SNPMiner Trials by Shray Alag


SNPMiner SNPMiner Trials (Home Page)


Report for Mutation K55R

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There are 3 clinical trials

Clinical Trials


1 The Role of the Functionally Relevant Single Nucleotide Polymorphisms CYP2J2 -50G>T (CYP2J2 7) and EPHX2 9846A>G (EPHX2 K55R) in Human Endothelial Function

Background: - The endothelium is the inner lining of blood vessels. The cells in this lining help regulate blood flow and immune system function. Problems with endothelial cells can contribute to heart disease, high blood pressure, and diabetes. Certain genes or parts of genes may be related to problems with endothelial function. Researchers want to study healthy adults who have genes that may affect their endothelial function. More information on these genes may provide more information on genetic risk for certain diseases. Objectives: - To study healthy adults who have genetic markers related to endothelial cell problems. Eligibility: - Healthy volunteers between 18 and 65 years of age. - Current participants of the Environmental Polymorphisms Registry and have certain genes related to endothelial cell problems. Design: - Participants will have a single study visit to collect information and samples. - Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected. - Participants will have an ultrasound of the artery in the arm and will be given a short-acting medication called nitroglycerin to study blood flow and blood pressure.

NCT01524549 Cardiovascular Disease
MeSH: Cardiovascular Diseases
HPO: Abnormality of the cardiovascular system

The Role of the Functionally Relevant Single Nucleotide Polymorphisms CYP2J2 -50G>T (CYP2J2 7) and EPHX2 9846A>G (EPHX2 K55R) in Human Endothelial Function. --- K55R ---

- INCLUSION CRITERIA: - Participant of the Environmental Polymorphisms Registry and current contact information available - Genotype information available for relevant CYP2J2 and EPHX2 polymorphisms, which indicates: - WT for EPHX2 K55R and WT for CYP2J2 7 - WT for EPHX2 K55R and heterozygous for CYP2J2 7 - WT for EPHX2 K55R and homozygous for CYP2J2 7 - WT for CYP2J2 7 and heterozygous for EPHX2 K55R (N=30) - WT for CYP2J2 7 and homozygous for EPHX2 K55R (N=30) - Age 18-70 years - Willing and able to provide informed consent - Able to comply with all protocol procedures EXCLUSION CRITERIA: - Currently pregnant or breast feeding - Hospitalized for a cardiovascular disease or stroke event within the previous 3 months - Current use of long-acting nitrates (e.g., isosorbide mononitrate, isosorbide dinitrate) - Current use of medications taken for hypertension. --- K55R ---

- INCLUSION CRITERIA: - Participant of the Environmental Polymorphisms Registry and current contact information available - Genotype information available for relevant CYP2J2 and EPHX2 polymorphisms, which indicates: - WT for EPHX2 K55R and WT for CYP2J2 7 - WT for EPHX2 K55R and heterozygous for CYP2J2 7 - WT for EPHX2 K55R and homozygous for CYP2J2 7 - WT for CYP2J2 7 and heterozygous for EPHX2 K55R (N=30) - WT for CYP2J2 7 and homozygous for EPHX2 K55R (N=30) - Age 18-70 years - Willing and able to provide informed consent - Able to comply with all protocol procedures EXCLUSION CRITERIA: - Currently pregnant or breast feeding - Hospitalized for a cardiovascular disease or stroke event within the previous 3 months - Current use of long-acting nitrates (e.g., isosorbide mononitrate, isosorbide dinitrate) - Current use of medications taken for hypertension. --- K55R --- --- K55R ---

- INCLUSION CRITERIA: - Participant of the Environmental Polymorphisms Registry and current contact information available - Genotype information available for relevant CYP2J2 and EPHX2 polymorphisms, which indicates: - WT for EPHX2 K55R and WT for CYP2J2 7 - WT for EPHX2 K55R and heterozygous for CYP2J2 7 - WT for EPHX2 K55R and homozygous for CYP2J2 7 - WT for CYP2J2 7 and heterozygous for EPHX2 K55R (N=30) - WT for CYP2J2 7 and homozygous for EPHX2 K55R (N=30) - Age 18-70 years - Willing and able to provide informed consent - Able to comply with all protocol procedures EXCLUSION CRITERIA: - Currently pregnant or breast feeding - Hospitalized for a cardiovascular disease or stroke event within the previous 3 months - Current use of long-acting nitrates (e.g., isosorbide mononitrate, isosorbide dinitrate) - Current use of medications taken for hypertension. --- K55R --- --- K55R --- --- K55R ---

- INCLUSION CRITERIA: - Participant of the Environmental Polymorphisms Registry and current contact information available - Genotype information available for relevant CYP2J2 and EPHX2 polymorphisms, which indicates: - WT for EPHX2 K55R and WT for CYP2J2 7 - WT for EPHX2 K55R and heterozygous for CYP2J2 7 - WT for EPHX2 K55R and homozygous for CYP2J2 7 - WT for CYP2J2 7 and heterozygous for EPHX2 K55R (N=30) - WT for CYP2J2 7 and homozygous for EPHX2 K55R (N=30) - Age 18-70 years - Willing and able to provide informed consent - Able to comply with all protocol procedures EXCLUSION CRITERIA: - Currently pregnant or breast feeding - Hospitalized for a cardiovascular disease or stroke event within the previous 3 months - Current use of long-acting nitrates (e.g., isosorbide mononitrate, isosorbide dinitrate) - Current use of medications taken for hypertension. --- K55R --- --- K55R --- --- K55R --- --- K55R ---

- INCLUSION CRITERIA: - Participant of the Environmental Polymorphisms Registry and current contact information available - Genotype information available for relevant CYP2J2 and EPHX2 polymorphisms, which indicates: - WT for EPHX2 K55R and WT for CYP2J2 7 - WT for EPHX2 K55R and heterozygous for CYP2J2 7 - WT for EPHX2 K55R and homozygous for CYP2J2 7 - WT for CYP2J2 7 and heterozygous for EPHX2 K55R (N=30) - WT for CYP2J2 7 and homozygous for EPHX2 K55R (N=30) - Age 18-70 years - Willing and able to provide informed consent - Able to comply with all protocol procedures EXCLUSION CRITERIA: - Currently pregnant or breast feeding - Hospitalized for a cardiovascular disease or stroke event within the previous 3 months - Current use of long-acting nitrates (e.g., isosorbide mononitrate, isosorbide dinitrate) - Current use of medications taken for hypertension. --- K55R --- --- K55R --- --- K55R --- --- K55R --- --- K55R ---

This is a cross-sectional, controlled study designed to investigate the association of two single nucleotide polymorphisms (SNPs) - a cytochrome P450 (CYP) epoxygenase gene CYP2J2 SNP, CYP2J2 7, and a soluble epoxide hydrolase (sEH) gene EPHX2 SNP encoding a K55R variant - with altered endothelial function in humans. --- K55R ---

Healthy adults, aged 18-65 years, who are either carriers of CYP2J2 7 or EPHX2 K55R, or who are wild type (WT) with respect to either SNP will be recruited into a total of five genotype groups. --- K55R ---

The primary objective of the study is to determine whether individuals who are homozygous or heterozygous for the CYP2J2 7 or EPHX2 K55R SNPs exhibit altered endothelial function compared with individuals who are WT for that SNP. --- K55R ---

Primary Outcomes

Description: Change in digital pulsatile pressure-Endothelium- independent vasodilation- Change in brachial artery blood flow velocity - Serum levels of inflammatory markers -Serum and urine levels of cytochrome P450 epoxygenase pathway biomarkers

Measure: Change in digital pulsatile pressure
-Endothelium- independent vasodilation
- Change in brachial artery blood flow velocity
- Serum levels of inflammatory markers
-Serum and urine levels of cytochrome P450 e...

Time: analysis

Secondary Outcomes

Description: Change in digital pulsatile pressure-Endothelium- independent vasodilation- Change in brachial artery blood flow velocity - Serum levels of inflammatory markers -Serum and urine levels of cytochrome P450 epoxygenase pathway biomarkers

Measure: Change in digital pulsatile pressure
-Endothelium- independent vasodilation
- Change in brachial artery blood flow velocity
- Serum levels of inflammatory markers
-Serum and urine levels of cytochrome P450 e...

Time: analysis

2 Role of Epoxyeicosatrienoic Acids in Chronic Allograft Nephropathy

Endothelial lesions within the transplanted kidney are a major determinant of chronic allograft nephropathy. Epoxyeicosatrienoic acids (EETs) are endothelium-derived hyperpolarizing factors with anti-inflammatory, antiproliferative and vasodilator properties. The main goal of the investigators' study is to evaluate whether genetic polymorphisms of specific enzymes responsible for the bioavailability of EETs are associated with post-transplant kidney function. To this end, 80 kidney transplant recipients will be included. Prespecified genetic polymorphisms of CYP 2J2, CYP 2C8, CYP 2C9, CYP 2C9, CYP 2C19 and EPHX2 will be determined. Kidney function will be recorded 3, 6, 12 and 36 months after transplantation. Flow-mediated dilatation, EETs and circulating biomarkers of endothelial function will be measured in the radial artery. The expected results of this study to provide preliminary evidence supporting a beneficial role of an increase in the bioavailability of EETs in kidney transplant recipients.

NCT02555566 Kidney Transplant Recipients Procedure: Blood sampling Procedure: flow-mediated distal stimulation of the forearm radial artery by cutaneous heating
MeSH: Kidney Diseases
HPO: Abnormality of the kidney Nephropathy

Difference between patients with the EPHX2 Lys55Arg polymorphism and patients without in estimated Glomerular Filtration Rate (eGFR). --- Lys55Arg ---

Primary Outcomes

Description: eGFR Scores range from 0 [kidney failure] to >90 [normal function]

Measure: Difference between patients with the EPHX2 Lys55Arg polymorphism and patients without in estimated Glomerular Filtration Rate (eGFR)

Time: 12 Months after transplantation

Secondary Outcomes

Description: eGFR Scores range from 0 [kidney failure] to >90 [normal function]

Measure: Difference between patients with the EPHX2 Lys55Arg polymorphism and patients without in estimated Glomerular Filtration Rate (eGFR)

Time: 3 Months after transplantation

Description: eGFR Scores range from 0 [kidney failure] to >90 [normal function]

Measure: Difference between patients with the EPHX2 Lys55Arg polymorphism and patients without in estimated Glomerular Filtration Rate (eGFR)

Time: 6 Months after transplantation

Description: eGFR Scores range from 0 [kidney failure] to >90 [normal function]

Measure: Difference between patients with the EPHX2 Lys55Arg polymorphism and patients without in estimated Glomerular Filtration Rate (eGFR)

Time: 36 Months after transplantation

Description: eGFR Scores range from 0 [kidney failure] to >90 [normal function]

Measure: Difference between patients with specified polymorphisms and patients without in estimated Glomerular Filtration Rate (eGFR)

Time: 3 Months after transplantation

Description: eGFR Scores range from 0 [kidney failure] to >90 [normal function]

Measure: Difference between patients with specified polymorphisms and patients without in estimated Glomerular Filtration Rate (eGFR)

Time: 6 Months after transplantation

Description: eGFR Scores range from 0 [kidney failure] to >90 [normal function]

Measure: Difference between patients with specified polymorphisms and patients without in estimated Glomerular Filtration Rate (eGFR)

Time: 12 Months after transplantation

Description: eGFR Scores range from 0 [kidney failure] to >90 [normal function]

Measure: Difference between patients with specified polymorphisms and patients without in estimated Glomerular Filtration Rate (eGFR)

Time: 36 Months after transplantation

Description: EEts plasma concentration is measured using liquid chromatography coupled to tandem mass spectrometry before and after distal cutaneous heating. Unit is ng per mL

Measure: Difference between blood EETs concentration at baseline and after distal cutaneous heating for patients with the specified polymorphisms.

