SNPMiner Trials (Home Page)
Report for Mutation E158K
 Developed by Shray Alag, 2020.
SNP Clinical Trial Gene 
There is one clinical trial. 
Clinical Trials
      Background: The association of trimethylamine-N-oxide (TMAO), a microbiota dependent
      metabolite from dietary choline and carnitine, with type 2 diabetes was inconsistent.
      Objective: The investigators planned to investigate the association between plasma TMAO and
      newly diagnosed type 2 diabetes as well as whether the association could be modified by the
      TMAO-generating enzyme flavin monooxygenase 3 (FMO3) polymorphisms.
      Design: This is an age- and sex-matched case-control study of 2694 participants: 1346 newly
      diagnosed cases of type 2 diabetes and 1348 controls. The patients of newly diagnosed type 2
      diabetes were consecutively recruited from those attending for the first time the outpatient
      clinics of Department of Endocrinology, Tongji Medical College Hospital, Wuhan, China, from
      2012 January to December 2014. Concomitantly, the investigators recruited healthy individuals
      who were frequency-matched by age (±5 years) and sex to patients from an unselected
      population undergoing a routine health check-up in the same hospital. The inclusion criteria
      for controls and newly diagnosed type 2 diabetes were: age ≥ 30 years, body mass index (BMI)
      < 40 kg/m2, no history of a diagnosis of diabetes and no history of receiving pharmacological
      treatment for hyperlipidaemia or hypertension. Patients with clinically significant
      neurological, endocrinological or other systemic diseases, as well as acute illness or
      chronic inflammatory or infective diseases, were excluded from the study. All the
      participants enrolled were of Chinese Han ethnicity. All the participants gave informed
      written consent to the study and did not take any medication known to affect glucose
      tolerance or insulin secretion before participation. The study was approved by the ethics
      committee of the Tongji Medical College. Concentrations of plasma TMAO were measured, and
      FMO3 E158K polymorphism (rs2266782) were genotyped.
    
Concentrations of plasma TMAO were measured, and
      FMO3 E158K polymorphism (rs2266782) were genotyped. --- E158K --- 
  Primary Outcomes 
 Description: odd ratio (OR) for type 2 diabetes
 Measure: type 2 diabetes
 Time: through recruitment completion, an average of 3 years
