SNPMiner Trials by Shray Alag


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Report for Mutation S9304A

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Investigation of Thioredoxin-1 Family Protein Expression in Rectal Cancer

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment. PURPOSE: This research study is looking at protein expression in tumor tissue samples from patients with stage II or stage III rectal cancer enrolled in clinical trial SWOG-9304.

NCT00972751 Colorectal Cancer
MeSH: Rectal Neoplasms
HPO: Neoplasm of the rectum

S9304A Study of Protein Expression in Tumor Tissue Samples From Patients With Stage II or Stage III Rectal Cancer Enrolled in Clinical Trial SWOG-9304 RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. --- S9304A ---

Primary Outcomes

Measure: Expression of thioredoxin-1, thioredoxin-interacting protein, and hypoxia inducible factor-1 alpha

Time: upon testing of specimens

Measure: Correlation of expression of these proteins with tumor stage, disease-free survival, overall survival, and risk of recurrence

Time: upon provision of expression to Statistical Center


HPO Nodes


Neoplasm of the rectum
Genes 45
FAN1 PDGFRA POLE SMAD4 MSH3 KIT POLD1 BMPR1A KRAS RNF43 KEAP1 DICER1 MSH2 BMPR1A POLE SDHC BMPR1A MLH1 MLH3 PMS2 SDHA SDHC PIK3CA MUTYH SDHB ENG GREM1 NTHL1 RPS20 STK11 SDHB MSH6 AXIN2 EPCAM KIT KLLN PMS1 SDHD SEC23B PTEN TGFBR2 SEMA4A POLD1 PIK3CA AKT1