Time: Day 1

Description: EEts plasma concentration is measured using liquid chromatography coupled to tandem mass spectrometry before and after distal cutaneous heating. Unit is ng per mL

Measure: Difference between blood EETs concentration at baseline and after distal cutaneous heating for patients without the specified polymorphisms.

Time: Day 1

Description: Variation of diameter of the radial artery is measured in millimeter.

Measure: Difference between variation of diameter of the forearm radial artery after distal cutaneous heating for patients with the specified polymorphisms.

Time: Day 1

Description: Variation of diameter of the radial artery is measured in millimeter.

Measure: Difference between variation of diameter of the forearm radial artery after distal cutaneous heating for patients without the specified polymorphisms.

Time: Day 1

3 Cytochrome P450 Epoxygenase Pathway Regulation of Macrophage Function

Background: Respiratory diseases affect more than 1 billion people worldwide. They are a growing public health concern. The lungs are constantly exposed to environmental factors such as dust, fumes, microbes, and pollutants. But much is still not known about how these pollutants lead to respiratory illnesses. Researchers want to collect samples from lungs and blood to see how genetics and environmental pollutants affect cellular responses or functioning. Objectives: To study how cytochrome P450 epoxygenase pathway enzymes affect macrophage function in the lungs and inflammatory responses. Eligibility: Adults ages 18 65 who can have a bronchoscopy. Design: All study visits will take place at the NIEHS Clinical Research Unit in Research Triangle Park, NC. At study visit 1, participants will be screened with medical history and physical exam. They will have blood and urine tests. They will take tests that measure their lung function. They will answer questionnaires. Before the visit, they will be given a list of medicines they cannot take. They also must not have caffeine on the day of their visit. The visit will last about 3 hours. At study visit 2, participants will give blood samples. They will undergo bronchoscopy. For this, they will get an intravenous line in a vein to get sedatives. Their airways will be numbed. Cells will be collected from their lungs. They will fast for 8 hours before the visit. They must have someone else drive them home from the visit. The visit will last about 3-4 hours. Participants will get a follow-up phone call about 1 day after study visit 2.

NCT02743468 Polymorphism Lung Inflammation
MeSH: Pneumonia Inflammation
HPO: Pneumonia

- INCLUSION CRITERIA: 1. Age 18 to 65 years, inclusive (males and females) 2. Able to travel to the NIEHS CRU for required study visits 3. Able to present a valid government-issued form of identification for entry to the NIEHS campus 4. Able to fast for 8 hours prior to the visit where bronchoscopy occurs 5. Has a responsible party who is willing and able to attend Visit 2 and drive the participant away from the CRU after completion of Visit 2, if the participant elects to undergo conscious sedation 6. Genotype information available for relevant CYP2J2 and EPHX2 polymorphisms, which indicates: - Wild type with respect to EPHX2 K55R, EPHX2 R287Q, and CYP2J2*7; or - Homozygous for EPHX2 K55R (wild type for the other SNPs); or - Homozygous for EPHX2 R287Q (wild type for the other SNPs); or - Homozygous for CYP2J2*7 (wild type for the other SNPs) EXCLUSION CRITERIA: 1. --- K55R ---

- INCLUSION CRITERIA: 1. Age 18 to 65 years, inclusive (males and females) 2. Able to travel to the NIEHS CRU for required study visits 3. Able to present a valid government-issued form of identification for entry to the NIEHS campus 4. Able to fast for 8 hours prior to the visit where bronchoscopy occurs 5. Has a responsible party who is willing and able to attend Visit 2 and drive the participant away from the CRU after completion of Visit 2, if the participant elects to undergo conscious sedation 6. Genotype information available for relevant CYP2J2 and EPHX2 polymorphisms, which indicates: - Wild type with respect to EPHX2 K55R, EPHX2 R287Q, and CYP2J2*7; or - Homozygous for EPHX2 K55R (wild type for the other SNPs); or - Homozygous for EPHX2 R287Q (wild type for the other SNPs); or - Homozygous for CYP2J2*7 (wild type for the other SNPs) EXCLUSION CRITERIA: 1. --- K55R --- --- R287Q --- --- K55R ---

EXCL 4. Any food or fluids for 8 hours prior to the bronchoscopy - INCLUSION CRITERIA: 1. Age 18 to 65 years, inclusive (males and females) 2. Able to travel to the NIEHS CRU for required study visits 3. Able to present a valid government-issued form of identification for entry to the NIEHS campus 4. Able to fast for 8 hours prior to the visit where bronchoscopy occurs 5. Has a responsible party who is willing and able to attend Visit 2 and drive the participant away from the CRU after completion of Visit 2, if the participant elects to undergo conscious sedation 6. Genotype information available for relevant CYP2J2 and EPHX2 polymorphisms, which indicates: - Wild type with respect to EPHX2 K55R, EPHX2 R287Q, and CYP2J2*7; or - Homozygous for EPHX2 K55R (wild type for the other SNPs); or - Homozygous for EPHX2 R287Q (wild type for the other SNPs); or - Homozygous for CYP2J2*7 (wild type for the other SNPs) EXCLUSION CRITERIA: 1. --- K55R ---

EXCL 4. Any food or fluids for 8 hours prior to the bronchoscopy - INCLUSION CRITERIA: 1. Age 18 to 65 years, inclusive (males and females) 2. Able to travel to the NIEHS CRU for required study visits 3. Able to present a valid government-issued form of identification for entry to the NIEHS campus 4. Able to fast for 8 hours prior to the visit where bronchoscopy occurs 5. Has a responsible party who is willing and able to attend Visit 2 and drive the participant away from the CRU after completion of Visit 2, if the participant elects to undergo conscious sedation 6. Genotype information available for relevant CYP2J2 and EPHX2 polymorphisms, which indicates: - Wild type with respect to EPHX2 K55R, EPHX2 R287Q, and CYP2J2*7; or - Homozygous for EPHX2 K55R (wild type for the other SNPs); or - Homozygous for EPHX2 R287Q (wild type for the other SNPs); or - Homozygous for CYP2J2*7 (wild type for the other SNPs) EXCLUSION CRITERIA: 1. --- K55R --- --- R287Q --- --- K55R ---

Primary Outcomes

Description: The primary outcome measure will evaluate macrophage phagocytosis of fluorescein isothiocyanate (FITC)-labeled beads and bacteria (Streptococcus pneumoniae) in an ex vivo assay, comparing alveolar macrophages from groups of individuals with and without EPHX2 and CYP2J2 polymorphisms of interest.

Measure: The primary outcome measure will evaluate macrophage phagocytosis of fluorescein isothiocyanate (FITC)-labeled beads and bacteria (Streptococcus pneumoniae) in an ex vivo assay, comparing alveolar macrophages from groups of individuals with and ...

Time: Cross-sectional

Secondary Outcomes

Description: Macrophage phagocytosis of FITC-labeled beads and bacteria (S. pneumoniae) in an ex vivo assay, comparing peripheral blood monocyte derived macrophages from groups of individuals with and without EPHX2 and CYP2J2 polymorphisms of interest

Measure: A

Time: Cross-sectional

Description: Ex vivo gene expression of inflammatory receptors [e.g., toll-like receptor (TLR) 2 and peptidoglycan recognition protein (PGLYRP) 1] and cytokines [e.g., interleukin (IL) -1beta, IL-6, and tumor necrosis factor (TNF)-alpha] in stimulated macrophages (alveolar and peripheral blood monocytederived)

Measure: B

Time: Cross-sectional

Description: Assessment of the lower airway microbiome from BAL fluid

Measure: C

Time: Cross-sectional

Description: Eicosanoid [EET and dihydroxyeicosatrienoic acids (DHET)] and cytokine (e.g., IL- 1beta, IL-6, and TNF-alpha) levels in serum and BAL

Measure: D

Time: Cross-sectional

Description: Differences in effect of functional polymorphisms on macrophage function, comparing interferon (IFN)- gamma-derived (M1) versusIL-4-derived (M2) macrophages

