SNPMiner Trials by Shray Alag

NCT00511368 (37) NCT00460382 (36) NCT04504071 (35) NCT03783286 (33) NCT04172597 (32) NCT02404233 (29) NCT00959894 (28) NCT00706147 (28) NCT00121017 (28) NCT01685801 (27) NCT04513626 (26) NCT01736761 (26) NCT04495348 (24) NCT02673398 (23) NCT02499978 (22) NCT01605084 (21) NCT04254705 (21) NCT02069834 (21) NCT00939770 (18) NCT01792570 (18) NCT01199939 (18) NCT00356616 (18) NCT02728258 (17) NCT02707601 (17) NCT02770508 (16) NCT00711009 (16) NCT00630864 (16) NCT00491556 (15) NCT04085315 (15) NCT02616029 (15) NCT00830804 (15) NCT01170962 (14) NCT00984152 (14) NCT03953898 (14) NCT00727597 (14) NCT03212274 (14) NCT00337467 (13) NCT00098293 (13) NCT02159599 (13) NCT00424814 (12) NCT04432454 (12) NCT02527096 (12) NCT01849003 (12) NCT03781063 (12) NCT03683524 (11) NCT01614457 (11) NCT00460746 (11) NCT00993148 (11) NCT03061331 (11) NCT02494882 (11) NCT03068312 (11) NCT04453436 (11) NCT01521338 (10) NCT01614470 (10) NCT01423812 (10) NCT00358917 (10) NCT04415268 (10) NCT00511381 (10) NCT03911713 (9) NCT02742519 (9) NCT02725567 (9) NCT03045523 (9) NCT00438152 (9) NCT01102972 (9) NCT02971839 (9) NCT00740064 (9) NCT02605954 (9) NCT00379405 (9) NCT01562847 (9) NCT02616783 (9) NCT04272242 (9) NCT02445053 (9) NCT00242840 (9) NCT02724527 (9) NCT04209465 (9) NCT04585737 (8) NCT02082977 (8) NCT00112775 (8) NCT00383318 (8) NCT03659214 (8) NCT03631732 (8) NCT00118898 (8) NCT01888562 (8) NCT02633189 (8) NCT03565692 (8) NCT03843775 (8) NCT01161576 (8) NCT02167165 (8) NCT00344461 (8) NCT04519398 (7) NCT02154490 (7) NCT03232892 (7) NCT00650832 (7) NCT04549025 (7) NCT00440947 (7) NCT02784639 (7) NCT03572140 (6) NCT01237444 (6) NCT00532168 (6) NCT01102569 (6) NCT04424368 (6) NCT01414985 (6) NCT00525733 (6) NCT02308332 (6) NCT01487265 (6) NCT00049933 (5) NCT02389920 (5) NCT03351699 (5) NCT04197934 (5) NCT02272998 (5) NCT00122590 (5) NCT04204330 (5) NCT02450591 (5) NCT01173029 (5) NCT02675829 (5) NCT02858921 (5) NCT01914484 (5) NCT00187733 (5) NCT02554591 (5) NCT01501604 (5) NCT02716116 (5) NCT01136460 (5) NCT00187655 (5) NCT00350272 (5) NCT00837135 (5) NCT03202862 (5) NCT01707199 (5) NCT03839342 (5) NCT01323010 (4) NCT02248324 (4) NCT01698905 (4) NCT01737359 (4) NCT01306045 (4) NCT02804100 (4) NCT01456676 (4) NCT00588172 (4) NCT03434418 (4) NCT03593993 (4) NCT01804140 (4) NCT02882308 (4) NCT03497767 (4) NCT04106024 (4) NCT02716311 (4) NCT04405674 (4) NCT03599518 (4) NCT01675778 (4) NCT01604122 (4) NCT01297777 (4) NCT04519970 (4) NCT00705679 (4) NCT04147351 (4) NCT04129502 (4) NCT03976856 (4) NCT02335944 (4) NCT03948763 (4) NCT03255083 (4) NCT04002830 (4) NCT02635815 (4) NCT03066206 (4) NCT01331642 (4) NCT00557245 (4) NCT01922583 (4) NCT02893332 (4) NCT03592888 (4) NCT02257424 (4) NCT03874858 (4) NCT00017732 (4) NCT00187720 (4) NCT02593539 (4) NCT01185587 (4) NCT04439292 (4) NCT03884348 (4) NCT01309243 (4) NCT03209063 (4) NCT04160546 (4) NCT03292302 (4) NCT02418234 (4) NCT02535338 (3) NCT02192697 (3) NCT03410043 (3) NCT03845296 (3) NCT02914990 (3) NCT02113813 (3) NCT01532011 (3) NCT04340388 (3) NCT00962533 (3) NCT03856411 (3) NCT04049266 (3) NCT02973763 (3) NCT02926092 (3) NCT00271973 (3) NCT04256941 (3) NCT03812809 (3) NCT02954523 (3) NCT01784068 (3) NCT03446417 (3) NCT02841579 (3) NCT02025114 (3) NCT01288521 (3) NCT01385683 (3) NCT02279004 (3) NCT00998582 (3) NCT03111901 (3) NCT01352715 (3) NCT01619774 (3) NCT01045369 (3) NCT02246998 (3) NCT03969823 (3) NCT00895596 (3) NCT02398929 (3) NCT00724711 (3) NCT04029350 (3) NCT03737994 (3) NCT01443806 (3) NCT02629822 (3) NCT03463525 (3) NCT00710112 (3) NCT03623750 (3) NCT04283955 (3) NCT02743923 (3) NCT01016106 (3) NCT01259089 (3) NCT03971474 (3) NCT02917993 (3) NCT02368990 (3) NCT00279110 (3) NCT02485652 (3) NCT00312169 (3) NCT04541407 (3) NCT02769286 (3) NCT00747487 (3) NCT04267913 (3) NCT01429597 (3) NCT04023617 (3) NCT03790228 (3) NCT01759888 (3) NCT04429152 (3) NCT01810718 (3) NCT02725632 (3) NCT01090011 (3) NCT04544111 (3) NCT02926768 (3) NCT02981108 (3) NCT02459743 (3) NCT00654823 (3) NCT01037127 (3) NCT04439305 (3) NCT01028222 (3) NCT01542411 (3) NCT01031446 (3) NCT02726269 (3) NCT01892644 (3) NCT03260491 (3) NCT01802632 (3) NCT02720094 (3) NCT02630186 (3) NCT01627132 (3) NCT02690675 (3) NCT01013506 (3) NCT04252339 (3) NCT02496663 (3) NCT03386955 (3) NCT03394118 (3) NCT04212702 (3) NCT01754025 (3) NCT01160276 (3) NCT00121979 (3) NCT03228277 (3) NCT04351555 (3) NCT01243346 (3) NCT04510415 (3) NCT02796274 (3) NCT02774005 (3) NCT02064491 (3) NCT04233021 (3) NCT03799601 (3) NCT00260260 (3) NCT02094261 (3) NCT04245085 (3) NCT01282151 (3) NCT03058094 (3) NCT02520778 (3) NCT03161808 (3) NCT04181060 (3) NCT01342679 (3) NCT01443273 (3) NCT01593254 (3) NCT04433481 (3) NCT02529995 (3) NCT03502850 (3) NCT02771314 (3) NCT03823807 (3) NCT03270527 (3) NCT02688881 (3) NCT01005602 (3) NCT02442349 (3) NCT02282267 (2) NCT02684591 (2) NCT03381430 (2) NCT02178397 (2) NCT03608215 (2) NCT02603107 (2) NCT03370770 (2) NCT03322696 (2) NCT00525473 (2) NCT03333343 (2) NCT03127449 (2) NCT01781026 (2) NCT02503722 (2) NCT00975871 (2) NCT03964233 (2) NCT03388099 (2) NCT02317016 (2) NCT03845270 (2) NCT03519958 (2) NCT03918304 (2) NCT02151721 (2) NCT02777658 (2) NCT01016444 (2) NCT02971501 (2) NCT03101254 (2) NCT03178617 (2) NCT01774721 (2) NCT03574753 (2) NCT01357655 (2) NCT01766713 (2) NCT02097225 (2) NCT00658164 (2) NCT03622593 (2) NCT02571036 (2) NCT00834665 (2) NCT00969137 (2) NCT02026011 (2) NCT03622580 (2) NCT03543683 (2) NCT01143493 (2) NCT03671538 (2) NCT04028778 (2) NCT00324961 (2) NCT01915576 (2) NCT02157883 (2) NCT01387022 (2) NCT03864042 (2) NCT03235245 (2) NCT03469960 (2) NCT02795884 (2) NCT00005541 (2) NCT01242813 (2) NCT02906020 (2) NCT03960645 (2) NCT00643058 (2) NCT03443336 (2) NCT02992860 (2) NCT02281760 (2) NCT02201602 (2) NCT04310007 (2) NCT03720665 (2) NCT04309019 (2) NCT00909532 (2) NCT00411944 (2) NCT01604681 (2) NCT01245062 (2) NCT00270231 (2) NCT03256136 (2) NCT03973918 (2) NCT00302692 (2) NCT00125281 (2) NCT02163733 (2) NCT02110407 (2) NCT00475176 (2) NCT03196882 (2) NCT01572818 (2) NCT02556333 (2) NCT04268550 (2) NCT02433717 (2) NCT03428126 (2) NCT01153763 (2) NCT02609776 (2) NCT01420211 (2) NCT03556176 (2) NCT03872440 (2) NCT01405079 (2) NCT03382795 (2) NCT02991950 (2) NCT00013598 (2) NCT03455764 (2) NCT02422628 (2) NCT03831932 (2) NCT03766490 (2) NCT02580474 (2) NCT00499577 (2) NCT02444884 (2) NCT01775943 (2) NCT03544814 (2) NCT01310036 (2) NCT01027663 (2) NCT01928160 (2) NCT01244438 (2) NCT00007150 (2) NCT04462081 (2) NCT02297425 (2) NCT02086071 (2) NCT01050400 (2) NCT03060590 (2) NCT01819428 (2) NCT02709668 (2) NCT02411448 (2) NCT03878719 (2) NCT04479306 (2) NCT03377023 (2) NCT01378026 (2) NCT00226551 (2) NCT03239145 (2) NCT04511533 (2) NCT02191891 (2) NCT04586270 (2) NCT04545710 (2) NCT02120222 (2) NCT02738593 (2) NCT00831272 (2) NCT04469543 (2) NCT00573495 (2) NCT04158544 (2) NCT00904150 (2) NCT02110056 (2) NCT02856893 (2) NCT02110043 (2) NCT02182986 (2) NCT04179890 (2) NCT00063232 (2) NCT02197234 (2) NCT03121235 (2) NCT01532089 (2) NCT03887169 (2) NCT02268864 (2) NCT01963845 (2) NCT00866736 (2) NCT03977194 (2) NCT03991013 (2) NCT02500927 (2) NCT02228382 (2) NCT02689570 (2) NCT01513785 (2) NCT02463435 (2) NCT03351361 (2) NCT04527549 (2) NCT03424759 (2) NCT02197247 (2) NCT02321046 (2) NCT04272034 (2) NCT04027647 (2) NCT02364609 (2) NCT02759835 (2) NCT04349865 (2) NCT00068159 (2) NCT00418015 (2) NCT04310397 (2) NCT03088176 (2) NCT03867175 (2) NCT00339209 (2) NCT00011258 (2) NCT01288430 (2) NCT01616199 (2) NCT03603262 (2) NCT03071705 (2) NCT00969930 (2) NCT00772408 (2) NCT02743468 (2) NCT00277342 (2) NCT04248829 (2) NCT01767454 (2) NCT00933127 (2) NCT03317873 (2) NCT03392246 (2) NCT01909453 (2) NCT03523104 (2) NCT00085917 (2) NCT02507921 (2) NCT03781752 (2) NCT03828422 (2) NCT02193282 (2) NCT03195452 (2) NCT02294487 (2) NCT01325441 (2) NCT02511106 (2) NCT02997501 (2) NCT04184921 (2) NCT00625092 (2) NCT01657786 (2) NCT01415011 (2) NCT02629523 (2) NCT01718847 (2) NCT02818023 (2) NCT00577707 (2) NCT01943422 (2) NCT00116636 (2) NCT01841463 (2) NCT04429542 (2) NCT03865511 (2) NCT01218477 (2) NCT03205267 (2) NCT02881320 (2) NCT01897480 (2) NCT02810990 (2) NCT04189757 (2) NCT01951001 (2) NCT04254939 (2) NCT03207867 (2) NCT00780949 (2) NCT03355768 (2) NCT00817089 (2) NCT02143466 (2) NCT04499053 (2) NCT01907776 (2) NCT00909727 (2) NCT01562028 (2) NCT03737253 (2) NCT00441974 (2) NCT02155465 (2) NCT04586335 (2) NCT00661999 (2) NCT02705339 (2) NCT04006340 (2) NCT04553887 (2) NCT03852290 (2) NCT02183922 (2) NCT03970239 (2) NCT00294372 (2) NCT03250676 (2) NCT03792074 (2) NCT00671892 (2) NCT00689182 (2) NCT00106379 (2) NCT01947023 (2) NCT00509652 (2) NCT03683251 (2) NCT02039986 (2) NCT03515837 (2) NCT04081688 (2) NCT03190005 (2) NCT01584648 (2) NCT02292654 (2) NCT03992456 (2) NCT03133546 (2) NCT01485809 (2) NCT01266967 (2) NCT02909712 (2) NCT00062764 (2) NCT01776684 (2) NCT03042221 (2) NCT01940809 (2) NCT01161537 (2) NCT01154816 (2) NCT01175759 (2) NCT01199731 (2) NCT02788058 (2) NCT03130452 (2) NCT01772732 (2) NCT02631447 (2) NCT02525692 (2) NCT02526537 (2) NCT03513666 (2) NCT02027961 (2) NCT03106779 (2) NCT04106544 (2) NCT04258943 (2) NCT00165984 (2) NCT00977470 (2) NCT02092974 (2) NCT03975231 (2) NCT01998295 (2) NCT03586453 (2) NCT02021305 (2) NCT03135197 (2) NCT00432016 (2) NCT03004625 (2) NCT03851445 (2) NCT04031898 (2) NCT04201418 (2) NCT01911507 (2) NCT03539224 (2) NCT01978236 (2) NCT00866177 (2) NCT00320879 (2) NCT00044304 (2) NCT01999179 (2) NCT00977730 (2) NCT02491775 (2) NCT00212147 (2) NCT02040064 (2) NCT00489385 (2) NCT01713023 (2) NCT04122729 (2) NCT03994393 (2) NCT02438722 (2) NCT02762448 (2) NCT00071903 (2) NCT00626223 (2) NCT01193829 (2) NCT03239340 (2) NCT02991274 (2) NCT02811354 (2) NCT03416530 (2) NCT02522988 (2) NCT00953706 (2) NCT02346955 (2) NCT03795688 (2) NCT02011945 (2) NCT00857675 (2) NCT00028262 (2) NCT02355431 (2) NCT02495233 (2) NCT04575415 (2) NCT03468985 (2) NCT00230087 (2) NCT02017600 (2) NCT04146298 (2) 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NCT01647711 (1) NCT03231722 (1) NCT03576937 (1) NCT04412070 (1) NCT00554866 (1) NCT03151161 (1) NCT01817166 (1) NCT02220855 (1) NCT02512627 (1) NCT04591197 (1) NCT03402048 (1) NCT04500704 (1) NCT02323724 (1) NCT01166126 (1) NCT03029858 (1) NCT04317599 (1) NCT00300573 (1) NCT00809211 (1) NCT01393730 (1) NCT02318368 (1) NCT02228369 (1) NCT01074398 (1) NCT04500717 (1) NCT03134131 (1) NCT01004497 (1) NCT02455167 (1) NCT02073279 (1) NCT02117817 (1) NCT00323687 (1) NCT01605981 (1) NCT01371955 (1) NCT04147767 (1) NCT04144257 (1) NCT03490123 (1) NCT04423185 (1) NCT02625337 (1) NCT03567629 (1) NCT03360929 (1) NCT00109278 (1) NCT04108156 (1) NCT02132598 (1) NCT00542451 (1) NCT01587573 (1) NCT00868465 (1) NCT01494402 (1) NCT00867139 (1) NCT03363139 (1) NCT01936051 (1) NCT02341131 (1) NCT00037076 (1) NCT00582907 (1) NCT02169869 (1) NCT03284684 (1) NCT04204473 (1) NCT01074359 (1) NCT01400191 (1) NCT04530565 (1) NCT03530319 (1) NCT04146402 (1) NCT02658682 (1) NCT04241835 (1) NCT03133234 (1) 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SNPMiner SNPMiner Trials (Home Page)


