SNPMiner Trials by Shray Alag

NCT00511368 (37) NCT00460382 (36) NCT04504071 (35) NCT03783286 (33) NCT04172597 (32) NCT02404233 (29) NCT00959894 (28) NCT00706147 (28) NCT00121017 (28) NCT01685801 (27) NCT04513626 (26) NCT01736761 (26) NCT04495348 (24) NCT02673398 (23) NCT02499978 (22) NCT01605084 (21) NCT04254705 (21) NCT02069834 (21) NCT00939770 (18) NCT01792570 (18) NCT01199939 (18) NCT00356616 (18) NCT02728258 (17) NCT02707601 (17) NCT02770508 (16) NCT00711009 (16) NCT00630864 (16) NCT00491556 (15) NCT04085315 (15) NCT02616029 (15) NCT00830804 (15) NCT04681820 (15) NCT01170962 (14) NCT00984152 (14) NCT03953898 (14) NCT00727597 (14) NCT03212274 (14) NCT01369199 (13) NCT00337467 (13) NCT00098293 (13) NCT01368497 (13) NCT02159599 (13) NCT00424814 (12) NCT04432454 (12) NCT02527096 (12) NCT01849003 (12) NCT03781063 (12) NCT03683524 (11) NCT01614457 (11) NCT00460746 (11) NCT00993148 (11) NCT03061331 (11) NCT02494882 (11) NCT03068312 (11) NCT04453436 (11) NCT01521338 (10) NCT02725567 (10) NCT01614470 (10) NCT01423812 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NCT02554591 (5) NCT01501604 (5) NCT02716116 (5) NCT01136460 (5) NCT00187655 (5) NCT00350272 (5) NCT00837135 (5) NCT03202862 (5) NCT01707199 (5) NCT03839342 (5) NCT01323010 (4) NCT02248324 (4) NCT01698905 (4) NCT01737359 (4) NCT01306045 (4) NCT02804100 (4) NCT01456676 (4) NCT00588172 (4) NCT03434418 (4) NCT03593993 (4) NCT01804140 (4) NCT02882308 (4) NCT03497767 (4) NCT04106024 (4) NCT02716311 (4) NCT04405674 (4) NCT03599518 (4) NCT01675778 (4) NCT01604122 (4) NCT01297777 (4) NCT04519970 (4) NCT00705679 (4) NCT04147351 (4) NCT04129502 (4) NCT03976856 (4) NCT02335944 (4) NCT04625647 (4) NCT03948763 (4) NCT03255083 (4) NCT04002830 (4) NCT02635815 (4) NCT03066206 (4) NCT01331642 (4) NCT00557245 (4) NCT01922583 (4) NCT02893332 (4) NCT03592888 (4) NCT02257424 (4) NCT03874858 (4) NCT00017732 (4) NCT00187720 (4) NCT02593539 (4) NCT01185587 (4) NCT04439292 (4) NCT03884348 (4) NCT01309243 (4) NCT03209063 (4) NCT04160546 (4) NCT03292302 (4) NCT02418234 (4) NCT02535338 (3) NCT02192697 (3) NCT03410043 (3) NCT03845296 (3) NCT02914990 (3) NCT02113813 (3) NCT01532011 (3) NCT04340388 (3) NCT00962533 (3) NCT03856411 (3) NCT04049266 (3) NCT02973763 (3) NCT02926092 (3) NCT00271973 (3) NCT04256941 (3) NCT03812809 (3) NCT02954523 (3) NCT01784068 (3) NCT03446417 (3) NCT02841579 (3) NCT02025114 (3) NCT01288521 (3) NCT01385683 (3) NCT02279004 (3) NCT00998582 (3) NCT03111901 (3) NCT01352715 (3) NCT01619774 (3) NCT01045369 (3) NCT02246998 (3) NCT03969823 (3) NCT00895596 (3) NCT02398929 (3) NCT00724711 (3) NCT04029350 (3) NCT03737994 (3) NCT01443806 (3) NCT02629822 (3) NCT03463525 (3) NCT00710112 (3) NCT03623750 (3) NCT04283955 (3) NCT02743923 (3) NCT01016106 (3) NCT01259089 (3) NCT03971474 (3) NCT02917993 (3) NCT02368990 (3) NCT00279110 (3) NCT02485652 (3) NCT00312169 (3) NCT04541407 (3) NCT02769286 (3) NCT00747487 (3) NCT04267913 (3) NCT01429597 (3) NCT04023617 (3) NCT03790228 (3) NCT01759888 (3) NCT04429152 (3) NCT01810718 (3) NCT02725632 (3) NCT01090011 (3) NCT04544111 (3) NCT02926768 (3) NCT02981108 (3) NCT02459743 (3) NCT00654823 (3) NCT01037127 (3) NCT04439305 (3) NCT01028222 (3) NCT01542411 (3) NCT01031446 (3) NCT02726269 (3) NCT01892644 (3) NCT03260491 (3) NCT01802632 (3) NCT02720094 (3) NCT02630186 (3) NCT01627132 (3) NCT02690675 (3) NCT01013506 (3) NCT04252339 (3) NCT02496663 (3) NCT03386955 (3) NCT03394118 (3) NCT04212702 (3) NCT01754025 (3) NCT01160276 (3) NCT00121979 (3) NCT03228277 (3) NCT04351555 (3) NCT01243346 (3) NCT04510415 (3) NCT02796274 (3) NCT02774005 (3) NCT02064491 (3) NCT04233021 (3) NCT03799601 (3) NCT00260260 (3) NCT02094261 (3) NCT04245085 (3) NCT03058094 (3) NCT01282151 (3) NCT02520778 (3) NCT03161808 (3) NCT04181060 (3) NCT01342679 (3) NCT01443273 (3) NCT01593254 (3) NCT04433481 (3) NCT02529995 (3) NCT03502850 (3) NCT02771314 (3) NCT03823807 (3) NCT03270527 (3) NCT02688881 (3) NCT01005602 (3) NCT02442349 (3) NCT02684591 (2) NCT02282267 (2) NCT03381430 (2) NCT02178397 (2) NCT03608215 (2) NCT02603107 (2) NCT03370770 (2) NCT03322696 (2) NCT03333343 (2) NCT00525473 (2) NCT03127449 (2) NCT01781026 (2) NCT02503722 (2) NCT00975871 (2) NCT03964233 (2) NCT03388099 (2) NCT02317016 (2) NCT03845270 (2) NCT03519958 (2) NCT03918304 (2) NCT02151721 (2) NCT02777658 (2) NCT01016444 (2) NCT02971501 (2) NCT03101254 (2) NCT03178617 (2) NCT01774721 (2) NCT03574753 (2) NCT01357655 (2) NCT01766713 (2) NCT02097225 (2) NCT00658164 (2) NCT03622593 (2) NCT02571036 (2) NCT00969137 (2) NCT00834665 (2) NCT02026011 (2) NCT03622580 (2) NCT03543683 (2) NCT01143493 (2) NCT03671538 (2) NCT04028778 (2) NCT00324961 (2) NCT01915576 (2) NCT02157883 (2) NCT01387022 (2) NCT03864042 (2) NCT03235245 (2) NCT03469960 (2) NCT02795884 (2) NCT04687241 (2) NCT00005541 (2) NCT01242813 (2) NCT03960645 (2) NCT00643058 (2) NCT03443336 (2) NCT02992860 (2) NCT02281760 (2) NCT02201602 (2) NCT04310007 (2) NCT04309019 (2) NCT03720665 (2) NCT00909532 (2) NCT00411944 (2) NCT01604681 (2) NCT01245062 (2) NCT00270231 (2) NCT03256136 (2) NCT03973918 (2) NCT00302692 (2) NCT00125281 (2) NCT02163733 (2) NCT02110407 (2) NCT00475176 (2) NCT03196882 (2) NCT01572818 (2) NCT02556333 (2) NCT04268550 (2) NCT02433717 (2) NCT03428126 (2) NCT01153763 (2) NCT02609776 (2) NCT01420211 (2) NCT03556176 (2) NCT03872440 (2) NCT01405079 (2) NCT03382795 (2) NCT02991950 (2) NCT00013598 (2) NCT03455764 (2) NCT02422628 (2) NCT03831932 (2) NCT03766490 (2) NCT02580474 (2) NCT00499577 (2) NCT02444884 (2) NCT01775943 (2) NCT03544814 (2) NCT01310036 (2) NCT01027663 (2) NCT01928160 (2) NCT01244438 (2) NCT00007150 (2) NCT04462081 (2) NCT02297425 (2) NCT02086071 (2) NCT01050400 (2) NCT03060590 (2) NCT01819428 (2) NCT02709668 (2) NCT02411448 (2) NCT03878719 (2) NCT04622072 (2) NCT04479306 (2) NCT03377023 (2) NCT01378026 (2) NCT03239145 (2) NCT04511533 (2) NCT00226551 (2) NCT02191891 (2) NCT04586270 (2) NCT04669535 (2) NCT04545710 (2) NCT02120222 (2) NCT02738593 (2) NCT00831272 (2) NCT04469543 (2) NCT00573495 (2) NCT04158544 (2) NCT00904150 (2) NCT02110056 (2) NCT02856893 (2) NCT02110043 (2) NCT02182986 (2) NCT04179890 (2) NCT00063232 (2) NCT02197234 (2) NCT03121235 (2) NCT01532089 (2) NCT03887169 (2) NCT02268864 (2) NCT01963845 (2) NCT00866736 (2) NCT03991013 (2) NCT02500927 (2) NCT04657991 (2) NCT02228382 (2) NCT02689570 (2) NCT01513785 (2) NCT02463435 (2) NCT03351361 (2) NCT04527549 (2) NCT03424759 (2) NCT02197247 (2) NCT02321046 (2) NCT04272034 (2) NCT04646824 (2) NCT04027647 (2) NCT02364609 (2) NCT02759835 (2) NCT04349865 (2) NCT00068159 (2) NCT00418015 (2) NCT04310397 (2) NCT03088176 (2) NCT03867175 (2) NCT00339209 (2) NCT00011258 (2) NCT01288430 (2) NCT01616199 (2) NCT03603262 (2) NCT03071705 (2) NCT00969930 (2) NCT00772408 (2) NCT02743468 (2) NCT00277342 (2) NCT04248829 (2) NCT01767454 (2) NCT00933127 (2) NCT03317873 (2) NCT03392246 (2) NCT01909453 (2) NCT03523104 (2) NCT00085917 (2) NCT02507921 (2) NCT03781752 (2) NCT03828422 (2) NCT02193282 (2) NCT03195452 (2) NCT04657289 (2) NCT02294487 (2) NCT01325441 (2) NCT02511106 (2) NCT02997501 (2) NCT04184921 (2) NCT00625092 (2) NCT01657786 (2) NCT01415011 (2) NCT02629523 (2) NCT01718847 (2) NCT02818023 (2) NCT00577707 (2) NCT01943422 (2) NCT00116636 (2) NCT04429542 (2) NCT01841463 (2) NCT03865511 (2) NCT03205267 (2) NCT01218477 (2) NCT02881320 (2) NCT01897480 (2) NCT02810990 (2) NCT04189757 (2) NCT01951001 (2) NCT04254939 (2) NCT03207867 (2) NCT00780949 (2) NCT03355768 (2) NCT00817089 (2) NCT02143466 (2) NCT04499053 (2) NCT01907776 (2) NCT00909727 (2) NCT01562028 (2) NCT03737253 (2) NCT00441974 (2) NCT02155465 (2) NCT04586335 (2) NCT00661999 (2) NCT02705339 (2) NCT04006340 (2) NCT04553887 (2) NCT04645225 (2) NCT03852290 (2) NCT02183922 (2) NCT03970239 (2) NCT00294372 (2) NCT03250676 (2) NCT03792074 (2) NCT00671892 (2) NCT00689182 (2) NCT00106379 (2) NCT01947023 (2) NCT00509652 (2) NCT03683251 (2) NCT02039986 (2) NCT03515837 (2) NCT04081688 (2) NCT03190005 (2) NCT01584648 (2) NCT02292654 (2) NCT03992456 (2) NCT03133546 (2) NCT01485809 (2) NCT01266967 (2) NCT04644315 (2) NCT02909712 (2) NCT00062764 (2) NCT01776684 (2) NCT03042221 (2) NCT01940809 (2) NCT04675008 (2) NCT01161537 (2) NCT01154816 (2) NCT01175759 (2) NCT01199731 (2) NCT02788058 (2) NCT03130452 (2) NCT04687423 (2) NCT01772732 (2) NCT02631447 (2) NCT02525692 (2) NCT02526537 (2) NCT03513666 (2) NCT02027961 (2) NCT03106779 (2) NCT04106544 (2) NCT04258943 (2) NCT00165984 (2) NCT00977470 (2) NCT02092974 (2) NCT03975231 (2) NCT03586453 (2) NCT01998295 (2) NCT02021305 (2) NCT03135197 (2) NCT00432016 (2) NCT04636437 (2) NCT03004625 (2) NCT03851445 (2) NCT04031898 (2) NCT04201418 (2) NCT01911507 (2) NCT03539224 (2) NCT01978236 (2) NCT00866177 (2) NCT00320879 (2) NCT00044304 (2) NCT01999179 (2) NCT00977730 (2) NCT02491775 (2) NCT00212147 (2) NCT02040064 (2) NCT00489385 (2) NCT01713023 (2) NCT04122729 (2) NCT03994393 (2) NCT02438722 (2) NCT02762448 (2) NCT00071903 (2) NCT00626223 (2) NCT01193829 (2) NCT03239340 (2) NCT02991274 (2) NCT02811354 (2) NCT03416530 (2) NCT02522988 (2) 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NCT03678506 (1) NCT02146365 (1) NCT04310943 (1) NCT02619955 (1) NCT02934139 (1) NCT00400387 (1) NCT00375219 (1) NCT00149305 (1) NCT03520946 (1) NCT02787447 (1) NCT04501614 (1) NCT03166631 (1) NCT04213313 (1) NCT02078531 (1) NCT02349048 (1) NCT02981784 (1) NCT04636593 (1) NCT01647711 (1) NCT03231722 (1) NCT03576937 (1) NCT04412070 (1) NCT00554866 (1) NCT03151161 (1) NCT01817166 (1) NCT02220855 (1) NCT02512627 (1) NCT04591197 (1) NCT03402048 (1) NCT04500704 (1) NCT02323724 (1) NCT01166126 (1) NCT03029858 (1) NCT04317599 (1) NCT00300573 (1) NCT00809211 (1) NCT01393730 (1) NCT02318368 (1) NCT02228369 (1) NCT04500717 (1) NCT01074398 (1) NCT03134131 (1) NCT02455167 (1) NCT01004497 (1) NCT02073279 (1) NCT02117817 (1) NCT00323687 (1) NCT01605981 (1) NCT01371955 (1) NCT04147767 (1) NCT04144257 (1) NCT03490123 (1) NCT04423185 (1) NCT02625337 (1) NCT03567629 (1) NCT03360929 (1) NCT00109278 (1) NCT04108156 (1) NCT02132598 (1) NCT00542451 (1) NCT01587573 (1) NCT00868465 (1) NCT01494402 (1) 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NCT02338011 (1) NCT04360005 (1) NCT02777567 (1) NCT04591002 (1) NCT02367859 (1) NCT03647956 (1) NCT04293562 (1) NCT02628314 (1) NCT03303833 (1) NCT01460134 (1) NCT02929706 (1) NCT03342170 (1) NCT04042558 (1) NCT02626130 (1) NCT03232307 (1) NCT00435513 (1) NCT02317562 (1) NCT01391260 (1) NCT02561533 (1) NCT01980550 (1) NCT00092404 (1) NCT03758677 (1) NCT01001273 (1) NCT03438318 (1) NCT02422797 (1) NCT02318407 (1) NCT02538926 (1) NCT02615015 (1) NCT01284712 (1) NCT04316351 (1) NCT03091491 (1) NCT01740648 (1) NCT01866410 (1) NCT01175161 (1) NCT01602939 (1) NCT04330664 (1) NCT01701037 (1) NCT03612869 (1) NCT00753480 (1) NCT00090688 (1) NCT03590522 (1) NCT01717404 (1) NCT02937727 (1) NCT03899857 (1) NCT04133870 (1) NCT03790397 (1) NCT03024281 (1) NCT03389256 (1) NCT04681001 (1) NCT03426371 (1) NCT02926638 (1) NCT04193553 (1) NCT00997334 (1) NCT04544202 (1) NCT04201457 (1) NCT00618631 (1) NCT04455594 (1) NCT03439215 (1) NCT02164916 (1) NCT02000882 (1) NCT03264794 (1) NCT03810066 (1) NCT01897116 (1) NCT04372498 (1) NCT00125489 (1) NCT02788669 (1) NCT00367952 (1) NCT00977756 (1) NCT03387072 (1) NCT01586195 (1) NCT02611492 (1) NCT01220648 (1) NCT01967940 (1) NCT01708954 (1) NCT03758287 (1) NCT02392871 (1) NCT04401059 (1) NCT02869932 (1) NCT00716014 (1) NCT01526928 (1) NCT00930215 (1) NCT04631172 (1) NCT03228667 (1) NCT04273581 (1) NCT04557956 (1) NCT00980018 (1) NCT01898039 (1) NCT03883087 (1) NCT04364451 (1) NCT04216524 (1) NCT04204551 (1) NCT03672968 (1) NCT03924050 (1) NCT03983252 (1) NCT01639872 (1) NCT02747277 (1) NCT04116918 (1) NCT00669396 (1) NCT02153398 (1) NCT03543306 (1) NCT01377376 (1) NCT01603446 (1) NCT01534520 (1) NCT01972529 (1) NCT01731704 (1) NCT04186377 (1) NCT01424475 (1) NCT02066636 (1) NCT02467270 (1) NCT01748149 (1) NCT02092909 (1) NCT02864251 (1) NCT03846427 (1) NCT03779191 (1) NCT00055848 (1) NCT01217437 (1) NCT04088734 (1) NCT03191786 (1) NCT01450319 (1) NCT04689347 (1) NCT03652090 (1) NCT00995553 (1) NCT01833572 (1) NCT00432900 (1) 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SNPMiner SNPMiner Trials (Home Page)


