The roles of thrombophilia and cardiovascular risk factors in sudden sensorineural hearing loss (SSNHL) remain controversial. Cochlear micro-thrombosis has been hypothesized as a possible pathogenic mechanism of SSNHL. The objective was thus to measure the levels of markers of macrovascular thrombosis and microvascular risk factors
Name: microvascular markers
Description: plasma serotonin level (HPLC, frequent value <15nM)
Measure: change from Baseline of plasma serotonin at three months Time: at three months and then once a year up to five yearsDescription: plasma homocystein (HPLC, fequent value <15 µM)
Measure: change from Baseline of plasma homocystein at three months Time: at three months and then once a year up to five yearsDescription: serum anticardiolipin antiboy (ELISA, frequent value <10units)
Measure: change from Baseline serum of anticardiolipine antibody at three months Time: at three months and then once a year up to five yearsDescription: audiogram
Measure: change from Baseline of hearing characteristics at three months Time: at three months and then once a year up to five yearsCohort
There are 2 SNPs
Thrombophilia screening included measurements of antithrombin , protein C, protein S, factor V Leiden, prothrombin G20210A, methylene tetrahydrofolate reductase (MTHFR) C677T, antiphospholipid antibodies anticardiolipin IgG and IgM and anti-beta2 glycoprotein 1 IgG), dilute Russell viper venom time , Rosner index, factor VIII, von Willebrand factor (vWF) activity and antigen. --- G20210A --- --- C677T ---
Thrombophilia screening included measurements of antithrombin , protein C, protein S, factor V Leiden, prothrombin G20210A, methylene tetrahydrofolate reductase (MTHFR) C677T, antiphospholipid antibodies anticardiolipin IgG and IgM and anti-beta2 glycoprotein 1 IgG), dilute Russell viper venom time , Rosner index, factor VIII, von Willebrand factor (vWF) activity and antigen. --- G20210A ---