Report for Clinical Trial NCT02730884

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

A Phase II Single-Arm Study of the Efficacy and Safety of Oral Rigosertib in Patients With Myelofibrosis (MF) and Anemia

The goal of this clinical research study is to learn if rigosertib can help to control MF in patients with anemia. The safety of this drug will also be studied. This is an investigational study. Rigosertib is not FDA-approved or commercially available. It is currently being used for research purposes only. The study doctor can explain how the study drug is designed to work. Up to 35 participants will be enrolled in this study. All will be enrolled at MD Anderson.

NCT02730884 Leukemia Myelofibrosis Anemia Splenomegaly
MeSH:Anemia Primary Myelofibrosis Splenomegaly
HPO:Anemia Splenomegaly

2 Interventions

Name: Rigosertib

Description: Participants take 560 mg Rigosertib by mouth in the morning (two 280 mg capsules) and 560 mg Rigosertib in the afternoon.
Type: Drug
Group Labels: 1

Rigosertib

Name: Questionnaire

Description: Quality of life questionnaire completed on Day 1 of Cycle 1. It should take about 10-15 minutes to complete.
Type: Behavioral
Group Labels: 1

Rigosertib


Primary Outcomes

Description: Spleen response defined as ≥ 35% spleen volume reduction from Baseline, which must be confirmed by MRI or CT measurement per revised International Working Group for Myelofibrosis Research and Treatment (IWG MRT) response criteria.

