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Description: This podcast covers several new topics, including celebrities who are convinced the earth is flat, the growing threat that is Zika virus, and how HIV is eluding CRISPR treatments. Keywords: glycans, glycobiology, podcast, Pascal Gagneux, sperm, evolution, biolegend, science, chimpanzees, non-human primates, Neanderthal, pathogen, Ajit Varki Having difficulty playing this episode? Description: In this episode, we discuss some a variety of current scientific news, including the discovery of woman who can smell Parkinson's disease, a correlation between bovine leukemia virus and breast cancer, using an individual's microbial cloud to identify them, and how we're using specialized antibodies to combat both HIV and cancer. Keywords: immunology, comics, cancer, chimeric antigen receptor, T cells, gene therapy, hypoxia, immune checkpoints, goinvivo, tumors, podcast, pedromics, pedro velica Having difficulty playing this episode?
Keywords: neuroscience, neurodegeneration, Parkinson's disease, microbes, microbial, gut microbiome, bacteria, asthma, allergy, leukemia, cancer, AML, antibody, virus, cow, bovine, breast cancer, HIV, AIDS Having difficulty playing this episode? Description: Special guest and global health scientist Jessica Taaffe joins us to discuss educating the public, funding research, and the passion needed in scientific role models.
Keywords: global health, Jessica Taaffe, HIV, ebola, education, Bill Nye, Neil degrasse Tyson, vaccines, anti-vaxxers, world bank, funding, research, NIH, primates, biolegend, podcast Having difficulty playing this episode? Description: The podcast team discusses the potential anti-venom shortage, a wasp-venom derived protein for cancer therapy, 30,000 year-old viruses, and a new hominid species discovered in South Africa.
Keywords: venom, anti-venom, snakebites, wasp venom, Fav-Afrique, MP1, Polybia-MP1, Polybia paulista, phosphatidylserine, annexin V, cancer cells, homo naledi, fossils, Mollivirus sibericum, viruses, Siberia, giant viruses Having difficulty playing this episode?
Description: On this podcast, we discuss current events in science, including recent outbreaks of polio in the Ukraine and Legionnaire's disease in California and Illinois. Keywords: polio, Legionnaire's disease, outbreaks, virus, bacteria, saturated fats, obesity, microbiome, mice, inflammation, leptin, neurons, brain, exercise, neutrophils, T cells, infection, lungs, influenza, open-access, journal, the wall of polio, science, podcast, virology, immunology Having difficulty playing this episode?
Description: Glioblastomas and medulloblastomas are two common forms of brain cancer that afflicts thousands of people a year. Description: We cover the latest science current events, including the new Ebola vaccine, limb regeneration, being hangry, and Kim K's flub with the FDA. Keywords: Kim Kardashian, ebola, vaccines, anti-vaxxers, current events, limb regeneration, repair, hangry, science, podcast, food and drug administration, morning sickness, FDA Having difficulty playing this episode? Description: In our latest podcast, we talk about narcolepsy and the fight between local colleges for the rights to an Alzheimer's disease database. Keywords: UCSD, USC, University of Southern California, University of California San Diego, Alzheimer's disease, Pandemrix, narcolepsy, sleep, Paul Aisen, BioLegend, science, podcast Having difficulty playing this episode? Description: Ed Chen and Rea Dabelic, two members of the BioLegend Technical Team, take over the podcast this week to discuss Selman Waksman (the Father of Antibiotics), tuberculosis, and giving credit where its due. Keywords: Selman Waksman, Albert Schatz, streptomycin, neomycin, antibiotics, Neosporin, tuberculosis, granulomas, macrophage, biolegend, immunology, mycobacterium tuberculosis, podcast, patents, inventions, royalties, tuberculin skin test, lab assistants, consumption, avastin, microbiology, birthday blog, controversy, Nobel prize Having difficulty playing this episode?