Measure: E

Time: Cross-sectional


HPO Nodes


Abnormality of the kidney
Genes 1660
GPC3 UBR1 FAT4 GLI3 IL17RA SOX9 STRA6 CASP10 PIGL PLCE1 SDCCAG8 KRT17 GLI1 SDHD COL4A4 LRP4 NDUFB10 LMNA FAT4 FGF8 WAS TXNL4A ROR2 CTU2 REN ENPP1 PLG LRP5 HSD11B2 GBA RAB23 AXIN2 DYNC2LI1 WDR19 SPRY2 ASXL1 PNPLA6 PIGV TBX1 NPHP4 TMEM67 CFH BLK MYO1E ZFPM2 SPINK5 HIRA GBE1 ALG9 WDR60 CFHR5 MCTP2 BUB1B LHX1 BCOR HLA-DPB1 KAT6B PET100 MEFV SF3B4 SSR4 IL10 PYCR2 CDK6 WDR73 SLC36A2 YAP1 PIK3C2A B3GLCT FCGR2A COG6 B9D2 IGF2 OGG1 ITGB4 HPRT1 IFT27 NUP205 COQ8B CWC27 RNU4ATAC LDLRAP1 GTF2I CCNQ SLC25A22 RPGRIP1L ZNF687 COA8 FAM20C RPS26 ACVRL1 VPS33B COPB2 GABBR2 RECQL4 CYP4F22 DLL1 ITGA2B ND4 CCR6 ND2 DCHS1 C1R BBS7 KLLN OCRL SIX3 PEX6 TRNE CD81 CHD7 CRB2 BRCA1 WDR35 ETFB MARS1 FLNB DVL1 LETM1 MAP2K2 HRAS WT1 NDUFB8 NEK8 GREB1L KCTD1 CEP41 ARID1B LRIG2 SERPINF2 GATA3 CC2D2A SDHB GPC4 XDH LDLR AR SAA1 MET ALG9 CLDN10 DUSP6 PACS1 SDHD EFEMP2 SMARCC2 AGGF1 MAP2K1 PIGA ESCO2 ITGA3 HNF1A CFI ALG1 RAD51C DNAJB11 DGKE MINPP1 APOA1 TTR KIF14 AFF4 FLNA ZAP70 WDR34 GLA MYH11 NDUFAF1 DYNC2LI1 KCNJ11 HYLS1 VHL ATP6 TTC21B RAD51C DDX59 RMRP FGA COL5A2 VAMP7 NDUFB3 APOB CCR1 SON PDE6D GP1BA KCNQ1OT1 STRA6 FANCD2 GAS1 KMT2D FAM20A ATRX RFC2 FAM20A WIPF1 TRNT CLDN19 PTH1R SLC37A4 TBC1D20 SRY TRNQ PTPN22 TRNN IL17F MEFV FIBP SCARB2 FANCI RPGRIP1L GP9 UMPS MKKS NSD2 MAP3K1 BSCL2 VANGL1 MAD2L2 PTPN22 SEMA3A SLC3A1 TMEM216 SCN2A OFD1 SMARCAL1 WDR4 UMOD GPR35 FGF10 FANCA COL4A4 HLA-DPA1 CD96 SLX4 STIL CEP290 TAPT1 CEP55 SIX5 MKS1 SCNN1A CEP83 FLNA BBS2 OSGEP PLVAP KMT2D LAMB2 PPP2R3C SMC1A TSC1 MICOS13 HNF1B TP53 FUT8 WT1 ZNF592 RFWD3 TMEM67 NPHP1 HLA-DRB1 BRAF BUB1 LPIN1 ELN TACR3 LRIG2 ITGB3 EMP2 PDSS2 NDUFV1 FREM2 SMOC1 LIPN PLD1 SLC2A2 FGFR3 ACSL4 PTPN11 SHANK3 KANSL1 ALPL SDHB PALB2 MYMK HNF1A KAT6A UMOD GPKOW SLC30A9 TREX1 WDR4 SNAP29 CCDC141 WASHC5 ND3 NPHP3 INS HPSE2 TSC2 NDUFS7 BUB1 CENPF SHH ERAP1 CEP290 COPA PEX12 EYA1 ANLN ZIC2 PLG SOX10 BRAF DLC1 ITGB3 FCGR2B ALMS1 NLRP3 ITGA8 PDX1 GANAB KDM6A NARS2 PQBP1 BBIP1 EVC CTLA4 AVPR2 TRNS1 H19 H19 BRCA2 AIRE NDUFS3 SDCCAG8 AKT1 CCND1 PBX1 HLA-DRB1 PGAP3 GPC4 ACP5 ARX CDC73 MAGI2 PEX16 ND1 IFT27 AHI1 OCRL RAB3GAP1 BBS1 TMEM127 TCF4 ARID2 NPHP1 PEX2 PIK3CA FRAS1 PIK3CA RAB3GAP2 CASR ETFDH WDR19 SF3B4 APPL1 FLII ACTN4 C1QA C4A FKRP AGPAT2 IQCB1 USP9X FANCC COLEC11 NIPAL4 WRN MEFV PKHD1 ZNF423 NTNG1 KIF1B TRNT1 PEX13 MMUT UBE2T DACT1 PEX1 DZIP1L ND5 SBDS ADGRG2 ABCG8 B2M RAI1 GATA4 LAGE3 NLRP3 BRCA2 ANOS1 IQSEC2 PKD1 SLC6A19 CYB561 WT1 CASR NUBPL MYLK TCTN3 TMEM216 TMEM231 STXBP1 NPHP4 CC2D2A IRF2BP2 KCNA1 KEAP1 SEC63 WT1 KYNU ERCC4 KCNJ5 OCRL FLNA VIPAS39 SOX4 PAX6 GLI3 CDKL5 SCNN1G SCNN1B FOXF1 INPP5E YAP1 RPGRIP1L POU6F2 CAMKMT NDUFA11 SIX5 SLC4A4 H19-ICR PORCN SLC7A7 TRIM28 CDKL5 GP1BA SI PUF60 GLIS2 GDF6 FIP1L1 NDUFS2 PIGW BMPER TMEM107 MAP3K7 COL5A1 TMEM216 AMMECR1 TBC1D24 COX20 IFT43 COG7 FANCI FAH SEC24C IL2RG CCND1 NUMA1 H19 NRAS FLI1 FGFR1 CA2 PAFAH1B1 CACNA1D NAA10 MKKS SOX11 REST TDGF1 HMGA2 GALNT3 PEX14 CORIN FANCA PRDM16 FOS BBS10 ARL3 GEMIN4 NDUFAF3 PIEZO2 TRIP11 HBB CAV1 STS FANCB RARB TBX15 MMUT ANTXR1 POLR3A BCOR SMAD4 UMOD LCAT EDNRB NOTCH2 SEMA3E ADAMTS13 PRKCSH AMMECR1 FASTKD2 SIX1 NDUFA6 SPP1 ALG8 GCM2 RPGRIP1 ATP7B CEP63 PEX1 KCNE5 ALDOB TRIM28 RPGRIP1L SNAI2 CCN2 FGFR2 TMEM231 GRHPR CPT2 FKTN LEMD3 PTPN22 COX1 COL14A1 ZEB2 WT1 CFTR KCNQ1OT1 C4A COQ7 TMEM237 CLDN19 FANCC EVC2 NDUFB9 LPIN2 RREB1 PDSS2 STK11 HESX1 PLAGL1 APC MYT1 CCDC22 GRHPR SCO1 SLC4A1 GDF3 RET PIGY TRIM32 PRKCD GSN PHYH COX10 TMEM126B DYNC2H1 FLT1 ADA BUB1B KNL1 CPLANE1 IFT43 CDC73 CLCNKB TREX1 PRTN3 COL3A1 FXYD2 FLNA BMPER MBTPS2 APC APC2 MME FOXI1 DYNC2H1 BBS9 WNT5A NDUFA1 NSD1 PEX7 NPHP4 TRNW RPL11 FLNB ND6 ABCC8 WDR35 FANCB TRNV ND4 INF2 GNAS WASHC5 SLC49A4 NDUFAF3 COL4A1 APRT ITPR3 ETFA ARHGDIA TACO1 SEC61A1 HNF1B CLCN5 TBX1 NEUROD1 ACTG2 NADK2 MSH3 GTF2IRD1 RAI1 SALL4 PML CACNA1S IFT140 GATA3 C1QBP NBN MAPKBP1 SPECC1L ADCY10 BMP4 PLCD1 SETD5 HPRT1 TMEM237 F10 MLH1 MUC1 AMER1 KIAA0753 TP53RK MAP3K7 NDUFAF4 HMGA2 HS6ST1 KDM6A CLCN5 FBXL4 ROR2 USP8 PGAP2 WNT4 KANK2 GLIS3 WDR34 CAVIN1 BNC2 GBA CFI SIX1 ZFP57 KCNJ11 FANCE FANCM MAX CASR RNF139 RAF1 NCAPD3 MAGED2 ZNF423 FLNA CFI HNF1B PGM3 AAGAB IL12A CYP11B2 ELP1 VHL FLCN SLC37A4 DZIP1L PIGN NCAPG2 SLC22A12 FH CLCNKB LRP5 CRTAP RBM10 NDUFB11 NDUFAF3 FAT4 IFT172 LRP2 DYNC2H1 TFAP2A INF2 STAT3 PTPN22 TRIP13 AKT1 ALOXE3 SGPL1 DHDDS SDHC TTC37 CTNS WDR35 GP1BB C1QB PDX1 EXT2 NUP107 SPART RRM2B OCLN ENPP1 FANCE COL4A3 PEX5 KCNJ10 PIGL RTTN MYO5B CYP27A1 BAP1 PAX2 PYGM WDR19 SETBP1 DCLRE1C RNU4ATAC FBN1 IL7R CEP290 PIGO COL4A5 PIK3CA NOD2 ADCY10 TMEM260 POR SLC2A9 MITF DYNC2LI1 NSD1 SLC35A2 TRNL1 WDR19 ITGB4 WAS SHH SMC1A NUP133 PGK1 NDUFS8 RET STAT4 GRIA3 IKZF1 HIC1 MYH9 KCNJ10 CACNA1D PCK2 RAD21 PEX19 HABP2 KLHL7 H19 CDC42 UBR1 HNF4A SCO2 ATP1A1 CPLANE1 ROBO2 TRAF3IP1 CDH23 WT1 NR0B1 ELP1 HSPA9 SLC3A1 POR KCTD1 DKC1 NUP133 ND3 IRAK1 GRIP1 MMUT ABCC6 MEFV UQCC2 SON KCNAB2 PTPRJ POLE ATRX B9D2 HOXA13 RBM8A PHF21A ATRX ARID1B CLPB HNF1B WDR34 RIPK4 TP63 HPSE2 NUP160 TRIM37 MBTPS2 STX3 AGPAT2 PORCN COQ2 FRAS1 LZTFL1 FH TGIF1 HMBS PHGDH C8ORF37 SALL1 WDPCP SCNN1B SLC25A11 PRKCD BBS4 COQ2 PIGA TMEM67 YY1AP1 NR5A1 CYP24A1 DICER1 CA2 IFT172 PMM2 NPHP3 GCK TTC21B DSTYK HGD PAH WDR73 GNAO1 ACTG1 NDUFAF5 SALL4 MKS1 NDUFV2 ALOX12B LAMB2 PREPL PAX2 WFS1 PPM1B INSL3 TRNL1 CEP290 HOXD13 COX8A EYA1 ALDH18A1 WDR19 WT1 WNT4 KAT6B PUF60 TCTN2 TRNF TBL1XR1 CLCN5 EP300 COX14 LIPT2 GLI2 ARX SLC1A1 DCC STRADA WT1 SLC6A20 PEX5 PTEN LEMD3 SNRPB C1QC BRCA2 GREB1L NOTCH3 CDKN1C ARVCF MST1 CFH TMEM237 B9D1 AQP2 PIGV TMEM127 SDHA IGF2 SULT2B1 CHST14 JMJD1C TFE3 PGAM2 ND5 FGF17 APC HSD17B4 NF1 CEP55 SDR9C7 TMEM138 SUFU ZIC3 SLITRK6 VDR TTC37 SHPK KIAA0586 TP53RK SMARCA4 NFIA BUB1B PEX2 BCS1L AIP HNF4A MOCS1 BCS1L MNX1 SDHB MEN1 XPNPEP3 CRB2 ERCC4 RMND1 LAGE3 VHL HNF1A FANCD2 