The aim of this study is to evaluate the conversion of OP to OC in individual X and the family member of individual X. The investigators hypothesize that one or more of the single nucleoprotein polymorphisms (SNPs) of the CES1 gene represent a clinically important functional polymorphism.
Description: Conversion of Oseltamivir at 2 and 4 hours post doseMeasure: Tmax Time: 2 and 4 hours
Description: Document the sequence of all 14 exons of CES1 from individual X and the family members of individual X.Measure: Conversion of oseltamivir phosphate to oseltamivir carboxylate Time: one year (anticipate)
Single Group Assignment
There are 3 SNPs
A study from Zhu HJ et al presented potentially 2 functional polymorphisms locating in exon 4 (Gly143Glu) and 6 (Asp260fs) that can impair the CES1 hydrolytic activity to methylphenidate in vitro. --- Gly143Glu ---
However, some CES1 variants (V21I, and R182H) have a higher rate of oseltamivir metabolism compared to wild-type. --- V21I --- --- R182H ---
However, some CES1 variants (V21I, and R182H) have a higher rate of oseltamivir metabolism compared to wild-type. --- V21I ---