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Report for Clinical Trial NCT01956786
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
To evaluate the efficacy of Amlodipine-Folic Acid Tablets on reduction of blood pressure and
plasma total homocysteine.
Name: Amlodipine-FA tablet,low dose group
Description: 5mg amlodipine combined with 0.4mg folic acid,once daily (Low-dose group)
Type: Drug
Group Labels: 1 Amlodipine-FA tablet,low dose group
Name: Amlodipine-FA tablet,high dose group
Description: 5mg amlodipine combined with 0.8mg folic acid,once daily (High-dose group)
Type: Drug
Group Labels: 1 Amlodipine-FA tablet,high dose group
Name: Amlodipine
Description: 5mg amlodipine,once daily
Type: Drug
Group Labels: 2 Amlo Amlodipine
Primary Outcomes
Measure: Combined effective rate of blood pressure and plasma homocysteine reduction Time: Blood pressure was examined at baseline and every 2 weeks for a total period of 8 weeks.Blood homocysteine concentrations were measured at baseline and at 4th and 8th week of the trial.
Secondary Outcomes
Measure: Blood pressure reduction or plasma homocysteine reduction Time: Blood pressure was examined at baseline and every 2 weeks of a total period of 8 weeks. Blood homocysteine concentrations was examined at baseline and at 4th and 8th week of the trial.
Purpose: Treatment
Allocation: Randomized
Parallel Assignment
There is one SNP
SNPs
1 C677T
Polymorphism of MTHFR C677T
leads to a reduction in enzyme activity, which may lead to an increased concentration of
plasma homocysteine and lower levels of serum folate, particularly in those with low folate
intake. --- C677T ---
In the present study, we sought to assess:(1)the efficacy and safety of Amlodipine-Folic Acid
Tablets in lowing blood pressure and homocysteine in patients with mild to moderate
hypertension, hyperhomocysteinemia (hcy≥10μmol/L)and ACEI intolerance;(2)whether the blood
pressure and homocysteine-lowing efficacy of Amlodipine-Folic Acid Tablets can be modified by
individual MTHFR C677T polymorphisms. --- C677T ---
MTHFR C677T
genotypes were determined for each study subject. --- C677T ---