SNPMiner Trials by Shray Alag

NCT00511368 (37) NCT00460382 (36) NCT04504071 (35) NCT03783286 (33) NCT04172597 (32) NCT02404233 (29) NCT00959894 (28) NCT00706147 (28) NCT00121017 (28) NCT01685801 (27) NCT04513626 (26) NCT01736761 (26) NCT04495348 (24) NCT02673398 (23) NCT02499978 (22) NCT01605084 (21) NCT04254705 (21) NCT02069834 (21) NCT00939770 (18) NCT01792570 (18) NCT01199939 (18) NCT00356616 (18) NCT02728258 (17) NCT02707601 (17) NCT02770508 (16) NCT00711009 (16) NCT00630864 (16) NCT00491556 (15) NCT04085315 (15) NCT02616029 (15) NCT00830804 (15) NCT04681820 (15) NCT01170962 (14) NCT00984152 (14) NCT03953898 (14) NCT00727597 (14) NCT03212274 (14) NCT01369199 (13) NCT00337467 (13) NCT00098293 (13) NCT01368497 (13) NCT02159599 (13) NCT00424814 (12) NCT04432454 (12) NCT02527096 (12) NCT01849003 (12) NCT03781063 (12) NCT03683524 (11) NCT01614457 (11) NCT00460746 (11) NCT00993148 (11) NCT03061331 (11) NCT02494882 (11) NCT03068312 (11) NCT04453436 (11) NCT01521338 (10) NCT02725567 (10) NCT01614470 (10) NCT01423812 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NCT02554591 (5) NCT01501604 (5) NCT02716116 (5) NCT01136460 (5) NCT00187655 (5) NCT00350272 (5) NCT00837135 (5) NCT03202862 (5) NCT01707199 (5) NCT03839342 (5) NCT01323010 (4) NCT02248324 (4) NCT01698905 (4) NCT01737359 (4) NCT01306045 (4) NCT02804100 (4) NCT01456676 (4) NCT00588172 (4) NCT03434418 (4) NCT03593993 (4) NCT01804140 (4) NCT02882308 (4) NCT03497767 (4) NCT04106024 (4) NCT02716311 (4) NCT04405674 (4) NCT03599518 (4) NCT01675778 (4) NCT01604122 (4) NCT01297777 (4) NCT04519970 (4) NCT00705679 (4) NCT04147351 (4) NCT04129502 (4) NCT03976856 (4) NCT02335944 (4) NCT04625647 (4) NCT03948763 (4) NCT03255083 (4) NCT04002830 (4) NCT02635815 (4) NCT03066206 (4) NCT01331642 (4) NCT00557245 (4) NCT01922583 (4) NCT02893332 (4) NCT03592888 (4) NCT02257424 (4) NCT03874858 (4) NCT00017732 (4) NCT00187720 (4) NCT02593539 (4) NCT01185587 (4) NCT04439292 (4) NCT03884348 (4) NCT01309243 (4) NCT03209063 (4) NCT04160546 (4) NCT03292302 (4) NCT02418234 (4) NCT02535338 (3) NCT02192697 (3) NCT03410043 (3) NCT03845296 (3) NCT02914990 (3) NCT02113813 (3) NCT01532011 (3) NCT04340388 (3) NCT00962533 (3) NCT03856411 (3) NCT04049266 (3) NCT02973763 (3) NCT02926092 (3) NCT00271973 (3) NCT04256941 (3) NCT03812809 (3) NCT02954523 (3) NCT01784068 (3) NCT03446417 (3) NCT02841579 (3) NCT02025114 (3) NCT01288521 (3) NCT01385683 (3) NCT02279004 (3) NCT00998582 (3) NCT03111901 (3) NCT01352715 (3) NCT01619774 (3) NCT01045369 (3) NCT02246998 (3) NCT03969823 (3) NCT00895596 (3) NCT02398929 (3) NCT00724711 (3) NCT04029350 (3) NCT03737994 (3) NCT01443806 (3) NCT02629822 (3) NCT03463525 (3) NCT00710112 (3) NCT03623750 (3) NCT04283955 (3) NCT02743923 (3) NCT01016106 (3) NCT01259089 (3) NCT03971474 (3) NCT02917993 (3) NCT02368990 (3) NCT00279110 (3) NCT02485652 (3) NCT00312169 (3) NCT04541407 (3) NCT02769286 (3) NCT00747487 (3) NCT04267913 (3) NCT01429597 (3) NCT04023617 (3) NCT03790228 (3) NCT01759888 (3) NCT04429152 (3) NCT01810718 (3) NCT02725632 (3) NCT01090011 (3) NCT04544111 (3) NCT02926768 (3) NCT02981108 (3) NCT02459743 (3) NCT00654823 (3) NCT01037127 (3) NCT04439305 (3) NCT01028222 (3) NCT01542411 (3) NCT01031446 (3) NCT02726269 (3) NCT01892644 (3) NCT03260491 (3) NCT01802632 (3) NCT02720094 (3) NCT02630186 (3) NCT01627132 (3) NCT02690675 (3) NCT01013506 (3) NCT04252339 (3) NCT02496663 (3) NCT03386955 (3) NCT03394118 (3) NCT04212702 (3) NCT01754025 (3) NCT01160276 (3) NCT00121979 (3) NCT03228277 (3) NCT04351555 (3) NCT01243346 (3) NCT04510415 (3) NCT02796274 (3) NCT02774005 (3) NCT02064491 (3) NCT04233021 (3) NCT03799601 (3) NCT00260260 (3) NCT02094261 (3) NCT04245085 (3) NCT03058094 (3) NCT01282151 (3) NCT02520778 (3) NCT03161808 (3) NCT04181060 (3) NCT01342679 (3) NCT01443273 (3) NCT01593254 (3) NCT04433481 (3) NCT02529995 (3) NCT03502850 (3) NCT02771314 (3) NCT03823807 (3) NCT03270527 (3) NCT02688881 (3) NCT01005602 (3) NCT02442349 (3) NCT02684591 (2) NCT02282267 (2) NCT03381430 (2) NCT02178397 (2) NCT03608215 (2) NCT02603107 (2) NCT03370770 (2) NCT03322696 (2) NCT03333343 (2) NCT00525473 (2) NCT03127449 (2) NCT01781026 (2) NCT02503722 (2) NCT00975871 (2) NCT03964233 (2) NCT03388099 (2) NCT02317016 (2) NCT03845270 (2) NCT03519958 (2) NCT03918304 (2) NCT02151721 (2) NCT02777658 (2) NCT01016444 (2) NCT02971501 (2) NCT03101254 (2) NCT03178617 (2) NCT01774721 (2) NCT03574753 (2) NCT01357655 (2) NCT01766713 (2) NCT02097225 (2) NCT00658164 (2) NCT03622593 (2) NCT02571036 (2) NCT00969137 (2) NCT00834665 (2) NCT02026011 (2) NCT03622580 (2) NCT03543683 (2) NCT01143493 (2) NCT03671538 (2) NCT04028778 (2) NCT00324961 (2) NCT01915576 (2) NCT02157883 (2) NCT01387022 (2) NCT03864042 (2) NCT03235245 (2) NCT03469960 (2) NCT02795884 (2) NCT04687241 (2) NCT00005541 (2) NCT01242813 (2) NCT03960645 (2) NCT00643058 (2) NCT03443336 (2) NCT02992860 (2) NCT02281760 (2) NCT02201602 (2) NCT04310007 (2) NCT04309019 (2) NCT03720665 (2) NCT00909532 (2) NCT00411944 (2) NCT01604681 (2) NCT01245062 (2) NCT00270231 (2) NCT03256136 (2) NCT03973918 (2) NCT00302692 (2) NCT00125281 (2) NCT02163733 (2) NCT02110407 (2) NCT00475176 (2) NCT03196882 (2) NCT01572818 (2) NCT02556333 (2) NCT04268550 (2) NCT02433717 (2) NCT03428126 (2) NCT01153763 (2) NCT02609776 (2) NCT01420211 (2) NCT03556176 (2) NCT03872440 (2) NCT01405079 (2) NCT03382795 (2) NCT02991950 (2) NCT00013598 (2) NCT03455764 (2) NCT02422628 (2) NCT03831932 (2) NCT03766490 (2) NCT02580474 (2) NCT00499577 (2) NCT02444884 (2) NCT01775943 (2) NCT03544814 (2) NCT01310036 (2) NCT01027663 (2) NCT01928160 (2) NCT01244438 (2) NCT00007150 (2) NCT04462081 (2) NCT02297425 (2) NCT02086071 (2) NCT01050400 (2) NCT03060590 (2) NCT01819428 (2) NCT02709668 (2) NCT02411448 (2) NCT03878719 (2) NCT04622072 (2) NCT04479306 (2) NCT03377023 (2) NCT01378026 (2) NCT03239145 (2) NCT04511533 (2) NCT00226551 (2) NCT02191891 (2) NCT04586270 (2) NCT04669535 (2) NCT04545710 (2) NCT02120222 (2) NCT02738593 (2) NCT00831272 (2) NCT04469543 (2) NCT00573495 (2) NCT04158544 (2) NCT00904150 (2) NCT02110056 (2) NCT02856893 (2) NCT02110043 (2) NCT02182986 (2) NCT04179890 (2) NCT00063232 (2) NCT02197234 (2) NCT03121235 (2) NCT01532089 (2) NCT03887169 (2) NCT02268864 (2) NCT01963845 (2) NCT00866736 (2) NCT03991013 (2) NCT02500927 (2) NCT04657991 (2) NCT02228382 (2) NCT02689570 (2) NCT01513785 (2) NCT02463435 (2) NCT03351361 (2) NCT04527549 (2) NCT03424759 (2) NCT02197247 (2) NCT02321046 (2) NCT04272034 (2) NCT04646824 (2) NCT04027647 (2) NCT02364609 (2) NCT02759835 (2) NCT04349865 (2) NCT00068159 (2) NCT00418015 (2) NCT04310397 (2) NCT03088176 (2) NCT03867175 (2) NCT00339209 (2) NCT00011258 (2) NCT01288430 (2) NCT01616199 (2) NCT03603262 (2) NCT03071705 (2) NCT00969930 (2) NCT00772408 (2) NCT02743468 (2) NCT00277342 (2) NCT04248829 (2) NCT01767454 (2) NCT00933127 (2) NCT03317873 (2) NCT03392246 (2) NCT01909453 (2) NCT03523104 (2) NCT00085917 (2) NCT02507921 (2) NCT03781752 (2) NCT03828422 (2) NCT02193282 (2) NCT03195452 (2) NCT04657289 (2) NCT02294487 (2) NCT01325441 (2) NCT02511106 (2) NCT02997501 (2) NCT04184921 (2) NCT00625092 (2) NCT01657786 (2) NCT01415011 (2) NCT02629523 (2) NCT01718847 (2) NCT02818023 (2) NCT00577707 (2) NCT01943422 (2) NCT00116636 (2) NCT04429542 (2) NCT01841463 (2) NCT03865511 (2) NCT03205267 (2) NCT01218477 (2) NCT02881320 (2) NCT01897480 (2) NCT02810990 (2) NCT04189757 (2) NCT01951001 (2) NCT04254939 (2) NCT03207867 (2) NCT00780949 (2) NCT03355768 (2) NCT00817089 (2) NCT02143466 (2) NCT04499053 (2) NCT01907776 (2) NCT00909727 (2) NCT01562028 (2) NCT03737253 (2) NCT00441974 (2) NCT02155465 (2) NCT04586335 (2) NCT00661999 (2) NCT02705339 (2) NCT04006340 (2) NCT04553887 (2) NCT04645225 (2) NCT03852290 (2) NCT02183922 (2) NCT03970239 (2) NCT00294372 (2) NCT03250676 (2) NCT03792074 (2) NCT00671892 (2) NCT00689182 (2) NCT00106379 (2) NCT01947023 (2) NCT00509652 (2) NCT03683251 (2) NCT02039986 (2) NCT03515837 (2) NCT04081688 (2) NCT03190005 (2) NCT01584648 (2) NCT02292654 (2) NCT03992456 (2) NCT03133546 (2) NCT01485809 (2) NCT01266967 (2) NCT04644315 (2) NCT02909712 (2) NCT00062764 (2) NCT01776684 (2) NCT03042221 (2) NCT01940809 (2) NCT04675008 (2) NCT01161537 (2) NCT01154816 (2) NCT01175759 (2) NCT01199731 (2) NCT02788058 (2) NCT03130452 (2) NCT04687423 (2) NCT01772732 (2) NCT02631447 (2) NCT02525692 (2) NCT02526537 (2) NCT03513666 (2) NCT02027961 (2) NCT03106779 (2) NCT04106544 (2) NCT04258943 (2) NCT00165984 (2) NCT00977470 (2) NCT02092974 (2) NCT03975231 (2) NCT03586453 (2) NCT01998295 (2) NCT02021305 (2) NCT03135197 (2) NCT00432016 (2) NCT04636437 (2) NCT03004625 (2) NCT03851445 (2) NCT04031898 (2) NCT04201418 (2) NCT01911507 (2) NCT03539224 (2) NCT01978236 (2) NCT00866177 (2) NCT00320879 (2) NCT00044304 (2) NCT01999179 (2) NCT00977730 (2) NCT02491775 (2) NCT00212147 (2) NCT02040064 (2) NCT00489385 (2) NCT01713023 (2) NCT04122729 (2) NCT03994393 (2) NCT02438722 (2) NCT02762448 (2) NCT00071903 (2) NCT00626223 (2) NCT01193829 (2) NCT03239340 (2) NCT02991274 (2) NCT02811354 (2) NCT03416530 (2) NCT02522988 (2) 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NCT03678506 (1) NCT02146365 (1) NCT04310943 (1) NCT02619955 (1) NCT02934139 (1) NCT00400387 (1) NCT00375219 (1) NCT00149305 (1) NCT03520946 (1) NCT02787447 (1) NCT04501614 (1) NCT03166631 (1) NCT04213313 (1) NCT02078531 (1) NCT02349048 (1) NCT02981784 (1) NCT04636593 (1) NCT01647711 (1) NCT03231722 (1) NCT03576937 (1) NCT04412070 (1) NCT00554866 (1) NCT03151161 (1) NCT01817166 (1) NCT02220855 (1) NCT02512627 (1) NCT04591197 (1) NCT03402048 (1) NCT04500704 (1) NCT02323724 (1) NCT01166126 (1) NCT03029858 (1) NCT04317599 (1) NCT00300573 (1) NCT00809211 (1) NCT01393730 (1) NCT02318368 (1) NCT02228369 (1) NCT04500717 (1) NCT01074398 (1) NCT03134131 (1) NCT02455167 (1) NCT01004497 (1) NCT02073279 (1) NCT02117817 (1) NCT00323687 (1) NCT01605981 (1) NCT01371955 (1) NCT04147767 (1) NCT04144257 (1) NCT03490123 (1) NCT04423185 (1) NCT02625337 (1) NCT03567629 (1) NCT03360929 (1) NCT00109278 (1) NCT04108156 (1) NCT02132598 (1) NCT00542451 (1) NCT01587573 (1) NCT00868465 (1) NCT01494402 (1) 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SNPMiner SNPMiner Trials (Home Page)


