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Report for Clinical Trial NCT02615015
 Developed by Shray Alag, 2020-2021.
SNP Clinical Trial Gene 
      Neutrophil extracellular traps (NETs) and deoxyribonuclease (DNase) activity determine
      outcome in ST elevation acute coronary syndrome (STE-ACS). DNase single nucleotide
      polymorphisms (SNPs) were increased in a japanese cohort.
      In the present study, the investigators seek to measure DNase SNPs frequency in a caucasian
      STE-ACS cohort compared to healthy controls (each n=400). The investigators will compute
      polymorphisms, DNase activity, NET surrogate markers and clinical variables in regression
      models.
    
Name: Blood draw
 Type: Other
Group Labels:  2  Healthy proband cohort  ST elevation myocardial infarction patient cohort   
  
Primary Outcomes 
 Measure: Frequency of SNPs of the DNase 1 and DNase gamma genes in the STE-ACS patient population compared to healthy controls Time: through study completion, an average of 2 years
   
Secondary Outcomes 
 Measure: Correlation of SNPs of the DNase 1 and gamma gene with DNase activity Time: through study completion, an average of 2 years
 Measure: Correlation of SNPs with major adverse cardiac events Time: through study completion, an average of 2 years
 Measure: Correlation of DNAse activity with major adverse cardiac events Time: through study completion, an average of 2 years
 Measure: Correlation of SNPs with DNA-Histone complex levels Time: through study completion, an average of 2 years
 Measure: Correlation of SNPs with MPO-DNA complex levels Time: through study completion, an average of 2 years
 Measure: Correlation of SNPs with dsDNA levels Time: through study completion, an average of 2 years
 Measure: Netosis quantification in STE-ACS patients and healthy controls Time: through study completion, an average of 2 years
 
Time Perspective: Cross-Sectional
  Cohort 
There is one SNP
SNPs
1 Q222R 
The single nucleotide polymorphism (SNP) Q222R in the DNase 1 gene, leading to impaired
      extracellular DNase activity, was correlated with increased incidence of myocardial
      infarction in Japanese patients(9). --- Q222R ---