Measure: Number of Participants With Spleen Volume Response

Time: Baseline and 48 weeks

Description: Anemia response defined as the proportion of transfusion-independent patients with Hgb increase of at least 2 g/dL from Baseline or the proportion of transfusion-dependent patients becoming transfusion independent for at least 12 weeks as defined in 2013 International Working Group for Myelofibrosis Research and Treatment (IWG-MRT) criteria.

Measure: Participants With Anemia Response

Time: Baseline and 48 weeks

Secondary Outcomes

Description: Symptoms response defined as the proportion of patients achieving ≥ 50% reduction in the Myeloproliferative Neoplasm Symptom Assessment Form Total Symptom Score (MPN-SAF TSS) at any time before Week 48.

Measure: Symptoms Response

Time: 48 weeks

Purpose: Treatment

Allocation: N/A

Single Group Assignment


There is one SNP

SNPs


1 V617F

Measurement of JAK2 V617F allele burden in Bone Marrow (BM) samples, if not done within 6 months prior to Screening, must be provided with the Screening BM biopsy/aspirate report (patients are eligible regardless of JAK2 mutation status); 3. Anemia or RBC-transfusion dependence defined as follows: a) Anemia: defined for the purpose of this protocol as 1) a hemoglobin level <10 g/L on every determination over 84 days before study-entry, without red blood cell (RBC)-transfusions, or 2) a hemoglobin level <10 g/L on a patient that is receiving RBC-transfusions periodically but not meeting criteria for transfusion-dependent patient as defined below. --- V617F ---