Report for Clinical Trial NCT03549689

Developed by Shray Alag, 2020-2021.
SNP Clinical Trial Gene

Effect of Reducing Nucleotide Exposure on Bone Health (ReNew)

This is an open-label, randomized pilot study to assess the effect on bone mineral density (BMD) of a switch from a tenofovir alafenamide-containing antiretroviral regimen to dolutegravir/lamivudine vs. a continuation of the tenofovir alafenamide-containing regimen.

NCT03549689 HIV/AIDS HIV-1-infection Osteopenia
MeSH:Bone Diseases, Metabolic
HPO:Osteopenia

2 Interventions

Name: Dolutegravir (DTG) 50MG/lamivudine (3TC) 300MG FIXED DOSE COMBINATION (FDC)

Description: Participants randomized to the Switch Arm will take DTG 50mg/3TC 300mg FDC once daily with or without food at approximately the same time each day.
Type: Drug
Group Labels: 1

Switch

Name: Current tenofovir alafenamide (TAF)-containing ART regimen

Description: Continuation of current TAF-containing ART for 96 weeks.
Type: Drug
Group Labels: 1

Continuation


Primary Outcomes

Description: Compare the percentage change from entry to 96 weeks in lumbar spine BMD in those randomized to DTG/3TC vs. those continuing a TAF-based regimen

