SNPMiner Trials by Shray Alag

NCT00511368 (37) NCT00460382 (36) NCT04504071 (35) NCT03783286 (33) NCT04172597 (32) NCT02404233 (29) NCT00959894 (28) NCT00706147 (28) NCT00121017 (28) NCT01685801 (27) NCT04513626 (26) NCT01736761 (26) NCT04495348 (24) NCT02673398 (23) NCT02499978 (22) NCT01605084 (21) NCT04254705 (21) NCT02069834 (21) NCT00939770 (18) NCT01792570 (18) NCT01199939 (18) NCT00356616 (18) NCT02728258 (17) NCT02707601 (17) NCT02770508 (16) NCT00711009 (16) NCT00630864 (16) NCT00491556 (15) NCT04085315 (15) NCT02616029 (15) NCT00830804 (15) NCT01170962 (14) NCT00984152 (14) NCT03953898 (14) NCT00727597 (14) NCT03212274 (14) NCT00337467 (13) NCT00098293 (13) NCT02159599 (13) NCT00424814 (12) NCT04432454 (12) NCT02527096 (12) NCT01849003 (12) NCT03781063 (12) NCT03683524 (11) NCT01614457 (11) NCT00460746 (11) NCT00993148 (11) NCT03061331 (11) NCT02494882 (11) NCT03068312 (11) NCT04453436 (11) NCT01521338 (10) NCT01614470 (10) NCT01423812 (10) NCT00358917 (10) NCT04415268 (10) NCT00511381 (10) NCT03911713 (9) NCT02742519 (9) NCT02725567 (9) NCT03045523 (9) NCT00438152 (9) NCT01102972 (9) NCT02971839 (9) NCT00740064 (9) NCT02605954 (9) NCT00379405 (9) NCT01562847 (9) NCT02616783 (9) NCT04272242 (9) NCT02445053 (9) NCT00242840 (9) NCT02724527 (9) NCT04209465 (9) NCT04585737 (8) NCT02082977 (8) NCT00112775 (8) NCT00383318 (8) NCT03659214 (8) NCT03631732 (8) NCT00118898 (8) NCT01888562 (8) NCT02633189 (8) NCT03565692 (8) NCT03843775 (8) NCT01161576 (8) NCT02167165 (8) NCT00344461 (8) NCT04519398 (7) NCT02154490 (7) NCT03232892 (7) NCT00650832 (7) NCT04549025 (7) NCT00440947 (7) NCT02784639 (7) NCT03572140 (6) NCT01237444 (6) NCT00532168 (6) NCT01102569 (6) NCT04424368 (6) NCT01414985 (6) NCT00525733 (6) NCT02308332 (6) NCT01487265 (6) NCT00049933 (5) NCT02389920 (5) NCT03351699 (5) NCT04197934 (5) NCT02272998 (5) NCT00122590 (5) NCT04204330 (5) NCT02450591 (5) NCT01173029 (5) NCT02675829 (5) NCT02858921 (5) NCT01914484 (5) NCT00187733 (5) NCT02554591 (5) NCT01501604 (5) NCT02716116 (5) NCT01136460 (5) NCT00187655 (5) NCT00350272 (5) NCT00837135 (5) NCT03202862 (5) NCT01707199 (5) NCT03839342 (5) NCT01323010 (4) NCT02248324 (4) NCT01698905 (4) NCT01737359 (4) NCT01306045 (4) NCT02804100 (4) NCT01456676 (4) NCT00588172 (4) NCT03434418 (4) NCT03593993 (4) NCT01804140 (4) NCT02882308 (4) NCT03497767 (4) NCT04106024 (4) NCT02716311 (4) NCT04405674 (4) NCT03599518 (4) NCT01675778 (4) NCT01604122 (4) NCT01297777 (4) NCT04519970 (4) NCT00705679 (4) NCT04147351 (4) NCT04129502 (4) NCT03976856 (4) NCT02335944 (4) NCT03948763 (4) NCT03255083 (4) NCT04002830 (4) NCT02635815 (4) NCT03066206 (4) NCT01331642 (4) NCT00557245 (4) NCT01922583 (4) NCT02893332 (4) NCT03592888 (4) NCT02257424 (4) NCT03874858 (4) NCT00017732 (4) NCT00187720 (4) NCT02593539 (4) NCT01185587 (4) NCT04439292 (4) NCT03884348 (4) NCT01309243 (4) NCT03209063 (4) NCT04160546 (4) NCT03292302 (4) NCT02418234 (4) NCT02535338 (3) NCT02192697 (3) NCT03410043 (3) NCT03845296 (3) NCT02914990 (3) NCT02113813 (3) NCT01532011 (3) NCT04340388 (3) NCT00962533 (3) NCT03856411 (3) NCT04049266 (3) NCT02973763 (3) NCT02926092 (3) NCT00271973 (3) NCT04256941 (3) NCT03812809 (3) NCT02954523 (3) NCT01784068 (3) NCT03446417 (3) NCT02841579 (3) NCT02025114 (3) NCT01288521 (3) NCT01385683 (3) NCT02279004 (3) NCT00998582 (3) NCT03111901 (3) NCT01352715 (3) NCT01619774 (3) NCT01045369 (3) NCT02246998 (3) NCT03969823 (3) NCT00895596 (3) NCT02398929 (3) NCT00724711 (3) NCT04029350 (3) NCT03737994 (3) NCT01443806 (3) NCT02629822 (3) NCT03463525 (3) NCT00710112 (3) NCT03623750 (3) NCT04283955 (3) NCT02743923 (3) NCT01016106 (3) NCT01259089 (3) NCT03971474 (3) NCT02917993 (3) NCT02368990 (3) NCT00279110 (3) NCT02485652 (3) NCT00312169 (3) NCT04541407 (3) NCT02769286 (3) NCT00747487 (3) NCT04267913 (3) NCT01429597 (3) NCT04023617 (3) NCT03790228 (3) NCT01759888 (3) NCT04429152 (3) NCT01810718 (3) NCT02725632 (3) NCT01090011 (3) NCT04544111 (3) NCT02926768 (3) NCT02981108 (3) NCT02459743 (3) NCT00654823 (3) NCT01037127 (3) NCT04439305 (3) NCT01028222 (3) NCT01542411 (3) NCT01031446 (3) NCT02726269 (3) NCT01892644 (3) NCT03260491 (3) NCT01802632 (3) NCT02720094 (3) NCT02630186 (3) NCT01627132 (3) NCT02690675 (3) NCT01013506 (3) NCT04252339 (3) NCT02496663 (3) NCT03386955 (3) NCT03394118 (3) NCT04212702 (3) NCT01754025 (3) NCT01160276 (3) NCT00121979 (3) NCT03228277 (3) NCT04351555 (3) NCT01243346 (3) NCT04510415 (3) NCT02796274 (3) NCT02774005 (3) NCT02064491 (3) NCT04233021 (3) NCT03799601 (3) NCT00260260 (3) NCT02094261 (3) NCT04245085 (3) NCT01282151 (3) NCT03058094 (3) NCT02520778 (3) NCT03161808 (3) NCT04181060 (3) NCT01342679 (3) NCT01443273 (3) NCT01593254 (3) NCT04433481 (3) NCT02529995 (3) NCT03502850 (3) NCT02771314 (3) NCT03823807 (3) NCT03270527 (3) NCT02688881 (3) NCT01005602 (3) NCT02442349 (3) NCT02282267 (2) NCT02684591 (2) NCT03381430 (2) NCT02178397 (2) NCT03608215 (2) NCT02603107 (2) NCT03370770 (2) NCT03322696 (2) NCT00525473 (2) NCT03333343 (2) NCT03127449 (2) NCT01781026 (2) NCT02503722 (2) NCT00975871 (2) NCT03964233 (2) NCT03388099 (2) NCT02317016 (2) NCT03845270 (2) NCT03519958 (2) NCT03918304 (2) NCT02151721 (2) NCT02777658 (2) NCT01016444 (2) NCT02971501 (2) NCT03101254 (2) NCT03178617 (2) NCT01774721 (2) NCT03574753 (2) NCT01357655 (2) NCT01766713 (2) NCT02097225 (2) NCT00658164 (2) NCT03622593 (2) NCT02571036 (2) NCT00834665 (2) NCT00969137 (2) NCT02026011 (2) NCT03622580 (2) NCT03543683 (2) NCT01143493 (2) NCT03671538 (2) NCT04028778 (2) NCT00324961 (2) NCT01915576 (2) NCT02157883 (2) NCT01387022 (2) NCT03864042 (2) NCT03235245 (2) NCT03469960 (2) NCT02795884 (2) NCT00005541 (2) NCT01242813 (2) NCT02906020 (2) NCT03960645 (2) NCT00643058 (2) NCT03443336 (2) NCT02992860 (2) NCT02281760 (2) NCT02201602 (2) NCT04310007 (2) NCT03720665 (2) NCT04309019 (2) NCT00909532 (2) NCT00411944 (2) NCT01604681 (2) NCT01245062 (2) NCT00270231 (2) NCT03256136 (2) NCT03973918 (2) NCT00302692 (2) NCT00125281 (2) NCT02163733 (2) NCT02110407 (2) NCT00475176 (2) NCT03196882 (2) NCT01572818 (2) NCT02556333 (2) NCT04268550 (2) NCT02433717 (2) NCT03428126 (2) NCT01153763 (2) NCT02609776 (2) NCT01420211 (2) NCT03556176 (2) NCT03872440 (2) NCT01405079 (2) NCT03382795 (2) NCT02991950 (2) NCT00013598 (2) NCT03455764 (2) NCT02422628 (2) NCT03831932 (2) NCT03766490 (2) NCT02580474 (2) NCT00499577 (2) NCT02444884 (2) NCT01775943 (2) NCT03544814 (2) NCT01310036 (2) NCT01027663 (2) NCT01928160 (2) NCT01244438 (2) NCT00007150 (2) NCT04462081 (2) NCT02297425 (2) NCT02086071 (2) NCT01050400 (2) NCT03060590 (2) NCT01819428 (2) NCT02709668 (2) NCT02411448 (2) NCT03878719 (2) NCT04479306 (2) NCT03377023 (2) NCT01378026 (2) NCT00226551 (2) NCT03239145 (2) NCT04511533 (2) NCT02191891 (2) NCT04586270 (2) NCT04545710 (2) NCT02120222 (2) NCT02738593 (2) NCT00831272 (2) NCT04469543 (2) NCT00573495 (2) NCT04158544 (2) NCT00904150 (2) NCT02110056 (2) NCT02856893 (2) NCT02110043 (2) NCT02182986 (2) NCT04179890 (2) NCT00063232 (2) NCT02197234 (2) NCT03121235 (2) NCT01532089 (2) NCT03887169 (2) NCT02268864 (2) NCT01963845 (2) NCT00866736 (2) NCT03977194 (2) NCT03991013 (2) NCT02500927 (2) NCT02228382 (2) NCT02689570 (2) NCT01513785 (2) NCT02463435 (2) NCT03351361 (2) NCT04527549 (2) NCT03424759 (2) NCT02197247 (2) NCT02321046 (2) NCT04272034 (2) NCT04027647 (2) NCT02364609 (2) NCT02759835 (2) NCT04349865 (2) NCT00068159 (2) NCT00418015 (2) NCT04310397 (2) NCT03088176 (2) NCT03867175 (2) NCT00339209 (2) NCT00011258 (2) NCT01288430 (2) NCT01616199 (2) NCT03603262 (2) NCT03071705 (2) NCT00969930 (2) NCT00772408 (2) NCT02743468 (2) NCT00277342 (2) NCT04248829 (2) NCT01767454 (2) NCT00933127 (2) NCT03317873 (2) NCT03392246 (2) NCT01909453 (2) NCT03523104 (2) NCT00085917 (2) NCT02507921 (2) NCT03781752 (2) NCT03828422 (2) NCT02193282 (2) NCT03195452 (2) NCT02294487 (2) NCT01325441 (2) NCT02511106 (2) NCT02997501 (2) NCT04184921 (2) NCT00625092 (2) NCT01657786 (2) NCT01415011 (2) NCT02629523 (2) NCT01718847 (2) NCT02818023 (2) NCT00577707 (2) NCT01943422 (2) NCT00116636 (2) NCT01841463 (2) NCT04429542 (2) NCT03865511 (2) NCT01218477 (2) NCT03205267 (2) NCT02881320 (2) NCT01897480 (2) NCT02810990 (2) NCT04189757 (2) NCT01951001 (2) NCT04254939 (2) NCT03207867 (2) NCT00780949 (2) NCT03355768 (2) NCT00817089 (2) NCT02143466 (2) NCT04499053 (2) NCT01907776 (2) NCT00909727 (2) NCT01562028 (2) NCT03737253 (2) NCT00441974 (2) NCT02155465 (2) NCT04586335 (2) NCT00661999 (2) NCT02705339 (2) NCT04006340 (2) NCT04553887 (2) NCT03852290 (2) NCT02183922 (2) NCT03970239 (2) NCT00294372 (2) NCT03250676 (2) NCT03792074 (2) NCT00671892 (2) NCT00689182 (2) NCT00106379 (2) NCT01947023 (2) NCT00509652 (2) NCT03683251 (2) NCT02039986 (2) NCT03515837 (2) NCT04081688 (2) NCT03190005 (2) NCT01584648 (2) NCT02292654 (2) NCT03992456 (2) NCT03133546 (2) NCT01485809 (2) NCT01266967 (2) NCT02909712 (2) NCT00062764 (2) NCT01776684 (2) NCT03042221 (2) NCT01940809 (2) NCT01161537 (2) NCT01154816 (2) NCT01175759 (2) NCT01199731 (2) NCT02788058 (2) NCT03130452 (2) NCT01772732 (2) NCT02631447 (2) NCT02525692 (2) NCT02526537 (2) NCT03513666 (2) NCT02027961 (2) NCT03106779 (2) NCT04106544 (2) NCT04258943 (2) NCT00165984 (2) NCT00977470 (2) NCT02092974 (2) NCT03975231 (2) NCT01998295 (2) NCT03586453 (2) NCT02021305 (2) NCT03135197 (2) NCT00432016 (2) NCT03004625 (2) NCT03851445 (2) NCT04031898 (2) NCT04201418 (2) NCT01911507 (2) NCT03539224 (2) NCT01978236 (2) NCT00866177 (2) NCT00320879 (2) NCT00044304 (2) NCT01999179 (2) NCT00977730 (2) NCT02491775 (2) NCT00212147 (2) NCT02040064 (2) NCT00489385 (2) NCT01713023 (2) NCT04122729 (2) NCT03994393 (2) NCT02438722 (2) NCT02762448 (2) NCT00071903 (2) NCT00626223 (2) NCT01193829 (2) NCT03239340 (2) NCT02991274 (2) NCT02811354 (2) NCT03416530 (2) NCT02522988 (2) NCT00953706 (2) NCT02346955 (2) NCT03795688 (2) NCT02011945 (2) NCT00857675 (2) NCT00028262 (2) NCT02355431 (2) NCT02495233 (2) NCT04575415 (2) NCT03468985 (2) NCT00230087 (2) NCT02017600 (2) NCT04146298 (2) 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NCT01647711 (1) NCT03231722 (1) NCT03576937 (1) NCT04412070 (1) NCT00554866 (1) NCT03151161 (1) NCT01817166 (1) NCT02220855 (1) NCT02512627 (1) NCT04591197 (1) NCT03402048 (1) NCT04500704 (1) NCT02323724 (1) NCT01166126 (1) NCT03029858 (1) NCT04317599 (1) NCT00300573 (1) NCT00809211 (1) NCT01393730 (1) NCT02318368 (1) NCT02228369 (1) NCT01074398 (1) NCT04500717 (1) NCT03134131 (1) NCT01004497 (1) NCT02455167 (1) NCT02073279 (1) NCT02117817 (1) NCT00323687 (1) NCT01605981 (1) NCT01371955 (1) NCT04147767 (1) NCT04144257 (1) NCT03490123 (1) NCT04423185 (1) NCT02625337 (1) NCT03567629 (1) NCT03360929 (1) NCT00109278 (1) NCT04108156 (1) NCT02132598 (1) NCT00542451 (1) NCT01587573 (1) NCT00868465 (1) NCT01494402 (1) NCT00867139 (1) NCT03363139 (1) NCT01936051 (1) NCT02341131 (1) NCT00037076 (1) NCT00582907 (1) NCT02169869 (1) NCT03284684 (1) NCT04204473 (1) NCT01074359 (1) NCT01400191 (1) NCT04530565 (1) NCT03530319 (1) NCT04146402 (1) NCT02658682 (1) NCT04241835 (1) NCT03133234 (1) 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SNPMiner SNPMiner Trials (Home Page)