Description: We welcome Chris Gould to discuss neuroscience, protein misfolding, aggregation, and prion-like proteins in neurodegenerative diseases. Keywords: neuroscience, tau, a-synuclein, alzheimer's disease, parkinson's disease, neuroinflammation, prions, Creutzfeldt-Jakob disease, mad cow disease, kuru, cannibalism, brain, aggregation, protein misfolding, blood brain barrier, lymphatic system, chris gould, biolegend, immunology, podcast, neurofibrillary tangles, lewy bodies, inclusion, Lou Gehrig's disease, ALS, amyotrophic lateral sclerosis, neurodegeneration, microglia Having difficulty playing this episode?
Description: Neuroinflammation can be beneficial in some instances, but too much of it can cause any number of neurological diseases.
Keywords: Kenya Cohane, neuroinflammation, neuroscience, alzheimer's disease, parkinson's disease, multiple sclerosis, tau protein, a-synuclein, aggregation, immunology, podcast, biolegend Having difficulty playing this episode? Description: Antibody therapies have become incredibly popular for the treatment of diseases, including cancer. Keywords: cancer, tumor, antibody therapy, therapeutics, immune checkpoints, PD1, PDL1, LAG3, TIM3, CD80, CD86, Galectin 9, MHC II, CTLA4, Pembrolizumab, Ipilimumab, Nivolumab, nanobody, melanoma, carcinoma, biolegend, science, podcast, merck, amgen Having difficulty playing this episode? Description: CRISPR is an amazing technology originally discovered in bacteria as a defense mechanism against invading foreign genetic material. Description: Despite our advances in science and technology, it seems like more and more people are outright denying scientific principles and concepts like evolution and climate change. Keywords: podcast, biolegend, immunology, biology, climate change, ted cruz, NASA, jim inholfe, brain, neuroscience, music, ignorance, science, education, ivory tower, spock, star trek, leonard nimoy, evolution, fluorine, fluoridination, fanta, Tourette Syndrome, nerdy, nerds, nerd, fandom Having difficulty playing this episode? Description: In this podcast, we discuss bacterial hot spots in New York, a brand new antibiotic found in dirt, telomeres and aging, and an interesting article published in 17 scientific journals about Cocoa Puffs. Keywords: podcast, podcasts, New York, subways, bacteria, antibiotics, MRSA, antibiotic resistance, telomeres, cocoa puffs, teixobactin, beer, alzheimer’s disease, parkinson’s disease, aging, BioLegend, immunology, biology, science, grad school, scientific journals Having difficulty playing this episode? Description: In this podcast, we take a look at how a lack of vaccinations has once again caused an outbreak of a once-controlled disease, the efficacy of the flu vaccine this year, and why people are clamoring to know if their food contains DNA.
Keywords: podcast, science, measles, vaccinations, vaccines, anti-vaxxers, Jenny McCarthy, research, cures, Disney, Disneyland, outbreak, flu vaccine, influenza, flu, dna, food, GMO, genetically modified organism, antibiotics, virus, viruses Having difficulty playing this episode?
Description: In this podcast, we examine why it’s so hard to transition from animal research into human cures and Obama’s latest visit to the NIH. Keywords: podcast, president, Obama, Barack Obama, BioLegend, NIH, National Institutes of Health, science, Ebola, HIV, Human immunodeficiency virus, AIDS, acquired immune deficiency syndrome, translational models, animal models, translation, research, bench to bedside, cures, vaccines Having difficulty playing this episode? Komuso- so you can use the amigusa.a€?Priest- so as to be able to approach both men and women.
The use of religion as an escape from prohibitions from traveling and staying in an area was rather common in some situations.
Still, they were not all so despised and many folks would open up to a traveling Buddhist monk (Below) if he were to ask questions about the provence he was traveling as part of his duties. 64 Shoninki-The True Records of the Shadow Warriors, Copyright Don Roley 2012were to ask questions about the provence he was traveling as part of his duties.
Thus a ninja dressed as a yamabushi had a ready made excuse for being ona€?the road into other provinces. Sometimes they even set up in areas to give shows showing off their goods whilea€?watching the roads and people. This disguise was very popular with the Koga ninja, who traveled the land selling medicine carried on bundles hung from a stick on their shoulder. Sarugakushi (Following picture, ) were related to performers, except that instead of singing and dancing, they were the performers of more traditional and high class entertainment. The common folks had their own way of dressing, and this changed a bit from place to place.
