SNPMiner Trials by Shray Alag

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Report for Mutation I431V

Developed by Shray Alag, 2020-2021.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Assessing the Prevalence and Impact of Dihydropteroate Synthase-431V Mutation on the Protective Efficacy of Intermittent Preventive Treatment During Pregnancy Using Sulphadoxine-pyrimethamine

Malaria in pregnancy (MiP) continues to be a significant public health issue, particularly in sub-Saharan Africa. The coverage of pregnant women with three or more doses of intermittent preventive treatment using sulphadoxine-pyrimethamine (IPTp-SP) is recommended to prevent risks associated with MiP in moderate-to-high transmission settings. Evidence has recently become available supporting the emergence of a novel Pfdhps-431V mutation in Nigeria. This new mutation may further confound the existing SP-resistance; thus, the intended follow-on project aims to assess the influence of Pfdhps-431V mutation on the protective efficacy of SP during pregnancy. The aims are to detect P. falciparum positivity at delivery and pregnancy outcome in participants who must have received three or more doses of IPTp_SP. We will attempt to check the presence of existing and new Pfdhps/Pfdhfr mutations in the samples positive for P. falciparum using a quantitative PCR (qPCR). The prevalence of novel Pfdhps-431V mutant and other Pfdhps/Pfdhfr resistance alleles among the study population will be estimated. The significance of the resistance genes on the efficacy of SP will be described by looking at its associations with the reported IPTp use, P. falciparum infection, maternal anaemia, low birth weight, and preterm delivery.

NCT04634695
Conditions
  1. Pregnancy Malaria
MeSH:Malaria

Point mutation at codon dhps-I431V will be carried out. --- I431V ---

Still, evidence has become available supporting the emergence of a novel Pfdhps-I431V mutation. --- I431V ---

The I431V mutation is found only in West and Central African countries, however, its impact on SP resistance has not been evaluated. --- I431V ---

Primary Outcomes

Description: P. falciparum malaria positivity will be confirmed using microscopy

Measure: Malaria infection at the time of delivery

Time: May 2021

Description: Point mutation at codon dhps-I431V will be carried out

Measure: Dhps-431V mutation

Time: May 2021

Secondary Outcomes

Description: Maternal haematocrit will be carried out to confirm whether the mother is anaemic or not

Measure: Average maternal haematocrit

Time: May 2021

Description: Birth weight of babies

Measure: Birth weight of babies

Time: May 2021

Description: Prevalence of placental malaria

Measure: Prevalence of placental malaria

Time: May 2021


HPO Nodes