SNPMiner Trials (Home Page)
Report for Mutation T117S
 Developed by Shray Alag, 2020.
SNP Clinical Trial Gene 
There is one clinical trial. 
Clinical Trials
      This is a prospective, observational study that will examine endothelial dysfunction in
      atrial fibrillation before and after treatment with anti-arrhythmic agents and the extent to
      which baseline endothelial dysfunction improves after treatment.
    
Whether missense mutation in Cyb5R3 T117S can predict atrial fibrillation recurrence.. null. --- T117S --- 
Whether missense mutation in Cyb5R3 T117S is correlated with atrial fibrillation severity.. null. --- T117S --- 
  Primary Outcomes 
 Description: Change in microvascular endothelium dependent dilation (in response to acetylcholine) assessed with laser speckle contrast imaging after initiating antiarrhythmic medical therapy.
 Measure: Change in microvascular endothelium dependent dilation following anti-arrhythmic therapy as measured in perfusion units
 Time: 1 year
  Secondary Outcomes 
 Measure: Correlation between microvascular endothelial dysfunction measured at baseline and atrial fibrillation recurrence.
 Time: 1 year
 Measure: Correlation between microvascular endothelial function improvement with antiarrhythmic medications and atrial fibrillation recurrence.
 Time: 1 year
 Measure: Correlation between microvascular endothelial function and atrial fibrillation severity represented by left atrial size and type of Afib (paroxysmal vs persistent).
 Time: 1 year
 Measure: Change in other vasodilation dysfunction indices measured after initiating antiarrhythmic medical therapy.
 Time: 1 year
 Measure: Correlation between vasodilation dysfunction indices measured at baseline and atrial fibrillation recurrence.
 Time: 1 year
 Measure: Whether missense mutation in Cyb5R3 
T117S can predict atrial fibrillation recurrence.
 Time: 1 year
 Measure: Whether missense mutation in Cyb5R3 
T117S is correlated with atrial fibrillation severity.
 Time: 1 year
HPO Nodes
Paroxysmal atrial fibrillation 
Genes 12
KCNJ5  SCN5A  CSRP3  KCNA5  KCNJ2  SCN2B  MYL4  ABCC9  TBX5  KCNE2  SCN1B  PRKAG2   hr>