The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased eyes and normal controls. There are two phases in this study. The first phase is an observational phase which studies the eye in various conditions. The second phase is an interventional phase which studies the changes in the eyes after taking an over-the-counter medical food (Ocufolin) for 6 months.
Name: Ocufolin
Description: Optical coherence tomography is used to measure the thickness of intraretinal layers. The measurement is in micrometer.
Measure: Retinal microstructure using OCT. Time: up to 2 yearsDescription: Retinal vascular network density in percentage.
Measure: Retinal vasculature by optical coherence tomography angiography (OCTA) Time: up to 2 yearsDescription: Conjunctival vascular network density in percentage.
Measure: Conjunctival vasculature by functional slit-lamp (FSLB) Time: up to 2 yearsDescription: Measured in micrometers using ultra high resolution OCT
Measure: Corneal epithelial thickness Time: up to 2 yearsDescription: Measured in micrometers using ultra high resolution OCT
Measure: Tear film thickness Time: up to 2 yearsDescription: Retinal blood flow velocity in mm/s
Measure: Retinal blood flow velocity by retinal function imager (RFI) Time: up to 2 yearsDescription: Conjunctival blood flow velocity in mm/s
Measure: Conjunctival blood flow velocity by functional slit-lamp (FSLB) Time: up to 2 yearsAllocation: Non-Randomized
Parallel Assignment
There is one SNP
Is at least 18 years old and has full legal capacity to volunteer; 2. Has read and signed the IRB Informed Consent Document; 3. Is willing and able to follow participant instructions; 4. Has clear corneas and crystalline lens; 5. Initial visual acuities were 20/80 or better; 6. MTHFR C677TT homozygous, or MTHFR C677T/A1298C compound heterozygous with mild to moderate micro-aneurismal vascular retinopathy disease; 7. Hemoglobin A1c is 10 or less; 8. Normotensive with or without medications; 9. Without retinal capillary dropout or macular edema; 10. --- C677T ---