Measure: Percent change in lumbar spine Bone Mineral Density (BMD) at 96 weeks

Time: Baseline and 96 weeks

Secondary Outcomes

Description: Compare the percentage change from entry to 48 weeks in lumbar spine BMD in those randomized to DTG/3TC vs. those continuing a TAF-based regimen

Measure: Percentage change in lumbar spine BMD at 48 weeks

Time: Baseline and 48 weeks

Description: Compare the percentage change from entry to 48 weeks in total hip BMD in those randomized to DTG/3TC vs. those continuing a TAF-based regimen

Measure: Percentage change in total hip BMD at 48 weeks

Time: Baseline, 48 weeks

Description: Compare the percentage change from entry to 96 weeks in total hip BMD in those randomized to DTG/3TC vs. those continuing a TAF-based regimen

Measure: Percentage change in total hip BMD at 96 weeks

Time: Baseline, 96 weeks

Description: Compare the changes in CTX from entry to 12, 48, and 96 weeks

Measure: Change in CTX (a bone resorption marker)

Time: Baseline, 12 weeks, 48 weeks, and 96 weeks

Description: Compare the changes in P1NP from entry to 12, 48, and 96 weeks

Measure: Change in P1NP (a bone deposition marker)

Time: Baseline, 12 weeks, 48 weeks, and 96 weeks

Description: Compare the changes in urine β2-microglobulin from entry to 48 weeks and 96 weeks.

Measure: Change in urine β2-microglobulin (renal tubular marker)

Time: Baseline, 48 weeks, and 96 weeks

Description: Compare the changes in RBP from entry to 48 weeks and 96 weeks.

Measure: Change in urine RBP (renal tubular marker)

Time: Baseline, 48 weeks, and 96 weeks

Description: Compare the changes in protein from entry to 48 weeks and 96 weeks.

Measure: Change in urine protein

Time: Baseline, 48 weeks, and 96 weeks

Description: Compare the changes in urine albumin from entry to 48 weeks and 96 weeks.

Measure: Change in urine albumin

Time: Baseline, 48 weeks, and 96 weeks

Description: Compare the changes in fractional excretion of phosphate from entry to 48 weeks and 96 weeks.

Measure: Change in fractional excretion in phosphate

Time: Baseline, 48 weeks, and 96 weeks

Description: Compare the percentage change from entry to 48 weeks and 96 weeks in total lean mass (as measured by whole body DXA)

Measure: Percentage change in total lean mass

Time: Baseline, 48 weeks, and 96 weeks

Description: Compare the percentage change from entry to 48 weeks and 96 weeks in trunk fat (as measured by whole body DXA)

Measure: Percentage change in trunk fat

Time: Baseline, 48 weeks, and 96 weeks

Description: Compare the percentage change from entry to 48 weeks and 96 weeks in limb fat (as measured by DXA)

Measure: Percentage change in limb fat

Time: Baseline, 48 weeks, and 96 weeks

Description: Compare the levels of HIV RNA <50 copies/mL and below the limit of quantification (BLQ) at 48 weeks and 96 weeks using the FDA snapshot algorithm

Measure: Maintenance of HIV RNA level

Time: 48 weeks and 96 weeks

Description: Compare rates of grade 3 or 4 adverse events experienced by participants through 96 weeks

Measure: Grade 3 or 4 adverse events

Time: 96 weeks

Description: Compare treatment discontinuation of study medication due to adverse effect experienced by participants through 96 weeks

Measure: Treatment discontinuation of study medication due to adverse effect

Time: 96 weeks

Description: Compare changes in fasting lipids (total cholesterol, LDL, HDL, and triglycerides) at entry, 48 weeks, and 96 weeks

Measure: Change in fasting lipids

Time: Entry, 48 weeks, and 96 weeks

Purpose: Treatment

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 M184V

Any antiretroviral history (even before routine virologic monitoring became standard of care) that would suggest the presence of the M184V mutation should be considered exclusionary 7. ALT ≥5 X ULN, OR ALT ≥3xULN and bilirubin ≥1.5xULN (with >35% direct bilirubin) 8. Severe hepatic impairment (Child Pugh Class C) 9. Anticipated need for antiviral therapy for HCV 10. --- M184V ---



