible side effect, FDA has revised the drug labels for Xenical and Alli to include new safety information about the rare occurrence of severe liver injury. This article appears on FDA's Consumer Updates page, which features the latest on all FDA-regulated products.

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