NODAL XRCC4 ND1 NPHP1 CCNQ FGFR3 CHD4 PKHD1 ZIC3 KIF14 ITGA2B CTLA4 POMT2 PEX11B SDHD KRAS RAI1 ITGA8 INVS NPM1 SLX4 USP8 DVL3 CCDC141 NPHS1 DDX59 ACTG2 COL1A1 CHRM3 MDM2 IL6 HSPG2 FGFR1 BBS10 ABCC8 RERE MSH6 CCBE1 WDR60 PGM3 CEP135 MKKS BBS5 FANCL CLCNKA COX3 FOXF1 RBM10 IGF2 NUP93 SLC12A1 MASP1 POMT1 CDC73 PHEX INVS HLA-B MAFB COX2 ARX SOX9 DNAJC21 FAS BBS12 FREM2 OSTM1 IFT140 BTNL2 GPC3 SLC34A3 DNA2 TRIM8 PEX3 GDNF ACTB PTEN ZBTB16 GPC4 DICER1 PIK3CA ABCC6 PPARG KITLG SLC9A3R1 BCOR STAT5B NLRP3 SF3B4 COQ6 G6PC3 CSPP1 COL7A1 PHYH NPHP1 EPG5 SETD2 REN LIG4 MKKS POU3F4 STOX1 RFWD3 HYMAI NRIP1 HLA-B RAP1A CDK4 CPT2 GSN PCK1 ATN1 ALX4 FGFR3 SIK1 CEP164 SLC25A20 PIGL STAT4 ABCA12 XYLT2 CCBE1 FLNA AP2S1 PEX3 CFH RET PIGY LZTFL1 STAT1 KISS1R CASP10 RAD21 TRIP13 MYD88 GLA B3GLCT NOTCH2 FAN1 GLMN BSND RAP1B CC2D2A CLDN16 TMCO1 TNXB FGF20 THOC6 ENPP1 GCK ELN SMARCAL1 DNASE1L3 MCM5 FLCN MAX PALB2 MKS1 PKD2 CD46 DIS3L2 MITF TBCK RPL26 LMX1B PTPRO HDAC8 SPRY4 HOGA1 IL23R PIK3CA JAM3 ANOS1 NOTCH2 ND6 COG1 KYNU PROKR2 ADA ATP7A LMNA DLST ZAP70 UFD1 F2 EIF2AK3 STAT3 CC2D2A TMEM67 TGM1 APOE APOE WDPCP GNA11 RYR1 LMNB2 KCNJ10 SERPINH1 SDHAF2 RBM8A SOX9 CASK OFD1 APC PEX13 ESCO2 EHMT1 SASS6 TMEM231 TTC8 DMP1 CD2AP GCM2 TMEM70 TRRAP EYA1 KCNH1 TPRKB FAS DCDC2 TP63 TCTN2 SDHC APOL1 VPS33A LDHA DCC G6PC PRKAR1A THBD CISD2 TTC8 DCHS1 CHRM3 B9D1 AVPR2 RPS19 LRP4 NEK8 TFAP2A ARMC5 SLC12A3 FGFR2 TCTN3 PIK3R2 KMT2A CEL TP53 ARL6 MAP11 PAX1 TMEM216 TRIP13 AKT1 TMEM126B DPH1 SMARCB1 VAC14 TTC21B C8ORF37 TNXB SCARB2 PC DIS3L2 HNF4A NPHS2 NPHP3 WT1 COL4A3 TRNK WDR19 ADAMTSL1 PNKP UBAC2 AKT3 IL17RD RAG2 CTNNB1 NPHP1 CFTR CTNS ASPM AGT SARS2 RECQL4 ERCC8 MMACHC EBP PRKCSH CSPP1 FLCN STXBP1 TBC1D24 TMEM67 NIPBL CDON LYZ CDKN1C RASGRP1 FLRT3 CEP290 CENPJ BICC1 NSDHL DHCR7 TMEM231 NUP85 CTNNB1 CLCNKB WNT4 RPGRIP1L PEX19 ALG8 FGFR3 SOX10 FN1 DISP1 COX6B1 LMOD1 TPRKB TBC1D8B NOD2 CTH MFSD2A FANCF TBX18 ND2 KLF11 TAF13 SURF1 OPLAH IFIH1 WNT4 CILK1 MLXIPL BRAF CLIP2 DHCR24 POU6F2 SERPINA1 FLCN LARGE1 SH2B1 AGXT CDK5RAP2 CEP290 SHANK3 REST PGK1 NDUFS2 SDCCAG8 PRSS1 MSH2 SRP54 IFT172 TBL2 ALMS1 DNASE1 PLEC DMRT3 KRAS SLC17A5 NPHP3 CSPP1 IL12A-AS1 NABP1 TSC1 FH FANCG MEOX1 TCN2 DSTYK SFTPC PDE6D SLC29A3 B4GAT1 COMT CD151 SLC26A1 CLEC7A MCPH1 SKI WWOX HPRT1 GPC3 SRCAP WDR62 SLC7A7 IFT122 TBX22 APRT CLCN5 SPECC1L FLCN TRNH PEX10 ARID1A PIEZO2 PHC1 NUP107 CASR GP1BB CHN1 MAFB TRNL1 SOX17 BBS1 CPT1A KMT2A RAD51 FREM1 NDUFS1 GABRD FREM1 GP1BB SKIV2L WDR11 OSGEP MRPS22 DIS3L2 KIAA0753 NDUFS4 TRPC6 CD96 SC5D SDCCAG8 FANCB PAX4 SLC26A4 VHL NSMF NEK1 TRNS1 NPHP1 CAD OFD1 XRCC2 FOXC2 PEX10 FIG4 PCSK9 FBLN5 INTU GNA11 ANKS6 NIPBL WT1 COL4A1 IFT80 KCNJ1 HAAO VHL NDUFS6 HPRT1 HNRNPU ATP6V0A4 LMX1B CIT CDC73 TRNW PRCC YWHAE CDKN1B KYNU C1QA GDF6 TIMMDC1 TSC2 KLRC4 KIF1B DICER1 FOXRED1 ADAMTS3 PLG USP9X GLI3 RBBP8 WT1 POGZ WNT3 RSPO2 IFT80 CEP290 FANCB TMEM216 SMARCE1 FASLG PAX2 CREBBP SLC7A9 NDUFAF2 CTRC LTBP4 XYLT1 SPINK1 C3 PRDX1 WDR73 ERCC6 FGFR1 ANTXR1 TMEM67 DPF2 BAZ1B EHMT1 COA8 BSCL2 SLC34A1 INS KIF7 PROK2 NUP133 ABCC8 SMS NXN RERE IQCB1 DACT1 DLL4 ATRX CPT1A FGFR2 AQP2 IL17RC PIGQ ATP6V1B1 TMEM107 SMC3 FN1 CC2D2A CFB PTPN11 ARNT2 CPT2 ITGA2 RARA EP300 HELLPAR PMM2 PEX7 GNB1 MECP2 FOXG1 C3 IFNG MDH2 PIGP PRODH TRNK IRF5 ENG CTNS TALDO1 NPHP3 SLC4A1 ALDOB JAG1 DEAF1 NEUROD2 MAFB TSC1 EIF2AK3 H19 IGF2 OFD1 KCNQ1 ACE LMX1B GNB1 TRIM32 ANKLE2 PTCH1 PEX26 BUB3 COL25A1 AMMECR1 NAA10 SLC34A1 TRAF3IP2 TCTN3 WFS1 TRAF3IP1 LIG4 CEP120 ZNF148 SRY FEZF1 PREPL DNASE1L3 FAM149B1 FLNA HMOX1 SETBP1 MOCOS CEP164 FOXH1 MBTPS2 RAB18 HNF4A PIGN H19 HOGA1 CCND2 BBS12 TMEM138 ABCG5 CFHR1 GDF2 TSC2 KCNJ11 SOX18 NUP107 DHODH FUZ RAG1 TREX1 ERBB3 LMNA LMNB2 PEX1 SRC ARL6 PIGT FOXP3 ITGA6 PPP1R15B HDAC4 INPP5E SLC5A2 CHD7 PDGFRB ARL6IP6 CEP120 NSUN2 TRNS2 TMEM67 MED25 SLC34A1 TBX3 NELFA NPHS1 CAV1 HPS1 FOXE1 LIMK1 FGFR2 CCDC28B CFHR3 BBIP1 SC5D PTCH1 FAS PEX12 DHCR7 AGXT TMEM231 ND1 TLR4 PIGN PROKR2 SLC12A3 CD109 NRAS TBX1 CDKN1B CHD7 AGTR1 FGF8 SNRPB WNT3 FGFR2 MGME1 KLLN SLC3A1 PEX6 PPP3CA KIF14 SEC23B GPC3 CD46 ADA2 HRAS SEMA3E PRPS1 SALL1 CHD7 BRIP1 FANCL BBS4 COL4A3 SDHB CEP152 CIT CEP57 TBX1 PLCD1 CPT2 LEMD3 PIK3R2 MOCS2 IARS1 ABCC6
Abnormality of the cardiovascular system
Genes 4016
CLDN1 LETM1 FAT4 TNFRSF11A CPLANE1 GLI3 IL17RA PRKAR1A CCDC115 SOX9 CYP11B1 MYPN CYP11B2 F2 TET2 SDCCAG8 SMAD6 LMNB1 KIT GLI1 NDUFB10 EMD MYH6 C2CD3 GDNF PEPD DLL3 NBAS ABCA1 NEDD4L ARL3 FGF8 ROR2 PTCH2 PDE6G PRKCH CDKN2C SELENON TFAP2B GBA TREX1 SMAD6 ASXL1 PRPF31 PIGV POMT2 NPHP4 DDC TMEM67 SFTPB ZFPM2 SPINK5 HIRA SLC19A2 GBA CYP7A1 GAS8 MEN1 CEP57 GP1BA FKRP WDR60 MCTP2 KDR LMNA CSTA SDHC KCNH1 OPA1 FHL1 SGO1 ALDH18A1 EXT2 XRCC2 GPX4 GDF2 TNFSF4 NF1 CDON HLA-DPB1 KAT6B DNAAF1 NDUFS1 KCNE3 BCR APP MEFV SPAG1 CYLD CCDC40 JAK2 SSR4 IL10 TRDN ACTN2 HAMP NOTCH3 MYH7 MC2R CALR SCN1B EYA4 DDX58 B3GLCT FCGR2A SUFU IGSF3 IGF2 STN1 IFNG SH2B1 SCYL1 LMNA COL5A1 NONO ATIC SMAD3 TGFBR1 IFNGR1 SDHAF1 LONP1 DSG2 LDLRAP1 GTF2I CDC45 PDE3A BMP2 CCNQ GFI1B TXNRD2 RYR2 ATP5F1D SLC25A22 RPGRIP1L SGCG ZNF687 LRP5 DNMT3A VWF PRPF6 RPS26 PROP1 JAG1 PEX1 NCF1 PAFAH1B1 DLL1 BEST1 PIK3R2 ITGA2B ND4 SDHA CCR6 KDSR TBX3 SHOC2 PRKACG JUP DPF2 SCN5A MRPL3 TRNE CD81 F7 SDHB IGBP1 DSC2 LZTR1 BRCA1 ACADVL MAP2K2 CNGA3 HRAS WT1 NDUFB8 GREB1L GATA1 MTHFR KCTD1 TMPO GJA8 MAK MTHFR POT1 HAVCR2 SERPINF2 GATA3 CC2D2A SDHB NLRP3 RAF1 KCNQ1 MPI FAM161A HESX1 LRRC56 GLB1 KIAA0586 STK4 SAA1 COL1A2 ALG9 NDUFA12 EWSR1 TRPM4 PACS1 MYORG EED EFEMP2 MRAS CNGB3 DYSF GYG1 GTF2E2 MAP2K1 PIGA SCN1B ESCO2 AKAP9 TGFB1 RNASEH2A DSP DNAJB11 FBLN5 SLC26A2 ZAP70 APC TTR TPK1 GATA4 NEK9 ARHGAP31 TMC6 DGUOK DSP TFAP2B KIT KRT2 SOX10 HADHA WDR34 ALX3 GABRA3 CCDC114 MYH11 SLC30A10 GATA6 HYLS1 NDP MGME1 STIM1 ATAD3A COL7A1 TPM3 SLC25A13 ADAMTSL4 FGA CD40 HEPHL1 ND6 DLD HYDIN ATM KCNQ2 USP45 VAMP7 MID1 FRG1 IDH2 PSEN1 BCL10 NDUFB3 CCR1 