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Report for Mutation S253N

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Association of 5-HT3 Receptor Gene Polymorphism With the Efficiency of Ondansetron for Postoperative Nausea and Vomiting

Postoperative nausea and vomiting (PONV) is a common and distressing complication in patients undergoing general anesthesia. However, although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, it is reported that over 35% of patients treated with ondansetron experience PONV. Though the cause of failure in ondansetron treatment is not clear, the investigators assumed that polymorphism in the 5-HT3 receptor gene would contribute to such inter-individual variation. In this study, the investigators examine whether the polymorphisms of 5-HT3 receptor gene affect the efficacy of ondansetron to prevent PONV in patients undergoing general anesthesia for laparoscopic surgery.

NCT01657786 Post Operative Nausea and Vomiting Dietary Supplement: administration of ondanstron and screening of genomic DNA
MeSH: Nausea Vomiting Postoperative Nausea and Vomiting
HPO: Nausea Vomiting

The relationship between the incidence of PONV after ondansetron administration and genotypes in 5-HT3 receptor gene polymorphisms ((5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG). --- S253N ---

The incidence of PONV after ondansetron administration is compared among genotypes in 5-HT3 receptor gene polymorphisms (5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG).. Inclusion Criteria: - Adult patients (20-90 years of age) scheduled for undergoing laparoscopic surgery undergoing general anesthesia Exclusion Criteria: - Patients with previous history of drug allergy, - administration of antiemetic drugs within 24 hours, - nausea/vomiting within 24 hours and liver or kidney disease Inclusion Criteria: - Adult patients (20-90 years of age) scheduled for undergoing laparoscopic surgery undergoing general anesthesia Exclusion Criteria: - Patients with previous history of drug allergy, - administration of antiemetic drugs within 24 hours, - nausea/vomiting within 24 hours and liver or kidney disease Post Operative Nausea and Vomiting Nausea Vomiting Postoperative Nausea and Vomiting null --- S253N ---

Primary Outcomes

Description: The incidence of PONV after ondansetron administration is compared among genotypes in 5-HT3 receptor gene polymorphisms (5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG).

Measure: The relationship between the incidence of PONV after ondansetron administration and genotypes in 5-HT3 receptor gene polymorphisms ((5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG)

Time: at first 2 h and 2-24 h after surgery.


HPO Nodes


Vomiting
Genes 258
CYP11A1 ACY1 RANBP2 AIMP1 NDUFA1 ND5 MPV17 NDUFB3 POLG TRNW COA8 ND6 HNF1A ND1 SLC25A15 HSD3B2 TRNS1 COQ2 CPS1 TRNV MCCC2 TYMP DBT MCCC1 ACADM SLC25A13 ETFA TYMP COX2 DHCR7 FBP1 NUBPL NDUFB10 SERPING1 TRNQ ACAD8 ACTG2 HMGCL BCKDHA CD55 STAT4 CYP24A1 CCM2 ND6 NBAS PMM2 CTNNB1 SCNN1B RELA CDH23 ALG11 NDUFAF5 HELLPAR PMM2 CPT2 NAXD TRNV CFH SUGCT NDUFV2 COX3 ND2 PPM1D RET HPRT1 GCDH TRMU HFE ABCC8 PCCB MMAB NDUFA11 OPLAH NDUFAF4 ALG8 MLYCD SLC7A7 ALDOB GLA BRAF CDH23 TRNW BTD SERPING1 PNPLA8 FARSB CPOX NDUFS2 NEUROG3 SLC22A5 BOLA3 SHANK3 HLCS ACAT1 CYP11B2 BCKDHB SCNN1G CFI NAGS CYTB GHSR ABCC8 TNFRSF1A KMT2E OTC CD46 SSR4 TNF SCNN1A ASS1 TP53 ST3GAL5 PPOX AIP FLNA INHBA SLC22A5 ACAT1 MC2R RARS1 GALC OXCT1 EGFR AQP2 PDSS2 NDUFV1 ELP1 NDUFS1 ACSF3 ACP2 MRPS7 ACADL ARG1 COX1 F12 ACADM AVP TRNF NDUFB11 SAR1B ALG11 ALPL TCN2 POLG DGAT1 NAGS MET SLC7A7 ACADVL HMGCL TXNRD2 TRNS2 ND3 SERPING1 NDUFS7 NNT UCP2 ST3GAL5 NDUFAF3 FOXP3 NDUFV1 TRNK ND4 SLC25A15 ND2 ALDH18A1 MMAA C1R NDUFS1 DBH KRIT1 SLC1A3 ND1 NDUFS4 LIPA HMBS CLMP ETFB ALAD ACADVL NDUFA6 SMPD1 SPP1 GALE AVPR2 GK GALT ALDOB TRNL1 SLC12A3 NDUFS3 ADNP MPI TRNL1 ND1 NDUFS8 KCNJ1 SAR1B ZEB2 SAA1 NDUFS6 ASL STAR MRAP TRNC POLG MVK MTHFD1 ATP6V0A4 HNF4A D2HGDH NDUFB9 LPL MEN1 CYP11B1 SLC12A1 CYP11A1 HADH STK11 CACNA1A C1QA TIMMDC1 TRNK SLC6A8 ESR1 ETFDH HIBCH APC FOXRED1 ALG3 NR3C2 EDNRA ND3 PDCD10 PIGY IRAK1 ACSF3 DGUOK C11ORF95 MMUT CTNS TMEM126B KCNJ11 ND5 PHGDH NDUFAF1 PCCA MVK HMGCS2 ATP6 NDUFAF2 IVD NEUROG3 ATRX NDUFS4 RRM2B KCNJ11 DLD
Nausea
Genes 59
FSHR NAGS SLC7A7 KCNJ5 ALDOB GLA SAA1 SNCA CYP11B1 SDHAF2 SERPING1 CYP11B2 FSHR VPS13C TYMP LPL UCHL1 KCNA1 MGME1 CFI ETFA PARK7 SLC25A11 ESR1 CD46 TNF KIF1B MAX VHL TP53 ETFDH LRRK2 APC PRKN RET SLC1A3 INHBA EDNRA HMBS SDHC FH DNAJC6 PINK1 TMEM127 PODXL HTRA2 ETFB HELLPAR SDHA SDHD MGME1 CFH DLST ALDOB MDH2 SDHB CACNA1D RRM2B POLG