There is one clinical trial.
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help
doctors learn more about changes that may occur in DNA and identify biomarkers related to
PURPOSE: This laboratory study is looking at DNA variations in the RASSF1A gene in young
patients with Wilms' tumor.
- Kidney Cancer
- Genetic: molecular genetic technique
- Genetic: polymerase chain reaction
- Genetic: polymorphism analysis
Whether the S131F RASSF1A variant is a true polymorphism. --- S131F ---
- Determine whether the S131F RASSF1A variant is a true polymorphism in these patients. --- S131F ---
Primary Outcomes Measure: Presence of the A133S polymorphism of the RASSF1A tumor suppressor gene in germline DNAs of children with Wilms' tumor
Measure: Inheritance pattern of the A133S polymorphism in the parents of children who carry this polymorphism
Secondary Outcomes Measure: Differences in age at diagnosis, stage, histology, site of primary tumor, and outcome between patients with vs without the A133S polymorphism
Measure: Whether the S131F RASSF1A variant is a true polymorphism
Measure: Polymorphic differences in this gene based on ethnicity and sex