SNPMiner Trials by Shray Alag


SNPMiner SNPMiner Trials (Home Page)


Report for SNP rs10766197

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Effects of Fat-soluble Vitamins Supplementation in Early Life on Common Complications and Neural Development in Very Low Birth Weight Infants

Vitamins A, D, and E play important roles in humans, such as vision function, immune function, bone metabolism, cell growth and differentiation and oxidation resistance. Deficiencies in these vitamins will result in a high prevalence of cardiovascular disease, infection, bone diseases, etc. Preterm infants, especially very low birth weight infants, are at risk of vitamin deficiency. Intravenous perfusion is the most common and widely used method to supply vitamins for the specific population in early life. However, the current dose of vitamin supplied by intravenous perfusion whether can meet the need of growth and development is not sure and the appropriate dose for preterm infants is still uncertain. The purpose of this study is to investigate whether current dose of fat-soluble vitamin supplementation is enough for very low birth weight infants, the safety of high dose of fat-soluble vitamin supplementation, and compare the differences of prevalence of common complications, such as bronchopulmonary dysplasia, patent ductus arteriosus, sepsis, anemia, and neural development between these two groups.

NCT03876704 Vitamin A Deficiency Vitamin D Deficiency Vitamin E Deficiency Very Low Birth Weight Infants Bronchopulmonary Dysplasia Anemia Sepsis Drug: High dose of fat-Soluble Vitamin Drug: Conventional dose of fat-Soluble Vitamin
MeSH:Bronchopulmonary Dysplasia Night Blindness Vitamin D Deficiency Vitamin A Deficiency Vitamin E Deficiency Body Weight Birth Weight
HPO:Low levels of vitamin A Low levels of vitamin D Low levels of vitamin E Nyctalopia

Association of rs4588 polymorphism in vitamin D receptor gene and rs10766197 polymorphism in the cytochrome P450 family 2 subfamily R member 1 gene with baseline level of vitamin D and change in vitamin D level after 4~6 weeks' supplementation.

Primary Outcomes

Description: Change from baseline level of vitamin A, vitamin D, and vitamin E at 4~6 weeks

Measure: Vitamin levels

Time: within 72 hours after birth, 4~6 weeks old

Secondary Outcomes

Description: The prevalence of bronchopulmonary dysplasia, patent ductus arteriosus, sepsis, anemia, intracranial hemorrhage, extrauterine growth retardation, etc.

Measure: Complications

Time: corrected age of 36 weeks

Description: White matter disease of the preterm infant, was semiquantitatively assessed from MRI at term-equivalent age based on an established scoring method.

Measure: Neural development

Time: corrected age of 40 weeks

Description: Association of rs4588 polymorphism in vitamin D receptor gene and rs10766197 polymorphism in the cytochrome P450 family 2 subfamily R member 1 gene with baseline level of vitamin D and change in vitamin D level after 4~6 weeks' supplementation

Measure: Gene polymorphism in vitamin deficiency preterm infants

Time: within 72 hours after birth, 4~6 weeks old


HPO Nodes


HP:0000662: Nyctalopia
Genes 315
RHO TRNF ARSG PEX5 MYO6 GUCY2D HGSNAT DRAM2 RP1 PHYH TRNS2 SEMA4A LRAT RDH12 BEST1 GUCA1A PEX6 IDH3A IFT172 CYP4V2 MAK PRPH2 CACNA2D4 IFT172 BEST1 CDHR1 POMGNT1 RHO FSCN2 RIMS1 TRNL1 CRX RP1 KCNV2 MERTK PROM1 C8ORF37 USH1G BBS2 CRB1 ROM1 PROM1 RDH11 PEX2 PDE6A AIPL1 RP9 PRPF4 NR2E3 FGFR2 ARL2BP CABP4 IMPG2 PEX10 POMGNT1 CA4 HADHA ROM1 RP9 TRNT1 RBP3 MFN2 KIZ CABP4 PRPF8 PRPH2 RDH5 PEX19 TOPORS GUCA1A USH2A BBS4 PCYT1A RPGR MAK REEP6 MFRP PRPH2 ABCA4 MMP19 PRPF4 GPR179 RLBP1 ND1 POU3F4 TUB RHO FAM161A CDH23 MYO7A AHR GUCY2D PRPF8 ABCA4 VPS13B ESPN COX2 AP3D1 CRX PEX7 PITPNM3 ITM2B ARL3 LRIT3 SAG TRAPPC9 PRPH2 NYX ZNF408 USH2A SNRNP200 HARS1 PRPF6 CNGA1 MERTK ELOVL4 OPN1MW POC1B NR2E3 ARHGEF18 KIAA1549 IDH3B KLHL7 SLC24A1 TRNQ PRPF3 SLC7A14 SEMA4A GPR179 AGBL5 CNGB1 MYO7A CDHR1 PDE6G OAT RBP3 ADAM9 AGBL5 CFAP410 CEP78 ATF6 RDH5 CRX CA4 RLBP1 TRNS1 CHM CRX RPGRIP1 HSD3B7 EYS CNNM4 NEK2 PRPH2 PDE6H PEX7 CERKL LRIT3 HGSNAT SCAPER PRCD RP2 PCARE GNAT1 PRPF3 DHDDS RHO CACNA1F GNAT1 ZNF513 TTLL5 AIPL1 CFAP410 RHO NRL CIB2 CACNA1F NR2E3 GUCA1B PDE6B ZNF513 SAG GRM6 CNGB1 ZNF408 CNGA1 PEX13 DRAM2 GNAT1 UNC119 PEX11B FSCN2 HBB TULP1 CDHR1 TRPM1 PRPF31 CLRN1 CNGA3 MVK CWC27 RHO TTPA ARHGEF18 CRB1 WHRN TRNW PEX1 COX3 ROM1 IMPDH1 C8ORF37 PDZD7 PDE6B LRAT SAG PRPH2 PDE6G PRPF31 STIM1 GRM6 CLRN1 TRNH SLC24A1 COX1 COG4 TTC8 NRL PDE6A CLRN1 PROM1 RAB28 RGR ND5 FLVCR1 PEX14 ND4 PROM1 SEMA4A PRPH2 C8ORF37 NMNAT1 SPATA7 ARL6 RLBP1 TRNS2 ABCA4 HK1 TTC8 PEX26 TULP1 FLVCR1 AIPL1 NMNAT1 ARL3 ARL6 RPE65 RAX2 REEP6 OPN1LW SEMA4A EYS GGCX AHI1 GRK1 CNGB3 SPATA7 C1QTNF5 SNRNP200 ADGRV1 DHX38 RBP3 AHR SLC7A14 ABCA4 SAG TULP1 PCARE RLBP1 CACNA2D4 RP2 RLBP1 CLRN1 CLRN1 PRPH2 NYX RPGR TRPM1 LRAT RPE65 PEX16 GNB3 PDE6B IMPDH1 IFT140 IMPG2 CACNA1F ND6 FAM161A OAT USH1C GNB3 BEST1 ARL3 IFT88 CHM KCNJ13 PCDH15 PEX3 C8ORF37 PEX12 GUCY2D GRK1 PHYH OFD1
Protein Mutations 1
S100A