SNPMiner Trials (Home Page)
Report for Mutation G1051A
 Developed by Shray Alag, 2020.
SNP Clinical Trial Gene 
There is one clinical trial. 
Clinical Trials
      Renin-angiotensin-aldosterone system (RAAS) polymorphisms influence 24h arterial pressure
      fluctuation. Resistant systemic arterial hypertension (RSAH) has an increased risk of end
      organ damage and unfavourable prognosis, whereas pseudo-RSAH usually respond favourably to
      drug therapy.
      To prospectively investigate, in subjects with RSAH in a tropical South American city: 1)
      Adverse cardiovascular events defined as fatal and non-fatal stroke or acute myocardial
      infarction (AMI); and 2) the association of RAAS polymorphisms and adverse cardiovascular
      events in this population.
      Study population: 212 hypertensives recruited from primary care assistance (time since first
      diagnosis of hypertension: 16.5±8.1 years) and without appropriate pressure control, between
      2001 and 2006, corresponding to 0.48% of all hypertensives under care (18 new cases/year),
      57±10 years old, 66% females. Under drug treatment schedule: three or more drugs including a
      diuretic. Ninety two randomly selected hypertensives basis had renin-angiotensin-aldosterone
      system genetic profile determined. Genetic assessment was carried out using a polymerase
      chain reaction assay amplification technique. The following single nucleotide polymorphisms
      were analyzed: renin (G1051A), angiotensinogen (M235T), angiotensin converting enzyme-ACE
      (I/D), angiotensin II type 1 receptor (A1166C), aldosterone synthase (C344T) and
      mineralocorticoid receptor (G3514C).
    
The following single nucleotide polymorphisms
      were analyzed: renin (G1051A), angiotensinogen (M235T), angiotensin converting enzyme-ACE
      (I/D), angiotensin II type 1 receptor (A1166C), aldosterone synthase (C344T) and
      mineralocorticoid receptor (G3514C). --- G1051A --- 
  Primary Outcomes 
 Description: Evidence of clinically definite stroke (focal neurological deficits persisting for more than 24 hours) confirmed or not by non-investigational computerized tomography.
Death was considered to be related to the event if occurring up to 30 days after the acute event.
Assessment twice an year by active and direct contact to patients or relatives and review of medical records.
 Measure: Strokes, Either Fatal or Nonfatal
 Time: up to 10 years
  Secondary Outcomes 
 Description: Evidence of clinically definite stroke (focal neurological deficits persisting for more than 24 hours) confirmed or not by non-investigational computerized tomography.
Evidence of clinically definite acute myocardial infarction (prolonged > 20min chest pain, not relieved by sublingual nitrate, ST-T segment deviation on 12-lead surface ECG, elevation of plasma troponin >0.2 ng/dL 6h following chest pain episode).
Death was considered to be related to the event if occurring up to 30 days after the acute event.
Assessment twice an year by active and direct contact to patients or relatives and review of medical records.
 Measure: Composite of Acute Myocardial Infarctions and/or Strokes Either Fatal or Nonfatal
 Time: up to 10 years
HPO Nodes
Hypertension 
Genes 410