SON SOS2 ERCC2 GP1BA HBA1 STRA6 MVK TFR2 KCNJ8 ATP6V0A2 CPS1 KMT2D KIF15 TMEM70 SH3PXD2B ATRX HPS3 RS1 GATA4 LRP1 NDUFS3 TRNT PIK3CA RSPH4A CSPP1 CYSLTR2 TRNQ SDHD PTPN22 TRNN GJB3 CD55 ALG12 CCM2 ATXN7 FANCI UMPS MKKS RLBP1 NSD2 RARB MAP3K1 ANKRD1 CDK4 BSCL2 VANGL1 CDH23 AK2 GATA4 MAD2L2 ERCC3 TNNI3 AHR ARID1A PTH1R SCN2A KCND3 OFD1 MYH11 FLT4 PRKAR1A ITPR1 KLHL3 GPR35 HFE NR2F2 COL4A4 CALM2 ABL1 KCNE1 TUBB CD96 SLX4 RAG2 MTOR CHRNA1 STAG2 KRT14 CEP55 TRNW AIP BTD CUL7 HSPG2 SCNN1A FARSB NR3C1 RNASEH2A FLNA BTD TGFBR2 ADA FSCN2 AKT1 KMT2D NOTCH1 ERGIC1 PPCS NF2 GCLC TNFRSF1A IL10 MICOS13 LRP6 PRKACA SLC25A4 MESP2 LBR RFWD3 SCNN1A PERP B3GALT6 DNMT3A CSF2RA MYH6 TCAP CYP7B1 CCR6 ACAT1 TSPYL1 ELN IL6 ELN MLH3 FGFR3 CACNA1C ACSL4 FLT4 SKI MTAP VPS13B CAVIN1 KANSL1 COL3A1 GATA4 MYMK F5 KAT6A ATP7A AKT1 PRKAG2 ITGB3 SNAP29 CCDC141 NCF1 WASHC5 ND3 NPHP3 POLG2 LORICRIN INS NDUFS7 WDPCP BUB1 TBXAS1 CENPF HGSNAT FGFR1 SGCG MEF2A CLCN7 CEP290 C8ORF37 SRCAP GNAQ HAVCR2 NOTCH1 GLI2 IGH ZIC2 DOCK6 PLG HABP2 LRRC8A GJA1 ITGB3 CHCHD2 FCGR2B NCF2 GLB1 TNFRSF13C GANAB WAS PRDM6 GATAD1 MYPN CD79A SCN5A TRNS1 H19 H19 RBP4 AIRE NCF2 POLG2 NDUFS3 AGBL5 RIT1 C12ORF57 AKT1 CCND1 PBX1 KIF5A PQBP1 CALM2 MVK ERCC5 DDRGK1 ACP5 EDNRA DAXX CDC73 KRT14 DNAJC19 PEX16 IFT27 PIK3R1 TERT CYP11B1 PEX14 BBS1 TMEM127 MYH9 PEX1 GNAS NKX2-1 TCF4 GNAS HBA2 FLAD1 OTC CACNB2 ARID2 MTTP PEX2 SEMA4A PIK3CA COL1A1 KIZ PIK3CA SF3B4 FLII ACTN4 GNPTAB NFIX BEST1 PTEN SPATA7 CCDC22 WRN CNTNAP2 RPS17 RIN2 VCL KIF1B GBA TRNT1 MCIDAS PEX1 FGA MRAS RANBP2 TGM5 GTF2H5 ND5 PTEN SBDS ALKBH8 COX3 ATP6 UPF3B ABCG8 ALDH3A2 COX15 ACTA2 ERCC2 DMD RPGRIP1 RAI1 NLRP3 POU2AF1 RNF168 ANOS1 SGCD IQSEC2 XPNPEP2 CYB561 GINS1 TERT IDUA APOB ND2 HYOU1 COX2 TUBB MBTPS2 IFT172 NUBPL CEP19 PROKR2 TMEM231 IRF2BP2 MYH6 PRPF4 KCNA1 SEC63 BAP1 ERCC4 KCNJ5 DNAI1 LRP5 VIPAS39 SHOC2 HSD3B7 PKLR RPL15 COX3 SCNN1G ZMYND10 MECP2 ATP5F1A RPS17 H19-ICR PITX2 MYPN CTSA SLC7A7 DHDDS GP1BA SELENON HLA-B ORAI1 IFT140 KCNE1 NFU1 GDF6 SPTA1 CALR BAP1 ENPP1 CNGA1 SMARCA2 PIGW KCNN4 RYR2 MOG MAP3K7 IFIH1 COL5A1 TMEM216 RET TBC1D24 APOA5 DCAF17 ND5 COX1 COG7 FAH JAK2 TNFRSF13C MEN1 FKTN SEC24C RPL31 IL2RG CCND1 DNAAF6 MYH7 TWIST1 KIAA1549 FLI1 MAPRE2 MIPEP APP ACTA1 MMP1 SPEF2 PAFAH1B1 CACNA1D NAA10 KRAS SMPD1 SPTA1 TDGF1 RPL11 HMGA2 GP1BA SLC52A2 PEX14 TBX2 EPB42 GYPC SMARCB1 GNS SERPINA6 FOS BBS10 LDB3 LARP7 PDGFRA NDUFAF3 B9D1 GBA GBA PROC NAA10 CAV1 FANCB SELENON FECH MMUT LIPA DBH DTNA POLR3A CALM3 POMT2 BCOR KRAS BCOR SMAD4 KCNH2 LMNA MYOC LCAT EDNRB MSX1 NOTCH2 WRN NLRP3 SEMA3E IRF5 RPL5 ND1 PACS2 EYS ACVR2B POLR1A SPP1 RPGRIP1 KCNE5 SDHAF1 RPGRIP1L F13B SNAI2 DPP6 DRC1 ADNP TMEM231 PSMB4 CPT2 TRNL1 ANAPC1 COX1 FOXC1 FGFR2 STAR TECRL AHI1 NOTCH3 KCNQ1OT1 COQ7 TMEM237 D2HGDH NKX2-5 RFT1 RPGR TGFB2 PLN TSHR MYL2 SCN11A LONP1 SIN3A GJA1 MYT1 SCNN1B CCDC22 NECTIN1 PDGFRA CFTR GDF3 RET EVC2 PRKCD GSN NOS3 ALB COX10 EIF4G1 PTPN11 ATR ROM1 TPM2 LMNB1 VPS35 DSG1 CDC73 SKI TREX1 SCN2B PRTN3 CAV3 GMPPB COL3A1 SLC39A13 FGB SLC25A4 FLNA APC2 COL3A1 BBS9 KRT5 WNT5A SMARCA4 NDUFA4 PEX7 TRNW SYNE2 HNF1A SUFU GM2A CFAP300 NFKB2 IFT88 FANCB GNAS NKX2-5 WASHC5 CALR NDUFAF3 RHO MMP14 MAP2K2 BPTF GBA IRX5 ATOH7 SEC61A1 LAMA4 B4GALT7 SERPING1 ELOVL4 PEX6 FOXC1 ACAD8 TBX1 THPO GTF2IRD1 SALL4 PML ND6 NDUFS7 DNM2 FLNC SOS1 GFI1 EFTUD2 NR3C2 SGCB TNFSF15 HDAC8 POR FAM111A PITX2 DMPK USB1 FAS GJC2 SOX10 SETD5 SLC26A2 KCNJ2 TBXA2R SLC20A2 ADNP TMEM237 F10 COL3A1 MYBPC3 CCDC47 HS6ST1 TPM1 ATP5F1E COG5 KDM6A FBXL4 ADCY5 ROR2 MAP3K7 CPOX RPS6KA3 WNT4 GLB1 CYP11B2 GLIS3 IL10RA SMC1A CAVIN1 BNC2 GBA CFI GATA4 COX7B F2 HBB IDUA FANCE SDHD PRKG1 FLNA PKP2 SLC22A5 PIBF1 ARL2BP PDHA1 TNFRSF1B PEX26 PSEN2 ELP1 SLC37A4 LIPC DNAH5 PIGN ARNT2 SFTPA2 CLCNKB PSEN2 ACADM RAC1 CRTAP SMAD4 NDUFB11 RPS6KA3 GDF1 FAT4 NDUFA11 IFT172 TFAP2A TRDN SALL4 DLD TNFSF11 STAT3 PTPN22 MEGF8 SDHC PSMB9 NLRP3 DCHS1 EXT2 NUP107 SMCHD1 EFTUD2 TRAC ANK2 OCLN HBB CALM2 LYST PEX5 RAF1 SCN5A PIGL RTTN ABCG8 MYO5B CRKL NKX2-5 TGFB3 CPLX1 PYGM DCLRE1C CALM1 HCRT CALM2 PARN PRKAG2 TPM1 SGCB SPEG RYR1 ZMPSTE24 SLMAP IL2RG CASP8 TMEM260 RAG1 CFAP410 PSTPIP1 SGCA MYH7 NDUFV1 KCNH2 ALOXE3 SLC26A2 TRPM4 FBN1 SLC35A2 LIPC ALB TRNL1 CASQ2 JPH2 PGM1 SCN1B RYR2 CCDC103 IL2RA LIPT1 ATM TFAP2B RET FBN1 CACNA1D MRPL44 IKZF1 HIC1 SH2B3 ZNF469 LTBP3 CACNA1D H19 UBR1 ADA2 IMPG2 HNF4A MYF6 COL6A3 NDUFA9 ALAS2 HLA-DRB1 C15ORF41 OBSL1 MEN1 TRAF3IP1 CDH23 PDE6H OFD1 PEX16 POR KCTD1 TPI1 CD28 TRIP11 ND3 DDB2 MYL2 GRIP1 MMUT BLOC1S3 PLCG2 TGFBR3 ABCC6 TSR2 PTEN MYO18B NCF4 NRAS FGFR2 FERMT1 SON KCNAB2 ARHGEF18 SERPINF2 MMP1 IRF5 EVC APOA1 FAT4 CP CNBP GNE DDX11 STIM1 CYP1B1 NDUFS4 DSP RASA1 SAMHD1 CNGB1 CYP11A1 IDH3A TMTC3 ARID1B GMPPA MGMT ZFPM2 MYH7 PCARE RIPK4 CYP27A1 ATP6 BTK SNCA STX3 AGPAT2 MYH7 CTC1 CTSH KRT5 FRAS1 LZTFL1 MTFMT GPC4 POMT2 TGIF1 HMBS TREX1 AKAP9 PROS1 STAT3 SALL1 TMEM43 RMRP GPR101 WDPCP PCARE CFTR SNCA HBB FBN1 SLC25A4 ASCL1 CFHR1 AGT YY1AP1 CYP24A1 ECE1 FZD4 PMM2 GCK NDP PAH OTUD6B ARMC4 CBS ERCC4 GUCY1A1 SLC2A10 AMER1 SDHA MKS1 NDUFV2 FTO WFS1 DBH DHCR24 RPS7 MYH7 TRNL1 NKX2-1 HOXD13 COX8A SGCD WDR19 STAC3 MLYCD DMD LEP KAT6B CFAP53 COL1A2 COX14 GNA11 CERKL ESS2 TF PNPLA2 PDE6C CYTB MFAP5 SPEG DES STRADA TLL1 PLAU CHRNG CPOX PTPRC SNRPB TGFB3 KDSR CDKN1C ARVCF BACH2 ATP6V1B2 ABCA1 ITCH CFH TMEM237 POMGNT1 PIGV TMEM127 SRD5A3 TBX5 ATRX IDUA CITED2 PEX13 IGF2 CHST14 PEX12 JMJD1C F12 ACTB CCDC103 FGF17 FCGR2A NAGA APC NF1 SLC25A20 GPC6 DNAL1 DES TTC37 ACTA2 BLNK SHPK FOXP1 MAT2A SMARCA4 F7 PIK3CA FLNB SIM1 GJB2 TPM2 GNAQ FOXC2 HLA-DRB1 GJA1 PMS2 MPLKIP AIP POMP NNT SDHB CLRN1 ACTG1 XPNPEP3 ERCC4 PSAP ARCN1 SIX3 BAG3 RPSA DNAAF5 TMEM237 DES USP18 AGK PEX10 NODAL XRCC4 ND1 SNX10 CHD4 JAK2 MAP2K1 KRT18 KRAS WHCR CTLA4 GJB3 GATA1 RAI1 ITGA8 INVS RPS20 PRKAR1A PROC DCAF8 DVL3 CCDC141 MEIS2 ACTG2 COL1A1 PSMB8 POLG CHRM3 TRAF7 LRRC6 TNNI3 SEMA5A RERE