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SNPMiner SNPMiner Trials (Home Page)


Report for Mutation M1106C

Developed by Shray Alag, 2020-2021.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 "Eye Protection After Mydriatic Use for ROP Screening: Impact on Vitals Signs and Pain Scores"

Pupillary dilation induced by mydriatic agents during Retinopathy of Prematurity exams can persist for hours. Despite regular use of eye protection for mydriatic-induced light sensitivity for infants, children and adults, eye protection after mydriasis has not been addressed in neonates. This study examines the use of eye patches to protect the dilated pupil from light exposure and their impact on vital signs and pain scores. prevents tachycardia, tachypnea and discomfort in neonates after ROP screening.

NCT01860534
Conditions
  1. Light Sensitivity
Interventions
  1. Behavioral: eye covers
MeSH:Photophobia
HPO:Photophobia

Heart rate was recorded directly from their cardio-respiratory monitor (Agilent M1106C). --- M1106C ---

Respiratory rate was recorded directly from their cardio-respiratory monitor (Agilent M1106C). --- M1106C ---

Oxygen percent saturation was recorded directly from their cardio-respiratory monitor (Agilent M1106C). --- M1106C ---

Primary Outcomes

Description: At 3 times (pre-mydriasis, 1 hour and 3 hours after Cyclomydril drops), subjects were exposed to ambient lighting for a period of five minutes. This usually entailed removing isolette covers and exposing the patient to the ambient room light. During this time, pain and vital signs were recorded every minute. Heart rate was recorded directly from their cardio-respiratory monitor (Agilent M1106C). The mean of the five recorded values for each variable was used

Measure: Heart Rate

Time: pre-mydriasis, 1 hour and 3 hours after mydriatic drops

Secondary Outcomes

Description: At 3 times (pre-mydriasis, 1 hour and 3 hours after Cyclomydril drops), subjects were exposed to ambient lighting for a period of five minutes. This usually entailed removing isolette covers and exposing the patient to the ambient room light. During this time, pain and vital signs were recorded every minute. Respiratory rate was recorded directly from their cardio-respiratory monitor (Agilent M1106C). The mean of the five recorded values for each variable was used

Measure: Respiratory Rate

Time: pre-mydriasis, 1 hour and 3 hours after mydriatic drops

Description: At 3 times (pre-mydriasis, 1 hour and 3 hours after Cyclomydril drops), subjects were exposed to ambient lighting for a period of five minutes. This usually entailed removing isolette covers and exposing the patient to the ambient room light. During this time, pain and vital signs were recorded every minute. Oxygen percent saturation was recorded directly from their cardio-respiratory monitor (Agilent M1106C). The mean of the five recorded values for each variable was used

Measure: Oxygen Percent Saturation

Time: pre-mydriasis, 1 hour and 3 hours after mydriatic drops

Description: At 3 times (pre-mydriasis, 1 hour and 3 hours after Cyclomydril drops), subjects were exposed to ambient lighting for a period of five minutes. This usually entailed removing isolette covers and exposing the patient to the ambient room light. During this time, pain and vital signs were recorded every minute. Pain scores were recorded by direct observation using the Neonatal and Infant Pain Scale (NIPS). The mean of the five recorded values for each variable was used. NIPS scoring consists of 6 measures associated with neonatal or infant pain, each with a range of 0-7 with low scores (0-2) associated with no pain and scores > to 4 associated with severe pain. Maximum scoring would be 42 for severe pain and minimal being 0 for no pain. The six measures on NIPS include: facial expression, crying, breathing patterns, arm movements, leg movements and state of arousal.

