SNPMiner Trials by Shray Alag

NCT00511368 (37) NCT00460382 (36) NCT04504071 (35) NCT03783286 (33) NCT04172597 (32) NCT02404233 (29) NCT00959894 (28) NCT00706147 (28) NCT00121017 (28) NCT01685801 (27) NCT04513626 (26) NCT01736761 (26) NCT04495348 (24) NCT02673398 (23) NCT02499978 (22) NCT01605084 (21) NCT04254705 (21) NCT02069834 (21) NCT00939770 (18) NCT01792570 (18) NCT01199939 (18) NCT00356616 (18) NCT02728258 (17) NCT02707601 (17) NCT02770508 (16) NCT00711009 (16) NCT00630864 (16) NCT00491556 (15) NCT04085315 (15) NCT02616029 (15) NCT00830804 (15) NCT04681820 (15) NCT01170962 (14) NCT00984152 (14) NCT03953898 (14) NCT00727597 (14) NCT03212274 (14) NCT01369199 (13) NCT00337467 (13) NCT00098293 (13) NCT01368497 (13) NCT02159599 (13) NCT00424814 (12) NCT04432454 (12) NCT02527096 (12) NCT01849003 (12) NCT03781063 (12) NCT03683524 (11) NCT01614457 (11) NCT00460746 (11) NCT00993148 (11) NCT03061331 (11) NCT02494882 (11) NCT03068312 (11) NCT04453436 (11) NCT01521338 (10) NCT02725567 (10) NCT01614470 (10) NCT01423812 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NCT02554591 (5) NCT01501604 (5) NCT02716116 (5) NCT01136460 (5) NCT00187655 (5) NCT00350272 (5) NCT00837135 (5) NCT03202862 (5) NCT01707199 (5) NCT03839342 (5) NCT01323010 (4) NCT02248324 (4) NCT01698905 (4) NCT01737359 (4) NCT01306045 (4) NCT02804100 (4) NCT01456676 (4) NCT00588172 (4) NCT03434418 (4) NCT03593993 (4) NCT01804140 (4) NCT02882308 (4) NCT03497767 (4) NCT04106024 (4) NCT02716311 (4) NCT04405674 (4) NCT03599518 (4) NCT01675778 (4) NCT01604122 (4) NCT01297777 (4) NCT04519970 (4) NCT00705679 (4) NCT04147351 (4) NCT04129502 (4) NCT03976856 (4) NCT02335944 (4) NCT04625647 (4) NCT03948763 (4) NCT03255083 (4) NCT04002830 (4) NCT02635815 (4) NCT03066206 (4) NCT01331642 (4) NCT00557245 (4) NCT01922583 (4) NCT02893332 (4) NCT03592888 (4) NCT02257424 (4) NCT03874858 (4) NCT00017732 (4) NCT00187720 (4) NCT02593539 (4) NCT01185587 (4) NCT04439292 (4) NCT03884348 (4) NCT01309243 (4) NCT03209063 (4) NCT04160546 (4) NCT03292302 (4) NCT02418234 (4) NCT02535338 (3) NCT02192697 (3) NCT03410043 (3) NCT03845296 (3) NCT02914990 (3) NCT02113813 (3) NCT01532011 (3) NCT04340388 (3) NCT00962533 (3) NCT03856411 (3) NCT04049266 (3) NCT02973763 (3) NCT02926092 (3) NCT00271973 (3) NCT04256941 (3) NCT03812809 (3) NCT02954523 (3) NCT01784068 (3) NCT03446417 (3) NCT02841579 (3) NCT02025114 (3) NCT01288521 (3) NCT01385683 (3) NCT02279004 (3) NCT00998582 (3) NCT03111901 (3) NCT01352715 (3) NCT01619774 (3) NCT01045369 (3) NCT02246998 (3) NCT03969823 (3) NCT00895596 (3) NCT02398929 (3) NCT00724711 (3) NCT04029350 (3) NCT03737994 (3) NCT01443806 (3) NCT02629822 (3) NCT03463525 (3) NCT00710112 (3) NCT03623750 (3) NCT04283955 (3) NCT02743923 (3) NCT01016106 (3) NCT01259089 (3) NCT03971474 (3) NCT02917993 (3) NCT02368990 (3) NCT00279110 (3) NCT02485652 (3) NCT00312169 (3) NCT04541407 (3) NCT02769286 (3) NCT00747487 (3) NCT04267913 (3) NCT01429597 (3) NCT04023617 (3) NCT03790228 (3) NCT01759888 (3) NCT04429152 (3) NCT01810718 (3) NCT02725632 (3) NCT01090011 (3) NCT04544111 (3) NCT02926768 (3) NCT02981108 (3) NCT02459743 (3) NCT00654823 (3) NCT01037127 (3) NCT04439305 (3) NCT01028222 (3) NCT01542411 (3) NCT01031446 (3) NCT02726269 (3) NCT01892644 (3) NCT03260491 (3) NCT01802632 (3) NCT02720094 (3) NCT02630186 (3) NCT01627132 (3) NCT02690675 (3) NCT01013506 (3) NCT04252339 (3) NCT02496663 (3) NCT03386955 (3) NCT03394118 (3) NCT04212702 (3) NCT01754025 (3) NCT01160276 (3) NCT00121979 (3) NCT03228277 (3) NCT04351555 (3) NCT01243346 (3) NCT04510415 (3) NCT02796274 (3) NCT02774005 (3) NCT02064491 (3) NCT04233021 (3) NCT03799601 (3) NCT00260260 (3) NCT02094261 (3) NCT04245085 (3) NCT03058094 (3) NCT01282151 (3) NCT02520778 (3) NCT03161808 (3) NCT04181060 (3) NCT01342679 (3) NCT01443273 (3) NCT01593254 (3) NCT04433481 (3) NCT02529995 (3) NCT03502850 (3) NCT02771314 (3) NCT03823807 (3) NCT03270527 (3) NCT02688881 (3) NCT01005602 (3) NCT02442349 (3) NCT02684591 (2) NCT02282267 (2) NCT03381430 (2) NCT02178397 (2) NCT03608215 (2) NCT02603107 (2) NCT03370770 (2) NCT03322696 (2) NCT03333343 (2) NCT00525473 (2) NCT03127449 (2) NCT01781026 (2) NCT02503722 (2) NCT00975871 (2) NCT03964233 (2) NCT03388099 (2) NCT02317016 (2) NCT03845270 (2) NCT03519958 (2) NCT03918304 (2) NCT02151721 (2) NCT02777658 (2) NCT01016444 (2) NCT02971501 (2) NCT03101254 (2) NCT03178617 (2) NCT01774721 (2) NCT03574753 (2) NCT01357655 (2) NCT01766713 (2) NCT02097225 (2) NCT00658164 (2) NCT03622593 (2) NCT02571036 (2) NCT00969137 (2) NCT00834665 (2) NCT02026011 (2) NCT03622580 (2) NCT03543683 (2) NCT01143493 (2) NCT03671538 (2) NCT04028778 (2) NCT00324961 (2) NCT01915576 (2) NCT02157883 (2) NCT01387022 (2) NCT03864042 (2) NCT03235245 (2) NCT03469960 (2) NCT02795884 (2) NCT04687241 (2) NCT00005541 (2) NCT01242813 (2) NCT03960645 (2) NCT00643058 (2) NCT03443336 (2) NCT02992860 (2) NCT02281760 (2) NCT02201602 (2) NCT04310007 (2) NCT04309019 (2) NCT03720665 (2) NCT00909532 (2) NCT00411944 (2) NCT01604681 (2) NCT01245062 (2) NCT00270231 (2) NCT03256136 (2) NCT03973918 (2) NCT00302692 (2) NCT00125281 (2) NCT02163733 (2) NCT02110407 (2) NCT00475176 (2) NCT03196882 (2) NCT01572818 (2) NCT02556333 (2) NCT04268550 (2) NCT02433717 (2) NCT03428126 (2) NCT01153763 (2) NCT02609776 (2) NCT01420211 (2) NCT03556176 (2) NCT03872440 (2) NCT01405079 (2) NCT03382795 (2) NCT02991950 (2) NCT00013598 (2) NCT03455764 (2) NCT02422628 (2) NCT03831932 (2) NCT03766490 (2) NCT02580474 (2) NCT00499577 (2) NCT02444884 (2) NCT01775943 (2) NCT03544814 (2) NCT01310036 (2) NCT01027663 (2) NCT01928160 (2) NCT01244438 (2) NCT00007150 (2) NCT04462081 (2) NCT02297425 (2) NCT02086071 (2) NCT01050400 (2) NCT03060590 (2) NCT01819428 (2) NCT02709668 (2) NCT02411448 (2) NCT03878719 (2) NCT04622072 (2) NCT04479306 (2) NCT03377023 (2) NCT01378026 (2) NCT03239145 (2) NCT04511533 (2) NCT00226551 (2) NCT02191891 (2) NCT04586270 (2) NCT04669535 (2) NCT04545710 (2) NCT02120222 (2) NCT02738593 (2) NCT00831272 (2) NCT04469543 (2) NCT00573495 (2) NCT04158544 (2) NCT00904150 (2) NCT02110056 (2) NCT02856893 (2) NCT02110043 (2) NCT02182986 (2) NCT04179890 (2) NCT00063232 (2) NCT02197234 (2) NCT03121235 (2) NCT01532089 (2) NCT03887169 (2) NCT02268864 (2) NCT01963845 (2) NCT00866736 (2) NCT03991013 (2) NCT02500927 (2) NCT04657991 (2) NCT02228382 (2) NCT02689570 (2) NCT01513785 (2) NCT02463435 (2) NCT03351361 (2) NCT04527549 (2) NCT03424759 (2) NCT02197247 (2) NCT02321046 (2) NCT04272034 (2) NCT04646824 (2) NCT04027647 (2) NCT02364609 (2) NCT02759835 (2) NCT04349865 (2) NCT00068159 (2) NCT00418015 (2) NCT04310397 (2) NCT03088176 (2) NCT03867175 (2) NCT00339209 (2) NCT00011258 (2) NCT01288430 (2) NCT01616199 (2) NCT03603262 (2) NCT03071705 (2) NCT00969930 (2) NCT00772408 (2) NCT02743468 (2) NCT00277342 (2) NCT04248829 (2) NCT01767454 (2) NCT00933127 (2) NCT03317873 (2) NCT03392246 (2) NCT01909453 (2) NCT03523104 (2) NCT00085917 (2) NCT02507921 (2) NCT03781752 (2) NCT03828422 (2) NCT02193282 (2) NCT03195452 (2) NCT04657289 (2) NCT02294487 (2) NCT01325441 (2) NCT02511106 (2) NCT02997501 (2) NCT04184921 (2) NCT00625092 (2) NCT01657786 (2) NCT01415011 (2) NCT02629523 (2) NCT01718847 (2) NCT02818023 (2) NCT00577707 (2) NCT01943422 (2) NCT00116636 (2) NCT04429542 (2) NCT01841463 (2) NCT03865511 (2) NCT03205267 (2) NCT01218477 (2) NCT02881320 (2) NCT01897480 (2) NCT02810990 (2) NCT04189757 (2) NCT01951001 (2) NCT04254939 (2) NCT03207867 (2) NCT00780949 (2) NCT03355768 (2) NCT00817089 (2) NCT02143466 (2) NCT04499053 (2) NCT01907776 (2) NCT00909727 (2) NCT01562028 (2) NCT03737253 (2) NCT00441974 (2) NCT02155465 (2) NCT04586335 (2) NCT00661999 (2) NCT02705339 (2) NCT04006340 (2) NCT04553887 (2) NCT04645225 (2) NCT03852290 (2) NCT02183922 (2) NCT03970239 (2) NCT00294372 (2) NCT03250676 (2) NCT03792074 (2) NCT00671892 (2) NCT00689182 (2) NCT00106379 (2) NCT01947023 (2) NCT00509652 (2) NCT03683251 (2) NCT02039986 (2) NCT03515837 (2) NCT04081688 (2) NCT03190005 (2) NCT01584648 (2) NCT02292654 (2) NCT03992456 (2) NCT03133546 (2) NCT01485809 (2) NCT01266967 (2) NCT04644315 (2) NCT02909712 (2) NCT00062764 (2) NCT01776684 (2) NCT03042221 (2) NCT01940809 (2) NCT04675008 (2) NCT01161537 (2) NCT01154816 (2) NCT01175759 (2) NCT01199731 (2) NCT02788058 (2) NCT03130452 (2) NCT04687423 (2) NCT01772732 (2) NCT02631447 (2) NCT02525692 (2) NCT02526537 (2) NCT03513666 (2) NCT02027961 (2) NCT03106779 (2) NCT04106544 (2) NCT04258943 (2) NCT00165984 (2) NCT00977470 (2) NCT02092974 (2) NCT03975231 (2) NCT03586453 (2) NCT01998295 (2) NCT02021305 (2) NCT03135197 (2) NCT00432016 (2) NCT04636437 (2) NCT03004625 (2) NCT03851445 (2) NCT04031898 (2) NCT04201418 (2) NCT01911507 (2) NCT03539224 (2) NCT01978236 (2) NCT00866177 (2) NCT00320879 (2) NCT00044304 (2) NCT01999179 (2) NCT00977730 (2) NCT02491775 (2) NCT00212147 (2) NCT02040064 (2) NCT00489385 (2) NCT01713023 (2) NCT04122729 (2) NCT03994393 (2) NCT02438722 (2) NCT02762448 (2) NCT00071903 (2) NCT00626223 (2) NCT01193829 (2) NCT03239340 (2) NCT02991274 (2) NCT02811354 (2) NCT03416530 (2) NCT02522988 (2) 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NCT03678506 (1) NCT02146365 (1) NCT04310943 (1) NCT02619955 (1) NCT02934139 (1) NCT00400387 (1) NCT00375219 (1) NCT00149305 (1) NCT03520946 (1) NCT02787447 (1) NCT04501614 (1) NCT03166631 (1) NCT04213313 (1) NCT02078531 (1) NCT02349048 (1) NCT02981784 (1) NCT04636593 (1) NCT01647711 (1) NCT03231722 (1) NCT03576937 (1) NCT04412070 (1) NCT00554866 (1) NCT03151161 (1) NCT01817166 (1) NCT02220855 (1) NCT02512627 (1) NCT04591197 (1) NCT03402048 (1) NCT04500704 (1) NCT02323724 (1) NCT01166126 (1) NCT03029858 (1) NCT04317599 (1) NCT00300573 (1) NCT00809211 (1) NCT01393730 (1) NCT02318368 (1) NCT02228369 (1) NCT04500717 (1) NCT01074398 (1) NCT03134131 (1) NCT02455167 (1) NCT01004497 (1) NCT02073279 (1) NCT02117817 (1) NCT00323687 (1) NCT01605981 (1) NCT01371955 (1) NCT04147767 (1) NCT04144257 (1) NCT03490123 (1) NCT04423185 (1) NCT02625337 (1) NCT03567629 (1) NCT03360929 (1) NCT00109278 (1) NCT04108156 (1) NCT02132598 (1) NCT00542451 (1) NCT01587573 (1) NCT00868465 (1) NCT01494402 (1) 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SNPMiner SNPMiner Trials (Home Page)