Report for Clinical Trial NCT01795131

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Role of Vitamin B12 Supplementation During Pregnancy and Postpartum to Reduce Nutritional Anemia and Improve Immunity in Bangladeshi Women and Their Infants

Nutritional anemia is a major public health problem among children and women in developing countries. Despite ongoing national program of supplementing pregnant women with iron-folate, prevalence of anemia is 39% among pregnant women and 78% among infants in Bangladesh. Vitamin B12 deficiency is a more prevalent cause of megaloblastic anemia than folate in many developing countries. This data raises the interest to address the role of vitamin B12 deficiency in nutritional anemia. Low dietary intake of animal products, a predominant source of vitamin B12 may cause anemia. Besides maintaining normal erythropoiesis, B12 is essential for immune function. However, no studies have evaluated the effect of maternal B12 supplementation on reduction of anemia and improving immunity of their infants. The investigators hypothesize that vitamin B12 supplementation plus iron-folate during pregnancy and 3-mo postpartum would: (a) Decrease anemia among mothers and infants; (b) Improve vaccine specific cellular and humoral immune responses among mothers; (c) Improve vaccine specific immunity in infants by passive transfer; (d) Improve DNA methylation and one-carbon metabolism in mother-child pairs; (e) Reduce antenatal/postnatal depression. Results from this study will guide and provide support to the policy makers to identify effective strategies to reduce nutritional anemia in population at risk. The investigators aim to conduct a double-masked placebo controlled trial to investigate the added effect of vitamin B12 on the iron-folate supplementation among pregnant women. Anemic (Hb level <11.0 g/dl) mothers at 11-14 weeks of gestation will be randomized into two groups: supplement group will receive 250 ug vitamin B12 plus 400 ug folate and 60 mg iron; placebo group will receive folate and iron only. This daily supplementation will continue up to 3-mo postpartum. At 26-28 wk of gestation mothers will be given inactivated influenza vaccine. Data on anthropometric indices of mothers and children, birth size, infant growth and morbidity (mothers and children) throughout the study period will be recorded. 24-h dietary recall data will be collected from the mothers bimonthly throughout the study. Biochemical indicators of anemia including Hb, vitamin B12, ferritin, folate and α-glycoprotein (AGP) will be assessed in plasma of mothers (pre- and post-supplementation) and infants (cord blood and 3-months). Additional measurements include serum transferrin receptor (sTfR) in plasma and methyl malonic acid (MMA) and total homocysteine (tHcy) in the urine of mothers. Plasma vaccine specific antibody responses will be measured in mothers (pre- and post supplementation) and in infants (cord blood and 3-months). In breast milk, B12, folate and s-IgA will be determined. Genetic polymorphism (one-carbon metabolism) and DNA methylation will be studied in mothers and in cord blood.

NCT01795131 Nutritional Anemia in Mothers. Nutritional Anemia in Infants.
MeSH:Anemia
HPO:Anemia

2 Interventions

Name: Vitamin B12

Type: Dietary Supplement
Group Labels: 1

Vitamin B12

Name: Placebo

Type: Dietary Supplement
Group Labels: 1

Placebo


Primary Outcomes

Description: The investigators will determine the percentage of nutritional anemia in mothers by measuring Hb, ferritin, sTfR, B12 levels in plasma. They will also measure urinary MMA and tHcy and B12 levels in breast milk.

Measure: a) Percent reduction in nutritional anemia among mothers (based on measurement of Hb, ferritin, sTfR, folate, B12 levels in plasma; urinary MMA and tHcy; B12 levels in breast milk.)