Report for Clinical Trial NCT04619693

Developed by Shray Alag, 2020-2021.
SNP Clinical Trial Gene

Determination of Biomarkers for the Prediction of Dexamethasone Response in Sars-Cov-2 / COVID-19 Pneumonia

The primary objective of this study is to demonstrate (at the time of admission) biomarkers of interest (Human Plasma BAK125 panel + interferon panel) for dexamethasone responders versus non-responders in SARS-CoV-2 hypoxemic pneumonia. The secondary objectives are to describe and compare between groups: - The number of days without mechanical ventilation - The need for mechanical ventilation - 28-day mortality - Progression towards acute respiratory distress syndrome (ARDS) - Change in the qSOFA score - Length of hospitalization - The change in the extent of lesions on thoracic computed tomography scan between inclusion and D7 (or the day of discharge from hospital if

NCT04619693 Pneumonia, Viral SARS-Cov-2
MeSH:Pneumonia, Viral Pneumonia
HPO:Pneumonia


Primary Outcomes

Description: Treatment failure is defined as the need to transfer the patient to intensive care for mechanical ventilation.

Measure: Treatment failure (yes/no)

Time: Hospital discharge (expected maximum of 28 days)

Secondary Outcomes

Description: PeptiQuantTM Plus, Human Plasma BAK 125, Cambridge Isotope Laboratories, Inc

Measure: Human Plasma BAK-125 proteomics profile

Time: Baseline (day 0)

Description: PeptiQuantTM Plus, Human Plasma BAK 125, Cambridge Isotope Laboratories, Inc

Measure: Human Plasma BAK-125 proteomics profile

Time: Day 7

Measure: Circulating blood interferon level

Time: Baseline (day 0)

Measure: Circulating blood interferon level

Time: Day 7

Description: Measured at least twice per day throughout the initial hospitalization period.

Measure: A vector of repeated measures of SpO2

Time: Throughout initial hospitalization (expected maximum of 28 days)

Description: Measured at least twice per day throughout the initial hospitalization period.

Measure: A vector of repeated measures of FiO2

Time: Throughout initial hospitalization (expected maximum of 28 days)

Description: Measured at least twice per day throughout the initial hospitalization period.

Measure: A vector of repeated measures of temperature (°C)

Time: Throughout initial hospitalization (expected maximum of 28 days)

Description: Measured at least twice per day throughout the initial hospitalization period.

Measure: A vector of repeated measures of respiratory rate (cycles per minute)

Time: Throughout initial hospitalization (expected maximum of 28 days)

Description: Measured at least twice per day throughout the initial hospitalization period.

Measure: A vector of repeated measures of pulse (bpm)

Time: Throughout initial hospitalization (expected maximum of 28 days)

Description: Measured at least twice per day throughout the initial hospitalization period.

Measure: A vector of repeated measures of systolic blood pressure (mmHg)

Time: Throughout initial hospitalization (expected maximum of 28 days)

Description: Measured at least twice per day throughout the initial hospitalization period.

Measure: A vector of repeated measures of diastolic blood pressure (mmHg)

Time: Throughout initial hospitalization (expected maximum of 28 days)

Description: Capillary glycemia will be measured at least twice per day throughout the initial hospitalization period.

Measure: A vector of repeated measures of capillary glycemia (g/L)

Time: Throughout initial hospitalization (expected maximum of 28 days)

Description: The Quick Sequential Organ Failure Assessment (qSOFA) score will be assessed at least twice per day throughout the initial hospitalization period. The quick Sepsis-related organ failure assessment (qSOFA) score ranges from 0 to 3 points, with '3' indicating the worst health state. It uses three criteria, assigning one point for low blood pressure (systolic blood pressure ≤100 mmHg), high respiratory rate (≥22 breaths per min), or altered mentation.

Measure: A vector of repeated measures of the qSOFA score

Time: Throughout initial hospitalization (expected maximum of 28 days)

Measure: Hemoglobin

Time: Baseline (day 0)

Measure: Hemoglobin

Time: Day 2

Measure: Hemoglobin

Time: Day 4

Measure: Hemoglobin

Time: Day 7 (or day of discharge if before day 7)

Measure: Platelet count

Time: Baseline (day 0)

Measure: Platelet count

Time: Day 2

Measure: Platelet count

Time: Day 4

Measure: Platelet count

Time: Day 7 (or day of discharge if before day 7)

Measure: White blood cell count

Time: Baseline (day 0)

Measure: White blood cell count

Time: Day 2

Measure: White blood cell count

Time: Day 4

Measure: White blood cell count

Time: Day 7 (or day of discharge if before day 7)

Measure: Neutrophil percentage

Time: Baseline (day 0)

Measure: Neutrophil percentage

Time: Day 2

Measure: Neutrophil percentage

Time: Day 4

Measure: Neutrophil percentage

Time: Day 7 (or day of discharge if before day 7)

Measure: Eosinophil percentage

Time: Baseline (day 0)

Measure: Eosinophil percentage

Time: Day 2

Measure: Eosinophil percentage

Time: Day 4

Measure: Eosinophil percentage

Time: Day 7 (or day of discharge if before day 7)

Measure: Basophil percentage

Time: Baseline (day 0)

Measure: Basophil percentage

Time: Day 2

Measure: Basophil percentage

Time: Day 4

Measure: Basophil percentage

Time: Day 7 (or day of discharge if before day 7)

Measure: Lymphocyte percentage

Time: Baseline (day 0)

Measure: Lymphocyte percentage

Time: Day 2

Measure: Lymphocyte percentage

Time: Day 4

Measure: Lymphocyte percentage

Time: Day 7 (or day of discharge if before day 7)

Measure: Monocyte percentage

Time: Baseline (day 0)

Measure: Monocyte percentage

Time: Day 2

Measure: Monocyte percentage

Time: Day 4

Measure: Monocyte percentage

Time: Day 7 (or day of discharge if before day 7)

Measure: Prothrombin rate (%)

Time: Baseline (day 0)

Measure: Prothrombin rate (%)

Time: Day 2

Measure: Prothrombin rate (%)

Time: Day 4

Measure: Prothrombin rate (%)

Time: Day 7 (or day of discharge if before day 7)