CSRP3 CCBE1 ALDH18A1 CTSB DSP SCN10A HES7 MKKS JUP BBS5 FANCL FLNA STN1 LIAS PLCB4 SDHD NF1 ALDH18A1 WRAP53 COL2A1 RAD21 HLA-B COX2 FAS POLR1D OSTM1 RRM2B RPS19 ERCC2 GPC3 ND5 TRIM8 SDHA COG7 VCL STAT3 ACVRL1 KCNA5 PTEN DLL4 ADAMTS10 HRAS GNAS FGFR2 ALG1 USH2A PPARG KITLG IFT172 BMP2 GATA1 SF3B4 G6PC3 NXN ACTG2 EPG5 SETD2 COL1A1 HJV DNAAF3 TXNL4A MYH3 NKX2-5 HSD3B2 LIG4 MKKS LMNA ATP11A FBLN5 PDE6B KRT83 NRAS PALLD APOE CA4 ARL3 PADI4 TCTN1 HBA1 RAF1 LIPA HLA-A PCNT SAMD9 VWF ATN1 CRB1 ALX4 BMPR1A TWNK FKTN PIGL TGFBR1 STAT4 HESX1 SMARCE1 DVL3 ZFPM2 RPL10 EBP XYLT2 CCBE1 EPG5 TET2 FLNA NR3C1 MRPS14 PEX3 GATAD1 SFTPC SUGCT HLA-DQB1 NPPA RET RPL26 WNK4 LZTFL1 PQBP1 STAT1 SLC35A1 FGFRL1 KISS1R CASP10 CACNA1C RAD21 MYD88 GLA B3GLCT GP9 RAP1B CTNNB1 PAX6 SERPING1 PTEN ATP2C1 TMCO1 CD244 TTN TNXB FGF20 RPS10 ELN KRT16 SMARCAL1 COL4A2 BCL2 EMG1 BOLA3 HADHA TGFB3 PKD2 LEPR NAGLU RAG2 ABCC9 ELN IDH3B ETHE1 MITF RPL26 ITGA2B LMX1B PNPLA2 BLM INHBA CASK ESR1 CALR VPS13B SNX10 GNPTG SLFN14 PIK3CA NOTCH2 B3GALT6 CLCN7 CLRN1 DSE PPARG PKP2 STEAP3 ADA KRAS TTC25 DLST LOX LOX UFD1 F2 EIF2AK3 NOTCH1 NEB DMD BRAT1 HGD LIFR TMEM67 KRT1 TCIRG1 APOE WDPCP GNA11 RYR1 ATP8B1 MYH7 SDHAF2 CHST3 CXCR4 RBM8A SOX9 NF2 CASK LMNA PEX13 RPS29 ESCO2 CFAP221 EHMT1 F10 NF1 DNAI2 ACTA2 TTC8 CD70 CCDC114 TMEM70 LTBP4 KCNH1 FAS POLA1 PPP1CB TCTN2 SH2B3 SDHC VPS33A ESCO2 DCC GJA5 CISD2 NID1 PAX3 TTC8 CCNO DCHS1 CHRM3 B9D1 ISG15 PEX11B FADD SLC4A1 SELENON RNASEH2B IDUA AVPR2 TRNE KCNK3 RSPH9 TFAP2A SLC12A3 F5 TCTN3 COX7B PIK3R2 MYC ARL6 CCN2 PLOD3 CBS FGB GATA6 SMARCB1 ABCA3 SCARB2 DIS3L2 POMT1 SCO2 UBE2A WT1 PIGS TRNK TGDS WDR19 FKTN PNKP POMGNT1 IL17RD SCNN1A HBB MERTK COL1A1 KCNJ11 POLE PPP2CA STAMBP AGT SOX18 TGFBR2 FGA ERCC8 MYMK SCN9A MYBPC3 NDUFS2 VCP CDKN1B B3GAT3 KIF23 JAK2 MTMR14 PDE6A ANK2 STXBP1 RPL35A NFIX XPC CRYAB COL5A2 GREM1 ARF1 TTN LYZ HBB FLRT3 DNAH1 CEP290 SNRNP200 DHCR7 HBA2 KRT1 RPGRIP1L MYL3 MYH7 AEBP1 HBA1 CFAP300 HNRNPA1 MTO1 KDSR FKBP14 SOX10 RRAS2 COL11A1 DISP1 KRT5 CENPE SH3PXD2B COX6B1 LMOD1 ATP6V1E1 MFAP5 SARDH SLC25A24 GMPPB RLBP1 NRAS ADA2 GCDH EDN3 SMAD4 SEC23A SDHD TOP3A CDH23 CLIP2 CTBP1 REEP6 PARS2 USB1 ABCB4 PRDM5 AARS2 CYLD MMP21 SRP54 KCNJ18 CFHR3 STX11 TBL2 FGG ALMS1 DNASE1 DMRT3 NPHP3 DNAI1 NABP1 TSC1 LMBR1 GUCA1B IRF8 MKS1 FANCG ZNF365 MEOX1 ARID2 GALNS TRPS1 SLC39A13 CD3E NKX2-5 ELANE COX1 GNE SLC26A3 MED12 MYOT COMT GJB4 KCNJ2 AGA ELN CDKN2A WWOX COA5 GJB6 STIM1 SRCAP SLC7A7 IFT122 TBX22 DHPS LMNA SPECC1L TRNH PEX10 ARID1A IDH1 FGFR1 CASR CHN1 MAFB SCN2B SRP54 TRNL1 BBS1 SLC26A2 AAAS TUB CPT1A KRAS KMT2A TNFRSF13B GABRD GP1BB VPS13A RP9 ARSA OSGEP MRPS22 DIS3L2 INPPL1 NDUFS4 ACAD9 TRPC6 CD96 DCAF17 TTC7A JAK3 COL2A1 NLRP12 NEK1 SETX TRNS1 KCNE2 SCN5A NPHP1 STK36 TPM1 IL7R PRDM16 OFD1 XRCC2 CD19 KCNJ18 FBLN5 NDUFB11 CYBB RIN2 WT1 APOC2 KIT KCNJ1 PLEC MAPT CAV1 NDUFS6 SMAD4 PRKAR1A PDGFB HNRNPU SOS2 KIT GJA1 GNAQ P2RY11 TRNW YWHAE TGFB1 AHI1 KYNU NOTCH1 C1QA TIMMDC1 PSAT1 KIF1B P2RY12 DKC1 TAB2 CKAP2L STK11 LMNA ERCC6 RBBP8 CDSN POGZ DST GTPBP3 RPL15 SCN9A TMEM216 SMARCE1 WARS2 TTN FASLG RPGR RGR NDUFAF2 LTBP4 NFE2L2 XYLT1 PPCS OFD1 C3 ND4 SNRNP200 ERCC6 FGFR1 FBN1 RYR1 DPF2 PAM16 ECHS1 BSCL2 FASLG KIF7 PROK2 MEOX1 ZMYND10 TBXAS1 PTPN22 TCIRG1 ERCC2 LTBP2 CKAP2L DSP IQCB1 DLL4 CHRNG BAG3 SCAPER CPT1A RPL27 FLNC GATA5 FN1 CC2D2A MYH11 AUTS2 ERBB3 PTPN11 EBP PARN RARA RNF113A HELLPAR PEX7 TEK ICOS IFNG FZD4 GLRX5 TWNK ROBO4 FBN1 NOS3 CYP3A5 TRNK MYRF KAT6A ENG PCCB MNX1 EZH2 TALDO1 DNAAF1 CDK13 TET2 HPS6 AGK PHOX2B JAG1 RBM20 LMNA DUX4 MCCC1 PTF1A BRAF TSC1 GNB5 FUCA1 IGF2 VPS45 ACE TPM3 TTN TMEM67 CYP11B2 ELMO2 PTCH1 ZFPM2 SIK3 BUB3 ACTA1 CYTB PLCG2 NAA10 SLC4A1 TSC1 SLC2A1 LDLRAP1 TRAF3IP2 TCTN3 LIG4 DHODH TP53 NFKBIL1 ZNF148 FEZF1 DNASE1L3 TSPYL1 CAP2 ELN HGSNAT TTN FOXH1 PIGN RNF213 KAT6B FMR1 NODAL ETV6 PMS1 FGB TBX4 ATP7A CYTB SUZ12 TMEM138 FERMT1 F5 CFHR1 AHCY TSC2 KCNJ11 CARD9 CAV1 NDUFA2 GJA1 FGFR2 FUZ TREX1 MLH1 MUC5B LMNA SDHC RAG1 FKTN DNAH5 HES7 TNNC1 RYR1 FGFR2 ANO5 PIEZO1 FOXP3 IRF8 INPP5E NFIX CD3D LHX4 NOS1AP PROS1 NDUFAF6 ARL6IP6 NAGA NSUN2 ZNF513 ND4 SMARCB1 RSPO2 SYNE1 MED25 TBX3 PDE3A PRKAR1A TPM3 NELFA NDUFV2 HBA2 RHBDF2 CAV1 NKX2-5 RDH5 HPS1 LMNA FOXE1 LIMK1 ABCB11 SH2B3 DNAH1 PTCH1 FAS RPL27 TULP1 TRIO AGXT TMEM231 ND1 SF3B1 RPS24 LAMA3 KCNQ1 HFE FLNB GLUL TBX1 MPIG6B LAMP2 GGCX FSHR FGF8 BLM LPL SERPIND1 NEK1 FGFR2 MGME1 RNASEH2C GIGYF2 LOXL1 NKX2-5 TRNL1 B2M TGFBR1 KLLN RANGRF CD46 ADA2 FAM13A PSEN1 COX7B HRAS SALL1 MALT1 SCNN1G LMNA NDUFB11 YARS2 BBS4 ABCA1 SDHB PCCA SOX18 CEP57 GGCX KRT8 PPA2 TBX1 SMN1 DSP PIK3R2 TGDS SMAD3 MLX GPC3 PIEZO1 UBR1 NONO BIRC3 RNASEH1 KIT COL5A1 RHO RP1 TRNS1 CACNA2D1 STRA6 TP63 CASP10 PIGL EYA4 ATRX TERT WDPCP SLC40A1 NDUFAF4 SDHD DNAAF4 BAP1 PROC LMNA HMCN1 ARL6 EPB41 RDH12 NGLY1 POLG PSAP WAS GYS1 TXNL4A TRPM4 CTU2 ENPP1 TRMT10C LRP5 HSD11B2 NT5E RAB23 INPP5E DYNC2LI1 ARL2BP SPRY2 PNPLA6 GYG1 TBX1 ADAMTS2 NPC2 CYP7B1 PTDSS1 KIAA0586 CAV3 ERCC5 GBE1 ALG9 RNASEH2C ANKRD26 NRXN1 SLC22A4 FLNC CHRND NPPA BUB1B TAF1A SMPD1 SCNN1G EDA GATA6 BCOR DMD MYH7 PET100 SF3B4 TRAIP CACNA2D1 SCNN1A EOGT ASS1 ALG10B PSMD12 BMPR1A DNAH9 RAI1 PIK3C2A RAG2 CDAN1 PRPF8 CACNB2 NDUFAF2 COG6 B9D2 RUNX1 PRCD SDHC MED12 DOCK6 IL12RB1 ISCU TPM2 ECHS1 RNF6 ACADS CWC27 CD247 RNU4ATAC IGH TMEM126A ATP6V0A2 IARS2 TRPM4 COA8 POMK LIPN ZNF408 ACVRL1 VPS33B KCNQ1 ERCC2 LMNA FOXE3 RECQL4 SMAD4 TPP2 RNU4ATAC SLC52A3 PCCA SOX4 ND2 KCNQ1 GATA6 SH2B3 PDGFB PIGM MIF C1R ND1 NDUFA2 BBS7 COQ2 SIX3 POU1F1 SFTPB EXT1 NOS3 GATA6 ATAD3A CHD7 SMAD4 CRB2 DOCK8 TAZ DVL1 LETM1 FKRP FGFR2 ATP6AP2 CR2 ARID1B LRIG2 GNAI3 MYH6 AKR1D1 HNRNPA2B1 PDSS1 NHLRC2 GPC4 DCLRE1C TOP3A CPN1 LDLR KRIT1 NEBL TMC8 MRAP DUSP6 TMEM94 COG4 KIAA0319L SLC52A2 SDHD EPHB2 GNAI2 SMARCC2 ALOX12B AGGF1 GPR101 POLR3A SMAD3 GJA1 GPI ITGA3 CFI TGFBR2 ALG1 TWNK RAD51C DNAI2 MINPP1 APOA1 MTFMT ITGB3 FCGR2C WWOX