The hypothesis to be tested is that acutely ill asthmatics who do not resolve their attacks following standard doses of albuterol and require admission to hospital have single nucleotide polymorphisms of their B2 adrenergic receptors that lower B2 agonist responsivity.
Case-Control
There are 2 SNPs
The results of this study will demonstrate whether Gly16Arg or Gln27Glu genotypes and/or β2AR haplotypes are associated with the response to albuterol in patients who experience acute episodes of asthma and whether genotype pattern varies between different clinical phenotypes. --- Gly16Arg ---
The results of this study will demonstrate whether Gly16Arg or Gln27Glu genotypes and/or β2AR haplotypes are associated with the response to albuterol in patients who experience acute episodes of asthma and whether genotype pattern varies between different clinical phenotypes. --- Gly16Arg --- --- Gln27Glu ---