Komuso- so you can use the amigusa.Priest- so as to be able to approach both men and women. Thus a ninja dressed as a yamabushi had a ready made excuse for being onthe road into other provinces. Sometimes they even set up in areas to give shows showing off their goods whilewatching the roads and people. We examine increasing cases of diabetes and how finding the "secret sauce" for beta cells might fight this trend.
BioLegend is working with Sean Parker and the Parker Institute’s collaboration in fighting back against cancer.
Recent studies have reported a link between Herpes Simplex Virus 1 (HSV-1) and increased AD risk. This blog will cover the major apps provided by BioLegend relevant to research steps from conceptualization to discovery, as well as a few useful apps not from BioLegend.
Look back at this year’s most popular posts and find out which blogs our writers enjoyed composing. Our latest podcast invites guest Pascal Gagneux to discuss his thoughts on glycans, evolution, and sex cells!


Learn what makes this virus dangerous and why some countries are advising women to avoid pregnancy.
Although respiration is considered the more efficient pathway because it has more ATP output per molecule of pyruvate, rapidly-dividing cells sometimes choose fermentation instead. Almost 50 BioLegend employees took part is this fun race which supports awareness for local charities trying to bring about positive change in San Diego. By controlling key molecules involved in regulating the immune response, researchers have obtained very promising results in the treatment of certain cancers. Read this blog to learn more about Mazumdar-Shaw’s humble beginnings and how she built her empire by literally starting in her garage.
Scientists would like to reanimate this virus to learn more about its origins and the evolution of giant viruses. We also cover recent research linking high-fat diets with a change in the gut microbiome and obesity-linked inflammation, as well as the role that leptin plays in the rewarding effects of exercise. Immunotherapy is a groundbreaking option because it can hypothetically target cancer cells specifically while leaving healthy cells intact, which can decrease the number of adverse effects associated with current treatment options. Some may notice a modest decline in their mental abilities, including memory function, while some may develop neurodegenerative diseases as they age. Tune in to hear our guest Mohar Chattopadhyay discuss its symptoms, treatments, and research. Using bioinformatics methods, they reconstructed the evolutionary tree of AAV and made viruses that represent different branching points. Resistance to anti-microbial drugs occurs naturally, however, the misuse of these drugs, among other factors, is helping the spread of multidrug resistant microbes. However, communication between the CNS and the periphery occurs through unknown mechanisms. The cause of this disease is unknown, and although there is presently no cure, there are some treatment options such as medication and surgery to manage its symptoms. Learn more about neuroinflammation and the newly discovered central nervous system lymphatic system with our special guest, Kenya Cohane. They are highly similar to peripheral macrophages and respond to pathogens and injury by becoming activated. But, how does this peer review work and why have so many controversies sprung up recently about this system? The Neuroinflammation page shows how neuronal injury can lead to immune infiltration, and how differential activation of microglia can be either neuroprotective or neurotoxic. This versatile system can accommodate your experimental needs, whether you are doing positive or negative selection. In cancer, it may be beneficial to prevent interaction of "immune checkpoints", which can inactivate T cells.
This time we contribute to science enrichment classes in elementary schools throughout San Diego. In this blog, we discuss the potential impact of sequencing or genotyping individuals and why the FDA temporarily shutdown one company for marketing their kit as a medical device. Quite often, they manage to subvert a highly evolved immune system and proliferate inside a host. It allows researchers to listen to important talks, collaborate, and see what companies have to offer.
Researchers are now repurposing this for useful applications in like increasing crop size and treating diseases like HIV and cancer. With open source sharing of 3D models, anyone with access to a 3D printer can print tube racks, 96 well plates, gel combs, and many other things. We also take a look at some of the inner workings of the brain including synchronization, implanting false memories, and how it blocks distractions.