Measure: Activated partial thromboplastin time ratio

Time: Baseline (Day 0)

Measure: Activated partial thromboplastin time ratio

Time: Day 2

Measure: Activated partial thromboplastin time ratio

Time: Day 4

Measure: Activated partial thromboplastin time ratio

Time: Day 7 (or day of discharge if before day 7)

Measure: Fibrinogen (g/L)

Time: Baseline (Day 0)

Measure: Fibrinogen (g/L)

Time: Day 2

Measure: Fibrinogen (g/L)

Time: Day 4

Measure: Fibrinogen (g/L)

Time: Day 7 (or day of discharge if before day 7)

Measure: D-Dimers (μg/mL)

Time: Baseline (Day 0)

Measure: D-Dimers (μg/mL)

Time: Day 2

Measure: D-Dimers (μg/mL)

Time: Day 4

Measure: D-Dimers (μg/mL)

Time: Day 7 (or day of discharge if before day 7)

Measure: Aspartate aminotransferase (ASAT; UI/L)

Time: Baseline (Day 0)

Measure: Aspartate aminotransferase (ASAT; UI/L)

Time: Day 2

Measure: Aspartate aminotransferase (ASAT; UI/L)

Time: Day 4

Measure: Aspartate aminotransferase (ASAT; UI/L)

Time: Day 7 (or day of discharge if before day 7)

Measure: Alanine aminotransferase (ALAT; UI/L)

Time: Baseline (Day 0)

Measure: Alanine aminotransferase (ALAT; UI/L)

Time: Day 2

Measure: Alanine aminotransferase (ALAT; UI/L)

Time: Day 4

Measure: Alanine aminotransferase (ALAT; UI/L)

Time: Day 7 (or day of discharge if before day 7)

Measure: Glucose (mmol/L)

Time: Baseline (Day 0)

Measure: Glucose (mmol/L)

Time: Day 2

Measure: Glucose (mmol/L)

Time: Day 4

Measure: Glucose (mmol/L)

Time: Day 7 (or day of discharge if before day 7)

Measure: Glycated haemoglobin (HbA1c; %)

Time: Baseline (Day 0)

Measure: Glycated haemoglobin (HbA1c; %)

Time: Day 2

Measure: Glycated haemoglobin (HbA1c; %)

Time: Day 4

Measure: Glycated haemoglobin (HbA1c; %)

Time: Day 7 (or day of discharge if before day 7)

Measure: Urea (mmol/L)

Time: Baseline (Day 0)

Measure: Urea (mmol/L)

Time: Day 2

Measure: Urea (mmol/L)

Time: Day 4

Measure: Urea (mmol/L)

Time: Day 7 (or day of discharge if before day 7)

Measure: Creatinine (µmol/L)

Time: Baseline (Day 0)

Measure: Creatinine (µmol/L)

Time: Day 2

Measure: Creatinine (µmol/L)

Time: Day 4

Measure: Creatinine (µmol/L)

Time: Day 7 (or day of discharge if before day 7)

Measure: Estimated glomerular filtration rate (eGFR, ml/min/1.73m^2)

Time: Baseline (Day 0)

Measure: Estimated glomerular filtration rate (eGFR, ml/min/1.73m^2)

Time: Day 2

Measure: Estimated glomerular filtration rate (eGFR, ml/min/1.73m^2)

Time: Day 4

Measure: Estimated glomerular filtration rate (eGFR, ml/min/1.73m^2)

Time: Day 7 (or day of discharge if before day 7)

Measure: Albumin (g/L)

Time: Baseline (Day 0)

Measure: Albumin (g/L)

Time: Day 2

Measure: Albumin (g/L)

Time: Day 4

Measure: Albumin (g/L)

Time: Day 7 (or day of discharge if before day 7)

Measure: C reactive protein (CRP, mg/L)

Time: Baseline (Day 0)

Measure: C reactive protein (CRP, mg/L)

Time: Day 2

Measure: C reactive protein (CRP, mg/L)

Time: Day 4

Measure: C reactive protein (CRP, mg/L)

Time: Day 7 (or day of discharge if before day 7)

Measure: Lactate dehydrogenase (LDH, UI/L)

Time: Baseline (Day 0)

Measure: Lactate dehydrogenase (LDH, UI/L)

Time: Day 2

Measure: Lactate dehydrogenase (LDH, UI/L)

Time: Day 4

Measure: Lactate dehydrogenase (LDH, UI/L)

Time: Day 7 (or day of discharge if before day 7)

Measure: Hypersensitive troponin T (µg/L)

Time: Baseline (Day 0)

Measure: Hypersensitive troponin T (µg/L)

Time: Day 2

Measure: Hypersensitive troponin T (µg/L)

Time: Day 4

Measure: Hypersensitive troponin T (µg/L)

Time: Day 7 (or day of discharge if before day 7)

Measure: Ferritin (µg/L)

Time: Baseline (Day 0)

Measure: Ferritin (µg/L)

Time: Day 2

Measure: Ferritin (µg/L)

Time: Day 4

Measure: Ferritin (µg/L)

Time: Day 7 (or day of discharge if before day 7)

Description: CD4 refers to cluster of differentiation 4.