Report for Clinical Trial NCT01871740

Developed by Shray Alag, 2020-2021.
SNP Clinical Trial Gene

Enalapril Maleate and Folic Acid Tablets for Prevention of Chronic Kidney Diseases in Patients With Hypertension: a Double-blind Randomized Controlled Trial

The purpose of this trial is to confirm that enalapril maleate and folic acid tablets is more effective in preventing renal function decline among the patients with primary hypertension when compared to enalapril maleate.

NCT01871740 Hypertension Hyperhomocysteinemia
MeSH:Kidney Diseases Renal Insufficiency, Chronic Hypertension Hyperhomocysteinemia
HPO:Abnormality of the kidney Chronic kidney disease Hypertension Nephropathy

2 Interventions

Name: Enalapril maleate and folic acid tablets

Description: Enalapril maleate and folic acid tablets, (10mg/0.8mg)/tablet, taken orally and once daily for a maximum of 5 years. Combination with other anti-hypertension drugs are allowed.
Type: Drug
Group Labels: 1

Enalapril maleate and folic acid tablets

Name: Enalapril maleate

Description: Enalapril, 10mg/tablet, taken orally once daily for a maximum of 5 consecutive years. Combination with other anti-hypertension drugs are allowed.
Type: Drug
Group Labels: 1

Enalapril maleate


Primary Outcomes

Description: Renal function decline was defined based on one of more of the following : (1) A certain drop in eGFR, was defined as a drop in GFR category (≥90[G1], 60-89[G2], 45-59[G3a], 30-44[G3b], 15-29[G4], <15[G5] ml/min/1.73m2) accompanied by a 25% or greater drop in eGFR from baseline; (2) Rapid progression, was defined as a sustained decline in eGFR of more than 5 ml/min/1.73m2/yr.

Measure: Renal function decline

Time: Serum creatinine was examined at baseline and at the final visit (5 years) of the trial.

Secondary Outcomes

Measure: Average decline rate in eGFR (ml/min/1.73m2/yr).

Time: Serum creatinine was examined at baseline and at the final visit (5 years) of the trial.

Measure: New-onset chronic kidney disease based on eGFR(eGFR<60 ml/min/1.73 m2)

Time: Serum creatinine was examined at baseline and at the final visit (5 years) of the trial.

Measure: New-onset albuminuria

Time: Albuminuria was examined at baseline and at the final visit (5 years) of the trial.

Description: The composite endpoint is consisted of: 1)End stage renal disease (ESRD);2)Doubling of serum creatinine; and 3)Renal disease-induced death.

Measure: A composite of renal events.

