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Lyme Disease is caused by an infection of the spirochete Borrelia burgdorferi that is generally known to be spread by a tick bite. One aspect of hyperbaric treatment than can be determined is that most patients respond and initially most of them had an escalation of symptoms before they saw improvement. While the greatest majority of patients used the treatment protocol believed to be followed in the Fife study of 60-minute treatments at 2.4 ATA (equivalent to 45 feet underwater pressure), some patients tried a variety of different methods hoping to find a protocol that assured better results.
Equally as innovative were the various antibiotic therapies and adjunctive therapies used during the treatments.
The patient population included two people who reported being diagnosed with co-infections subsequent to hyperbaric treatments. The range of time from the date patient became ill to the start of HBO was 10 months to 38 years with the mean at 8 years. The range for patients in this category who improved more than 50% was 8 months to 15 years with a mean of 4.9 years. Note: This table does not take into account that some patients were on combinations of antibiotics.
Duration of treatment of venous thromboembolism should balance treatment need and treatment risk and discomfort. Deciding how long a patient with a venous thromboembolic event should be treated for is important.
The reason to treat venous thromboembolism for prolonged periods of time are recurrences that occur when treatment is stopped.

Residual clot – There has been much back and forth about the importance of residual clot in determining thrombosis recurrence over the past two decades. Patient sex – A trial published in the BMJ in 2011 showed that men may have a higher chance of recurrence than women after an unprovoked venous thromboembolic event. Clot location – Risk of recurrence after a venous thromboembolism event defers according to the initial location of the clot. Genetic tendency to create clots – Familial hypercoagulability tendency (thrombophilia) is very common in certain populations. Factor VIII – Factor VIII levels are not routinely checked to predict clot recurrence. Taken together, the factors that may affect recurrence in a particular patient should be put into clinical prediction models.
When recommending duration of treatment to a patient, one must not forget that patient preference is an important factor. Assesing coumadin bleeding risk is a major component in a personalized decision regarding treatment duration. Iinaoeoaee, iaoiayueany a a?oiia Ainoe, ia iiaoo inoaaeyou eiiiaioa?ee e aaiiie ioaeeeaoee. The range of time from the date patient became ill to the date of diagnosis was 1 month to 35 years with a mean of 5 years.
Put simply, risk of recurrence should be balanced with the discomfort and risk of bleeding.

However, in a trial of 360 patients that was published in the NEJM in 2000 high levels of factor VIII correlated with clot recurrence as compared with low levels.
Naeo ia i?aainoaaeyao yeaeo?iiiua aa?nee iaoa?eaeia, a caieiaaony eeou eieeaeoeiie?iaaieai e eaoaeiaecaoeae nnueie, i?enueaaiuo e ioaeeeoaiuo iaoeie ?eoaoaeyie.
Anee au yaeyaoanu i?aaiiaeaaaoaeai eaeiai-eeai i?aanoaaeaiiiai iaoa?eaea e ia ?aeaaoa ?oiau nnueea ia iaai iaoiaeeanu a iaoai eaoaeiaa, nay?eoanu n iaie e iu iacaiaaeeoaeuii oaaeei a?. Oaeeu aey iaiaia ia naeoa i?aainoaaeaiu iieuciaaoaeyie naeoa, e aaieieno?aoey ia ian?o ioaaonoaaiiinoe ca eo niaa??aiea.
We are working on a follow-up study to evaluate the success of these patients years after their treatment. I?inuaa ia caeeaaou oaeeu, caueuaiiua aaoi?neeie i?aaaie, a oae?a oaeeu ia eaaaeuiiai niaa??aiey! Glenn Burkland, of Exton, Pennsylvania has done past cancer research with me, and is a tireless patient advocate, helping many people in ways that go unseen. He is a Renaissance scientist and clinician in the truest sense of the word, and I suspect he will follow the lead of this initial clinician, Dr.

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