HPO Nodes


HPO:
HP:0001903: Anemia
Genes 775
DKC1 RPS19 SNX10 NDUFA10 LPIN2 COL7A1 PGM3 PUS1 GATA1 SPTB TERC NTRK1 HBB ABCD3 ZBTB24 FANCI FANCC TARS1 SEC61A1 TGFB1 DAXX STING1 HBB DHFR TINF2 SMARCD2 THRA DBH UNC13D MPIG6B PLEC HELLS PIEZO1 OCRL JAK2 GTF2E2 PTF1A PRF1 GPI RAD51 HBA1 RPS27 STAT5B ERCC4 HPRT1 RMRP PRKCD GSS LYST CUBN FANCG FANCL SF3B1 RPS14 TNFRSF4 GNA14 CAT HBA2 PET100 ITGB3 PKLR HBA1 NRAS MECOM TRNH SPTA1 SLC46A1 CD59 SLC2A1 RASGRP1 LYST XIAP RPL15 IGH DNAJC21 RPS28 RTEL1 RPS15A IL2RB WRAP53 GATB UQCRFS1 NDUFV1 TNFRSF13C DDX41 G6PD RPL26 SBDS GATA1 CD40LG RPS27 IFNG FANCM FASLG CFHR3 TNFAIP3 FOXP3 COX14 HBA2 ALAD NDUFA13 PIEZO1 KRT14 ENG PLEKHM1 COQ2 HBB RPS15A SPTA1 HBA2 NOP10 SURF1 TACO1 SLX4 COL4A1 PHF21A FANCG HYOU1 TBXAS1 HBB ND5 RPS19 KCNN4 CFB ZBTB20 MTRR PGM3 KCNQ1 IL7R NT5C3A SMAD4 MUC1 PRKACG RPL27 PRDX1 TOR1A PHGDH SFXN4 HBD TCIRG1 RBM8A SLC4A1 ITGA2B CD55 TET2 BMPR1A PEPD NPHP4 RFX5 STAT2 PALB2 PSMB4 LYRM7 SURF1 LAT TRNW FTCD ABCD4 RRM2B SLC25A21 CTLA4 MTFMT EFL1 FMO3 CIITA NDUFAF3 GATA1 PCNT TRNF CFHR1 FOXP3 TBXAS1 FANCB DNM1L OSTM1 HBB TSR2 POLG UMPS RPL26 GSS DKC1 TRNT1 NDUFV2 NSUN2 TERT EPB42 ATP7B PRKCD STIM1 STIM1 UMPS CTC1 KRAS ANK1 CASR NHEJ1 LIG4 STK11 AK2 TBCE SPTB CD3G LCAT COA3 RPL5 STAT1 SMAD4 SLC4A1 HBG1 ABCG8 HPRT1 CHD7 TERT GBA CDAN1 RAD51C CTSK MLX KLF1 CLPX UBE2T SEC23B PDGFRA SAMD9L LRBA FERMT1 TPI1 RFXAP GDF2 AMMECR1 LAMC2 COX20 MMUT BRCA1 FANCD2 VPS45 IDH2 TRNQ EPO KIF15 STEAP3 CLCN7 WAS PNPO HBG2 RPS7 HAVCR2 SPP1 TRNS1 SPTB TMEM67 FAM111A BRIP1 FLI1 ERCC3 PRKCD RPL35 SLC7A7 SLCO2A1 CD46 DKC1 PGK1 ABCB6 BCOR TTC7A NDUFAF5 RARA BCL10 PTH1R FARS2 ND1 NDUFS4 MYD88 NPM1 BMPR1A SMAD4 ATRX MMAB MTTP CASK SLC12A3 ADA AIRE UBR1 NDUFB8 SDHA FANCC WFS1 COA8 PSAP TERT IKZF1 UBE2T FAM111A CAD CLCNKB MMP1 RPL27 RHAG EPB42 COX10 TTC7A STIM1 APOA1 STAT3 RUNX1 GATA1 HBA2 RPS24 ACTN4 WT1 NDUFS2 RPL35 RPS17 NLRP3 ASAH1 SBDS GLA ACVRL1 MVK CLCN7 RIPK1 LAMB3 ANK1 REN NFKB2 ATP11C PHKA2 CPOX PHGDH SLC40A1 SNX10 RHAG TGFB1 HBG1 LAMB3 TNFRSF13B PHKG2 CLCN7 LARS2 SP110 HBG2 HAMP XRCC4 FANCA PIGT PPOX NLRP1 PNP ALPL PET100 ACP5 TERT TFRC RPL31 SRD5A3 EPB41 IDH1 RPS26 SLC4A1 RPL18 HBB-LCR PRKAR1A ABCA1 EPB41 TALDO1 FECH DNMT3B IRF2BP2 SPTA1 SRP54 TINF2 SMAD4 SHPK ATP7B CPOX GP1BA GSR RMRP WAS PFKM PSTPIP1 CISD2 COL7A1 USB1 MEFV ELMO2 COX4I2 TNFSF12 TFR2 LIG4 PGK1 GATC NHLRC2 RMRP LIPA IFNGR1 SDHB CTLA4 ENG HLA-DRB1 CASP10 COL7A1 F8 CA2 TRNL1 CD81 NABP1 NUMA1 ALX4 FECH COL7A1 FANCB YARS2 FCGR2B SDHC GBA TYMP