Measure: CD4 cell count

Time: Baseline (Day 0)

Description: CD4 refers to cluster of differentiation 4.

Measure: CD4 cell count

Time: Day 2

Description: CD4 refers to cluster of differentiation 4.

Measure: CD4 cell count

Time: Day 4

Description: CD4 refers to cluster of differentiation 4.

Measure: CD4 cell count

Time: Day 7 (or day of discharge if before day 7)

Description: CD8 refers to cluster of differentiation 8.

Measure: CD8 cell count

Time: Baseline (Day 0)

Description: CD8 refers to cluster of differentiation 8.

Measure: CD8 cell count

Time: Day 2

Description: CD8 refers to cluster of differentiation 8.

Measure: CD8 cell count

Time: Day 4

Description: CD8 refers to cluster of differentiation 8.

Measure: CD8 cell count

Time: Day 7 (or day of discharge if before day 7)

Measure: Natural killer cell count

Time: Baseline (Day 0)

Measure: Natural killer cell count

Time: Day 2

Measure: Natural killer cell count

Time: Day 4

Measure: Natural killer cell count

Time: Day 7 (or day of discharge if before day 7)

Measure: Activated T cell percentage

Time: Baseline (Day 0)

Measure: Activated T cell percentage

Time: Day 2

Measure: Activated T cell percentage

Time: Day 4

Measure: Activated T cell percentage

Time: Day 7 (or day of discharge if before day 7)

Measure: Change in SARS-CoV-2 real-time polymerase chain reaction cycle threshold

Time: Baseline to day 7 (or day of discharge if before day 7)

Measure: Change in SARS-CoV-2 IgG serology (% of control signal = PCS)

Time: Baseline to day 7 (or day of discharge if before day 7)

Measure: Change in SARS-CoV-2 IgM serology (% of control signal = PCS)

Time: Baseline to day 7 (or day of discharge if before day 7)

Measure: Change from positivity at baseline to negativity at Day 7: yes/no for SARS-CoV-2 real time polymerase chain reaction

Time: Day 7 (or day of discharge if before day 7)

Measure: Change from positivity at baseline to negativity at Day 7: yes/no for SARS-CoV-2 IgG serology

Time: Day 7 (or day of discharge if before day 7)

Measure: Change from positivity at baseline to negativity at Day 7: yes/no for SARS-CoV-2 IgM serology

Time: Day 7 (or day of discharge if before day 7)

Description: A reduction in the extent of lesions is defined by a ⩾20% reduction in parenchymal involvement compared to the initial assessment

Measure: Reduction in the extent of lesions visualized on computed tomography chest scan: yes/no for grand glass opacities

Time: Day 7 (or day of discharge if before day 7) +- 1 day of leeway for logistics

Description: A reduction in the extent of lesions is defined by a ⩾20% reduction in parenchymal involvement compared to the initial assessment

Measure: Reduction in the extent of lesions visualized on computed tomography chest scan: yes/no for consolidation

Time: Day 7 (or day of discharge if before day 7) +- 1 day of leeway for logistics

Description: A reduction in the extent of lesions is defined by a ⩾20% reduction in parenchymal involvement compared to the initial assessment

Measure: Reduction in the extent of lesions visualized on computed tomography chest scan: yes/no for total lesions

Time: Day 7 (or day of discharge if before day 7) +- 1 day of leeway for logistics

Measure: Requirement for low flow oxygen therapy during the initial hospitalisation: yes/no

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Requirement for high flow oxygen therapy during the initial hospitalisation: yes/no

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Requirement for non-invasive ventilation during the initial hospitalisation: yes/no

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Requirement for invasive ventilation during the initial hospitalisation: yes/no

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Requirement for dialysis during the initial hospitalisation: yes/no

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Requirement for extracorporeal membrane oxygenation during the initial hospitalisation: yes/no

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Classification of acute respiratory distress syndrome (ARDS) according to the Berlin criteria during initial hospitalization: absent, mild, moderate or severe

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Length of stay (hours) in intensive care

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Length of stay (hours) in hospital

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Days alive and without low flow oxygen therapy

Time: Day 28

Measure: Days alive and without high flow oxygen therapy

Time: Day 28

Measure: Days alive and without any oxygen therapy

Time: Day 28

Measure: Days alive and without non-invasive ventilation

Time: Day 28

Measure: Days alive and without invasive ventilation

Time: Day 28

Measure: Days alive and without extracorporeal membrane oxygenation

Time: Day 28

Measure: Days alive and without intensive care

Time: Day 28

Measure: Days alive and without hospitalisation

Time: Day 28

Measure: Mortality

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Mortality

Time: Day 28

Measure: Club cell secrectory protein polymorphism A38G

Time: Between day 0 and day 28

Other Outcomes

Measure: Presence/absence of incident hyperglycemia during hospitalization

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Presence/absence of secondary infection during hospitalization

