SNPMiner Trials by Shray Alag


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Report for SNP rs174547

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There are 2 clinical trials

Clinical Trials


1 Gene - Diet Interactions in Fatty Acid Desaturase 1 Gene (FADSDIET)

Interactions between genes and environment, are likely to be crucial in the development of the common diseases such as type 2 diabetes. It was recently shown that FADS1 and FADS 2 genotypes are the strongest genes in a genome-wide analysis regulating serum fatty acid profile.The aim of this study is to test if subjects with the CC and TT genotypes of the FADS1 gene (rs174547) respond differentially to a diet supplemented with linoleic acid (substrate for FADS). We hypothesize that subjects with the TT genotype with more active desaturases will be more sensitive to dietary modification leading to more robust differences in serum FA profile, tissue inflammation and serum lipids.

NCT02543216 Fatty Acid Dietary Supplement: Sunflower oil

It was recently shown that FADS1 and FADS 2 genotypes are the strongest genes in a genome-wide analysis regulating serum fatty acid profile.The aim of this study is to test if subjects with the CC and TT genotypes of the FADS1 gene (rs174547) respond differentially to a diet supplemented with linoleic acid (substrate for FADS).

Inclusion Criteria: Participant of Metabolic syndrome in men (METSIM) cohort BMI 20-30 kg/m2 Healthy CC/TT genotype (rs 174547) Exclusion Criteria: Type 2 diabetes Other chronic disease Inclusion Criteria: Participant of Metabolic syndrome in men (METSIM) cohort BMI 20-30 kg/m2 Healthy CC/TT genotype (rs 174547) Exclusion Criteria: Type 2 diabetes Other chronic disease Fatty Acid Lean and overweight subjects (BMI >20kg/m2 <29kg/m2 ) with CC and TT genotypes of FADS1 polymorphism (rs174547) were recruited from the METSIM study (METabolic Syndrome in Men, currently >10000 men included from the population living in Kuopio).

Primary Outcomes

Measure: Fatty acid profile of serum lipid fractions

Time: 4 weeks

Secondary Outcomes

Measure: Serum lipids an lipoproteins

Time: 4 weeks

Measure: Adipose tissue biopsies

Time: 4 weeks

Measure: white blood cell samples

Time: 4 weeks

2 Fatty Acid Desaturase Gene Locus Interactions With Diet (FADSDIET2)

Interactions between genes and environment, are likely to be crucial in the development of the common diseases such as type 2 diabetes. Recently, the investigators have obtained data that genotypes of genes encoding for fatty acid desaturases 1 and 2 (FADS1 and FADS2) are the strongest genes in a genome-wide analysis regulating serum fatty acid profile.The aim of this study is to test if subjects with different genotypes of the FADS2 gene respond differently to a diet supplemented with linoleic acid or alpha-linolenic acid (substrates for FADS2). The study hypothesizes that subjects will be more sensitive to the dietary modifications according to their genotype leading to more robust differences in serum FA profile, tissue inflammation and serum lipids.

NCT03572205 Fatty Acids Genetics Dietary Supplement: LA Dietary Supplement: ALA

Subcutaneous adipose tissue taken by open biopsy to collect 1-5 g of adipose tissue.. Inclusion Criteria: - Participants of METSIM study cohort with CC/TT FADS1 rs174547 SNP genotype.

Inclusion Criteria: - Participants of METSIM study cohort with CC/TT FADS1 rs174547 SNP genotype.

Primary Outcomes

Description: Fatty acid composition of serum lipid fractions

Measure: Change in fatty acid composition of serum lipid fractions

Time: 8 weeks

Secondary Outcomes

Description: Oral glucose tolerance test (OGTT) variables: fasting, 30 min and 120 min glucose and insulin measurements

Measure: Glucose and insulin metabolism response

Time: 8 weeks

Description: Serum circulating levels of high-sensitivity C-reactive protein

Measure: Inflammatory markers response

Time: 8 weeks

Description: Subcutaneous adipose tissue taken by open biopsy to collect 1-5 g of adipose tissue.

Measure: Adipose tissue biopsies

Time: 8 weeks


HPO Nodes