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While many organs use active stem cells to replenish and repair tissues, other highly regenerative organs lack active stem cells. Please try selecting a menu item from above or to the side of this message to get where you'd like to go.


Our lab uses genetic, genomic, and cell biological approaches to understand how organ repair and remodeling occur through the use of inducible repair mechanisms. One model for the origin and retention of instability and subsequent tumor aneuploidy is the formation of polyploid cells, which undergo error-prone division in vitro. Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium. Drosophila stem cell niches: A decade of discovery suggests a unified view of stem cell regulation.
The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage.


Our model tissue, the Drosophila hindgut, possesses quiescent adult cells that can be induced to repair the tissue following injury.
Further, during metamorphosis, this tissue undergoes a natural "injury" that prompts whole-scale organ regeneration.
Our lab characterizes polyploid cell cycles to identify the origins of this cancer-enabling phenomenon.



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