AFF4 FLNA SEC23B SCN3B ABHD5 MED13L GLA NDUFAF1 SETD5 DYNC2LI1 TCOF1 CALM1 KCNJ11 MAP2K2 PIK3R1 CTSK KLF1 VHL ATP6 CST3 IL6 TBX19 RAD51C DDX59 RMRP POGZ DNAH11 ANK1 PDGFRB LRP5 COL5A2 DNAH11 RPL35A TRAPPC11 NT5E APOB PDE6D PAX3 KCNQ1OT1 ACAD9 FANCD2 SLURP1 GAS1 BMPR2 SOS1 NEXN MYOZ2 RFC2 TKT KCNE5 TGFBR2 PTEN PKP1 WIPF1 IL7 HIBCH TNFRSF1B LBR GJB6 SLC37A4 FBP1 TERC SRY RPS6KA3 IDS IL17F MEFV FIBP MPLKIP RPGRIP1L GP9 SCNN1B DCDC2 KIAA1109 AIPL1 HLA-DRB1 SMCHD1 RET GFI1B COG2 FGFR2 TRNK SEMA3A GBE1 TAF2 ACTC1 COL1A1 SOX5 LYST NAA10 PLP1 FANCA NSMCE2 CYBC1 HLA-DPA1 LBR ANKRD11 IDUA UVSSA GNB5 DPM1 TAPT1 CLCN7 CLCF1 MKS1 SPARC ATP6 ARX BBS2 DNAAF2 PLVAP IL7R SMG9 BBS2 TSC1 FUT8 WT1 NPHP1 HLA-DRB1 TNNT2 BRAF SLC29A3 TTN NSMCE3 NMNAT1 ACTA1 TACR3 AKAP10 ITGB3 ND4L FRA16E RAB23 PDSS2 NDUFV1 SMOC1 SCN4B CERKL PLD1 CSRP3 PTPN11 RNASEH1 GLI3 ABCA1 RASA1 NRAS PLIN1 TP53 ALPL IGHM SDHB PALB2 TRIP11 SMAD4 TNPO3 GBA FECH ABCD4 ADD1 ZNF469 TREX1 HOXA13 IGF1R AIRE KCNE2 GUCY1A1 HPSE2 TSC2 GGCX ABCC9 ANO10 UCP2 MCM4 DOLK DCTN1 ERAP1 MSH6 COPA PEX12 F13A1 VEGFC HRAS PIGO SLC25A24 SOX10 KCNE3 BRAF CRYAB TERT BIN1 CRX HBG2 EXOC6B KLHL7 POLR1C TNNC1 ALMS1 NLRP3 ITGA8 CHRNA7 LIPT1 KIAA0556 KDM6A ERCC3 PQBP1 BBIP1 EVC CTLA4 BANF1 CDK10 CHST3 FTL GNE BRCA2 AHI1 GNAT2 SCARF2 EDN1 KCNH2 DHX38 HLA-DRB1 PGAP3 DNAAF3 GPC4 KRT5 POMT1 HLA-DRB1 SCN5A TXNRD2 TET2 GATA6 ACAD8 MVK EOGT ND1 ADAR PDE8B DNAAF6 EPHB4 DMPK TPM2 SDHA NPHP1 FRAS1 GCH1 FGD1 C4A PSAP COA6 AGPAT2 SOX2 BMPR1A USP9X NFKB1 FANCC IL2RG MEFV PKHD1 ZNF423 KRT14 MVK RB1 CITED2 EXT1 PLN GJB2 UBE2T NKX2-5 SELENOI DNAH9 SCN4B GMPPB COL2A1 FERMT3 SCN5A BCOR ND1 TNNT2 GAS2L2 MTM1 RECQL4 GPD1L ARPC1B SPINK5 ERCC4 B2M ZNF513 MMP2 GATA4 COG4 BRCA2 FHL2 PKD1 BSCL2 PLEC WT1 HYMAI TAB2 CASR MYLK KCNN3 TCTN3 MAP3K7 TRNQ TBX1 TMEM216 RORC FOXE3 LAMA2 ADK MBTPS2 WT1 KYNU ECE1 FLNA PLOD1 PDE11A KLF1 TCIRG1 NKX2-6 NR2E3 SOX4 COL7A1 IFNGR1 CPT2 GLI3 PLAGL1 CDKL5 SUFU PRCD SCNN1B FOXA2 PTGIS FOXF1 SCN5A C12ORF57 NDUFA11 DGCR2 FBN2 PORCN SDHB ASAH1 PKD1L1 TRIM28 SLCO2A1 PUF60 KIF7 BMP2 BRCA2 NDUFS2 RP2 STEAP3 FIP1L1 NDUFS2 PRF1 CITED2 NDP KCND3 TMEM107 NPM1 ITK TNXB NTRK1 JAK2 COL6A1 CASQ2 AMMECR1 COX20 AIP PRPH2 ATP7A FANCI NKX2-5 PHKG2 ACTC1 TGFB2 ITGA2 CIZ1 ARMC5 ALX1 NUMA1 CDKN2A FUCA1 AIP NRAS RIPPLY2 TSFM PRRX1 NEXN FBN1 FGFR1 CA2 KLF13 SACS SPTB SNIP1 SOX11 REST VHL HEXA AKT2 CAPN5 TNFRSF11B EED GALNT3 XPA FGFR3 GPD1 CORIN NEU1 SERPING1 FANCA LAMB3 CD79B PEX6 PRDM16 LYST FOXE3 GNAQ FOXRED1 DTNBP1 PAX8 CCDC174 PIEZO2 BGN HADHA CYP17A1 GATA4 GATA4 HBB THOC2 RARB FGF23 TCOF1 ARMC9 ANTXR1 COG1 KRIT1 TACO1 ELOVL4 AP3B1 GATA2 CEP41 ATM TNNC1 PRKCSH AMMECR1 FASTKD2 CCDC151 HBB NDUFA6 GBA CACNA1S JAK3 SPTB CDKN1A TP63 ACTC1 ALOX5AP ALDOB RSPH3 TRIM28 NDP EBP BEST1 CCN2 FGFR2 LEMD3 PTPN22 PDCD10 KAT6B NSD1 SP110 AGL ZEB2 SP7 TRNC ACTA2 PCGF2 C4A CLIC2 NDUFA13 PRKACA CD27 FANCC IDH2 EVC2 NDUFB9 LPIN2 TCAP MEGF8 RREB1 TTPA PEPD RNU4ATAC STK11 TGFBR2 HESX1 PLAGL1 APC TET2 SDHA BTK DSP SCO1 HIBCH CANT1 PHKG2 CD81 WDR60 PIGY PHYH ATP6AP1 NLRP1 TMEM126B ATP6V1E1 MAP3K20 TNFSF12 KAT6B FLT1 ADA IGFBP7 KRAS CPLANE1 IFT43 CLCNKB DNAJC19 RIT1 GP1BB LDB3 NDUFA1 NSD1 CSNK2A1 SDHC LACC1 F13A1 RPL11 ND6 CRELD1 ABCC8 OTX2 WDR35 TARS1 TRNV ND4 MYH7 NDUFS8 NEK2 PLEKHM1 COL4A1 PHOX2B TRMU TACO1 DPP9 TNFSF11 SIX6 SLC19A2 IDH2 RBCK1 RAI1 CDKN2B ANK1 KRAS POLD1 CACNA1S LRRK2 MECP2 G6PD SCN3B LAT C1QBP ANGPTL6 TNNI3 PDE11A ATP6V0A2 LCAT SPECC1L APP FBN1 CASQ2 GATA1 PDGFB COL18A1 BRAF MGP TRNV NAGA LAMP2 AGA TPI1 GATA6 TAZ ABCC8 MUC1 AMER1 TBX1 HPGD MAP3K7 NDUFAF4 FGG CFAP298 CDHR1 ATP6 PROS1 GDF1 SLC18A2 NPC1 USP8 PGAP2 NEUROG3 CAV3 ABCC9 GATA4 ANTXR1 JAK2 FGFR2 VCL COL1A2 GP6 TALDO1 FHL1 ZFP57 PIGT ABL1 PPP1CB COL3A1 FANCM MAX NEXN IGHM BIN1 MITF RAF1 ZNF423 HJV KDM6A CFI POLH KLHL41 PGM3 IL12A PSMB8 PEX5 EGFR ARID1B CYP11B2 PDGFRB PNP DDB2 APOE CR2 NCAPG2 ACADL KRT10 HADH RBM10 TRNF IFIH1 ADCY5 PEX3 DNAAF5 BRAF LRP2 DYNC2H1 COL6A2 F8 CD19 ACADVL ABCA4 TRIP13 AKT1 SLC2A10 CYBA TTC37 JAK2 NSD2 WDR35 GP1BB TP63 PDX1 TERC CD19 F13B NLRC4 FANCE PLIN1 IDH3B COL4A3 GPX4 BCHE CYP27A1 ABCA4 SETBP1 NDE1 DCLRE1C BAG3 FBN1 MCCC2 SMAD9 IL7R PIGO COL4A5 NOD2 ARFGEF2 TRDN FOXJ1 NDUFA10 MYH8 POR PIK3CA XYLT2 DNM2 TERC GNA14 KRAS SLC2A1 NSD1 ANK1 MAP2K1 CACNA1H FRG1 CACNA1S NAGA AKR1D1 WAS SHH SMC1A ADA2 NDUFS8 CRYAB LRRC56 RAB3GAP2 STAT4 NEK9 KDM5B ATRX EDA2R SOX3 MYH9 SH2D1A CCND1 RAD21 PEX19 HABP2 KLHL7 CDC42 NEB SCO2 MAPK1 CYP26C1 KCNQ1 KCNJ2 JUP HOXA1 ANKRD11 LMNA EPCAM NR0B1 DVL1 ELP1 HSPA9 PEX7 ABCC9 DKC1 ROR2 NR3C2 GLB1 IRAK1 DGUOK ENG BCR MECP2 PHKA2 FN1 SLC7A14 MC4R MAN2B1 POMT1 PIK3CD ARL13B CCDC8 HTRA1 CALM1 IVD ITGA7 IKBKG TERT RBM8A PHF21A NFKB2 AVPR2 MPL RPL18 GPC6 CLPB FLNA TP63 TRIM37 PORCN COQ2 ADGRE2 TTC8 NDUFV2 ANTXR2 PHGDH FGFR1 C8ORF37 SF3B1 COL4A1 SCNN1B DOLK SLC25A11 TP63 XRCC4 TMEM43 FOXC1 PRKCD CCM2 PTPN14 COQ2 PIGA MPL LRP5 HMGCL ZMPSTE24 NR5A1 TNFRSF4 CA2 IFT172 AP1S1 CIB1 KCNE1 HTRA2 DNAAF2 HGD SLC25A11 SCN5A SFTPA2 FBN2 MYH6 GNAO1 FBN1 ACTG1 NDUFAF5 RSPH1 TNNT2 SUMF1 SALL4 DNAL1 IRF6 UNG IL2RB RRM2B CEP290 PLN ALDH18A1 ERCC6 ALG8 MYOC POLR1A CFAP298 RBM20 GNPTAB TP53 MYPN PUF60 MANBA TRNF CYBA TBL1XR1 PEX5 UBE3A EP300 CTNNA3 ATPAF2 ACD EFEMP2 GLI2 PCCB RBPJ ICOS CTSA KIF11 PEX5 HYLS1 CEP104 AP1B1 MYLK2 OTC BPGM NKX2-5 PTEN LZTR1 HLA-DQB1 LEMD3 SLC4A1 FGB RYR1 SEC23A SPIB RLIM DGCR6 MST1 FGG TTR F5 CD28 RNF113A MGP RAF1 SDHA MAB21L1 MEN1 CEP41 ND5 MMEL1 SLC25A3 GJA1 POLG SCN4A SUFU ZIC3 HPS5 ADAM17 SOX2 RHAG BVES TNFRSF1A ATP7B HADHA MIB1 NFIA GJA5 HSD11B2 PEX2 FLNA MYPN ATP2C1 ACTN2 KCNH2 PROM1 INPP5E TCTN2 MAF ITPA PRPH2 BCS1L EIF2AK4 MNX1 NGLY1 LRBA POLG RMND1 VHL RUNX1 FANCD2 CLCN7 FLI1 DLEC1 MSH2 CCNQ FGFR3 SFTPC HMBS GNAS ZIC3 COQ9 JAG1 TULP1 APOE NDUFAF5 SMPD1 ITGA2B IDH1 CACNA1C SCN10A PEX11B SDHD KRAS NPM1 PRKG1 USP8 JAK2 MPL SRD5A3 FOXP3 SCNN1G TTC8 HSPG2 DDRGK1 PRKAR1A FGFR1 