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From the Toronto Hospital and the Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario. Requests for Reprints: Jenny Heathcote, MD, 399 Bathurst Street, ECW 7-006, Toronto, Ontario M5T 2S8, Canada. Anyone can submit a comment any time after publication, but only those submitted within 4 weeks of an article’s publication will be considered for print publication.
Effect of Alpha-Interferon Treatment in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B: A Meta-Analysis.

Detsky is supported by a National Health Research Scholar Award from Health and Welfare Canada.
The transition from the replicative to the nonreplicative phase may be rapid and smooth () or prolonged and fluctuating ( ).
One month after publication, editors review all posted comments and select some for publication in the Letters section of the print version of Annals. Naylor is supported by a Career Scientist Award (02387) from the Ontario Ministry of Health.

Follow-up studies are required to determine whether interferon reduces the risk for developing cirrhosis or hepatocellular carcinoma.

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