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Presence/absence of cardiovascular event (ischemic, stroke, other) during hospitalization

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Presence/absence of digestive hemorrhage during hospitalization

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Presence/absence of neuro-psychiatric event (acute delirium, depressive syndrome, decompensation of an underlying psychiatric pathology) during hospitalization

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Adverse events

Time: Day of hospital discharge (expected maximum of 28 days)

Measure: Adverse events

Time: Day 28

Time Perspective: Prospective

Cohort


There is one SNP

SNPs


1 A38G

The secondary objectives are to describe and compare between groups: - The number of days without mechanical ventilation - The need for mechanical ventilation - 28-day mortality - Progression towards acute respiratory distress syndrome (ARDS) - Change in the qSOFA score - Length of hospitalization - The change in the extent of lesions on thoracic computed tomography scan between inclusion and D7 (or the day of discharge from hospital if A38G polymorphism of the gene coding for Club Cell Secretory Protein (CCSP) for each patient - Short-term complications related to corticosteroid therapy - The quantitative and qualitative impact of corticosteroid therapy on lymphocytes from patients with COVID-19. --- A38G ---

Club cell secrectory protein polymorphism A38G. --- A38G ---



HPO Nodes


HPO:
HP:0002090: Pneumonia
Genes 280
TLL1 CHD7 TGIF1 KMT2D ACP5 PIGN JAK3 NOS1 SFTPB SRP54 MS4A1 NODAL USB1 CD79B SGCG ACTC1 CASP8 TGFB1 OFD1 CD19 CD247 NHLRC1 SHH NTRK1 EGFR LAMA3 PLOD1 FANCF JAK3 RAG2 PGM3 CACNA1C BTK IL2RG PIK3CD CREBBP KCNJ6 FMO3 ACTA1 TNFSF12 GATA6 ZAP70 PLOD1 UNC119 FGF8 GAS1 DNAI1 WAS GNPTAB FOXH1 CYBC1 LAMC2 RAG1 PEPD PDHA1 PMM2 PAFAH1B1 CD19 CD3D SIX3 CD81 DLL1 LTBP3 EP300 TNFRSF13B SIX3 GLI2 SMARCD2 TIMM8A MYH6 DCLRE1C ABCA3 IL7R TBC1D24 STAT3 CFB FOXH1 FOXP3 FCGR2A P4HTM AP3B1 POLA1 TK2 CDON PKHD1 TAF1 CDON NIPBL GRHL3 GAS1 EFEMP2 CRLF1 SLC35A1 SLC25A24 DOCK8 ZIC2 LEP AFF4 DDR2 CD3E PTPRC BLM RNU4ATAC TNFRSF13C KNSTRN CDON SELENON FOXH1 ORC6 RAG1 RNF168 SHH DISP1 CYBA IL7R CARD11 LONP1 COL11A2 CR2 FGF8 ZIC2 CARD11 CYBB NBN ICOS DNAJC21 DNMT3B DISP1 TGIF1 HLA-DQB1 ADA SETBP1 MED25 FOXH1 SLC35C1 ACADVL TDGF1 PNP SP110 SMC1A ICOS SREBF1 TDGF1 NBN DCLRE1C ALMS1 GLI2 MCIDAS FGF8 NCF1 RAG1 PTCH1 NADK2 IL2RG ZBTB24 ZAP70 GLI2 FGFR1 GAS1 TNFRSF13B GAS1 IFNGR1 CFTR COL11A2 CR2 SAMD9 CD247 TGIF1 TREX1 CARMIL2 TCIRG1 BLNK UBB SRP54 LAMB3 DISP1 RMRP TNFRSF13C NFKB1 STAG2 IRF8 PTCH1 SIX3 KPTN TBX20 TDGF1 CSPP1 IGHM BTK NFIX RNU4ATAC CXCR4 NFKB2 RAC1 CD27 TGIF1 ADA TBX20 ZIC2 MTHFD1 RAG2 GATA4 TNFRSF11A DZIP1L FGF8 KIAA0586 SHH TDGF1 RYR1 ODAD1 WDR1 CREBBP CITED2 DLL1 NCF2 TBCD SHH NODAL RAC2 SIX3 GBA PTCH1 DNAI2 ZIC2 TNFRSF13C ALMS1 PURA STAG2 DLL1 SBDS ICOS EFL1 ACP5 SFTPC CFAP410 MASP2 IL2RG IGLL1 AFF4 BTK LIG4 NFKB2 WDR19 CD55 CDON GAS8 EPM2A NKX2-1 RNF125 DCLRE1C NODAL LRBA ELANE MAN2B1 DLL1 PTCH1 HLA-DQA1 EXTL3 SLC35C1 MAN2B1 FOXN1 PRKCD GLI2 RANBP2 MID1 IL2RG FBLN5 NKX2-5 NODAL GFI1 TNFSF12 RAG2 ADA IL21R KDM6A OSTM1 ASAH1 DISP1 PANK2 FGFR1
SNP 0