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For millions of people around the world, the unwelcome and often deafening intrusion of jet aircraft roaring overhead is a daily annoyance. At the same time, the demand for aviation, both from private consumers and from businesses, is growing rapidly. Rather than looking, for example, at the engine fan blades or the wingtips on their own, OPENAIR was set up with the specific purpose of taking a whole aircraft approach. The project is using the latest techniques in computer analysis of the ways in which air flows behave and how aerodynamic forces interact with surfaces to create noise. Key to the project’s success is the unique collaboration it has been able to generate between a range of organisations across Europe. Given the extensive participation in the project of major players from the aviation industry, any positive results should be quickly implemented in future aircraft construction, as well as being retro-fitted where possible on existing aircraft. It is hoped that the results will make major contribution to the aviation industry’s official goal of reducing aviation noise by 50% by 2020, compared with the year 2000. The following is the fourth in a series of posts from senior NCI scientists and leaders on NCI’s Annual Plan and Budget Proposal for Fiscal Year (FY) 2017, which was submitted to the President on September 17, 2015. Although we are making progress against cancer, little progress has been made in one important area: reducing the unequal burden of cancer borne by many racial and socioeconomic groups. Such cancer health disparities are a critical problem for affected individuals, their families and communities, and the nation as a whole. Accelerating progress against this frustratingly stubborn problem will require breaking down research silos, fostering collaboration among researchers from different disciplines, and attracting new investigators.
To involve the research community in setting priorities in cancer health disparities research, NCI has organized a meeting of leading researchers, to be held later this month in Atlanta. As with many other areas of science today, a multidisciplinary approach is needed to address the complex problem of cancer health disparities. It will be critical to include and involve a wide variety of experts to truly solve this problem in the laboratory, clinic, and community.
NCI has a strong foundation upon which to continue building research capacity and breaking down barriers to advancing science in this important area.
The role of genetics and biology in cancer health disparities is a crucial area of research with much potential for directly and indirectly improving this problem. Last year, for example, NCI funded several research projects to develop cell lines and animal models specifically designed to improve our understanding of the biological factors associated with cancer health disparities.

We’re also funding individual researchers who are delving deeper into the genetic and epigenetic mechanisms that may be associated with cancer health disparities. NCI supports investigators at community-based hospitals located in areas that serve underrepresented populations to help ensure equitable access to clinical trials. Much of this is being done through the NCI Community Oncology Research Program (NCORP), a relatively new network of investigators who participate in an array of research in cancer control, prevention, symptom science, and screening. NCI is committed to training underrepresented minorities in cancer research in general and in catalyzing interest in doing research in the area of cancer health disparities in particular.
One such program, the Continuing Umbrella of Research Experiences (CURE), supports underrepresented students from high school through their first academic appointment. We have also created NCI programs such as the Partnerships to Advance Cancer Health Equity (PACHE), which partners NCI-designated cancer centers with minority-serving institutions.
More than that, the stress it causes is increasingly being associated with physical and mental health problems. People living miles away but under the take-off or landing paths can find their lives similarly plagued. The inexorable move towards more and more flights (and more and more airports or runways), means the need to find ways of making aeroplanes significantly quieter is an urgent one. In this way, it is able to take the interaction between all the different parts into account. With 15 months still to go of the four-year life of the project, large-scale testing of a number of new technologies and methods is well under way.
This has been the crucial factor enabling the researchers to take a holistic view of the issue and to develop techniques which make it possible not just to know what noise reduction is achieved at, for example, a wing tip, but to measure the total effect people on the ground would actually be hearing if an aircraft were flying overhead. Recognizing that complex factors underlie health disparities, NCI is taking a holistic approach in our efforts to address this serious public health issue.
Information gained from the workshop will be used to develop a strategy to move research forward in this area. By taking such an approach, the advances made in different disciplines and the increasing knowledge about the factors that contribute to unequal outcomes can be more readily integrated to advance progress. The effort will benefit from involving scientists, clinicians, patients, consumer advocates, educators and community leaders, as well as others. We see new opportunities before us even as we continue to make strides and witness important accomplishments.

Studies have consistently revealed a higher incidence of aggressive forms of breast cancer in African American women, prostate cancer in African American men, and liver cancer in Hispanic populations. This basic research is necessary to create new approaches to addressing such disparities, including precise methods for identifying biological markers of risk and new targets for treatment for affected patients. However, accruing patients from diverse ethnic and racial backgrounds to trials is challenging. We also fund community health educators who provide much needed education and outreach to communities of color, and to connect patients to research opportunities and clinical trials. A diverse scientific and clinical workforce lends important perspectives to all areas of cancer research, including disparities research. As part of the program, high school and undergraduate students from underserved and under-represented populations have the opportunity to perform laboratory and clinical research. These partnerships not only increase minority students’ involvement in cancer research, but also provide the cancer centers with access to minority patient populations that are needed to participate in clinical trials. Tell us what you think in the comments section on this important topic as well as the NCI priorities outlined in the Annual Plan and Budget Proposal for FY 2017.
Given the advanced biomedical tools and approaches available today, there is a tremendous opportunity for us to better understand the biological factors that contribute to these health disparities.
Barriers to participation include a higher likelihood of comorbidities, costs of care, lack of trust in the health care system, and lack of education about clinical trials. This area of investigation evaluates strategies for improving care through the study of health systems and clinicians. Please note that blog posts that are written by individuals from outside the government may be owned by the writer, and graphics may be owned by their creator.
In such cases, it is necessary to contact the writer, artist, or publisher to obtain permission for reuse.

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