SNPMiner Trials by Shray Alag


SNPMiner SNPMiner Trials (Home Page)


Report for Mutation G17T

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 An Open Label, Sequential Multi-Center Multi Dose Study Of G17T Immunogen In Combination With Cisplatin (CDDP) And 5-Fluorouracil (5-FU) In Subjects With Metastatic Or Locally Recurrent Gastric Or Gastroesophageal Cancer Previously Untreated With Chemotherapy For Advanced Disease (Stage IV)

RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining vaccine therapy with chemotherapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining vaccine therapy and chemotherapy in treating patients who have metastatic or locally recurrent stomach cancer or esophageal cancer.

NCT00020787 Esophageal Cancer Gastric Cancer Biological: G17DT Immunogen Drug: cisplatin Drug: fluorouracil
MeSH: Stomach Neoplasms Esophageal Neoplasms
HPO: Esophageal neoplasm Neoplasm of the stomach

An Open Label, Sequential Multi-Center Multi Dose Study Of G17T Immunogen In Combination With Cisplatin (CDDP) And 5-Fluorouracil (5-FU) In Subjects With Metastatic Or Locally Recurrent Gastric Or Gastroesophageal Cancer Previously Untreated With Chemotherapy For Advanced Disease (Stage IV). --- G17T ---

Primary Outcomes

Measure: To determine whether a concomitant G17DT-chemotherapy regimen affects tumor response in subjects with gastric or gastroesophageal cancer.

Time: 6 months to 1 year

Secondary Outcomes

Measure: Time to disease progression, best overall response, and survival will be evaluated in the intent-to-treat population and the evaluable population.

Time: 6 months to 1 year


HPO Nodes


Esophageal neoplasm
Genes 21
RHBDF2 PDGFRA FH KIT RAD21 CTHRC1 DLEC1 WWOX STK11 ASCC1 TGFBR2 SDHB KIT RNF6 APC SDHA SDHC RHBDF2 STAT1 MSR1 APC
Neoplasm of the stomach
Genes 75
CASP10 IL1B SMAD4 KIT IL1RN TRIP13 MGMT SMAD4 FLCN AKT1 BCL10 SUFU MSH6 APC SDHC NRAS CDKN2B BUB1B SRC BUB1 ACD APC KLF6 APC MSH3 STK11 SDHB APC BUB3 DCC KRAS KIT MSH2 TP53 SEMA4A BAP1 PDGFRA CTNNB1 MITF MSH3 BMPR1A BUB1 DLC1 PIK3CA FGFR3 BMPR1A IRF1 MUTYH PTCH2 SDHA BMPR1A CDK4 CDKN2A EP300 BUB1B ENG FGFR2 AXIN2 TREX1 TERF2IP MC1R ERBB2 CEP57 RPS20 PTPRJ PRKAR1A PIK3CA POT1 PTCH1 CHEK2 TERT APC MLH1 CDH1 APC