SNPMiner Trials by Shray Alag

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SNPMiner SNPMiner Trials (Home Page)


Report for Mutation A227G

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Potential Association of a Common L-FABP Polymorphism With Lipid-induced Hepatic Insulin Resistance

The investigators hypothesise that a common A277G polymorphism of the liver fatty acid binding protein (L-FABP) gene, which leads to an amino acid exchange, may be associated with alterations of lipid-induced hepatic insulin resistance. In the present study the investigators will investigate potential differences in lipid-induced hepatic insulin resistance, and in the relation between glycogenolysis and gluconeogenesis, in healthy subjects with the A277G polymorphism vs. subjects carrying the wildtype.

NCT00277342
Conditions
  1. Wildtype
  2. Polymorphism Liver FABP
Interventions
  1. Procedure: measurement of lipid-induced hepatic insulin resistance
MeSH:Insulin Resistance
HPO:Insulin resistance

Only one common non-synonymous polymorphism (A227G) leading to an amino-acid exchange in the exonic region of the L-FABP gene has been previously identified. --- A227G ---

Primary Outcomes

Measure: lipid-induced hepatic insulin resistance(WT vs.SNP L-FABP)

Measure: changes in the relation GNG to GL

Secondary Outcomes

Measure: changes in peripheral plasma glucose and lipid responses


HPO Nodes