In this blog, we discuss one of the biggest scientific scandals in recent memory: The publication of high-profile stem cell papers in one of the most reputable journals that was riddled with errors, and, in at least a couple of spots, obvious data manipulation. Depending on the requirements of your assays, as well as your equipment at hand, you may need to use a colorimetric assay.
This blog discusses the implications of red meat consumption in humans and the characterization Neu5Gc as a xeno-autoantigen capable of inducing low level inflammation leading to cancer. These are called plantibodies, and in fact, there are already companies developing therapeutic antibodies using them. There we showcased some of our newly released products, such as LEGENDplex and newly aquired NeoClone antibodies. Our blog examines possible causes, treatments, and mechanisms of action for food allergens.
Keywords: BioLegend, science, podcast, podcasts, immunology, neuroscience, memory, alcohol, beer, neurons, ion channels, NMDA receptor, redox, oxidation, reduction, calcium, potassium, sodium, hippocampus, GIRK receptor, addiction, Karthik Bodhinathan, Stuart Lipton Having difficulty playing this episode?
Here is a post to show some of the cool costumes and pumpkin carving contest we had this year.
Nanobodies®, a tenth of the size of a normal antibody, have multiple advantages over conventional antibodies.
The text has now been translated and published by Don Roley of the Colorado Springs Bujinkan Dojo. But as the last line of the Shoninki points out, these were not just costumes that were thrown on. Thisa€?was a member of the Fukke sect of Buddhism that wandered while playing aa€?flute and concealing their face.
Many of these samurai from the rural provinces became enamored of the big city life of Edo and did not want to return.
Even today religious figures are looked on with less suspicion than most folks, even knowing what we do about how some of them have abused that trust. Even though the idea that the ninja came from yamabaushi is largely a myth, the disguise was a good one for someone on the road a lot with a need to carry a weapon. At the same time, it believes that the Shinto gods exist and can give aid to those purifying themselves. He also could carry a weapon on the road, which would look rather strange for any other Buddhist missionary.
Under the guise of seeking to convince them to buy his products, he could draw them into conversations of what they did, what was the situation in the area and other topics and be totally without suspicion.
Wandering performers (Below) had excuses to travel, could talk to people without suspicion and were frequently invited to perform in places of interest.
Thiswas a member of the Fukke sect of Buddhism that wandered while playing aflute and concealing their face.
It was used in at least one murder done by samurai and the most famous case is of Musashibo Benkei sneaking his lord past troops by having them all dress up and pretend to be yamabushi gathering funds for a temple.Japanese Buddhism has a close relationship with Shinto but Shugendo is probably the best example of the two existing together in one faith. And, we talk about Sean Parker's new $250 million grant to establish the Parker Institute for Cancer Immunotherapy. In this blog, we discuss a landmark case study, and human trial, in which gene editing was successfully used in the treatment of leukemia. As hard as it is to secure funding, prioritizing how to stay within the lab’s budget is an equally daunting task. The use of monoclonal antibodies against some of these molecules, called immune checkpoint receptors, have provided some answers and hope in the search for a cure.
Tune in to hear our discussion on the release of an open-access journal that will publish ideas as well as data and results, and other exciting research on influenza infection.


In this blog, read about adoptive cell transfer, the process of training and expanding a patient's own immune cells and placing it back into the patient to fight the cancer with their own cells. Scientists are increasingly interested to understand the factors and mechanisms that may impact brain health.
These viruses were used to circumvent detection by the immune system to successfully deliver genes to various mammalian tissues. This is a serious public health issue at the moment, and if we don’t act with energy, there can be hard consequences. In this blog, we discuss a recent paper published in Nature that discovered that the CNS does, in fact, have a lymphatic system that can be used to communicate with immune cells in the periphery. Read our blog to learn more about Selman Waksman, his work in antibiotics, and the controversy over streptomycin. Read our blog to learn more about the correlation between the flu vaccine and narcolepsy, and the evidence to support or refute the hypothesis. Read our blog to learn about the work being done to uncover how bacteria can influence the mental state. This blog discusses the blood-brain barrier, which can be compromised under certain conditions, leading to immune cell infiltration and chronic neuroinflammation.
