The common polymorphism in MTHFR gene (C677T) has a significant effect on (6S)-5-CH3-H4folate after folic acid supplementation. For example, post supplementation differences in (6S)-5-CH3-H4folate between CC and TT are above 30%.
Name: folic acid plus B6 and B12
Name: folic acid
Description: we will measure primary folate forms after folic acid supplementMeasure: blood metabolic markers Time: 18 months
There is one SNP
Effect of Folic Acid on Primary Folate Forms in Relation to MTHFR The common polymorphism in MTHFR gene (C677T) has a significant effect on (6S)-5-CH3-H4folate after folic acid supplementation. --- C677T ---
methotrexate) treatment - Ileum resection - Current B-vitamin supplement - Epilepsy medications - Megaloblastic anemia or other indications for treatment with high doses of folate or vitamin B12. the Effect of MTHFR C677T on Folate Metabolism The investigators aim to test the effect of low doses of folic acid with or without B6 and B12 on folate forms in relation to polymorphisms in folate catabolising enzymes in elderly people. --- C677T ---