Measure: Pain

Time: pre-mydriasis, 1 hour and 3 hours after mydriatic drops


HPO Nodes


HP:0000613: Photophobia
Genes 327
MERTK PCNA RPGR TYR TIMM8A GALC GRHL2 DKK1 RPE65 NLRP3 ALDH3A2 DHX38 IFT172 GUCA1A PITPNM3 ZEB1 WNT10A SLC7A14 LYST RPGR RP1 ERCC6 MAPT DDB2 SLC39A4 ARL2BP PRCD PDE6A CNGB1 PIKFYVE PRPH2 TP63 NEK2 ZNF408 IKZF1 POLH ANTXR1 RPGRIP1 SLC1A3 TACSTD2 TOPORS VSX1 REEP6 KCNJ13 AGBL5 PROM1 RBP3 ABCA4 UNC119 SAG CACNA1F PRPH2 GUCA1A XPA ERCC6 CNGA3 IL10 GJB6 BBS2 RPGR MAPT RPGRIP1 CTNS IFT140 MPLKIP GJB2 SEMA4A TP63 PRPH2 LRAT TARS1 PDE6H RAX2 AP3D1 OPN1MW ST14 CNNM4 OFD1 ABCA4 IDH3A GPR143 RGS9BP TIMM8A RLBP1 CNGA3 TULP1 OPN1MW KIZ COL17A1 CACNA2D4 ZNF408 PDE6C ERCC8 POC1B GNAT2 SNRNP200 GNAT2 IMPG2 CRYGC CNGA3 SLC6A19 AP3B1 POLA1 RNF113A KRT12 NOD2 HPS6 CABP4 FOXC2 NR2E3 TUB RGS9 PITPNM3 PROM1 EYS CNNM4 ERCC2 ERCC3 RP9 IFT88 OVOL2 GJB6 CRX ERCC2 RTN4IP1 RHO IL23R C8ORF37 ADAM9 ARL3 RAX2 GUCY2D RPGR PDE6B LSS HARS1 CNGB3 CDHR1 MCOLN1 GUCY2D ZNF513 FOXE3 TTLL5 ERCC8 ESR1 RLBP1 PRPH2 POMGNT1 PDE6G FAM161A HLA-B SREBF1 AHSG TAT ROM1 ERCC6 ALMS1 TLR4 GNB3 OPN1MW AHI1 TTC8 SLC45A2 PRPH2 RIMS1 ERCC2 RP1L1 CHST6 CRB1 IDH3B CNGA1 PSAP ERCC5 BEST1 PCYT1A C8ORF37 RP2 HGSNAT ATXN7 ATF6 DRAM2 STAT4 AIRE IMPDH1 MBTPS2 LTBP2 PRPF3 TYR GUCA1B DHDDS CACNA2D4 GJB2 TYR GTF2H5 C4A SCN1A ALDH3A2 DRAM2 SLC1A3 RPE65 OPN1LW DDB2 AP1B1 ITM2B OVOL2 CCR1 GUCY2D UBAC2 HADHA NMNAT1 CHST6 SPATA7 MEFV NR2E3 PCARE MAK MFRP FAS TGFBI TNF TYR PLCD1 HK1 ARHGEF18 OPN1SW OPN1LW MBTPS2 PDE6C FSCN2 ERAP1 ERCC6 CTNS CA4 MC1R TTC8 ATF6 PNPLA6 CTNS CACNA1F AIPL1 LYST RGR AHR PRPF4 GJB6 KLHL7 PCNA ALMS1 ITGB6 SEMA4A XPA USH2A MBTPS2 CFAP410 LRAT RIMS2 CERKL KLRC4 NMNAT1 ERCC8 FOXC2 CST6 CA4 SCAPER MCOLN1 CRX KIAA1549 ATF6 NLRP1 KRT3 PRPF31 CRX GUCA1A PRPF6 ERCC1 PRPF8 SLC24A5 HLA-DRB1 RAB28 LRMDA IL12A-AS1 CEP78 RDH5 GTF2E2 NRL SLC24A5 CTNS CDHR1 ERCC4 EDNRA CFAP410 RDH12 ELOVL1 ARL6 CLCC1 PDE6H RHO OPN1LW EYS XPC SEMA4A ERCC4 CDHR1 PDE6C PRPH2 CEP250 ERCC3 GNAT2 CNGB3 COL8A2 CNGB3 HLA-A ERCC2 IL12A OCA2 RPGRIP1 C8ORF37 CTNS CLRN1 GPR143 AFG3L2 KCNV2 POLH XPC TGFBI HLA-B SREBF1
Protein Mutations 1
M1106C
SNP 0