Time: Every 3 months during the trial, up to 5 years

Purpose: Prevention

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 C677T

The composite endpoint is consisted of: 1)End stage renal disease (ESRD);2)Doubling of serum creatinine; and 3)Renal disease-induced death.. Inclusion Criteria: - BP≥140/90 mmHg in both of the two screening visits or currently under anti-hypertension treatment; - 45-75 years old; - Successful determination of methylenetetrahydrofolate reductase (MTHFR) C677T genotype; - For pre-menopausal women, agreed to use contraceptives during the trial; - Signed the written informed consent. --- C677T ---

Inclusion Criteria: - BP≥140/90 mmHg in both of the two screening visits or currently under anti-hypertension treatment; - 45-75 years old; - Successful determination of methylenetetrahydrofolate reductase (MTHFR) C677T genotype; - For pre-menopausal women, agreed to use contraceptives during the trial; - Signed the written informed consent. --- C677T ---



HPO Nodes


HPO:
HP:0000077: Abnormality of the kidney
Genes 1801
SH2B1 SMARCB1 IGF2 RPS7 SLC34A1 WT1 TRNK B3GLCT MITF NDUFS4 ALG9 MME KAT6B OFD1 CEP164 CRB2 FREM1 NTRK1 ARVCF RPS15A ND1 WDR11 ANTXR1 RREB1 LETM1 GNA11 IFT172 NPHP3 MAFB MET ANTXR1 PEX11B PAX4 APOB ZIC3 STK11 BUB1B SNAI2 FLRT3 DYNC2H1 MCC CEP290 KCTD1 BRIP1 BRAF SEC24C FGFR3 TBC1D20 PEX13 SLC37A4 PIGA TSC1 FANCG FOXF1 NDUFV2 ADAMTSL1 ENPP1 EVC2 DLST CRB2 ADGRG2 COQ8B ACTN4 DNMT3A PC FLNB ITGA8 NOD2 EFEMP2 C8ORF37 WASHC5 KRAS XYLT1 CYB561 KMT2A BMPER CLCNKA PIGT PRKCD SUFU PTCH1 KIF14 CCR6 DNAJB11 HOXD13 IGF2 CLCN5 TRRAP PLAGL1 PALB2 RRM2B IFT27 INTS1 PEX19 MAP2K2 WT1 PPP1R15B AMMECR1 HNF4A ADA2 MED25 ERCC8 FANCL RAB23 ALDOB TKT VPS33A KIAA0753 HRAS NUP160 PIK3CA DLL4 F8 TBX15 MVK GALNT3 KIAA0753 PREPL SCO2 CAV1 PUF60 RYR1 CCBE1 ELP1 NLRP3 FANCF PIK3CA WDPCP APPL1 ND4 RPS19 PNKP IFT80 CPT1A PEX1 IGF2 FLI1 MBTPS2 DGKE IFT140 HOGA1 DSTYK PEX12 NPHP4 PRKCSH TCTN3 SOX10 TRNN NOTCH3 SLC5A2 DICER1 CFTR CCBE1 NDUFB11 SLC6A19 KYNU CD2AP NADSYN1 UMPS CDC42 HMBS ALG8 BRAF SC5D TMEM216 MCFD2 SCARB2 CREBBP TMEM107 PTPRO XPNPEP3 NOTCH2 ABCC6 PORCN CEP57 PEX10 PIK3R2 CEP41 RAD21 RERE FLNA CASK TCTN3 PTPN22 TRNS2 CDON EDNRB TIMMDC1 PPM1B STRA6 LRIG2 SIK1 RPS19 IL12A-AS1 CIT CDKN1B CCN2 TSC2 TRIM32 GPKOW ARL6 WDR73 TCTN2 PCSK9 CIT PHYH DSE PEX1 DHODH DYNC2H1 NSUN2 RET IFT80 FGFR3 MKS1 DYNC2LI1 NPHP3 WFS1 VHL POU6F2 EBP PMM2 COL4A3 MNX1 TP63 RPGRIP1L SLC29A3 THBD BAX CLCN5 RAG2 SPOP PGM3 MMUT FANCE TP53 SDR9C7 SHANK3 MYOD1 NDUFS6 TRNK ZEB2 AGTR1 GRHPR ATRX ENG CCNQ SLC34A1 COLEC11 MDM2 SLC22A12 LAMC2 NPHS2 GREB1L IL17F VAMP7 MKKS FANCC PYGL BLK ZNF592 ITGA3 CAMKMT PIGL MKS1 COQ2 ATP7B RNU4ATAC TASP1 SAA1 TBC1D24 TTC37 LTBP4 IL17RA MCTP2 ATN1 NPHP1 TAF13 PDGFRB PUF60 NDUFAF6 FOXI1 SLC4A1 IQSEC2 SDHB APC GLMN HYMAI TMEM216 CISD2 BUB1B GDF2 BUB1B TNXB NDUFA1 RAD54B NEU1 BSCL2 NPHS1 