SNPMiner Trials (Home Page)
Report for Clinical Trial NCT02615015
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
Neutrophil extracellular traps (NETs) and deoxyribonuclease (DNase) activity determine
outcome in ST elevation acute coronary syndrome (STE-ACS). DNase single nucleotide
polymorphisms (SNPs) were increased in a japanese cohort.
In the present study, the investigators seek to measure DNase SNPs frequency in a caucasian
STE-ACS cohort compared to healthy controls (each n=400). The investigators will compute
polymorphisms, DNase activity, NET surrogate markers and clinical variables in regression
models.
Name: Blood draw
Type: Other
Group Labels: 2 Healthy proband cohort ST elevation myocardial infarction patient cohort
Primary Outcomes
Measure: Frequency of SNPs of the DNase 1 and DNase gamma genes in the STE-ACS patient population compared to healthy controls Time: through study completion, an average of 2 years
Secondary Outcomes
Measure: Correlation of SNPs of the DNase 1 and gamma gene with DNase activity Time: through study completion, an average of 2 years
Measure: Correlation of SNPs with major adverse cardiac events Time: through study completion, an average of 2 years
Measure: Correlation of DNAse activity with major adverse cardiac events Time: through study completion, an average of 2 years
Measure: Correlation of SNPs with DNA-Histone complex levels Time: through study completion, an average of 2 years
Measure: Correlation of SNPs with MPO-DNA complex levels Time: through study completion, an average of 2 years
Measure: Correlation of SNPs with dsDNA levels Time: through study completion, an average of 2 years
Measure: Netosis quantification in STE-ACS patients and healthy controls Time: through study completion, an average of 2 years
Time Perspective: Cross-Sectional
Cohort
There is one SNP
SNPs
1 Q222R
The single nucleotide polymorphism (SNP) Q222R in the DNase 1 gene, leading to impaired
extracellular DNase activity, was correlated with increased incidence of myocardial
infarction in Japanese patients(9). --- Q222R ---