Time: 24 months

Description: Influenza vaccine-specific antibody responses (IgA, IgG) in plasma and colostrum/ breast milk [secretory IgA (s-IgA)] will be measured by ELISA. PBMC will be stimulated with Flu vaccine for blastogensis response.

Measure: Increase in influenza vaccine specific cellular and humoral responses among mothers (blastogenesis and T cell phenotyping,serum IgA, and IgG).

Time: 24 monnths

Description: Influenza vaccine-specific antibody responses (IgA, IgG) in plasma and colostrum/ breast milk [secretory IgA (s-IgA)] will be measured by ELISA. PBMC will be stimulated with Flu vaccine for blastogensis response.

Measure: Increase in influenza vaccine specific immunity in infants by passive transfer (vaccine specific IgG in cord blood and breast milk and IgA in children at 3 mo).

Time: 24 months

Description: The investigators will determine the percentage of nutritional anemia in mothers by measuring Hb, ferritin, B12 levels in plasma.

Measure: Percent reduction in nutritional anemia in infants (based on measurement of Hb, ferritin, B12 levels in plasma;

Time: 24 months

Secondary Outcomes

Description: Genomic DNA methylation will be measured by the methyl acceptance assay . Total homocysteine (tHcy) will be measured in urine samples by using HPLC with fluorimetric detection. Mutations in the ALPL, MTHFR C677T and FUT2 genes will be determined by PCR- RFLP assay and DNA sequencing.

Measure: Effect of B12 status on DNA methylation and one-carbon metabolism in mother-child pairs.

Time: 24 months

Description: Participants will be interviewed on their mental status using the Centre for Epidemiological Studies-Depression questionnaire. The questionnaire contains 20 items comprising six major aspects of depression: depressed mood, hopelessness, worthlessness, fatigue, appetite and sleep disturbances. It has been previously used in rural and urban Bangladeshi women (J Hamadani) and found to correlate sensibly to children's growth and development. The interview will be conducted twice at the homes of the women first at baseline and at 3 mo postpartum.

Measure: Reduce depression scores

Time: 24 months

Purpose: Health Services Research

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 C677T

Mutations in the ALPL, MTHFR C677T and FUT2 genes will be determined by PCR- RFLP assay and DNA sequencing.. Reduce depression scores. --- C677T ---

Mutations in the ALPL, MTHFR C677T and FUT2 genes will be determined by PCR- RFLP assay and DNA sequencing. --- C677T ---