CDKN1B KANK2 AURKA PRKAR1A APRT YWHAE FLCN COX3 IFT43 CC2D2A USF3 FGFR2 TREX1 ACVRL1 FLNA CC2D2A ZFPM2 XDH WAC ITGA6 STRA6 NDUFAF3 IL17RD FANCB ANLN SLC1A1 ROBO2 ETFB RNU4ATAC SIX5 GLI2 CLCNKB OGG1 PAX6 CCDC141 SLC2A2 RPL31 FH RPGRIP1L AQP2 HNF1A COL4A1 SIX1 ABCC8 BRCA2 BSND NDUFAF2 CCDC22 COL4A3 PTCH1 CFI STAT3 TMEM67 C1QBP COQ6 TREX1 ARMC5 SLC26A1 KAT6B MEFV GNA11 HOGA1 TMEM126B IRAK1 REN FUT8 PEX12 PLCD1 GP1BB MDH2 HNRNPK FREM2 PIGY SLC34A3 MAX NSDHL SERPINH1 EYA1 HSPA9 PROK2 SETD2 SLITRK6 SMARCD1 TELO2 F10 DZIP1L SOX17 PDGFRL NUP107 TP53RK CDC73 RIPK4 BCS1L TSR2 PYCR2 BMPER CTNS PML LAGE3 CPT2 SOX9 TMEM67 CHD7 CEP290 FH SDCCAG8 ATRX FOXC2 RBM10 GDF6 MAP3K1 CC2D2A BBS12 MDM2 CASR RFWD3 OPLAH VHL H19 SDHD SLC12A1 NUP133 WFS1 GPC3 ALG9 NUP93 CYP11B2 FANCB IL2RG OSTM1 SLC17A5 ABCG8 ETFA TMEM231 ROR2 GP1BA SMAD4 KDM6A CDK5RAP2 HPSE2 INVS LEMD3 MYLK NXN UBR1 PGAM2 NODAL ND6 CSPP1 BBIP1 DHCR7 GSN KCNJ5 ARID2 BBS1 ASXL1 FGFR1 ARX NDUFAF3 TBX18 HNF4A GPC4 RAB3GAP2 GRHPR DNA2 AGT CACNA1S TMEM231 SOX4 NFIA CEP63 FGFR2 BCOR BBS10 CD81 FUZ TMEM67 OCRL CRTAP PEX13 B3GLCT ABCC6 TRIP13 ABCC8 BMP4 CPLANE1 CYBC1 ELN FANCD2 NPHP1 REST ACE CLEC7A RTL1 GP1BB TP53 GLI3 FRAS1 DIS3L2 PMM2 INSL3 WT1 TGM1 CCNQ PTEN ARID1B AGGF1 NPHP1 ARL3 NDUFAF5 SLX4 RPL27 SEC23B UMOD PPOX KRT17 SLC3A1 CA2 CC2D2A AP2S1 CEP83 STAT5B WNT4 CREBBP FAM20C SOX9 BBS4 SLC7A7 BCS1L GCM2 CD46 DIS3L2 KNSTRN GRIP1 FANCD2 PTPN22 COL4A4 TMEM67 KIF14 IL7R GPC4 H19-ICR SMARCAL1 RMND1 PUS3 G6PC3 MARS1 CEP290 NDUFB10 FREM2 PEX26 TPRKB SPRY4 PEX19 CLDN19 ENPP1 MED25 NCAPG2 SEMA3E IQCB1 PRTN3 ARID1A XYLT2 C1QB HPSE2 GP1BB TRNS1 FCGR2B SDHD NRIP1 SALL4 SI MOCS1 DSTYK NADK2 FANCI ZAP70 ALDOB LMNA ND2 ALOX12B ND5 C3 TMEM260 BBIP1 USP8 DPH1 USP8 MASP1 SALL4 PEX3 IL6 C4A TRNQ COLEC10 GCK RAI1 GATM SON AGXT SBDS TBC1D24 PEX1 CHRM3 DMXL2 NPHP3 TRNE PRMT7 KIF14 SMARCA4 DHCR7 MMACHC KITLG KIAA0586 SDHB TRIM32 AMER1 GBA SPP1 KIF7 MKKS PTPN22 FOXP3 FGFR2 AKT1 SDHB TRNF TMEM138 SDCCAG8 CDKN1C CDC73 IFT43 KANSL1 HBB COL4A1 SLC4A1 FN1 ACP5 FANCB AFF4 SDHB ZFP57 CLDN10 TMEM231 OFD1 KLHL7 NPHP4 PTPN11 RPL26 COG1 PHGDH ACTG1 KDM6A CDC73 STRADA PTPN12 NUP133 MLH3 FBLN5 MSH6 LAMB2 TMEM107 PEX16 NIPBL HABP2 CD109 TRNL1 CHD7 PRODH SLC37A4 CFI LRP2 PHF21A NPHP4 ZIC2 SOX18 FAM20A DYNC2LI1 COL14A1 INSR CDKN2C PIGN ND2 ADAT3 WWOX EIF2AK3 CPOX RPS17 APC2 DHX37 NSMF GLIS2 TBX1 NSD1 PIEZO2 LMNB2 DYNC2I1 CREBBP TMEM237 PDE6D TMEM231 TBX1 ATRX PGAP3 IL10 MLH1 MAGED2 GCK EHMT1 CTNS SDHD PRCC FLNB STRADA FOXP1 BCOR TMCO1 NDUFS1 PPP2R3C APOE PEX5 PDHA1 FH CLCNKB BBS1 MYH9 SLC2A9 MYO1E FAM149B1 CCND1 ALG8 HESX1 AVPR2 TGIF1 NEUROD2 MBTPS2 TRAF3IP2 TBX1 TRIM28 WDPCP KISS1R SSR4 PIGP HNRNPU TRNS1 CEP152 CCND1 STIL HAAO MAP2K1 MKKS LMAN1 SC5D ADCY10 AFF4 TFAP2A IL23R COX2 COQ2 FBXW11 OFD1 INS TSC2 RAI1 MYH11 ITPR3 PROKR2 GBE1 FGF10 PLA2G2A AMMECR1 ATP1A1 LMNA POGZ ENPP1 TCTN3 WDR62 CLCN5 GLI3 SREBF1 