LAMA3 AGXT TF HBA1 BMPR1A PTEN MTRR GATA1 SLX4 BIRC3 NPHP4 KMT2D MDM4 ITGB4 SMARCAL1 PRF1 ETV6 EPHB4 KLF1 KIF1B TRNT1 VPS33A TNFSF11 RAG1 COX2 HBB RPS17 MAD2L2 UROD APC ACAD8 EWSR1 TNFSF11 HK1 ERCC4 PUS1 GATA1 FIP1L1 ITK NPHP1 CALR MMAA HBB VPS33A GPX1 SCO1 TET2 RPS29 ISCU TCN2 GLA NBN HBB ALAS2 RPL35A PSMB8 TINF2 FANCE FCGR2A HBB UROS SPTA1 CP HLA-B KIT HBA1 SMARCAL1 ATRX HBA2 TEK RAG1 LIPT1 SLC19A2 TRNS2 DNASE1 TRNS1 RAG2 RPL11 PARN CLCN7 ZAP70 GYPC RECQL4 OPA1 LAMA3 HBB WFS1 ND4 GBA SLC19A2 PSMB9 FAS AASS COX6B1 ALDOA ORAI1 G6PC3 MS4A1 HBB ELANE CD19 TCIRG1 CP COX1 LMBRD1 SAMD9 KIT MMACHC RAG1 FOXP1 FANCD2 SPTA1 TBL1XR1 NDUFS7 MPL HELLPAR ADAMTS13 THBD CYBC1 NPHP1 SLC11A2 STX11 IRAK1 SPTB SLC2A1 RPS7 ADAR CA2 RAG2 NDUFS3 HMGCL MYSM1 IRX5 SARS2 BTK SLC4A1 RPS24 ANK1 FANCL BTNL2 NDUFA12 PLEC NDUFA9 ALAS2 RPS29 KIF23 TET2 MARS1 PIGA RPL11 NDUFA4 KCNN4 GCLC ACVRL1 RPL15 ADA TPP2 FARSB LPIN2 C3 TNFSF12 RASGRP1 COX15 PTPN22 NDUFA2 RPS26 GREM1 HPGD FERMT3 SDHA DCLRE1C ZBTB16 CFH TRNN PNPO CCND1 DNAJC21 GATA1 PCCA ABCA1 NDUFAF6 RPL5 ADA2 SLC4A1 SLC25A10 SCARB2 HLA-B TCIRG1 COL7A1 STAT4 SCO2 HMOX1 PKLR IFT140 NDUFS1 NFKB1 GALNT2 RHAG NDUFS2 FANCF ATRX NDUFS8 LARS1 CFH TP53 FASLG HBA1 ICOS CDCA7 ERCC6L2 LAMC2 XRCC2 TET2 AGGF1 ATRX PLEKHM1 ABCB7 TKFC TALDO1 ASXL1 KCNE1 KDM6A AK1 NHP2 PDHA1 SLC25A13 SRD5A3 MTHFD1 MYSM1 RAG2 TSR2 PFKM NLRP3 ABCB7 MPLKIP COX3 RPL35A EXT2 QRSL1 NLRC4 SLC4A1 STEAP3 PARN ECHS1 COG1 COX8A FANCF HBB TMPRSS6 GBA DNAJC19 DGKE BRCA1 FOXRED1 CR2 COL17A1 SRP54 RFXANK IL2RA MPL IL2RG STAT3 PLA2G4A PNP SRSF2 RPS10 SH2D1A WIPF1 GLRX5 F2 MTR CTC1 SLC19A3 FAS ATRX DCLRE1C RPS14 GCLC CFI PACS2 TET2 BMPR1A CBLIF ERCC2 TERC CBL MMADHC SAMD9L NOD2 SLC29A3 IREB2 ADA2 SLC25A38 ITGB4 GBA MALT1 TF HSPA9 MAD2L2 SBDS TACO1 FAS FDX2 TNFRSF11A CDIN1 RFWD3 FANCE ERCC8 TRNW RTEL1 FANCA TERC ACVR1 NFKB1 IFNG YARS2 NPM1 AMN BRCA2 ND6 PML RAG1 TREX1 SMPD1 IL12B UROS MMP1 ALG8 PCCB NDUFAF2 ENG BPGM MMUT TERT RPS10 CFI RNF113A SLC46A1 CD46 ERCC6 STK11 SLC7A7 ALAS2 ERBB3 HMGCL GTF2H5 ACD COA8 DNAJC19 RPS28 GALT CASP10 EFL1 NBN CRIPT STAT1
Protein Mutations 4
C282Y C677T H63D V617F
HP:0001744: Splenomegaly
Genes 489