HPO Nodes


HPO:
HP:0001903: Anemia
Genes 775
DKC1 RPS19 SNX10 NDUFA10 LPIN2 COL7A1 PGM3 PUS1 GATA1 SPTB TERC NTRK1 HBB ABCD3 ZBTB24 FANCI FANCC TARS1 SEC61A1 TGFB1 DAXX STING1 HBB DHFR TINF2 SMARCD2 THRA DBH UNC13D MPIG6B PLEC HELLS PIEZO1 OCRL JAK2 GTF2E2 PTF1A PRF1 GPI RAD51 HBA1 RPS27 STAT5B ERCC4 HPRT1 RMRP PRKCD GSS LYST CUBN FANCG FANCL SF3B1 RPS14 TNFRSF4 GNA14 CAT HBA2 PET100 ITGB3 PKLR HBA1 NRAS MECOM TRNH SPTA1 SLC46A1 CD59 SLC2A1 RASGRP1 LYST XIAP RPL15 IGH DNAJC21 RPS28 RTEL1 RPS15A IL2RB WRAP53 GATB UQCRFS1 NDUFV1 TNFRSF13C DDX41 G6PD RPL26 SBDS GATA1 CD40LG RPS27 IFNG FANCM FASLG CFHR3 TNFAIP3 FOXP3 COX14 HBA2 ALAD NDUFA13 PIEZO1 KRT14 ENG PLEKHM1 COQ2 HBB RPS15A SPTA1 HBA2 NOP10 SURF1 TACO1 SLX4 COL4A1 PHF21A FANCG HYOU1 TBXAS1 HBB ND5 RPS19 KCNN4 CFB ZBTB20 MTRR PGM3 KCNQ1 IL7R NT5C3A SMAD4 MUC1 PRKACG RPL27 PRDX1 TOR1A PHGDH SFXN4 HBD TCIRG1 RBM8A SLC4A1 ITGA2B CD55 TET2 BMPR1A PEPD NPHP4 RFX5 STAT2 PALB2 PSMB4 LYRM7 SURF1 LAT TRNW FTCD ABCD4 RRM2B SLC25A21 CTLA4 MTFMT EFL1 FMO3 CIITA NDUFAF3 GATA1 PCNT TRNF CFHR1 FOXP3 TBXAS1 FANCB DNM1L OSTM1 HBB TSR2 POLG UMPS RPL26 GSS DKC1 TRNT1 NDUFV2 NSUN2 TERT EPB42 ATP7B PRKCD STIM1 STIM1 UMPS CTC1 KRAS ANK1 CASR NHEJ1 LIG4 STK11 AK2 TBCE SPTB CD3G LCAT COA3 RPL5 STAT1 SMAD4 SLC4A1 HBG1 ABCG8 HPRT1 CHD7 TERT GBA CDAN1 RAD51C CTSK MLX KLF1 CLPX UBE2T SEC23B PDGFRA SAMD9L LRBA FERMT1 TPI1 RFXAP GDF2 AMMECR1 LAMC2 COX20 MMUT BRCA1 FANCD2 VPS45 IDH2 TRNQ EPO KIF15 STEAP3 CLCN7 WAS PNPO HBG2 RPS7 HAVCR2 SPP1 TRNS1 SPTB TMEM67 FAM111A BRIP1 FLI1 ERCC3 PRKCD RPL35 SLC7A7 SLCO2A1 CD46 DKC1 PGK1 ABCB6 BCOR TTC7A NDUFAF5 RARA BCL10 PTH1R FARS2 ND1 NDUFS4 MYD88 NPM1 BMPR1A SMAD4 ATRX MMAB MTTP CASK SLC12A3 ADA AIRE UBR1 NDUFB8 SDHA FANCC WFS1 COA8 PSAP TERT IKZF1 UBE2T FAM111A CAD CLCNKB MMP1 RPL27 RHAG EPB42 COX10 TTC7A STIM1 APOA1 STAT3 RUNX1 GATA1 HBA2 RPS24 ACTN4 WT1 NDUFS2 RPL35 RPS17 NLRP3 ASAH1 SBDS GLA ACVRL1 MVK CLCN7 RIPK1 LAMB3 ANK1 REN NFKB2 ATP11C PHKA2 CPOX PHGDH SLC40A1 SNX10 RHAG TGFB1 HBG1 LAMB3 TNFRSF13B PHKG2 CLCN7 LARS2 SP110 HBG2 HAMP XRCC4 FANCA PIGT PPOX NLRP1 PNP ALPL PET100 ACP5 TERT TFRC RPL31 SRD5A3 EPB41 IDH1 RPS26 SLC4A1 RPL18 HBB-LCR PRKAR1A ABCA1 EPB41 TALDO1 FECH DNMT3B IRF2BP2 SPTA1 SRP54 TINF2 SMAD4 SHPK ATP7B CPOX GP1BA GSR RMRP WAS PFKM PSTPIP1 CISD2 COL7A1 USB1 MEFV