ITGA2B SMARCE1 ALMS1 GCM2 POU3F4 SEMA3A FGA RPGRIP1L H19-ICR LIPT2 CFH CDKN1C SDHA CACNA1D WAS CASR GNB1 LAGE3 F2 MOCS2 EHMT1 DYRK1A FAS WDR35 HPS1 G6PC1 CCDC28B GTF2I SCN2A GPC3 PDE6D TPRKB ATP6V0A4 DMRT3 APOA1 SMARCAL1 NEK8 IFIH1 TMEM127 KCNJ11 CLPB EP300 OSGEP SETD5 AHI1 CSPP1 CCR1 UQCC2 MINPP1 PLEC POR OFD1 WNT4 WDR35 FAS MKS1 RAD51 DUSP6 TRNT1 MMUT HYLS1 MKKS NPHP1 XRCC2 NRAS VHL GREB1L ERAP1 ERCC6 INF2 SLC3A1 KEAP1 SLC25A22 PGK1 MYMK RFWD3 COL4A4 MBTPS2 CEP290 GPC4 ITGA8 HPRT1 CDKN1B KLRC4 C4A TRPC6 DNASE1 CA2 PREPL DICER1 PLCE1 MMP1 PROKR2 MLXIPL VIPAS39 PIGN STX3 HLA-DRB1 WDR19 TMEM237 ANOS1 MEG3 APOE GNAO1 HELLPAR FLCN WT1 GPR35 BAZ1B CDKN1A ALG1 WT1 GRIA3 MID1 GP1BA NIPAL4 AKT1 KCNAB2 CENPJ CTNS CEL TRNL1 LCAT KMT2D FIBP UBR1 KCNA1 FEZF1 COL7A1 HSPG2 IARS1 TFE3 GTF2IRD1 PIGY CDK6 SPINK5 SOX9 PGAP2 PUF60 STAG1 CCND2 FANCM CTNS NOTCH2 PACS1 NELFA NAA10 KCNJ11 PIK3C2A GLI1 PAX2 FXYD2 PIK3CD HNF1B USP9X TCF4 WDR35 SHPK HLA-DPA1 SETBP1 WT1 CEP164 PIEZO2 SLC30A9 CYP27A1 ARHGDIA WAS NLRP3 TP63 TBX3 NF1 RARA RPL26 TREX1 DDX59 KLF11 LMNB2 COL3A1 CD96 ERCC8 HLA-DPB1 GLIS3 PEX2 CFHR1 BRF1 LIPN SLC25A20 DICER1 HRAS CASP10 TSC1 SIX5 NIPBL NEUROD1 WDR19 CEP290 ATP7A TRNW B4GAT1 GDNF CTLA4 EPAS1 ADAMTS3 SPECC1L BLM PKD2 PPP3CA TTC21B PKD2 PDX1 NPHP1 FKTN ADA2 KCNJ1 FGFR1 POU6F2 CFI SNRPB MYOCD GATA4 TMEM70 FLNA STAT2 ARL6IP6 FAH PYGM RASA1 NEK1 FAN1 NR0B1 LIG4 NF1 NF1 UMOD SLC7A9 RPL35 SRY SDHAF2 FAS TAPT1 TMEM216 SDHD ZNF687 SLC35A2 SLC4A4 MSH2 CTLA4 DZIP1L ESCO2 FOXE1 LRP5 TRIM37 EXT2 ITGA2B KIF1B KMT2A ITGB3 STXBP1 SLC9A3R1 PAX1 BBS9 SERPINF2 ATP6V1B1 SPRY2 STAT1 FGF8 ELP1 SCNN1A SNRPN RMRP LMX1B MAX LRIG2 GATA3 KCNJ10 LDHA CYP4F22 ERCC8 MEFV WT1 WT1 NDUFAF8 CCND1 KCNQ1OT1 FANCC SKIV2L PHEX FANCI NRAS SDHC LDLRAP1 PEX6 SALL4 SLC36A2 TRIM28 MFSD2A TBX22 PIGV ALMS1 FGF8 CPLANE1 GPC3 WNT5A B9D1 MAFB DHDDS DACT1 MDM2 LEMD3 FGF20 BBS7 DDX6 PQBP1 HNF4A LDLR DVL1 DNASE1L3 RASGRP1 CHD7 CCDC141 FANCA TRAPPC14 DMP1 PCK2 KLLN B9D1 IARS1 KNL1 HNF1A GAS1 KCNQ1OT1 MGME1 TTC21B HIC1 APC CWC27 IL12A PTPRJ MMUT CHRM3 CLDN16 SF3B4 PEX7 IL17RC CFB COL4A5 LYZ SLC26A4 CD96 CILK1 ACP5 DNAJC21 MYCN BRAF DDX59 PAH WRN RBM8A NDUFB9 RPS26 PIGA CDH23 SCARB2 HPRT1 PIGL PEX10 WDR73 MSH3 C1QA JAK1 RET RAI1 SULT2B1 JMJD1C BUB1 PALB2 COQ7 OCLN GEMIN4 ETFDH TBX1 WDR19 PIGT ZAP70 IFT172 FKRP CORIN PTPN22 HPRT1 GCDH LIMK1 HMGA2 ASPM KRAS FGF23 EP300 SPART BRCA2 NDUFA6 CDC42 CDKL5 RPS10 RPGRIP1L NDUFS2 PIGO STAT4 MAP3K7 VAC14 PKHD1 ND3 TMEM216 RBBP8 CD151 GNB1 SOX10 BRCA2 ARX ZMIZ1 NUP107 WDR4 HNRNPK RAF1 FASLG ATRX TNXB SMARCC2 CFH DEAF1 C3 TXNL4A INTU STAT3 PLG ESCO2 LONP1 TMEM126B PIGV BCOR TMEM127 LPIN2 KYNU NUP205 SLC12A3 ADA SETBP1 CFH FIBP HLA-B HDAC4 SLX4 TSC1 PIGQ RECQL4 LEMD3 TBC1D8B PKDCC FGFR2 RPS26 MEFV NEK8 GABRD IRF2BP2 EHMT1 ABCG5 TRIM8 DCC WNT4 RPL5 WNT4 RPS27 SURF1 TFAP2A RPS24 VPS33B RPL35A RET UFD1 SHH HNF1B APRT HNF4A DHX16 