SNPMiner Trials by Shray Alag

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SNPMiner SNPMiner Trials (Home Page)


Report for Mutation A277G

Developed by Shray Alag, 2020-2021.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Potential Association of a Common L-FABP Polymorphism With Lipid-induced Hepatic Insulin Resistance

The investigators hypothesise that a common A277G polymorphism of the liver fatty acid binding protein (L-FABP) gene, which leads to an amino acid exchange, may be associated with alterations of lipid-induced hepatic insulin resistance. In the present study the investigators will investigate potential differences in lipid-induced hepatic insulin resistance, and in the relation between glycogenolysis and gluconeogenesis, in healthy subjects with the A277G polymorphism vs. subjects carrying the wildtype.

NCT00277342
Conditions
  1. Wildtype
  2. Polymorphism Liver FABP
Interventions
  1. Procedure: measurement of lipid-induced hepatic insulin resistance
MeSH:Insulin Resistance
HPO:Insulin resistance

Potential Association of a Common L-FABP Polymorphism With Lipid-induced Hepatic Insulin Resistance The investigators hypothesise that a common A277G polymorphism of the liver fatty acid binding protein (L-FABP) gene, which leads to an amino acid exchange, may be associated with alterations of lipid-induced hepatic insulin resistance. --- A277G ---

In the present study the investigators will investigate potential differences in lipid-induced hepatic insulin resistance, and in the relation between glycogenolysis and gluconeogenesis, in healthy subjects with the A277G polymorphism vs. subjects carrying the wildtype. --- A277G ---

The function of the L-FABP gene may be altered by polymorphisms in coding regions of the gene, probably leading to modifications in hepatic triglyceride accumulation and hepatic insulin resistance.We hypothesize that carriers of the A277G SNP, when compared to matched wild-type subjects, may show altered responses of hepatic glucose production upon exposure to increased peripheral fatty acid concentrations, as achieved by lipid / heparin infusions. --- A277G ---

Primary Outcomes

Measure: lipid-induced hepatic insulin resistance(WT vs.SNP L-FABP)

Measure: changes in the relation GNG to GL

Secondary Outcomes

Measure: changes in peripheral plasma glucose and lipid responses


HPO Nodes