GPC3  MPL  PRKAR1A  ABCG8  ND1  CYP11B1  TRNS1  B2M  MMP2  BRCA2  SDCCAG8  HMBS  LYZ  PKD1  C8ORF37  BSCL2  WT1  SCNN1B  SLC25A11  COX2  CEP19  TRNQ  YY1AP1  ECE1  WT1  KCNJ5  ENPP1  FN1  PDE11A  HGD  SLC25A11  HSD11B2  MFAP5  GUCY1A1  DYRK1B  SPRY2  SLC2A10  SMAD6  COX3  SCNN1G  SCNN1B  LARS2  FOXF1  NPHP4  TRNL1  TMEM67  IL12B  HIRA  TRIM28  MLXIPL  CDH23  CLIP2  HLA-B  TRNF  POU6F2  NFU1  SDHC  CEP290  ENPP1  EDA  CYTB  SDCCAG8  HLA-DPB1  SCNN1A  NKX2-5  COL5A1  LEMD3  YY1AP1  TBL2  ALMS1  NOTCH3  CLCN2  ARVCF  SEC24C  CFH  FH  TGFB2  TMEM127  ARMC5  AIP  SDHA  JMJD1C  COX1  ND5  COMT  NF1  CACNA1D  TGFBR1  REST  LDLRAP1  GTF2I  PDE3A  TNFRSF11B  MAT2A  HSD11B2  TRNH  CORIN  SERPINA6  BBS10  AIP  MAFB  FOXE3  SCN2B  SMAD4  CYP11B1  TRNK  SLC52A3  TRNL1  CYP17A1  GBA  SDHB  BBS1  HBB  CCR6  XPNPEP3  ERCC4  VHL  BBS7  GP1BB  TRNE  OSGEP  PPARG  NOS3  TRPC6  HMBS  JAK2  VHL  KRT18  TRNS1  WT1  NPHP1  SDHD  INVS  KCTD1  OFD1  USP8  FIG4  TRIM28  LRIG2  PCSK9  SDHB  SCNN1G  CCN2  COL1A1  TRNL1  WT1  PTPN22  LDLR  PRKAR1A  COX1  VHL  TRNC  COQ7  LEMD3  PRKACA  MKKS  BBS5  SLC52A2  SDHD  TRNW  COX3  RREB1  GPR101  SMAD3  INVS  KIF1B  DNAJB11  COX2  APOA1  RET  ARHGAP31  KCNJ5  WT1  ND5  GDNF  CUL3  GLA  FLT1  ACVRL1  TNFRSF11A  VHL  GNAS  PRTN3  COL3A1  ABCC6  XYLT1  CYP11B1  ADAMTSL4  FGA  C3  COL5A2  BBS9  ERCC6  KCNJ5  FBN1  APOB  BAZ1B  PAM16  POU3F4  TMEM70  ND4  STOX1  GNAS  RFC2  TGFBR2  CALR  IQCB1  CYP21A2  MMP14  SLC37A4  ALX4  TRNQ  TBX1  THPO  GTF2IRD1  GATA5  ND6  FN1  RPGRIP1L  CFB  ANGPTL6  RET  XYLT2  VANGL1  NR3C1  PDE11A  NR3C2  POR  TRNK  BMPR2  MGP  TRNV  SUGCT  RET  MYH11  PRKAR1A  MDH2  FMO3  KLHL3  WNK4  TMEM237  LZTFL1  TRNK  IRF5  STAT1  NSMCE2  MUC1  COL4A4  HLA-DPA1  GLA  IDUA  NOTCH2  TRNW  CC2D2A  SCNN1A  NR3C1  CPOX  USP8  BBS2  ELN  CYP11B2  SMARCAL1  LMX1B  BNC2  TRIM32  MAX  MKS1  PKD2  LRP6  PRKACA  COL3A1  SDHD  NPHP1  MAX  PRKG1  MYLK  HLA-DRB1  DIS3L2  CFI  LMX1B  ACAT1  ELN  EGFR  ND6  ELP1  ELN  SLC37A4  PPARG  CEP164  LMNA  PLIN1  DLST  TP53  TRNF  SMAD4  LOX  UFD1  FMR1  SDHB  NOTCH1  SMAD4  BBS12  IFT172  ABCG5  MYMK  CFHR1  TRIP13  SLC2A10  GJA1  WDPCP  FUZ  CYP17A1  TRNS2  WDR35  MYH7  SDHAF2  LMNA  NPHP3  GUCY1A1  EXT2  HPSE2  OFD1  LMNA  FGFR2  MEF2A  PLIN1  COL4A3  CEP290  ACTA2  KIF1B  CD2AP  TGFB3  FBN1  TRNS2  SH2B3  COL4A5  NOD2  SDHC  PDE3A  G6PC  THBD  FBN1  CAV1  TTC8  ALMS1  ITGA8  LMNA  GANAB  LIMK1  BBIP1  CTLA4  BANF1  CCDC28B  CFHR3  FBN1  H19  CACNA1H  ARMC5  AIP  CCND1  ADA2  ARL6  EDA2R  CBS  SH2B3  TET2  CACNA1D  ADA2  ND1  VAC14  IFT27  PDE8B  CYP11B1  TRAF3IP1  CDH23  BBS1  TMEM127  COL4A3  GNAS  ELP1  ACTA2  NPHP1  MTTP  WNK1  WDR19  ZMPSTE24  CD46  GCH1  KCTD1  ADA2  ABCB6  ACTN4  NFIX  ENG  TGFBR3  ABCC6  WRN  LMNA  BBS4  PKHD1  FGFR2  MC4R  ERCC8  KIF1B  KRT8  TBX1  JAK2  PHF21A  MLX  ABCC6   hr>
Myocardial infarction 
Genes 79
IL12B  TLR4  LDLRAP1  LDLR  GTF2I  GLA  APOB  STAT4  CCR1  BAZ1B  IKZF1  TP53  SH2B3  CLIP2  ABCG8  CYP27A1  MYH9  CTNNB1  HLA-B  AGPAT2  ELN  FOS  RFC2  ENPP1  CAVIN1  ERAP1  MEF2A  MYH9  BCHE  CAV1  MEFV  LRP6  LMNA  HLA-B  LPL  THOC2  CYP27A1  KLRC4  TET2  IL10  SCNN1B  UBAC2  CEP19  HLA-B  PIGA  TBL2  CFTR  RAF1  MPL  BRAF  C4A  GTF2IRD1  IL12A-AS1  CALR  IL12A  IL23R  JAK2  SCNN1A  ABCA1  WRN  JAK2  SCNN1G  HGD  PTPN11  MEFV  BSCL2  CBS  LIMK1  ABCA1  DYRK1B  BRAF  SLC2A10  SH2B3  PPARG  PCSK9  FAS  ABCG5  MLX  ABCC6   hr>