SNPMiner Trials by Shray Alag

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Report for Mutation T351I

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 Allogeneic Hematopoietic Cell Transplantation Using α/β+ T-lymphocyte Depleted Grafts From HLA Mismatched Donors

This study is being done to learn whether a new method to prevent rejection between the donor immune system and the patient's body is effective.

NCT03615105 Acute Lymphoid Leukemia (ALL) Acute Myeloid Leukemia (AML) Chronic Myeloid Leukemia (CML) Hodgkin Lymphoma Non-Hodgkin Lymphoma Chronic Lymphocytic Leukemia Radiation: Hyperfractionated total body irradiation Drug: Thiotepa Drug: Cyclophosphamide Drug: Busulfan Drug: Fludarabine Drug: Melphalan Drug: Clofarabine Procedure: HPC(A) stem cell allograft Drug: Rituximab Device: Rabbit antithymocyte globulin
MeSH:Lymphoma Leukemia Leukemia, Myeloid Leukemia, Myeloid, Acute Leukemia, Lymphoid Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Myelogenous, Chronic, BCR-ABL Positive Precursor Cell Lymphoblastic Leukemia-Lymphoma
HPO:Acute megakaryocytic leukemia Acute myeloid leukemia Chronic lymphatic leukemia Chronic myelogenous leukemia Leukemia Lymphoid leukemia Lymphoma Myeloid leukemia

T351I mutation). --- T351I ---

Primary Outcomes

Description: The intervention will be considered unpromising if the rate of GVHD is greater than 40% and promising if the rate is 20% or less.

Measure: the number of incidences of grade 3-4 acute GVHD

Time: 2 years

HPO Nodes