HPO Nodes
Diabetes mellitus 
Genes 523
PDE6A  IDH3A  UBR1  IER3IP1  SPINK1  HNF1B  PCARE  ND1  OPA1  RP1  AGPAT2  TRNS1  MMP2  TTC8  PDX1  TGIF1  TREX1  CDON  CFTR  MKRN3  GCK  INS  PPARG  HYMAI  COX2  XRCC4  SNRNP200  NUBPL  PTRH2  CEP19  NDUFB10  PROKR2  EYS  LMNA  TRNQ  MAPK8IP1  LEPR  TCF7L2  NSMCE2  PRPF4  ARL6  RDH12  ARL3  FGF8  GCK  KDSR  CEL  DISP1  NR2E3  NDUFAF5  ARL2BP  ERGIC1  PLAGL1  PRPF31  PNPLA6  NDUFV2  COX3  PRCD  RLBP1  WFS1  KLF11  TRNL1  PDX1  NDUFA11  BLK  KCNJ11  GPD2  SLC19A2  DHDDS  MLXIPL  LEP  CLIP2  BMP2  BRCA2  TRNF  IFT140  LMNA  RP2  REEP6  NDUFS2  PDX1  PDE4D  LIG4  RETN  CNGA1  GLI2  NDP  PNPLA2  EDA  CYTB  LHX1  PRSS1  NPM1  IFIH1  TBL2  ALMS1  GCK  PRPH2  HAMP  DCAF17  ABCC8  SNORD115-1  PRPF8  ENPP1  GUCA1B  MEN1  MST1  NEUROD1  POMGNT1  HNF4A  PTPN1  PPP1R3A  FXN  AIP  KIAA1549  IGF2BP2  NKX2-5  EIF2S3  COX1  SLC29A3  ND5  SUFU  CDKN2A  HERC2  FXN  CYP19A1  STAT3  MKKS  SOX2  LIPC  INSR  GTF2I  TDGF1  GCGR  HMGA2  TWNK  HFE  TRNH  HLA-DRB1  CORIN  PRPF6  ZNF408  FGFR1  PROM1  FOS  ZMPSTE24  PEX1  CPA1  HNF4A  NPAP1  NDUFAF3  DLL1  BEST1  TRNK  TRNL1  POLG  CAV1  XRCC4  ND2  TUB  CP  SLC2A2  KRAS  EFL1  NDUFS1  HNF1A  SIX3  POLR3A  RP9  TRNE  AKT2  NODAL  PPARG  XRCC4  ND1  NDUFS4  GATA6  WRN  DCAF17  TTC7A  AKT2  RBP3  POC1A  PAX4  RTEL1  NDUFA6  TRNS1  KCNJ11  INSR  GJB3  INS  CASR  USP8  MAK  FOXC2  FOXP3  HNF1B  GATA3  IMPDH1  APOA5  LIPE  TRNL1  LEMD3  IL6  PRKAR1A  FGFR1  NDN  COX1  FAM161A  HESX1  INSR  NRL  NDUFS6  ABCC8  TRNC  CFTR  GJA1  PRKACA  NDUFB9  TRNW  COX3  TTPA  GPR101  PLAGL1  TIMMDC1  GJA1  WRAP53  RNASEH2A  HNF4A  COX2  PAX4  FOXRED1  PAX4  DKC1  RRM2B  SMAD4  BLK  TMEM126B  ND5  NDUFAF1  FLT1  KCNJ11  MAFA  GATA6  IL2RA  CLCNKB  NDUFAF2  CTRC  PPARG  OFD1  IFT172  SPINK1  PRKAR1A  RPGR  ATM  SNORD116-1  OTX2  NDUFA1  ZFYVE26  NDUFB3  BAZ1B  PRSS2  BSCL2  ABCC8  INS  WFS1  IFT88  PDE6B  GAS1  ABCC8  ABCC8  RGR  PALLD  ND4  STOX1  GNAS  NEK2  RFC2  CA4  HYMAI  CTRC  LIPE  RHO  MMP14  SCAPER  NOP10  ITPR3  GCK  SLC19A2  NHP2  HNF1B  CRB1  PEX6  TWNK  TRNQ  NEUROD1  GTF2IRD1  ABCC8  ND6  DNAJC3  POLD1  GJB4  SPINK1  PARN  BSCL2  VANGL1  SLC29A3  PDE11A  PTPN22  PTF1A  BRAF  AHR  PWRN1  HYMAI  TRNV  GLRX5  USB1  HLA-DQB1  ITCH  SBDS  TRNK  GPR35  PRSS2  PROK2  STAT1  NSMCE2  CTNS  PIK3R1  NDUFAF4  CDHR1  ZFP57  ATP6  TRNW  PTF1A  CTNNB1  AIP  EIF2AK3  POLA1  GCK  TRNE  ELN  NEUROG3  CISD2  GLIS3  DNAJC21  CAVIN1  ELMO2  PTCH1  ROM1  ZFP57  BBS2  