CARD11 SNX10 RNASEH2A GALE GLIS3 PSAP NOTCH2 LPIN2 CD81 GNPTAB ERCC8 HLA-DRB1 LIPA SPTB LBR PDGFRA HBB GBA ABCD3 GP1BB SEC24C TP53 CCND1 NPC1 HJV NBEAL2 CYBB RINT1 GATA1 MPIG6B GPC1 IRF8 GPC3 RPGRIP1L KCNH1 INPPL1 PIEZO1 GPR35 JAK2 SLC29A3 KLF1 PRF1 GPI JMJD1C VPS33A UFD1 TNFSF11 CTLA4 PRKCD LYST AKT1 BTD ABCB11 GLB1 ATP8B1 CYBA SF3B1 APOE TNFRSF4 RAB27A CYP7B1 TCF4 NAGLU GUSB HK1 RNU4ATAC TMEM67 INPP5E PKLR CCBE1 TMEM67 HBA1 NRAS ITK CALR CALR SPTA1 HGSNAT HBB SLC2A1 RASGRP1 LYST OTC IDUA TET2 IL7R XIAP HLA-DRB1 HBB BRAF ALAS2 GBA NCF1 PSMB8 MCM4 CD28 IL2RB GPC4 UROS WRAP53 CD19 PIGM BCR TNFRSF13C G6PD GATA1 ITCH CD40LG ICOS FASLG IDUA APOC2 ATRX FOXP3 MEFV HBA2 PTEN THPO HBA2 RAG1 PIEZO1 PLEKHM1 RAG2 NEU1 HBB IDUA CASR DPM1 NOP10 SCYL1 CALR GYPC GNPTAB GBA HBB TBXAS1 GBA LACC1 PSMB9 F5 KCNN4 FAS PEX2 IL7R ALDOA GPD1 G6PC3 MS4A1 CD19 TCIRG1 UBAC2 GUSB NGLY1 THPO MST1 NEU1 HLA-B FAT4 RAG1 ALMS1 HFE LIPA SLC4A1 TET2 IGH TTC37 LPL CLDN1 BCL2 SPTA1 ASAH1 MPL PEPD OCLN DCDC2 LMNA MIF SUMF1 CYBC1 ABCA1 PSMB4 SKIV2L LAT FAH STX11 AP3D1 SPTB BCL6 JAK2 ERAP1 TNFRSF1B CA2 CTLA4 FMO3 AP3B1 GPC3 ERCC6 AGA GATA1 PKHD1 ZAP70 ANK1 PEPD OSTM1 IL12A ERCC8 ICOS KCNN4 DKC1 SH2B3 TNFRSF13B ADA TPP2 CCDC47 DGUOK NOTCH1 GPC4 EPB42 IL23R TNFSF12 PRKCD RASGRP1 UMPS KRAS PEX7 HPGD FERMT3 SH2B3 LYZ ANK1 CASR DCLRE1C LCAT BTNL2 B2M MAN2B1 DDRGK1 KLRC4 CCND1 HSD3B7 COG7 IL12A-AS1 CAV1 HFE ABCA1 TNFRSF13C CAVIN1 NLRP12 SCARB2 GBA SLC4A1 HBG1 CALR ABCG8 CHD7 BSCL2 MVK TCIRG1 KCNN3 COG4 ATP6V1B2 GBA PKLR RREB1 CDAN1 IDUA ARVCF CTSK KLF1 NFKB1 SEC23B FUCA1 TBX1 MKS1 RHAG SAMD9L JAK2 ALG1 NCF4 TPI1 MPL GPIHBP1 NCF2 CD28 PTEN GFI1B AKT1 JAK2 MMUT CR2 JAK2 VPS45 PIK3CA FASLG HBA1 GATA2 IL6 ICOS CTLA4 NCF1 STEAP3 DNASE1L3 IFT172 TET2 CLCN7 SGSH HBG2 HAVCR2 SPTB NBEAL2 CLCN7 ASXL1 PRKCD NHP2 NPC2 SLC7A7 JAK2 HLA-DRB1 SLCO2A1 RAG2 FAH XIAP SH2B3 CYBB NLRP3 IGH DOLK IL10 SMPD1 DGUOK BMP2 NLRC4 SLC4A1 ABCB4 PARN MYD88 PIK3C2A NPM1 HBB PIK3R1 ATM MPL GBA PIK3CD CASP8 CASK PTEN ADA PHKG2 GAA IFIH1 NCF2 CR2 IL2RA IL2RG MEFV ARSB ERCC6 CYBC1 WDR1 SMPD1 RHAG FGA APOE HSD3B7 CC2D2A SLC30A10 EPB42 TREX1 WDR35 LMNA MVK APOA1 ABL1 BACH2 SRSF2 RUNX1 SH2D1A GLRX5 CCDC115 TET2 DYNC2LI1 CTC1 GNE FAS CD27 COMT NLRP3 TBX1 DCLRE1C CFAP410 MEFV MVK MPL FAS RIPK1 APOA1 ANK1 NFKB2 DCDC2 COG6 TERC CBL ADAMTS3 PHKA2 SLC39A4 CPOX IL1RN AGPAT2 PSAP SNX10 NOD2 STAT4 TGFB1 ADA2 GBA CC2D2A TNFRSF13B SOX10 PHKG2 CLCN7 VPS13A CYBA HAMP TNFRSF1B CTNS PIEZO1 NLRP1 PNP PKHD1 FAS TNFRSF11A CDIN1 DZIP1L TLR4 EPB41 RTEL1 SLC4A1 DDRGK1 RPGRIP1L IFNG EPB41 TALDO1 TNFRSF1A CYP7B1 MPL SUMF1 C4A TINF2 ATP6AP1 RAG1 SMPD1 UROS ATP7B CPOX GP1BA IDUA JAK2 DHCR24 USB1 RMRP TET2 BPGM TERT PTPRC PHYH SLC17A5 RUNX1 AKR1D1 USB1 CCR1 COX4I2 HIRA TNFSF12 AKR1D1 ERBB3 KCNH1 LIG4 SH2B3 LIPA IFNGR1 CASP10 IDS PPARG GBA GNS GBA CASP10 JAK2
SNP 0