Exploratory, prospective, randomized, comparative, open trial with control group treated to assess whether the effective use of urinary FSH (uFSH) or recombinant FSH (rFSH) can be influenced by genotype of receptor N680S FSH Gene Polymorphism.
Name: Urinary follicle-stimulating hormone
Name: Recombinant follicle-stimulating hormone
Description: number of cumulus-oocyte complexes obtained by follicle puncture at the end of ovarian stimulation
Measure: number of cumulus-oocyte complexes obtained Time: through study completion, an average of 2 weeksDescription: number of metaphase II (MII) oocytes obtained by follicle puncture at the end of ovarian stimulation
Measure: number of metaphase II (MII) oocytes Time: through study completion, an average of 2 weeksDescription: number of useful oocytes after artificial insemination or microinjection
Measure: number of useful oocytes (inseminated or microinjected) Time: through study completion, an average of 2 weeksDescription: mean number of days between the start of ovarian stimulation until the day of the follicular puncture
Measure: duration of stimulation (days) Time: through study completion, an average of 2 weeksDescription: FSH treatment units administrated per oocyte obtained
Measure: FSH treatment units obtained by oocyte Time: through study completion, an average of 2 weeksDescription: FSH treatment cost per oocyte obtained
Measure: FSH treatment cost per oocyte obtained Time: through study completion, an average of 2 weeksDescription: fertilization rate at 18 hours post-insemination
Measure: fertilization rate Time: through study completion, an average of 2 weeksDescription: occurrence of side effects associated with urinary FSH and recombinant FSH
Measure: occurrence of side effects Time: through study completion, an average of 2 weeksAllocation: Randomized
Parallel Assignment
There is one SNP
Prospective, Randomized Open Trial to Evaluate the Efficacy of Highly Purified Urinary FSH Versus Recombinant FSH in Oocyte Donors Undergoing Controlled Ovarian Stimulation Based on Receptor N680S FSH Gene Polymorphism. --- N680S ---
Efficacy of Urinary Vs Recombinant FSH in Oocyte Donors Based on Receptor N680S FSH Gene Polymorphism (Genodon Trial) Exploratory, prospective, randomized, comparative, open trial with control group treated to assess whether the effective use of urinary FSH (uFSH) or recombinant FSH (rFSH) can be influenced by genotype of receptor N680S FSH Gene Polymorphism. --- N680S ---
Efficacy of Urinary Vs Recombinant FSH in Oocyte Donors Based on Receptor N680S FSH Gene Polymorphism (Genodon Trial) Exploratory, prospective, randomized, comparative, open trial with control group treated to assess whether the effective use of urinary FSH (uFSH) or recombinant FSH (rFSH) can be influenced by genotype of receptor N680S FSH Gene Polymorphism. --- N680S --- --- N680S ---
Inclusion Criteria: - Be considered eligible to get into the oocyte donation program of Instituto Bernabeu - Age between 18 and 30 years - Body Mass Index over 18 and under 28 - Antral follicle count greater than 9 and less than 25 (adding both ovaries) - Patients starting ovarian stimulation with 225 IU of FSH - Presence of both ovaries - Ability to participate and comply with the study protocol - Signing the written consent form - Not having received treatment with ovulation stimulators in the 3 months prior to stimulation Exclusion Criteria: - Not suitable for inclusion in the oocyte donation program of Institute Bernabeu - Concurrent participation in another study Inclusion Criteria: - Be considered eligible to get into the oocyte donation program of Instituto Bernabeu - Age between 18 and 30 years - Body Mass Index over 18 and under 28 - Antral follicle count greater than 9 and less than 25 (adding both ovaries) - Patients starting ovarian stimulation with 225 IU of FSH - Presence of both ovaries - Ability to participate and comply with the study protocol - Signing the written consent form - Not having received treatment with ovulation stimulators in the 3 months prior to stimulation Exclusion Criteria: - Not suitable for inclusion in the oocyte donation program of Institute Bernabeu - Concurrent participation in another study Reproductive Techniques, Assisted The aim of this study is to determine whether the number of oocytes obtained in women oocyte donors may be different with the use of rFSH or uFSH based on receptor N680S FSHR gene polymorphism. --- N680S ---