LEPR  LRP6  KCNJ11  PRKACA  PRPF3  SLC25A4  DNM1L  GCK  HJV  LRAT  WFS1  HNF1B  TP53  PNPLA2  ELN  IRS2  NDUFV1  ND6  PRSS1  CERKL  CLRN1  PPARG  BBS2  MOG  TOPORS  ARNT2  FOXH1  RAC1  HNF4A  PLIN1  TP53  TRNF  NDUFB11  EIF2AK3  CFTR  SNRPN  USH2A  KCNJ11  HNF1A  STAT3  C8ORF37  APOE  FUZ  LMNB2  IGF1R  TRNS2  LMNA  IPW  POLG2  PDX1  TERC  SLC16A2  INS  CAV1  NDUFS7  AR  LMNA  HGSNAT  KLF11  SEMA4A  FOXP3  CIDEC  CTC1  PLIN1  IDH3B  PCNT  PEX10  GCK  SPINK1  APPL1  HNF1A  ZIC2  ABCA4  FBN1  ZNF513  TRNS2  CRX  STUB1  NEUROD1  KLHL7  CISD2  PSTPIP1  ALMS1  LMNA  PDX1  LIMK1  HNF1A  RPE65  BRCA1  RNASEH2B  CCDC28B  STAT1  AHI1  AIRE  ARMC5  NDUFS3  AGBL5  PDE4D  TULP1  SHH  DHX38  IL2RA  HMGA1  CEL  NDUFS8  ATM  DNAJC3  INS  MAGEL2  HNF1A  EDA2R  HFE  MKRN3-AS1  SLC12A3  SLC30A8  UBR1  ND1  IMPG2  KCNJ11  PWAR1  CNOT1  ADAR  BLM  PDE8B  PDX1  HNF4A  IRS1  RNASEH2C  INSR  PIK3R1  CDH23  BBS1  TCF4  ZMPSTE24  ZBTB20  KIZ  TINF2  KCTD1  WFS1  SRP54  APPL1  ND3  WFS1  PRSS1  SPATA7  AGPAT2  HBB  MERTK  WRN  KCNJ11  PALB2  HNF1A  LMNA  PAX4  SARS2  SLC7A14  SOX3  MC4R  PDE6G  LMNA  ARHGEF18  SAG  AMACR  MTNR1B  CP  CNBP  PLCD1  CTRC  FSCN2  TERT  SAMHD1  CNGB1   hr>
Type II diabetes mellitus 
Genes 182
SNRPN  USH2A  PDE6A  IDH3A  LIPC  SNORD116-1  GTF2I  GCGR  C8ORF37  BAZ1B  PCARE  TRNH  RP1  PRPF6  LMNA  IPW  IFT88  PDE6B  ZNF408  ABCC8  RGR  TTC8  PROM1  PDX1  AR  ND4  NPAP1  HGSNAT  NEK2  RFC2  CA4  KLF11  SEMA4A  BEST1  TRNL1  RHO  IDH3B  MKRN3  SCAPER  PPARG  PCNT  PEX10  TUB  XRCC4  SNRNP200  SLC2A2  CEP19  CRB1  ABCA4  EYS  MAPK8IP1  TRNQ  TCF7L2  POLR3A  RP9  GTF2IRD1  TRNE  FBN1  PRPF4  AKT2  ZNF513  ARL6  TRNS2  RDH12  CRX  STUB1  ARL3  NEUROD1  KLHL7  RBP3  SPINK1  NR2E3  ALMS1  TRNS1  KCNJ11  LIMK1  INSR  HNF1A  ARL2BP  BRAF  RPE65  AHR  PWRN1  GLRX5  PRPF31  MAK  PNPLA6  PRCD  RLBP1  HNF1B  AHI1  IMPDH1  TRNK  AGBL5  TRNL1  TULP1  DHX38  GPD2  HMGA1  ATM  NDN  COX1  FAM161A  NRL  DHDDS  CDHR1  MAGEL2  MKRN3-AS1  CLIP2  CTNNB1  AIP  TRNF  SLC12A3  IFT140  SLC30A8  RP2  POLA1  ND1  REEP6  IMPG2  ELN  PWAR1  LIG4  RETN  BLM  PDX1  CNGA1  TRNW  COX3  IRS1  INSR  ROM1  BBS2  PRPF3  GCK  KIZ  TBL2  COX2  WFS1  GCK  PRPH2  LRAT  ABCC8  SNORD115-1  PRPF8  SPATA7  ENPP1  GUCA1B  MEN1  IRS2  MERTK  POMGNT1  HNF4A  WRN  ND6  HNF1A  PTPN1  PPP1R3A  CERKL  CLRN1  PAX4  SLC7A14  KIAA1549  MC4R  IGF2BP2  PDE6G  ARHGEF18  SAG  MOG  AMACR  TOPORS  MTNR1B  CLCNKB  ND5  PLCD1  OFD1  FSCN2  IFT172  HERC2  CYP19A1  RPGR  CNGB1   hr>