SGSH FGA NRL HPS4 BTNL2 CCDC40 ABCC8 PEX16 BTK DGCR8 KCNJ5 ACTC1 LEMD3 OTULIN PGM3 PSAP CAV3 SCN9A LMNA HLA-DRB1 COX3 FOXF1 FLNA RBM10 SLC12A1 DSP MASP1 TRDN CIITA LMNA INVS TOPORS MAFB ARX SOX9 DNAJC21 CD79B LIG4 FREM2 MAP1B SNTA1 BTNL2 DES GDNF POLG CUL3 AKAP9 ACTB TNFRSF11A ZBTB16 FOXRED1 HACD1 ERCC3 PIK3CA ABCC6 COX4I2 GATA5 TWIST1 RB1 BCOR STAT5B NLRP3 RPGR CSPP1 COL7A1 PHYH OTX2 HPGD KRAS AK2 CALM1 RASA2 SLC35A1 MS4A1 REN CCDC151 PEX6 PSMD12 POU3F4 IGF2 STOX1 RFWD3 GGCX HYMAI CYP21A2 IFT81 UROS LFNG HADHB NOP10 CSRP3 STXBP2 HLA-B COQ2 SUMF1 RAP1A HBG1 NHP2 GSN FZD2 NDUFS4 XK CCDC65 SIK1 GJA5 SLC25A20 SIM1 COL11A2 CRLF1 GBA GJB4 KCNMB1 GPD1L KIF7 SLC29A3 CCDC39 CRPPA GBA NAXD BMPR2 CFH CHST3 ITCH LRRC6 CFC1 PIGY HOXA11 MYCN NUP155 INTU MED13L HLA-DRB1 PHGDH TRIP13 NOTCH2 SULT2B1 TBX20 AICDA GLMN COQ4 COLGALT1 HAMP CC2D2A KCNE2 THOC6 ENPP1 PYCR1 ALPK3 FLCN MAX PALB2 MKS1 LPL PRPF3 CD46 IKBKG HCCS SDHD DIS3L2 PDGFB FHL1 RAG1 UMPS HDAC8 SPRY4 IL23R HCCS MRE11 CTLA4 ND6 SLC39A4 WT1 EPHB4 KYNU TTC25 MC1R ATP7A NOTCH3 TOPORS HLA-B MYOT LMNA KCNQ1 KBTBD13 ZAP70 ATP8 STAT3 FLT4 TAZ CC2D2A RPS15A NAGS ARMC4 DSG2 TGM5 F13A1 FADD TECRL CARD11 ATP6V1A OFD1 LRP2 RAF1 XYLT1 PRNP CTC1 SDHB FMR1 KIF1B MPL CD2AP CASR TRRAP SOX2 ICOS DCDC2 NKX2-6 PLEKHM1 SLC25A4 WNT10A G6PC PRKAR1A THBD CLIC2 RPE65 C1R BRCA1 SCN10A RPS19 NEK8 ATP6V1A ARMC5 PRRX1 DSG4 AIP PPA2 AHCY LTBP2 ALDOA COX3 POMT2 TMEM126B DPH1 VAC14 RAG1 LBR TAB2 NOS2 PRPF3 GATA5 FAH CYP11A1 IL36RN TANGO2 CCDC39 NPHP3 NLRP3 COL4A3 GATA6 ACTA2 WNK1 ADAMTSL1 XPA UBAC2 COL1A1 TINF2 PPARG SDHB AKT3 PDCD10 RAG2 ND2 CTNNB1 PRPH2 NPHP1 PET100 SCN1B FKBP14 LMNA SARS2 ERMARD PDE6G RECQL4 SAG FGA GMPPB GUSB SLC25A3 XPC SP110 PRKCSH TET2 PTCH1 FBP1 GATA1 ABCC9 POLH RHOH AGTR1 GNB3 GUSB EPHB4 TBC1D24 SPAG1 DNAJC13 NIPBL TNNI3 ND5 JAK2 CRELD1 DPM3 CDKN2B F2 DSG2 CDON GNPTAB SBDS RASGRP1 NSDHL FKRP ENG SURF1 COLQ TBX5 EYS SLC19A3 MPL WNT4 HSPG2 PEX19 SMC3 FN1 GPC1 BMPR1A FGFR3 SCN5A ENG CPT2 CTSB COX15 DYRK1B NOD2 FANCF ND2 TRPV3 HEXB CRYAB RPE65 LARS2 GLRX5 MYLK FKRP SURF1 IL12B IFIH1 PLOD1 TRPM4 TMEM43 MLXIPL BRAF DHCR24 DPM3 POU6F2 SFTPA1 HCN4 PRG4 MYH7 LIG4 AGXT CEP290 SHANK3 BRAF SAMD9 ABCD3 SCN5A ELAC2 NDUFS2 SDCCAG8 COQ2 SEC23B MUC5B TGM1 APP CLN3 XPR1 YY1AP1 KRAS PPOX DNAAF4 CLCN2 SLC17A5 IL12A-AS1 THPO ND4L FH IDUA HSD17B10 ADAMTS10 FXN SAMHD1 SPTB RPS26 RPS27 ASCC1 TCF3 SLC29A3 JUP MYBPC3 F9 LAMB2 ALOXE3 CLEC7A FXN SKI GPC3 BCL11B ITGA2B CST3 SERPINC1 MGAT2 TWNK MEIS2 HFE DVL3 SLC20A2 PIEZO2 NDUFB11 MPL NUP107 NDUFA10 CHKB GP1BB APP FGFR3 PACS1 DMD CYP11B1 TRNK IL1RN CEP120 WNT5A MYH11 RAD51 SCYL1 NDUFS1 ADAMTSL2 SKIV2L WDR11 ZDHHC9 PPARG KIAA0753 CAV1 PRF1 CSF2RB SC5D PDE6A KCNQ1 RBP3 POLG RTEL1 VHL NSMF EMD TDP2 TK2 RNF125 BRAF ASXL1 SCN5A FOXC2 FIG4 TP63 PCSK9 INTU IMPDH1 TERT ANKS6 SYNE1 NIPBL COL4A1 ARX IFT80 PTPN11 ARSB HAAO HSD3B7 VHL CEP120 GDAP1 ASAH1 STX16 RPL5 LDB3 GATA6 RRAS SPECC1L HCN4 SERPINC1 F11 UNC13D DOLK LIMS2 GDF6 RPL35 TSC2 IL12A KLRC4 LMNA CTCF TBX1 FOXRED1 ADAMTS3 PLG EPB42 USP9X GLI3 GJA5 SMAD4 KCNJ5 WT1 ELANE CEP290 NLRC4 FANCB RPS15A NDUFB11 SNTA1 SYNE2 XYLT2 ELN CREBBP ATF6 CYP11B1 PMPCA ETHE1 KCNJ5 ANTXR1 BAZ1B TNNI3 EHMT1 KRAS ARHGAP31 COA8 NBEAL2 MED12 RGR KCNQ1 NXN COL2A1 FHL1 LMNA NEU1 RERE DACT1 GDF1 UBE3B HTRA1 FGFR2 NME8 AQP2 IL17RC FAN1 PIGQ CBL PROP1 HK1 SMC3 BMPR1A ABCA12 CFB ITGA2 FGG PMM2 ABCC6 MARS2 TERF2IP TNFSF12 KDM6B MDH2 PIGP MKS1 FMO3 PCNA TTC7A SLC39A4 SGCD IRF5 NLRC4 CTNS SLC4A1 RPL10 SLC25A26 PKLR TNFRSF13B DEAF1 COG8 NEUROD2 MRPS16 COL1A2 KRAS SAMD9L LDB3 NDUFS2 OFD1 KCNQ1 FBN1 LMX1B FBLN5 PTEN TRIM32 PEX26 LRP5 ROM1 RRM2B TWIST1 COL25A1 WNT10A AMMECR1 COG4 HLCS HCN4 NR2F2 TSC2 MYLK LRAT WFS1 ND6 SRY SMOC1 FAM149B1 PLEC TPM3 KRT9 ACTA1 SETBP1 OTX2 CEP164 BBS2 RTEL1 PIK3CA AP3D1 MBTPS2 H19 FMR1 CCND2 BBS12 TJP2 TEK FIG4 ABCG5 ABCC9 CACNA1S USH2A GDF2 SOX18 CYBB C8ORF37 RYR1 GAA OTUD6B RAG1 PTH1R TNNI3K CYP17A1 COL4A1 TRNS2 ERF ERBB3 TNNT2 TF CAV1 PEX1 TFRC ARL6 C1S PIGT PRDM16 SEMA4A KIT PPP1R15B PRKAG2 PCNT HDAC4 A2ML1 CHD7 LMNA HYLS1 KCNJ2 PEX2 CTLA4 CEP120 CTLA4 XIAP TRNS2 LIPA TMEM67 BCL6 EPB41 RNF135 FHL1 IGLL1 FBN1 KCNJ8 GALE NDUFAF1 CCDC28B CFHR3 MED12 POMT1 TRIP4 IRF8 PEX12 DHCR7 TLR4 ACTA1 PIGN PRKCD PROKR2 AKT3 C2 SLC12A3 SDHA CD109 RHAG LAMC2 XIAP ASXL2 CDKN1B CHD7 IGH AGTR1 FLNA SNRPB WNT3 LAMA4 CHRNA7 HADH NOTCH3 TBX6 STING1 PEX6 CD40LG ZMPSTE24 SEC23B RAB27A ABCB6 GATA1 NBEAL2 SEMA3E GPIHBP1 EXT2 PEX19 NRXN1 WIPI2 HADHB PALB2 UROS CHD7 CTNND2 BRIP1 TCIRG1 SOX3 AQP5 TBX1 MYL4 VWF DNAJB13 CPT2 RPS28 FSCN2 KCNE1 NDUFS8 ABCC6
Pneumonia
Genes 208
TIMM8A DNAH9 GAS8 DNAH11 TNFRSF11A TBC1D24 SPAG1 MS4A1 GAS2L2 CCDC151 NIPBL BTK LIG4 NFKB2 TCIRG1 IGLL1 RNF168 STAT3 TAF1 RSPH4A CFTR NME8 DNAAF4 LEP CCDC65 NADK2 CD55 COL11A2 NHLRC1 PEPD CFAP300 LTBP3 WAS DNAI1 TBCD IL2RG GFI1 NBN RSPH1 CCDC39 PMM2 ICOS TNFSF12 IFNGR1 CARD11 SFTPC DNAL1 OFD1 ZMYND10 IL21R FMO3 SLC35A1 PLOD1 ORC6 RAG2 CACNA1C GAS8 RYR1 CFAP298 GNPTAB TNFRSF13B KDM6A PANK2 RANBP2 CYBA USB1 UBB DOCK8 ADA DNAAF2 KMT2D SAMD9 MUC5B IL7R DNAAF1 ICOS RAG2 CARD11 PTPRC ALMS1 NOTCH3 NSMCE3 DNAI1 TNFRSF13C GRHL3 EGFR IL2RG DNAAF6 PNP DNAH5 SETBP1 CR2 CD3E ADA MASP2 SFTPA2 ACTA1 RAC1 TTC25 FCGR2A ZAP70 SPEF2 IGHM DNAAF5 NBN CD247 DDR2 CD19 ACADVL KIAA0586 TK2 BLNK ARMC4 SGCG RAG1 CXCR4 NCF1 SRP54 FOXP3 IRF8 CFAP221 RNU4ATAC KCNJ6 LRBA CD3D P4HTM SELENON CCDC114 TNFRSF13B PLG DCLRE1C SLC25A24 DCLRE1C ICOS IL7R FOXJ1 JAK3 IL2RG CASP8 RAG1 OSTM1 CFAP410 CCNO NCF2 UNC119 TNFRSF13C JAK3 RNF125 STK36 POLA1 CD19 CR2 DNAH1 RSPH3 RSPH9 CYBB DRC1 DCLRE1C CCDC103 DNAAF3 LRRC56 PIGN LRRC6 SP110 PRKCD ACP5 CCDC40 SLC35C1 BTK MTHFD1 PGM3 RAG1 TERT CHD7 CFB TGFB1 RNU4ATAC SMARCD2 NKX2-1 OFD1 ZBTB24 BTK DNAI2 WDR19 ZAP70 CD79B CD81 COL11A2 NFIX RAG2 ELANE AFF4 NFKB1 IL2RG TNFRSF13C TNFSF12 CCDC114 ADA GBA DNAJB13 RPGR CSPP1 RMRP EPM2A DNMT3B NFKB2 MCIDAS HYDIN