Non-interventional, multi-country, multi-centre cohort study based on existing data from medical records (paper or electronic) or electronic health records of patients with advanced NSCLC harbouring EGFR mutations and treated with an EGFR-TKI
Name: Epidermal Growth Factor Tyrosine Kinase Inhibitor
Name: Afatinib
Description: assessed as the time from start of EGFR-TKI treatment until the end of treatment or death date by any cause.
Measure: Time on treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Time: Up to 30 monthsDescription: uncommon mutation cohort only
Measure: Time on treatment until failure of second-line (TTF2) Time: Up to 30 monthsCohort
There are 2 SNPs
Sequencing cohort: 5. Patients with common EGFR mutations (Del19, L858R) 6. Patients were treated with afatinib (Gi(l)otrif®) in the first-line setting and for acquired T790M mutation with osimertinib in the second line; 7. Patients must have started osimertinib treatment at least 10 months prior to data entry. --- L858R ---
Sequencing cohort: 5. Patients with common EGFR mutations (Del19, L858R) 6. Patients were treated with afatinib (Gi(l)otrif®) in the first-line setting and for acquired T790M mutation with osimertinib in the second line; 7. Patients must have started osimertinib treatment at least 10 months prior to data entry. --- L858R --- --- T790M ---
For uncommon mutation cohort: Patients treated with osimertinib with no further uncommon mutation than acquired T790M Further exclusion criteria apply Inclusion Criteria: 1. Adult patients 2. Diagnosed with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFRTKI) naïve advanced EGFR mutated non-small cell lung cancer (NSCLC), 3. treated for Epidermal Growth Factor Receptor (EGFR) mutated NSCLC within regular clinical practice. --- T790M ---
For uncommon mutation cohort: Patients treated with osimertinib with no further uncommon mutation than acquired T790M Further exclusion criteria apply Non-squamous, Non-Small Cell Lung Cancer Lung Neoplasms Carcinoma, Non-Small-Cell Lung null --- T790M ---