ELMO2 COX4I2 TNFSF12 TFR2 LIG4 PGK1 GATC NHLRC2 RMRP LIPA IFNGR1 SDHB CTLA4 ENG HLA-DRB1 CASP10 COL7A1 F8 CA2 TRNL1 CD81 NABP1 NUMA1 ALX4 FECH COL7A1 FANCB YARS2 FCGR2B SDHC GBA TYMP LAMA3 AGXT TF HBA1 BMPR1A PTEN MTRR GATA1 SLX4 BIRC3 NPHP4 KMT2D MDM4 ITGB4 SMARCAL1 PRF1 ETV6 EPHB4 KLF1 KIF1B TRNT1 VPS33A TNFSF11 RAG1 COX2 HBB RPS17 MAD2L2 UROD APC ACAD8 EWSR1 TNFSF11 HK1 ERCC4 PUS1 GATA1 FIP1L1 ITK NPHP1 CALR MMAA HBB VPS33A GPX1 SCO1 TET2 RPS29 ISCU TCN2 GLA NBN HBB ALAS2 RPL35A PSMB8 TINF2 FANCE FCGR2A HBB UROS SPTA1 CP HLA-B KIT HBA1 SMARCAL1 ATRX HBA2 TEK RAG1 LIPT1 SLC19A2 TRNS2 DNASE1 TRNS1 RAG2 RPL11 PARN CLCN7 ZAP70 GYPC RECQL4 OPA1 LAMA3 HBB WFS1 ND4 GBA SLC19A2 PSMB9 FAS AASS COX6B1 ALDOA ORAI1 G6PC3 MS4A1 HBB ELANE CD19 TCIRG1 CP COX1 LMBRD1 SAMD9 KIT MMACHC RAG1 FOXP1 FANCD2 SPTA1 TBL1XR1 NDUFS7 MPL HELLPAR ADAMTS13 THBD CYBC1 NPHP1 SLC11A2 STX11 IRAK1 SPTB SLC2A1 RPS7 ADAR CA2 RAG2 NDUFS3 HMGCL MYSM1 IRX5 SARS2 BTK SLC4A1 RPS24 ANK1 FANCL BTNL2 NDUFA12 PLEC NDUFA9 ALAS2 RPS29 KIF23 TET2 MARS1 PIGA RPL11 NDUFA4 KCNN4 GCLC ACVRL1 RPL15 ADA TPP2 FARSB LPIN2 C3 TNFSF12 RASGRP1 COX15 PTPN22 NDUFA2 RPS26 GREM1 HPGD FERMT3 SDHA DCLRE1C ZBTB16 CFH TRNN PNPO CCND1 DNAJC21 GATA1 PCCA ABCA1 NDUFAF6 RPL5 ADA2 SLC4A1 SLC25A10 SCARB2 HLA-B TCIRG1 COL7A1 STAT4 SCO2 HMOX1 PKLR IFT140 NDUFS1 NFKB1 GALNT2 RHAG NDUFS2 FANCF ATRX NDUFS8 LARS1 CFH TP53 FASLG HBA1 ICOS CDCA7 ERCC6L2 LAMC2 XRCC2 TET2 AGGF1 ATRX PLEKHM1 ABCB7 TKFC TALDO1 ASXL1 KCNE1 KDM6A AK1 NHP2 PDHA1 SLC25A13 SRD5A3 MTHFD1 MYSM1 RAG2 TSR2 PFKM NLRP3 ABCB7 MPLKIP COX3 RPL35A EXT2 QRSL1 NLRC4 SLC4A1 STEAP3 PARN ECHS1 COG1 COX8A FANCF HBB TMPRSS6 GBA DNAJC19 DGKE BRCA1 FOXRED1 CR2 COL17A1 SRP54 RFXANK IL2RA MPL IL2RG STAT3 PLA2G4A PNP SRSF2 RPS10 SH2D1A WIPF1 GLRX5 F2 MTR CTC1 SLC19A3 FAS ATRX DCLRE1C RPS14 GCLC CFI PACS2 TET2 BMPR1A CBLIF ERCC2 TERC CBL MMADHC SAMD9L NOD2 SLC29A3 IREB2 ADA2 SLC25A38 ITGB4 GBA MALT1 TF HSPA9 MAD2L2 SBDS TACO1 FAS FDX2 TNFRSF11A CDIN1 RFWD3 FANCE ERCC8 TRNW RTEL1 FANCA TERC ACVR1 NFKB1 IFNG YARS2 NPM1 AMN BRCA2 ND6 PML RAG1 TREX1 SMPD1 IL12B UROS MMP1 ALG8 PCCB NDUFAF2 ENG BPGM MMUT TERT RPS10 CFI RNF113A SLC46A1 CD46 ERCC6 STK11 SLC7A7 ALAS2 ERBB3 HMGCL GTF2H5 ACD COA8 DNAJC19 RPS28 GALT CASP10 EFL1 NBN CRIPT STAT1
Protein Mutations 4
C282Y C677T H63D V617F