NOTCH2 UBE2T SRP54 SCNN1B DKC1 SHANK3 BBS5 SF3B4 LAMB3 SMS ERCC6 KCNQ1 GLI3 SLC6A20 KANSL1 EIF2AK3 RAB18 FBN1 ARL6 BBS4 FGFR1 YAP1 RAI1 NDUFS2 SALL1 STXBP1 CPT1A ZEB2 SMC1A NDUFAF4 ERCC4 ERBB3 INPP5E SIX3 OCRL CTU2 ADCY10 CENPF AR CDC73 SMC3 PDX1 FLNA GATA1 DIS3L2 WDR19 APOL1 INF2 HLA-DRB1 CPT2 DPH1 DLC1 CEP290 H19-ICR SARS2 MTRR TCN2 HDAC8 TBL1XR1 EYA1 BUB3 RAD51C AQP2 ITGB3 NSD1 SLC6A17 TRIP13 FAM20A KMT2C AIRE NARS2 LIG4 AMMECR1 POLE BBS2 REN ABCC8 FANCA IGF2 VHL EXTL3 KCNE5 COMT KAT6A AIP KCNJ10 TP53 PDSS2 LARGE1 FCGR2A CYTB SALL1 CLDN19 BTNL2 WNT3 CYP24A1 LHX1 ALOXE3 PIGN VHL BAP1 VDR PAFAH1B1 HGD FN1 FAT4 YY1AP1 NPM1 ZBTB16 FREM1 EPG5 INSR ERCC6 MCM5 ARID1B OSGEP CDKN2A LAMA3 ANKLE2 SPECC1L IKZF1 SHH RORA LMNA YY1 PIK3C2A AKT1 LMBRD1 IFT172 PDSS2 IFT140 LZTFL1 COPA MYO5B SRY SNRPB SEC63 PTEN DYNC2I1 CTNNB1 CASR SCNN1G ZNF423 RAD51C DLL1 PRDX1 SDHB ABCA12 MUC1 REST KYNU TTC8 CLIP2 H19 PKD1 RSPO2 HIRA DYNC2LI1 GNAS IRF5 LMX1B MEN1 COX1 HSD17B4 PEX3 ELN CEP135 TMEM67 MYD88 CLCNKB BUB1 RPL11 PORCN ACTB CFHR5 SOX11 FOXP3 H19 WDR19 USP9X ND4 SDCCAG8 PKHD1 TTR SON KLLN MAFB RPL11 CHEK2 SCNN1B PAX2 HNF1B PCK1 IFT122 AKT3 PTPN11 MEOX1 CPT2 ARL6 PEX2 MRPS22 FAT4 TTC37 DACT1 WT1 TDGF1 GLA RPL15 NF1 DYNC2I2 CHST14 TRNV MEN1 FLNA SLC12A3 TMEM67 OCRL BBS10 MAGI2 CASR NDUFA11 NDUFS3 GSN ALDH18A1 ARX MEFV NOD2 SERPINA1 FRAS1 MYCN NBN TRNH AAGAB RAG1 RNF139 CEP55 AGXT NUP85 FGF17 SASS6 SLC7A7 UMOD RARB JAM3 ND1 KMT2D TBCK WDR73 NPHP3 FOXRED1 MICOS13 CSPP1 TMEM216 CASP10 DCHS1 GATA3 DLK1 DCHS1 ZEB2 CHN1 PIK3R2 RPL18 CHRNA3 PGK1 KCNH1 EYA1 LMOD1 FGFR3 PHC1 ADA FIG4 XRCC4 TLR2 FLNA KCTD1 ND3 TRAF3IP1 TTC21B SMO NUMA1 TMEM231 GLA FANCL FBXL4 GDF3 ROR2 NSD2 NUP107 HS6ST1 DPF2 ITGA2 CEP290 FLNA PKD1 CHD4 ZIC3 FLCN SLC3A1 ERCC4 CDK4 POLR3A AGPAT2 PIGW SMOC1 ACTG2 ND1 FOXH1 COG7 STS MOCOS PRKCD SLC34A1 BICC1 PEX7 NDUFAF3 GP9 DYNC2I2 RBM10 KCNJ11 DISP1 GANAB TACR3 VANGL1 NR5A1 TRIP11 TSC2 PEX14 WDR19 KANSL1 IFNG PHYH HNF1B HOXA13 RPS28 NLRP3 NABP1 B2M FLCN PLVAP DYRK1A ARNT2 RAD21 INVS HMOX1 ADAMTS13 MCPH1 AXIN2 LMX1B ITGB4 GBA ZNF423 CEP120 KIF1B CTH PIGL NDUFS8 NDUFB8 PBX1 TOR1A B9D2 TBL2 EVC SDCCAG8 FANCE WIPF1 CEP120 RFC2 NPHP3 CAD SGPL1 PAX7 BBS12 HNF1A NPHP1 WDR4 FLT1 TRNT PPP2R1A SURF1 B9D2 BRCA1 LRP4 CACNA1D SRCAP CDKN2B SIX1 LRP5 IQCB1 MAPKBP1 TRIP13 YAP1 MST1 ANKS6 SEMA3E MMACHC LPIN1 PRPS1 PIK3CA SMC1A WNT3 AVPR2 PLG TRAF3IP1 COG6 PRDM16 FGFR2 STOX1 LAMB2 C8ORF37 NDUFS7 TALDO1 NUBPL DYNC2H1 RPGRIP1 APC CLCN5 EXT2 ALX4 NDUFB3 NUP133 GPC3 HMGA2 LRP4 RERE MAD2L2 DCDC2 PNPLA6 SKI TMEM237 PIK3CA POR PGM3 DCC WT1 VHL PIK3CA TRNW POMT2 RTTN PLD1 F5 FOXF1 CHST14 SDHC DCLRE1C TLR4 WT1 RAB3GAP1 FANCB B3GALT6 SF3B4 HBB F8 FGFR3 ZNF148 ANOS1 COPB2 NDUFV1 ABCC6 PEX6 STAT4 LMX1B FAT4 HPRT1 METTL5 COX14 UBAC2 THOC6 PAX2 COL4A3 TTC8 SCN1B TMEM138 CHD7 RBM8A NCAPD3 CFHR3 PLCD1 POMT1 PRKCSH BNC2 ALPL SNAP29 BICC1 RECQL4 THOC6 TRNL1 PEX5 SRC CEP55 IFT27 PRPS1 JAG1 GDF6 EMP2 FIP1L1 TP53RK FLCN ND5 APC NDNF AVIL ACSL4 NPHS1 NAA10 ND6 EP300 LZTFL1 CTNNB1 PTH1R INPP5E MAP3K7 RPS29 DYNC2I2 ACTG2 ERCC4 DNASE1L3 NDUFAF1 C1QC SEC61A1 SLC25A11 GNAS RET FLII CPT2 ATP6 DHCR24 HSD11B2 WASHC5 COA8 TCTN2 GANAB TMEM67 CD46 VPS33A NEU1 PIGQ ITGB4 INS HLA-B