As part of their response, they secrete cytokines and chemokines, which help in the resolution of the inflammatory response. The page also features IHC reagents for detection of neuroinflammation and a list of our neuroinflammation products. Learn more with our podcast about some of the more popular antibody and nanobody treatments. Read about BioLegend at IMMUNOLOGY 2015™ in this blog, and we’re excited for next year's AAI Annual Meeting! Check out our blog to learn how Joseph Lister turned it all around and why he is now known as "the father of modern surgery". In this post, we comment on the number of mechanisms that HIV, a retrovirus, has to escape the immune system. Learn about BioLegend's involvement in scholarships, talks, and interesting facts about this year's host city, New Orleans.
There's a battle brewing over the CRISPR patents with millions in funds (and profit) at stake.
This allows for on-the-fly access to lab goods, and also nearly infinite customizability for lab supplies in your experiments. The fallout after the retraction of these papers just goes to show that scientific misconduct is not worth the risk. Luckily, our immune system has also “learned” how to deal with most of these pathogens, so we can eliminate most of these infections.
Read through our blog to learn more about the logistics of picking out the right animal for you. Unfortunately, they also have their limitations and more research will be needed before their utility is completely known. You should study the things they would know to an extent that you are familiar, and without fear of playing the part. Due to the restrictions, even if they left their lord's service they would not be allowed to stay in Edo. Before the Meiji government required the separation of religions into either Buddhism or Shinto it is believed that Shugendo, the religion of the yamabushi might have been the most popular form among the common people.
Shugenja travel to areas holy according to Shinto belief to perform training and develop religious energy.
Too handsome, loud or other characteristics that drew attention to them were to be avoided. Read this blog to get an idea about how much it costs to run an academic research lab in the U.S.
BioLegend develops and manufactures world-class, cutting-edge immunological reagents for biomedical research, offered at an outstanding value. If you're able to score a perfect 100%, you'll win a goodie bag filled with BioLegend prizes.
But these cells are also known for their harmful roles in neurodegenerative diseases and brain injuries, such as Alzheimer’s and Parkinson’s disease. In this post, we comment on a number of mechanisms that Salmonella has to escape the immune system. In this post, we comment on a number of mechanisms that Listeria has to escape the immune system. During the Edo period when the Shoninki was written travela€?by the people was highly regulated. To get around this, a nearby training center for yamabushi would allow samurai to train there for a while, get certified as yamabushi and then the restrictions would not apply to them. They then distribute this energy (for a a€?donationa€?) to folks on their travels to other holy areas. In order to get by when they were not in a more familiar guise, they tried to be plain vanilla to those around them. During the Edo period when the Shoninki was written travelby the people was highly regulated. It was rather difficult for most of thea€?population to get permission to travel to another area and stay there for any period of time. Before the rise of modern society and its new forms of entertainment, the shows that the yamabushi put on to convince people of the religious power they had (and thus the wisdom of donating) was possibly as big as the circus was for many people in the early 20th century western countries. Their highest aim was to be so boring and part of the back ground that no one would notice them at all.
It was rather difficult for most of thepopulation to get permission to travel to another area and stay there for any period of time. Religious figures were rather exempt from most of the need to get permission and other prescriptions on travel.
Like the clergy of Chaucera€™s time when he wrote a€?Canterbury Talesa€?, much of the clergy had degraded to such an extent that they were held in open contempt. They would walk on fire, run up and down stairs made of swords and other tricks to impress the folks. The famous poet Matsuo Basho was known for taken the tonsure just before he went on one of his famous trips to make it easier to move around. Ihara Saikaku openly made fun of them in his book a€?Life of an Amorous Womana€? when he has the main character describe how she went out and bought meat for her priestly lover.
There will be a digital version for Kindle and iBook coming out (hopefully) in May and you may wish to wait for that if you live overseas. The humor is from the fact that technically both meat and sex were forbidden to them, but the rule was broken so often and so openly that it was common knowledge.



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