HPO Nodes


HPO:
HP:0000938: Osteopenia
Genes 291
HECW2 PIGU BNC1 SLC34A1 DPM2 OCA2 MAGEL2 PROK2 FGFR2 PLS3 COL7A1 LIFR FAT4 SRP54 TRPV6 MAGEL2 COL1A1 ATP6V0A2 SPRY4 OTX2 GTF2IRD1 CAVIN1 DDOST IARS2 CHD7 PIGY MMP14 TACR3 FKBP14 GATA1 PMM2 PHGDH POLE SLC39A8 GBA FBN1 NDN NOTCH2 SOX3 OCA2 PIK3CD GLI2 CDH23 TCF4 AEBP1 PSAP XYLT2 CYP3A4 IL17RD GEMIN4 LMNA PSAT1 TBL2 NDN PIGT STN1 PLOD1 CRTAP COX4I2 TAC3 SIM1 GNPTAB PLEKHM1 CLIP2 FOXA2 MPLKIP SLC34A1 RFC2 GPAA1 ELN SNORD116-1 TARS1 NF1 GNPAT TMEM38B SPIDR PROP1 PYGL LIMK1 KISS1 HESX1 ADAMTS2 KRAS PMM2 LMNA BRAF ZMPSTE24 HSD17B4 SMPD1 SMARCD2 MGAT2 ELN UROS SEC23A GNAS GNRH1 RPL11 SATB2 STAT3 CCND1 POLR3H HS6ST1 GLIS3 USP9X PDE11A MST1 FGFR1 SLC39A13 FKBP10 HRAS PSMC3IP MEN1 B4GALT7 RNF113A HNRNPK FGFR1 SLC39A8 PROP1 COL1A1 PYCR1 NPAP1 PIGT COL5A1 GCM2 FAT4 CDH23 ERCC2 KNSTRN CHST3 KCNJ1 TMEM67 GORAB NUP107 SMARCAL1 MEN1 FLRT3 SNRPN MTTP SNORD115-1 DNAJC21 MBTPS2 NAGA STAT3 DUSP6 MKRN3-AS1 CTC1 CRIPT GNRHR B4GALT7 UNC80 AIP IFITM5 ALDH18A1 TAPT1 RNU4ATAC MDM4 P3H1 RSPRY1 GCM2 SLC35A2 POU1F1 GZF1 LHX4 ATP6V0A2 TRPS1 SNRPN PDGFRB B3GALT6 DCAF17 SGMS2 SEC24D SLC7A7 COL1A1 TAF1 PRLR ANTXR2 PWRN1 FGF17 IPW SLC9A3R1 CREB3L1 TCIRG1 GTF2I MAGEL2 FBN2 DCHS1 ESR1 STAT1 SRP54 KISS1R NPR2 DCHS1 IL1RN MTAP EED GTF2H5 EIF2AK3 B3GAT3 NSMF RECQL4 SNRPN FUT8 DUSP6 HNRNPK HPGD SERPINH1 NDN SKI STAT1 ANTXR2 KL ADCY10 FKBP14 TERT CDC73 COG1 NRAS SCARB2 FARSB MMP2 PRKACA OCA2 SNRPN LRP5 NOTCH2 SKI RSPRY1 LRP5 MMP2 GPAA1 HERC2 SBDS HBB AVP SATB2 EFL1 MAFB ESR1 CYP19A1 MMP1 UROS ATP7A MAGEL2 MLXIPL ANO5 POLR3A BMP15 TREM2 MAGEL2 PTH1R ADAMTS2 MRPS22 PLOD2 RNF125 P4HB SLC12A1 TONSL COG1 ELANE ANOS1 GTF2E2 PRKAR1A NR5A1 MAN2B1 GPR35 BAZ1B SH3PXD2B MAN2B1 FSHR PROKR2 ANAPC1 PWAR1 CTCF SLC17A5 COL5A2 FGF8 ERCC3 GFI1 SLC39A13 FGF17 IER3IP1 KISS1R PLOD3 ANO5 NDN IRX5 ADAMTSL2 TRPS1 WDR11 IGF1 MKRN3
Protein Mutations 2
H295R M184V
SNP 0