Protein Mutations 4
C282T C677T K55R Y93H
HP:0000822: Hypertension
Genes 424
MAT2A WT1 LMNA HGD FN1 TRNL1 SERPINA6 YY1AP1 TRNK BBIP1 GTF2IRD1 TRNC KCNJ5 CLCN2 MGP TGFBR2 BBS1 CYP11B2 RET ARVCF KCNJ5 EGFR OSGEP SH2B3 TRNS2 SLC2A10 NKX2-5 LMNA RREB1 IFT172 LZTFL1 ND1 FBN1 FMO3 HLA-DPA1 GUCY1A1 APOB SCNN1G CEP164 BBS10 FUZ SDHB MUC1 REST ABCC6 TTC8 CLIP2 H19 ELN FGFR2 GATA5 PKD1 NF1 NPHP1 KCTD1 WNK4 HIRA GP1BB GNAS IRF5 EDA2R LMX1B NFU1 PLIN1 MEN1 SEC24C ELN GNAS COL3A1 NPHP1 SLC37A4 ERCC8 HLA-DPB1 NOTCH1 CFHR1 THSD1 SDCCAG8 DLST PKHD1 PPOX ACTN4 DNMT3A NOD2 SCNN1B C8ORF37 ECE1 XYLT1 ACTA2 GDNF CTLA4 PAM16 EPAS1 BBS4 ARL6 CCR6 DNAJB11 CDH23 ENPP1 WT1 DIS3L2 PKD2 MFAP5 GLA PKD2 NPHP1 TRNW NF1 IFT27 BANF1 CFI LMNA WNK1 WT1 ARHGAP31 SMARCAL1 FGFR2 STAT2 ACVRL1 CEP290 ADA2 NF1 SDHAF2 ENPP1 PRKAR1A IQCB1 PRTN3 TET2 SMAD6 XYLT2 NOD2 SDHD HPSE2 MYH11 SDHD COX1 PDE8B CAV1 C3 SMAD4 SCNN1G ELP1 USP8 EXT2 USP8 KIF1B SLC25A11 FBN1 CBS WDPCP BBS9 BRCC3 ACAT1 SPRY2 TRNF STAT1 SUGCT ELP1 SCNN1A GPR101 PPARG ZMPSTE24 MAX LRIG2 TRNS1 GJA1 ERCC8 BSCL2 CYP11B1 NPHP3 TRNE FIG4 CCND1 CD2AP KCTD1 TRAF3IP1 TRNK GBA TGFB2 CYTB HMBS GLA TRIM32 EDA SDHC TNFRSF11A LDLRAP1 MMP2 XPNPEP3 PKD1 KIF1B ABCC6 TRIM28 SDHB SDCCAG8 ALMS1 MAFB FN1 PTPN22 ACP5 ERCC4 LEMD3 CYP11B1 BBS7 SDHB LDLR SCNN1A NPHP4 KRT18 HSD11B2 CDKN1B CCN2 CUL3 GANAB PDE3A VANGL1 TSC2 ACTA2 PCSK9 CEP19 CFB SMAD4 MTTP COL4A5 LYZ FOXE3 IDS PRKG1 SLC37A4 PHF21A GUCY1A1 B2M RET INVS KCNJ5 PPARG WRN PLIN1 BMPR2 CDKN2C MMP14 VHL POU6F2 ELN COL4A3 CPOX ABCB6 CDH23 LMX1B THBD KIF1B SLC2A10 PDE11A JMJD1C CYP17A1 TRNK TBX1 IL12B COQ7 TBL2 TBX1 WDR19 LRP6 FMR1 SDHD CORIN RFC2 CACNA1H CYP11B1 MKKS ADA2 LIMK1 NOTCH3 MKS1 FLT1 BBS1 CACNA1D YY1AP1 CDKN2B ND6 LMNA MLX VAC14 PKHD1 TRIP13 PDE11A MEF2A IDS TRIM28 NDUFAF6 NOS3 TRNQ SDHB SDHC STOX1 SMAD3 ALX4 APRT LOX OFD1 IDUA TMEM127 COL3A1 AIP FBN1 LMNA CFH WT1 VHL NR3C1 CYP17A1 TSC1 ALMS1 SMAD4 POU3F4 FGA HMBS TP53 HBB ARMC5 BRCA2 SDHA CACNA1D ABCG5 RET UFD1 TREX1 NOTCH2 ABCC6 G6PC1 ARMC5 SCNN1B CCDC28B GTF2I JAK2 KLHL3 BBS5 MYH7 ERCC6 APOA1 TRNV TMEM127 TGFBR1 GNAS FBN1 ARL6 GCH1 COX2 MDH2 NFIX OFD1 AIP COL4A3 WDR35 ENG MAX CFHR3 TMEM70 NSMCE2 LARS2 LEMD3 ND5 CYP21A2 NR3C1 DZIP1L BNC2 VHL BICC1 ERCC6 PRKACA MC4R PRKACA ADA2 CYP11B1 INF2 HLA-DRB1 MYLK TGFB3 MTRR MYMK POR COL4A4 JAK2 SDHD SCN2B CEP290 ITGA8 FH DYRK1B TRPC6 HLA-B PRKAR1A MLXIPL BBS12 MDM2 MPL TMEM237 VHL BBS2 PDE3A NR3C2 KRT8 GPC3 PRKAR1A BAZ1B ERCC4 VHL TGFBR3 CDKN1A COMT WT1 SLC25A11 RET COX3 AIP ABCG8 HSD11B2 GANAB TMEM67 CD46 ADAMTSL4 TNFRSF11B ANGPTL6 INVS TRNL1